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| 1 | Keystone design perforator island flap in facial defect reconstruction显示文摘Facial defect coverage is a common subject in the field of reconstructive surgery.There are many methods for facial defect reconstruction,and reconstructive surgeons should choose the most appropriate method on a case-by-case basis to achieve both functional and aesthetic improvement.Among various options for facial reconstruction,the local flap technique is considered the best reconstructive modality to provide good tissue matches of color and texture,which is consistent with the ideal goal of reconstruction(replacement of like-with-like).Keystone design perforator island flap(KDPIF),devised by Behan in 2003,has been applied to various fields of reconstructive surgery in the past decade due to its design simplicity,robust vascular supply,and reproducibility.Several studies have reported KDPIF reconstruction of facial defects,such as large parotid defects,small-to-moderate nasal defects,and eyelid defects.However,KDPIF has been used relatively less in facial defects than in other body regions,such as the trunk and extremities.The purpose of this review is to provide an organized overview of facial KDPIF reconstruction including the classification of KDPIF,modifications,physiology,mechanism of flap movement,consideration of facial relaxed skin tension lines and aesthetics,surgical techniques,clinical applications,and precautions for successful execution of KDPIF reconstruction. | Soo Yeon Lim Chi Sun Yoon Hyun Gun Lee Kyu Nam Kim | 2020 | World Journal of Clinical Cases2020，8，10： | 5 |
| 2 | Thioredoxin Reductase Type C (NTRC) Orchestrates Enhanced Thermotolerance to Arabidopsis by Its Redox-Dependent Holdase Chaperone Function显示文摘Genevestigator 分析为 NADPH-thioredoxin reductase 显示了抄本感应的热吃惊,在光的类型 C (NTRC ) 。这里,我们在 Arabidopsis 显示出 NTRC 的 overexpression | Ho Byoung Chae Jeong Chan Moon Mi Rim Shin Yong Hun Chi Young Jun Jung Sun Yong Lee Ganesh M. Nawkar Hyun Suk Jung Jae Kyung Hyun Woe Yeon Kim Chang Ho Kang Dae-Jin Yun Kyun Oh Lee Sang Yeol Lee | 2013 | Molecular Plant2013，6，2： | 5 |
| 3 | Biocompatible custom ceria nanoparticles against reactive oxygen species resolve acute inflammatory reaction after intracerebral hemorrhage显示文摘Intracerebral 出血(ICH ) 是有高死亡率,当前为没有有效治疗的击的一种破坏子类型。强烈煽动性的反应引起的 perihematomal 浮肿自己比 hematoma 更有害并且能导致神经病学的恶化和死亡。Ceria nanoparticles (CeNPs ) 是有势力有为生物医学的应用的潜力的免费激进的 scavengers。当氧化应力在 post-ICH 发炎起一个主要作用,我们假设了那 CeNPs 可能免于 ICH。测试这个假设,核心 CeNPs 用一个修改反向的 micelle 方法被综合并且用 phospholipid 聚乙烯乙二醇(木钉) 盖住完成 biocompatibility。我们调查了是否我们的定做的 biocompatible CeNPs 对 ICH 有保护的效果。CeNPs 在 vitro 减少了氧化应力,导致 hemin 的 cytotoxicity,和发炎。在一个啮齿类动物 ICH 模型,静脉内地管理了 CeNPs,建议他们能通过损坏血大脑障碍扩散是主要在出血性的半球散布了。而且, CeNPs 在出血性的损害和煽动性的蛋白质表示附近稀释了 microglia/macrophage 招募。最后, CeNP 处理作为与控制相比在 68.4% 减少了大脑浮肿。这些结果与 ICH 为病人作为一个新奇治疗学的代理人揭示 CeNPs 的大潜力。 | Dong-Wan Kang Chi Kyung Kim Han-Gil Jeong Min Soh Taeho Kim In-Young Choi SeuI-Ki Ki Do Yeon Kim Wookjin Yang Taeghwan Hyeon Seung-Hoon Lee | 2017 | Nano Research2017，10，8： | 3 |
| 4 | Bioelectrocatalytic detection of glycated hemoglobin (HbA 1c ) based on the competitive binding of target and signaling glycoproteins to a boronate-modified surface显示文摘 | Seung Yeon Song Yong Duk Han Yoo Min Park Chi Yong Jeong Yong Ju Yang Moo Sub Kim Yunhee Ku Hyun C. Yoon | 2012 | Biosensors and Bioelectronics2012，，1： | 1 |
| 5 | Phospholipid profiling of 57 soybean(Glycine max)varieties by high-performance liquid chromatography-tandem mass spectrometry and principal component analysis to classify Korean soybean germplasm显示文摘 | Semin Park Soo Taek Kim Chi Yeon Kim | 2012 | Biomedical Chromatography2012，27，1： | 1 |
| 6 | Endodermal sinus tumour associated with benign teratoma of the common bile duct显示文摘 | W. S. Kim B. I. Choi Y. S. Lee J. G. Chi H. R. Park I. Kim K. M. Yeon M. C. Han | 1993 | Pediatric Radiology1993，，1： | 1 |
| 7 | Synthesis and PGE2 inhibitory activity of vinylated and allylated chrysin analogues显示文摘 | Tran Thanh Dao Jeong Won Oh Yeon Sook Chi Hyun Pyo Kim Kwan-Seog Sin Haeil Park | 2003 | Archives of Pharmacal Research2003，，8： | 1 |
| 8 | Effects of the chestnut inner shell extract on the expression of adhesion molecules, fibronectin and vitronectin, of skin fibroblasts in culture显示文摘 | Yeon Sook Chi Moon Young Heo Ji Hun Chung Byoung Kee Jo Hyun Pyo Kim | 2002 | Archives of Pharmacal Research2002，，4： | 1 |
| 9 | Effects of wogonin, a plant flavone from Scutellaria radix , on skin inflammation: in vivo regulation of inflammation-associated gene expression显示文摘 | Yeon Sook Chi Hyun Lim Haeil Park Hyun Pyo Kim | 2003 | Biochemical Pharmacology2003，，7： | 1 |
| 10 | Fragmentation stability and retention time-shift obtained by LC-MS/MS to distinguish sialylated N-glycan linkage isomers in therapeutic glycoproteins显示文摘Sialylated N-glycan isomers withα2-3 orα2-6 linkage(s)have distinctive roles in glycoproteins,but are difficult to distinguish.Wild-type(WT)and glycoengineered(mutant)therapeutic glycoproteins,cytotoxic T lymphocyte-associated antigen-4-immunoglobulin(CTLA4-Ig),were produced in Chinese hamster ovary cell lines;however,their linkage isomers have not been reported.In this study,N-glycans of CTLA4-Igs were released,labeled with procainamide,and analyzed by liquid chromatography-tandem mass spectrometry(MS/MS)to identify and quantify sialylated N-glycan linkage isomers.The linkage isomers were distinguished by comparison of 1)intensity of the N-acetylglucosamine ion to the sialic acid ion(Ln/Nn)using different fragmentation stability in MS/MS spectra and 2)retention time-shift for a selective m/z value in the extracted ion chromatogram.Each isomer was distinctively identified,and each quantity(>0.1%)was obtained relative to the total N-glycans(100%)for all observed ionization states.Twenty sialylated N-glycan isomers with onlyα2-3 linkage(s)in WT were identified,and each isomer's sum of quantities was 50.4%.Furthermore,39 sialylated N-glycan isomers(58.8%)in mono-(3 N-glycans;0.9%),bi-(18;48.3%),tri-(14;8.9%),and tetra-(4;0.7%)antennary structures of mutant were obtained,which comprised mono-(15 N-glycans;25.4%),di-(15;28.4%),tri-(8;4.8%),and tetra-(1;0.2%)sialylation,respectively,with onlyα2-3(10 N-glycans;4.8%),bothα2-3 andα2-6(14;18.4%),and onlyα2-6(15;35.6%)linkage(s).These results are consistent with those forα2-3 neuraminidase-treated N-glycans.This study generated a novel plot of Ln/Nn versus retention time to distinguish sialylated N-glycan linkage isomers in glycoprotein. | Chi Soo Park Minju Kang Ahyeon Kim Chulmin Moon Mirae Kim Jieun Kim Subin Yang Leeseul Jang Ji Yeon Jang Ha Hyung Kim | 2023 | Journal of Pharmaceutical Analysis2023，13，3： | 0 |
| 11 | Customized lipid-coated magnetic mesoporous silica nanoparticle doped with ceria nanoparticles for theragnosis of intracerebral hemorrhage显示文摘Intracerebral 出血(ICH ) ,在大脑以内由一根动脉的突然的破裂引起了,是击的一种破坏子类型,它当前没有有效处理。在 ICH 以后发生在 peri-hematomal 区域的强烈煽动性的反应自己比 hematoma 更有害,导致随后的大脑浮肿和神经恶化。因此,我们开发了与 ceria nanoparticles (CeNPs ) 做的类脂化合物涂的磁性的 mesoporous 硅石 nanoparticles,作为 LMC 缩短了,它两个都有有势力经由清除的反煽动性的治疗学的效果在在 peri-hematomal 区域增加磁性的回声成像改进的功效的反应的氧种类和帮助。LMC 由支持 nanoparticle 的类脂化合物 bilayers,为反应的氧种类清除与大量 CeNPs 被装载,和为磁性的回声成像的氧化铁 nanoparticles 对比的 mesoporous 硅石组成。与 CeNPs 装载的 LMC 在 vitro 展出了强壮的抗氧化、反煽动性的活动。在啮齿类动物 ICH 模型, intracerebrally 注射了 LMC 到达了 peri-hematomal 区域并且被巨噬细胞吞没,它被大脑的磁性的回声成像清楚地设想。而且, LMC 减少了煽动性的巨噬细胞渗入,并且显著地因此减少了大脑浮肿。最后, LMC 处理显著地与 ICH 改进了动物的神经结果。因此, LMC 是成功地在 ICH 显示出 theragnostic 效果的第一 nanobiomaterial。 | Bong Geun Cha Han-Gil Jeong Dong-Wan Kang Myong-Joo Nam Chi Kyung Kim Do Yeon Kim In-Young Choi Seul Ki Ki Song I Kim Ju hee Han Jaeyun Kim Seung-Hoon Lee | 2018 | Nano Research2018，11，7： | 0 |
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