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| 1 | Prevalence of minimal hepatic encephalopathy and quality of life evaluations in hospitalized cirrhotic patients in China显示文摘AIM:To investigate the prevalence of minimal hepatic encephalopathy(MHE)and to assess corresponding health-related quality of life(HRQoL)in hospitalized cirrhotic patients in China.METHODS:This multi-center cross-sectional study included 16 teaching hospitals,which were members of 'Hepatobiliary Cooperation Group,Society of Gastroenterology,Chinese Medical Association',from different areas of China carried out between June and October in 2011.All the eligible hospitalized cirrhotic patients(n = 538)were required to complete triplicate number connection tests combined with one digit symbol test for diagnosing MHE.Patients' clinical examination data were complemented by a modified questionnaire assessing HRQoL.Written informed consent was obtained from each patient.RESULTS:Male was predominant(68.6%)in 519 patients who met the criteria of the study,with a mean age of 49.17 ± 11.02 years.The most common cause of liver cirrhosis was chronic hepatitis B(55.9%).The prevalence of MHE was 39.9% and varied by ChildPugh-Classification score(CPC-A:24.8%,CPC-B:39.4% and CPC-C:56.1%,P < 0.01).MHE(P < 0.01)and higher CPC scores(P < 0.01)were associated with a high HRQoL scores(reflecting poorer quality of life).The prevalence of MHE was proportionate to CPC(P = 0.01)and high quality of life scores(P = 0.01).CONCLUSION:Hospitalized cirrhotic patients have a high prevalence of MHE that is proportionate to the degree of liver function and HRQoL impairment. | Ji-Yao Wang Ning-Ping Zhang Bao-Rong Chi Yu-Qing Mi Li-Na Meng Ying-Di Liu Jiang-Bin Wang Hai-Xing Jiang Jin-Hui Yang Yun Xu Xiao Li Jian-Ming Xu Guo Zhang Xin-Min Zhou Yu-Zheng Zhuge De-An Tian Jin Ye Yu-Lan Liu | 2013 | World Journal of Gastroenterology2013，19，30： | 64 |
| 2 | Predictive Value of Serum Creatinine, Blood Urea Nitrogen,Uric Acid, and β2-Microglobulin in the Evaluation of Acute Kidney Injury after Orthotopic Liver Transplantation显示文摘 | Hai-Yang Lu Xin-Yu Ning Ying-Qi Chen Shu-Jun Han Ping Chi Sai-Nan Zhu Yun Yue | 2018 | Chinese Medical Journal2018，，9： | 23 |
| 3 | Differences in cognitive profiles between traumatic brain injury and stroke: A comparison of the Montreal Cognitive Assessment and Mini-Mental State Examination显示文摘与长期的创伤的大脑损害(TBI ) 或击在病人通过蒙特利尔认知评价(MoCA ) 和微型心理的州的检查(MMSE ) 调查认知缺陷的侧面并且评估二的敏感的目的与 TBI 在病人可伸缩。在这个队的方法学习, 230 个病人的一个总数被评估,包括 TBI 组(n = 103 ) 并且击组(n = 127 ) 。二个组的认知功能被指明的专家用 MoCA (北京版本) 和 MMSE (中国版本) 评估。结果与有击的病人,相比,有收到的 TBI 的病人显著地在两测试在取向 subtest 和召回 subtest 降低 20。当 MMSE 反常的率分别地是 69.90% 和 57.48% 时,在 TBI 组和击组的 MoCA 反常的率分别地是 94.17% 和 86.61% 。在 TBI 组,有正常 MMSE 分数的 87.10% 病人让反常 MoCA 得分并且在击组织,有正常 MMSE 的大约 70.37% 病人获得有的反常 MoCA 分数。在 TBI 组和击组的二规模的诊断一致性分别地是 72% 和 69% 。在我们的康复中心的结论,有 TBI 的病人可以与击比病人有更广泛、严重的认知缺陷,显著地在取向和召回领域。在屏蔽 post-TBI 认知缺陷, MoCA 趋于比 MMSE 更敏感。 | Hao Zhang Xiao-Nian Zhang Hui-Li Zhang Liang Huang Qian-Qian Chi Xin Zhang Xiao-Ping Yun | 2016 | Chinese Journal of Traumatology2016，19，5： | 8 |
| 4 | Effects of adding bulking agents on the biodrying of kitchen waste and the odor emissions produced显示文摘The effects of adding a bulking agent on the performance and odor emissions(ammonia and eight sulfur-containing odorous compounds) when biodrying kitchen waste were investigated. Three treatments were considered: the addition of either cornstalks(CS) or wood peat(WP) to kitchen waste as a bulking agent before biodrying, and a control treatment(CK). The water-removal rates for CK, CS, and WP treatments were 0.35, 0.56, and0.43 kg/kg, respectively. Addition of bulking agents to kitchen waste produced less leachate,higher moisture-removal rates, and lower consumption of volatile solids. The CS treatment had the highest biodrying index(4.07), and those for the WP and CK treatments were 3.67 and 1.97, respectively. Adding cornstalks or wood peat decreased NH3 emissions by 55.8%and 71.7%, respectively. Total sulfur losses were 3.6%–21.6% after 21 days biodrying, and H2 S and Me2 SS were the main(> 95%) sulfur compounds released. The smallest amounts of sulfur-containing odorous compounds were emitted when cornstalks were added, and adding cornstalks and wood peat decreased total sulfur losses by 50.6%–64.8%. | Jing Yuan Yun Li Hongyu Zhang Difang Zhang David Chadwick Guoxue Li Guoying Wang Menghao Chi Fan Yang | 2018 | Journal of Environmental Sciences2018，30，5： | 7 |
| 5 | Serum Hepatitis B Surface Antigen Quantitation Can Reflect Hepatitis B Virus in the Liver and Predict Treatment Response显示文摘 | Henry Lik–Yuen Chan Vincent Wai–Sun Wong Ada Mei–Ling Tse Chi–Hang Tse Angel Mei–Ling Chim Hoi–Yun Chan Grace Lai–Hung Wong Joseph Jao–Yiu Sung | 2007 | Clinical Gastroenterology and Hepatology2007，，12： | 7 |
| 6 | MicroRNA-29a attenuates angiotensin-Ⅱ induced-left ventricular remodeling by inhibiting collagen,TGF-β and SMAD2/3 expression显示文摘Background Left ventricular(LV)remodeling is the most common target organ damage in hypertension.Previously,our study found that plasma microRNA-29a(miR-29a)level was associated with the LV remodeling in hypertensive patients.However,the causal relationship between miR-29a and LV remodeling remains unknown.Thus,the aim of this study was to investigate the regulation mechanism of miR-29a in LV remodeling.Methods&Results Overexpression and knockdown miR-29a mice were generated by tail-intravenous injection of miR-29a-mimic and inhibitor lentivirus for one week respectively.Then the mice were subjected to angiotensin-II(AngII)induced LV remodeling by subcutaneous AngII capsule osmotic pumping into AngII for four weeks.AngII-induced LV remodeling mice as the model group(n=9).Age-matched male SPF C57/BL6J mice(6–8 weeks old)were treated with the pumping of saline as a vehicle(n=6).In vivo,overexpression miR-29a ameliorated AngII-induced LV remodeling,while knockdown miR-29a deteriorated LV remodeling.Simultaneously,we observed that overexpression miR-29a mice inhibited but knockdown miR-29a mice increased cardiac cross-sectional area,indicating that miR-29a has an antagonistic effect on cardiac hypertrophy.Further studies found that overexpression miR-29a inhibited the content of the LV collagen including collagen I and III.Moreover,the expression of transforming growth factor-β(TGF-β)and phosphorylated SMAD2/3 decreased with the down-regulation of collagen I and III in overexpression miR-29a mice.Conclusions Our finding indicates that overexpression miR-29a attenuates LV remodeling by inhibiting collagen deposition,TGF-β,and phosphorylated SMAD2/3 expression.Thus,intervention miR-29a may be a therapeutic target for attenuating LV remodeling. | Si-Jin ZHANG Cui-Juan YUN Jie LIU Si-Yu YAO Yao LI Miao WANG Chi WANG Yong-Yi BAI Hao XUE | 2020 | Journal of Geriatric Cardiology2020，17，2： | 7 |
| 7 | Study of Clinical and Genetic Risk Factors for Aspirin-inducec Gastric Mucosal Injury显示文摘 | Yun Wu Ying Hu Yu-Jing Chi Jian-Hua Zhou Yuan-Yuan Zhang Yu-Lan Liu | 2016 | Chinese Medical Journal2016，，2： | 6 |
| 8 | Thioredoxin Reductase Type C (NTRC) Orchestrates Enhanced Thermotolerance to Arabidopsis by Its Redox-Dependent Holdase Chaperone Function显示文摘Genevestigator 分析为 NADPH-thioredoxin reductase 显示了抄本感应的热吃惊,在光的类型 C (NTRC ) 。这里,我们在 Arabidopsis 显示出 NTRC 的 overexpression | Ho Byoung Chae Jeong Chan Moon Mi Rim Shin Yong Hun Chi Young Jun Jung Sun Yong Lee Ganesh M. Nawkar Hyun Suk Jung Jae Kyung Hyun Woe Yeon Kim Chang Ho Kang Dae-Jin Yun Kyun Oh Lee Sang Yeol Lee | 2013 | Molecular Plant2013，6，2： | 5 |
| 9 | Establishing a nonlethal and efficient mouse model of male gonadotoxicity by intraperitoneal busulfan injection显示文摘An ideal animal model of azoospermia would be a powerful tool for the evaluation of spermatogonial stem cell(SSC)transplantation.Busulfan has been commonly used to develop such a model,but 30%–87%of mice die when administered an intraperitoneal injection of 40 mg kg^?1.In the present study,hematoxylin and eosin staining,Western blot,immunofluorescence,and quantitative real-time polymerase chain reaction were used to test the effects of busulfan exposure in a mouse model that received two intraperitoneal injections of busulfan at a 3-h interval at different doses(20,30,and 40 mg kg^?1)on day 36 or a dose of 40 mg kg^?1 at different time points(0,9,18,27,36,and 63 days).The survival rate of the mice was 100%.When the mice were treated with 40 mg kg^?1 busulfan,dramatic SSC depletion occurred 18 days later and all of the germ cells were cleared by day 36.In addition,the gene expressions of glial cell line-derived neurotrophic factor(GDNF),fibroblast growth factor 2(FGF2),chemokine(C-X-C Motif)ligand 12(CXCL12),and colony-stimulating factor 1(CSF1)were moderately increased by day 36.A 63-day,long-term observation showed the rare restoration of endogenous germ cells in the testes,suggesting that the potential period for SSC transplantation was between day 36 and day 63.Our results demonstrate that the administration of two intraperitoneal injections of busulfan(40 mg kg^?1 in total)at a 3-h interval to mice provided a nonlethal and efficient method for recipient preparation in SSC transplantation and could improve treatments for infertility and the understanding of chemotherapy-induced gonadotoxicity. | Yun Xie Cun-Can Deng Bin Ouyang Lin-Yan Lv Jia-Hui Yao Chi Zhang Hai-Cheng Chen Xiao-Yan Liang Xiang-Zhou Sun Chun-Hua Deng Gui-Hua Liu | 2020 | Asian Journal of Andrology2020，22，2： | 5 |
| 10 | Exposure Effects of Terahertz Waves on Primary Neurons and Neuron-like Cells Under Nonthermal Conditions显示文摘Objective This study aimed to explore the potential effects of terahertz(THz) waves on primary cultured neurons from 4 rat brain regions(hippocampus, cerebral cortex, cerebellum, and brainstem)and 3 kinds of neuron-like cells(MN9 D, PC12, and HT22 cells) under nonthermal conditions.Methods THz waves with an output power of 50(0.16 THz) and 10(0.17 THz) m W with exposure times of 6 and 60 min were used in this study. Analysis of temperature change, neurite growth, cell membrane roughness, micromorphology, neurotransmitters and synaptic-related proteins(SYN and PSD95) was used to evaluate the potential effects.Results Temperature increase caused by the THz wave was negligible. THz waves induced significant neurotransmitter changes in primary hippocampal, cerebellar, and brainstem neurons and in MN9 D and PC12 cells. THz wave downregulated SYN expression in primary hippocampal neurons and downregulated PSD95 expression in primary cortical neurons.Conclusion Different types of cells responded differently after THz wave exposure, and primary hippocampal and cortical neurons and MN9 D cells were relatively sensitive to the THz waves. The biological effects were positively correlated with the exposure time of the THz waves. | TAN Sheng Zhi TAN Peng Cheng LUO Lan Qing CHI Yun Liang YANG Zi Long ZHAO Xue Long ZHAO Li DONG Ji ZHANG Jing YAO Bin Wei XU Xin Ping TIAN Guang CHEN Jian Kui WANG Hui PENG Rui Yun | 2019 | Biomedical and Environmental Sciences2019，32，10： | 5 |
| 11 | Long‐term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B显示文摘 | Ting‐Tsung Chang Yun‐Fan Liaw Shun‐Sheng Wu Eugene Schiff Kwang‐Hyub Han Ching‐Lung Lai Rifaat Safadi Samuel S. Lee Waldemar Halota Zachary Goodman Yun‐Chan Chi Hui Zhang Robert Hindes Uchenna Iloeje Suzanne Beebe Bruce Kreter | 2010 | Hepatology2010，，： | 4 |
| 12 | High performance and stability of double perovskite-type oxide NdBa0.5Ca0.5Co1.5Fe0.5O5+δas an oxygen electrode for reversible solid oxide electrochemical cell显示文摘In this study,we successfully synthesized double perovskite-type oxide NdBa0.5Ca0.5Co1.5Fe0.5O5+δ(NBCCF)using a conventional wet chemical method as the oxygen electrode for reversible solid oxide electrochemical cells(RSOCs).The polarization resistance(Rp)of the composite electrode NBCCFGd0.1Ce0.9O2(GDC)is only 0.079Ωcm^2 at 800℃under air.The single cell based on NBCCF-GDC electrode displays a peak power density of 0.941 W/cm^2 in fuel cell mode and a low Rp value of 0.134Ωcm^2.In electrolysis cell mode,the cell displays an outstanding oxygen evolution reaction(OER)activity and shows current density as high as 0.92 A/cm^2 with 50 vol%AH(Absolute Humidity)at 800℃and applied voltage of 1.3 V.Most importantly,the cell exhibits admirable durability of 60 h both in electrolysis mode and fuel cell mode with distinguished reversibility.All these results suggest that NBCCF is a promising candidate electrode for RSOC. | Yunfeng Tian Yun Liu Wenjie Wang Lichao Jia Jian Pu Bo Chi Jian Li | 2020 | Journal of Energy Chemistry2020，29，4： | 4 |
| 13 | Integrin β4 was downregulated on the airway epithelia of asthma patients显示文摘流上皮的功能的动态平衡的上皮的房间和损失是的航线气喘的主要病理学的特征;然而,位于这些病理下面的机制仍然保持阴暗。我们的以前的工作证明在 integrin 的 5 flanking 区域有三个变化地点 4 在气喘病人,它与 integrin 的减少的表示被相关 4 在外部白血球。Integrin 4 是航线 epithelia 上的一个重要结构的粘附分子保留上皮的房间的结构的粘附。在这个工作,我们进一步表明了 4 表示是的那 integrin 在气喘病人的航线 epithelia 的 downregulated。探查在 integrin 的 imbalanced 表示之间的关系 4 并且航线的机能障碍在气喘的上皮的房间, integrin 4 由 integrin 是在人的支气管的上皮房间(16HBE14O ) 的 silenced 4 小介入的 RNA lentivirus 向量。在 integrin 的 silencing 之上 4, 16HBE14O 房间显示出减少的增长和创伤修理。大多数房间被显示在 integrin 以后在 G1 阶段被逮捕 4 silencing,和增加的 apoptosis 在 integrin 4 沉默房间被导致。在摘要,我们的结果提供了引人注目的证据那 integrin 4 涉及结构的正直和航线的功能的动态平衡上皮的房间。它是可能的 4 在气喘航线 epithelia 上贡献的 integrin 的那 downregulation 航线的结构的混乱和机能障碍上皮的房间。 | Chi Liu Yang Xiang Huijun Liu Yun Li Yurong Tan Xiaolin Zhu DanZeng Menglan Li Liwen Zhang Xiaoqun Qin | 2010 | Acta Biochimica et Biophysica Sinica2010，42，8： | 4 |
| 14 | Phase-field simulation of solidification dendritic segregation in Ti-45Al alloy显示文摘The microstructures and mechanical properties of Ti Al alloys are directly linked to micro-segregation which cannot be avoided during solidification. So a thorough understanding of the micro-segregation should be a great help to further enhance the mechanical properties of the cast products. Theoretical analysis and experiments have been used to predict the micro-segregation, but it is very difficult to observe and determine the dendritic segregation in the micro region. Phase-field method has been employed for the simulation of dendritic growth. However, due to the complicated quasi-sub regular solution model for Ti-45Al(at.%) alloy, the classic phase-field models have difficulty to deal with the free energy. In this work, a phase-field model by linking thermodynamic calculation was used to simulate solidification dendritic segregation of Ti-45 Al alloy for Liquid→Liquid+β(Ti). The free energies of solid phase and liquid phase for Ti-45 Al alloy were calculated by Thermo-Calc and then coupled with the phase-field equations. The simulation results show the dendritic morphology and Al content variations between liquid and growing solid phase for Ti-45 Al alloy. With the growth of the β(Ti), dendritic segregation is formed in the liquid and solid phases due to the solute partitioning and rejection into the liquid. As a result, the dendrite arms are depleted of Al element, while the inter-dendrites are enriched. The dendritic tip growth velocity decreases with the progress of solidification, whereas the segregation ratio increases. | Yu-tuo Zhang Yun Chi Chun-qing Hu | 2017 | China Foundry2017，14，3： | 3 |
| 15 | Current status and future applications of contrast-enhanced endoscopic ultrasonography显示文摘Endoscopic ultrasonography(EUS) is currently an in-tegral investigation of many gastrointestinal disorders.It has been shown to have a higher efficacy thanconventional computed tomography in detection andcharacterization of small lesions especially in the pan-creas. Much effort has been put to further improvethe sensitivity, specificity and overall accuracy of EUS.One of the major advances is the utilization of contrastagents for better delineation of the vascularity and tis-sue perfusion of the target lesion. This article describesthe basic principles of ultrasound contrast agents andthe different modalities used in contrast-enhanced EUS(CE-EUS) including contrast-enhanced Doppler EUS(CED-EUS) and contrast-enhanced harmonic EUS(CEH-EUS). In addition, the current applications of contrastenhanced EUS in different gastrointestinal conditionswere discussed. Furthermore, the future developmentof hybrid approaches combining CE-EUS with other im-aging modalities and the potential therapeutic aspectof using it as a vector for drug delivery were also dis-cussed. | Hon Chi Yip Anthony Yuen Bun Teoh Charing Ching Ning Chong James Yun Wong Lau | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，4： | 3 |
| 16 | Effects of Cerium on Microstructures and Mechanical Properties of Zn-22%Al Vibration Damping Alloy显示文摘Using natural aging and artificial aging treatment, the effects of cerium on microstructures and mechanical properties of Zn 22%Al vibration damping alloy were studied by optical microscope, transmission electron microscope and scanning electron microscope. The results show that cerium can refine the microstructure of Zn 22%Al alloy, slow the grain growth and retain the equiaxial degree during aging. The strength of Zn 22%Al (0 07%~0 20%)Ce alloy and Zn 22%Al alloy remains constant after aging below the hot rolling temperature of 80 ℃, and cerium can improve the strength and the stability of mechanical properties of Zn 22%Al alloy. | PANG Shao ping, SHI Yun bao, LI Jun, YANG Bin jiu, QUAN Mei hua, QIAO Yan hui, ZHANG Chi zhong (College of Mechanical Engineering, Beihua University, Jilin 132021, China) | 2000 | Journal of Rare Earths2000，18，4： | 3 |
| 17 | Liver fibrosis progression in chronic hepatitis B patients positive for hepatitis B e antigen: A prospective cohort study with paired transient elastography examination显示文摘 | Grace Lai‐Hung Wong Henry Lik‐Yuen Chan Zhuo Yu Hoi‐Yun Chan Chi‐Hang Tse Vincent Wai‐Sun Wong | 2013 | J Gastroenterol Hepatol2013，，11： | 2 |
| 18 | Accuracy of Risk Scores for Patients With Chronic Hepatitis B Receiving Entecavir Treatment显示文摘 | Grace Lai–Hung Wong Henry Lik–Yuen Chan Hoi–Yun Chan Pete Chi–Hang Tse Yee–Kit Tse Christy Wing–Hin Mak Stanley King–Yeung Lee Zoe Man–Yi Ip Andrew Ting–Ho Lam Henry Wing–Hang Iu Joyce May–Sum Leung Vincent Wai–Sun Wong | 2013 | Gastroenterology2013，，5： | 2 |
| 19 | Antifungal and antiviral products of marine organisms显示文摘 | Randy Chi Fai Cheung Jack Ho Wong Wen Liang Pan Yau Sang Chan Cui Ming Yin Xiu Li Dan He Xiang Wang Evandro Fei Fang Sze Kwan Lam Patrick Hung Kui Ngai Li Xin Xia Fang Liu Xiu Yun Ye Guo Qing Zhang Qing Hong Liu Ou Sha Peng Lin Chan Ki Adnan A Bekhit Alaa | 2014 | Applied Microbiology and Biotechnology2014，，8： | 2 |
| 20 | A novel spoof surface plasmon polariton structure to reach ultra-strong field confinements显示文摘Ultrathin corrugated metallic structures have been proved to support spoof surface plasmon polariton (SPP) modes on two-dimension (2D) planar microwave circuits.However,to provide stronger field confinement,larger width of strip is required to load deeper grooves,which is cumbersome in modern large-scale integrated circuits and chips.In this work,a new spoof SPP transmission line (TL) with zigzag grooves is proposed.This new structure can achieve stronger field confinement compared to conventional one with the same strip width.In other words,the proposed spoof SPP TL behaves equivalently to a conventional one with much larger size.Dispersion analysis theoretically indicates the negative correlation between the ability of field confinement and cutoff frequencies of spoof SPP TLs.Numerical simulations indicate that the cutoff frequency of the proposed TL is lower than the conventional one and can be easily modified with the fixed size.Furthermore,two samples of the new and conventional spoof SPP TLs are fabricated for experimental demonstration.Measured S-parameters and field distributions verify the ultra-strong ability of field confinement of the proposed spoof SPP TL.Hence,this novel spoof SPP structure with ultra-strong field confinement may find wide applications in microwave and terahertz engineering. | Pei Hang He Hao Chi Zhang Xinxin Gao Ling Yun Niu Wen Xuan Tang Jiayuan Lu Le Peng Zhang Tie Jun Cui | 2019 | Opto-Electronic Advances2019，2，6： | 2 |
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