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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Composition, source, mass closure of PM_(2.5) aerosols for four forests in eastern China显示文摘PM2.5 aerosols were collected in forests along north latitude in boreal-temperate, temperate, subtropical and tropical climatic zones in eastern China, i.e., Changbai Mountain Nature Reserve (CB), Dongping National Forest Park in Chongming Island (CM), Dinghu Mountain Nature Reserve (DH), Jianfengling Nature Reserve in Hainan Island (HN). The mass concentrations of PM2.5, organic carbon (OC), elemental carbon (EC), water soluble organic carbon (WSOC) as well as concentrations of ten inorganic ions (F-, Cl-, NO3-, SO42-, C2O42-, NH4+, Na+, K+, Ca2+, Mg2+) were determined. Aerosol chemical mass closures were achieved. The 24-hr average concentrations of PM2.5 were 38.8, 89.2, 30.4, 18 μg/m3 at CB, CM, DH and HN, respectively. Organic matter and EC accounted for 21%-33% and 1.3%-2.3% of PM2.5 mass, respectively. The sum of three dominant secondary ions (SO42-, NO3-, NH4+) accounted for 44%, 50%, 45% and 16% of local PM2.5 mass at CB, CM, DH and HN, respectively. WSOC comprised 35%-65% of OC. The sources of PM2.5 include especially important regional anthropogenic pollutions at Chinese forest areas. | Li Li Wu Wang Jialiang Feng Dongping Zhang Huaijian Li Zeping Gu Bangjin Wang Guoying Sheng Jiamo Fu | 2010 | Journal of Environmental Sciences2010，22，3： | 45 |
| 3 | Simultaneous heterotrophic nitrification and aerobic denitrification at high initial phenol concentration by isolated bacterium Diaphorobacter sp. PD-7显示文摘A strain capable of phenol degradation, heterotrophic nitrification and aerobic denitrification was isolated from activated sludge of coking-plant wastewater ponds under aerobic condition. Based on its morphology, physiology,biochemical analysis and phylogenetic characteristics, the isolate was identified as Diaphorobacter sp. PD-7.Biodegradation tests of phenol showed that the maximum phenol degradation occurred at the late phase of exponential growth stages, with 1400 mg·L-1phenol completely degraded within 85 h. Diaphorobacter sp. PD-7accumulated a vast quantity of phenol hydroxylase in this physiological phase, ensuring that the cells quickly utilize phenol as a sole carbon and energy source. The kinetic behavior of Diaphorobacter sp. PD-7 in batch cultures was investigated over a wide range of initial phenol concentrations(0–1400 mg·L-1) by using the Haldane model,which adequately describes the dynamic behavior of phenol biodegradation by strain Diaphorobacter sp. PD-7. At initial phenol concentration of 1400 mg·L-1, batch experiments(0.25 L flask) of nitrogen removal under aerobic condition gave almost entirely removal of 120.69 mg·L-1ammonium nitrogen within 75 h, while nitrate nitrogen removal reached 91% within 65 h. Moreover, hydroxylamine oxidase, periplasmic nitrate reductase and nitrite reductase were successfully expressed in the isolate. | Qilong Ge Xiuping Yue Guoying Wang | 2015 | Chinese Journal of Chemical Engineering2015，23，5： | 26 |
| 4 | QTG-Seq Accelerates QTL Fine Mapping through QTL Partitioning and Whole-Genome Sequencing of Bulked Segregant Samples显示文摘Deciphering the genetic mechanisms underlying agronomic traits is of great importance for crop improvement. Most of these traits are controlled by multiple quantitative trait loci (QTLs), and identifying the underlying genes by conventional QTL fine-mapping is time-consuming and labor-intensive. Here, we devised a new method, named quantitative trait gene sequencing (QTG-seq), to accelerate QTL fine-mapping. QTGseq combines QTL partitioning to convert a quantitative trait into a near-qualitative trait, sequencing of bulked segregant pools from a large segregating population, and the use of a robust new algorithm for identifying candidate genes. Using QTG-seq, we fine-mapped a plant-height QTL in maize (Zea mays L.), qPH7, to a 300-kb genomic interval and verified that a gene encoding an NF-YC transcription factor was the functional gene. Functional analysis suggested that qPH7-encoding protein might influence plant height by interacting with a CO-like protein and an AP2 domain-containing protein. Selection footprint ana卜 ysis indicated that qPH7 was subject to strong selection during maize improvement. In summary, QTG-seq provides an efficient method for QTL fine-mapping in the era of “big data'. | Hongwei Zhang Xi Wang Qingchun Pan Pei Li Yunjun Liu Xiaoduo Lu Wanshun Zhong Minqi Li Linqian Han Juan Li Pingxi Wang Dongdong Li Yan Liu Qing Li Fang Yang Yuan-Ming Zhang Guoying Wang Lin Li | 2019 | Molecular Plant2019，12，3： | 13 |
| 5 | Regulation of Seed Vigor by Manipulation of Raffinose Family Oligosaccharides in Maize and Arabidopsis thaliana显示文摘棉白糖家庭 oligosaccharides (RFO ) 在许多植物种类在成熟干燥期间在种子积累。然而, RFO 是否在建立种子活力有一个角色,仍然保持不清楚。GALACTINOL SYNTHASE (GOLS ) ,棉白糖 SYNTHASE (RS ) ,和 STACHYOSE SYNTHASE (圣) 是为 RFO 负责的酶 ? 在植物的生合成。有趣地,仅仅棉白糖在玉米种子被检测,并且唯一的玉米 RS 基因(ZmRS ) 被识别。在这研究,我们发现二独立 mutator (亩) 打断了 zmrs 线,不包含棉白糖但是 hyperaccumulating galactinol, ? 显著地减少了种子活力,与空 segregant 控制相比。不同于玉米, Arabidopsis thaliana 种子包含几 RFO (棉白糖, stachyose,和 verbascose ) 。A 的操作。thaliana RFO ? 由 overexpressing ZmGOLS2, ZmRS,或 AtSTS 的内容表明了那 co-overexpression ZmGOLS2 和 ZmRS,或 ZmGOLS2 的 overexpression 独自一个,显著地增加了 RFO 的全部的内容并且提高了 Arabidopsis 种子活力。令人惊讶地,当 ZmRS 的 overexpression 增加了种子棉白糖内容时,它的 overexpression 戏剧性地减少了种子活力并且减少了 galactinol, stachyose,和 verbascose 的种子数量。相反, atrs5 异种种子类似于关于种子活力和 RFO 内容的野类型的那些,除了 stachyose 它在 atrs5 种子积累了。全部的 RFO, RFO/sucrose 比率,然而并非绝对单个 RFO ? 数量,断然与 A 相关。thaliana 种子活力, stachyose 和 verbascose 多于棉白糖作出贡献到。一起拿,这些结果提供新卓见进种子活力的规章的机制并且在 monocot 和 dicot 在 modulating 种子活力为 RFO 揭示不同要求。 | Tao Li Yumin Zhang Dong Wang Ying Liu Lynnette M.A. Dirk Jack Goodman A. Bruce Downie Jianmin Wang Guoying Wang Tianyong Zhao | 2017 | Molecular Plant2017，10，12： | 13 |
| 6 | The first observation of the atmospheric tides in the mesosphere and lower thermosphere over Hainan, China显示文摘Fuke (19.5°N, 109.1°E) meteor radar is the first radar of the low latitudes of China, which is used to detect the wind in the meso- sphere and lower thermosphere. In this paper, by using the wind data near three months (1 February-20 April, 2009), we first present the variation of the atmospheric diurnal tide, semidiurnal tide and mean wind in the height range 80-100 km over the low latitudes of China. The results from our analysis are summarized below. During spring months, there are quite strong tides in the mesopause region of Fuke. The diurnal tidal amplitude is significantly larger than the amplitude of semidiurnal tide, and the maximum amplitude (about 100 m/s) of diurnal tide appear in the meridional wind. The vertical phases of both diurnal tide and semidiurnal tide propagate downward. In addition, the observed tides are compared with the linear tide model (Global Scale Wave Model, GSWM02), and the results show that Fuke diurnal tide agrees well with the model, but there are many differences between Fuke semidiurnal tide and the results from model. | JIANG GuoYing XU JiYao SHI JianKui YANG GuoTao WANG Xiao YAN ChunXiao | 2010 | Chinese Science Bulletin2010，55，11： | 12 |
| 7 | CD59 Silencing via Retrovirus-Mediated RNA Interference Enhanced Complement-Mediated Cell Damage in Ovary Cancer显示文摘CD59,belonging to membrane complement regulatory proteins(mCRPs) ,inhibits the cytolytic activity of complement and is over-expressed in solid cancers,including ovary cancer. The aim of the present study was to construct recombinant retrovirus encoding shRNA targeted human CD59 and infect A2780 cells in order to investigate the relationship between decreased CD59 expression and tumorigenesis of ovary cancer. siCD59 and siCD59-C were successfully constructed and identified by PCR,restriction endonuclease analyses and DNA sequencing,respectively. The siCD59 was able to efficiently infect A2780 cells,which was confirmed by Western blotting. When incubated with fresh normal human serum(8%,v/v) for 1 h at 37°C,the cell viability was decreased and cell damage was increased in siCD59 infected A2780 cells compared to siCD59-C infected cells. This led to the activation of caspase-3. The apoptosis in siCD59 infected cells was shown with hypercondensed nuclei using Hoechst staining. Meanwhile,the weight of ovary tumor graft in nude mice was significantly decreased in siCD59 group compared to that of siCD59-C group. And the expression of CD59 protein in tumor tissue in siCD59 group was significantly decreased. These results suggested that CD59 silencing in ovary cancer cells via retrovirusmediated RNAi can enhance complement-mediated cell damage,inhibiting growth of ovary cancer. CD59 might be a potential target for gene therapy in ovary cancer. | Xuexiang Shi Bei Zhang Jinlin Zang Guoying Wang Meihua Gao | 2009 | Cellular & Molecular Immunology2009，6，1： | 12 |
| 8 | Observations of the first meteorological rocket of the Meridian Space Weather Monitoring Project显示文摘On June 3,2010,the first meteorological rocket of the Meridian Space Weather Monitoring Project was successfully launched at the Hainan rocket launch site(19.5°N),China.This paper analyzes the vertical profiles of atmospheric temperature and wind recorded by the rocket and its supportive balloons,and investigates wind shear,gravity waves and atmospheric stability.In addition,we compare the vertical profiles of atmospheric temperature and wind with SABER/TIMED temperature measurements and the modeling results of MSIS00 and HWM07. | JIANG GuoYing XU JiYao SHI DongBo WEI Feng WANG LianZhong | 2011 | Chinese Science Bulletin2011，56，20： | 9 |
| 9 | Construction of a genetic map and location of quantitative trait loci for dwarf trait in maize by RFLP markers显示文摘Using F2 population derived from the cross of tall inbred 7922 by dwarf inbred 5003, an RFLP linkage map of maize has been constructed, on which 85 markers are distributed among 10 linkage groups and span maize genome about 1827.8 cM with an average distance (24.4 cM) between markers. 106 F2:3 lines of the population were grown in a 10×11 simple rectangular lattice design of one-raw plots with two replications and evaluated for plant height (PH). With interval mapping procedure, 5 QTLs controlling plant height have been identified and their genetic effects and gene action determined. 2 major OTLs with opposite effect have been discovered. One for increasing plant height is ph 1 which is located at chromosome 2 and accounts for 51.8% of the total phenotypic variation; the other for decreasing plant height is ph3 which is located at chromosome 5 and accounts for 38.6% of the total phenotypic variation. The chromosomal location of ph3 might be the same as or close to the position of bv1, a dwarf mutant | CAO Yongguo WANG Guoying WANG Shoucai WEI Yanling LU Jiang XIE Youju DAI Jingrui | 2000 | Chinese Science Bulletin2000，45，3： | 9 |
| 10 | Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies显示文摘Background:Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperpla-sia,the positive rate for malignancy identification during biopsy is low,thus leading to delayed or missed diagnosis for nasopharyngeal malignancies upon initial attempt.Here,we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies under endoscopic examination based on deep learning.Methods:An endoscopic images-based nasopharyngeal malignancy detection model(eNPM-DM)consisting of a fully convolutional network based on the inception architecture was developed and fine-tuned using separate training and validation sets for both classification and segmentation.Briefly,a total of 28,966 qualified images were collected.Among these images,27,536 biopsy-proven images from 7951 individuals obtained from January 1st,2008,to December 31st,2016,were split into the training,validation and test sets at a ratio of 7:1:2 using simple randomiza-tion.Additionally,1430 images obtained from January 1st,2017,to March 31st,2017,were used as a prospective test set to compare the performance of the established model against oncologist evaluation.The dice similarity coef-ficient(DSC)was used to evaluate the efficiency of eNPM-DM in automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images,by comparing automatic segmentation with manual segmenta-tion performed by the experts.Results:All images were histopathologically confirmed,and included 5713(19.7%)normal control,19,107(66.0%)nasopharyngeal carcinoma(NPC),335(1.2%)NPC and 3811(13.2%)benign diseases.The eNPM-DM attained an overall accuracy of 88.7%(95%confidence interval(CI)87.8%-89.5%)in detecting malignancies in the test set.In the prospective comparison phase,eNPM-DM outperformed the experts:the overall accuracy was 88.0%(95%CI 86.1%-89.6%)vs.80.5%(95%CI 77.0%-84.0%).The eNPM-DM required less time(40 s vs.110.0±5.8 min)and exhibited encouraging performance in automatic segmentation of nasopharyngeal malignant area from the background,with an average DSC of 0.78±0.24 and 0.75±0.26 in the test and prospective test sets,respectively.Conclusions:The eNPM-DM outperformed oncologist evaluation in diagnostic classification of nasopharyngeal mass into benign versus malignant,and realized automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images. | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2018 | Cancer Communications2018，38，1： | 9 |
| 11 | Geochemical characteristics and applications of 18α(H)-neohopanes and 17α(H)-diahopanes显示文摘Distributions and geochemical significances of 18α(H)-neohopanes and of 17α(H)-diahopanes in oils from west Xialiaohe depression of the Bohai Bay Basin have been studied. Relative abundance of 18α(H)-neohopanes and of 17α(H)-diahopanes can be effectively used as maturity parameters, in a range of medium-high mature stage, based on consideration on sedimentary-organic facies of source rocks. With a dual geochemical significance of maturity and sedimentary-organic facies, neohopane and diahopane parameters can be well used in oil-source correlation and in petroleum population division. Formation, primary concentration and preservation of precursors of rearranged hopanes are closely related to depositional conditions such as Eh-pH and clays content. A series of probable diahopanes (series D) was detected in the oils, which exhibits a similar distribution pattern and geochemical behavior as that of 17α(H)-diahopanes (series B). | WANG Chunjiang, FU Jiamo, SHENG Guoying, XIAO Qianhua, LI Jinyou, ZHANG Yali & PIAO Mingzhi1. Slate Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences. Guang/hou 510640, China 2. Department of Geosciences, Petroleum University, Beijing 102200, China 3. Institute of Petroleum Exploration and Exploitation, Liaohe Bureau of Petroleum Exploration, Panjin 240000, China | 2000 | Chinese Science Bulletin2000，45，19： | 9 |
| 12 | Transgenic tobacco plants expressing synthetic Cry1Ac and Cry1Ie genes are more toxic to cotton bollworm than those containing one gene显示文摘Transgenic tobacco plants carrying Cry1Ac, Cry1Ie or both genes were obtained. In the leaves of transgenic plants carrying both genes, the contents of Cry1Ac and Cry1Ie proteins were 0.173% and 0.131% of the total proteins, respectively. Cry1Ac protein content was 0.182% and Cry1Ie protein con- tent was 0.124% of the total proteins in the leaves of transgenic plants containing only one Bt gene. Fresh leaves of transgenic tobacco and wild-type plants were used for the insect bioassay against wild-type and Cry1Ac-resistant cotton bollworm (Helicoverpa armigera). The bioassay results showed that transgenic plants carrying both genes were significantly more toxic to wild-type and Cry1Ac-resistant cotton bollworm than those carrying Cry1Ac or Cry1Ie alone. This study indicates that the higher toxicity of transgenic tobacco plants carrying both genes is caused by the cooperative function of both Bt proteins, thus providing a potential way to delay the development of insect resis- tance to transgenic crops. | LIAN Yun JIA ZhiWei HE KangLai LIU Yundun SONG FuPing WANG BaoMin WANG GuoYing | 2008 | Chinese Science Bulletin2008，53，9： | 7 |
| 13 | Effects of adding bulking agents on the biodrying of kitchen waste and the odor emissions produced显示文摘The effects of adding a bulking agent on the performance and odor emissions(ammonia and eight sulfur-containing odorous compounds) when biodrying kitchen waste were investigated. Three treatments were considered: the addition of either cornstalks(CS) or wood peat(WP) to kitchen waste as a bulking agent before biodrying, and a control treatment(CK). The water-removal rates for CK, CS, and WP treatments were 0.35, 0.56, and0.43 kg/kg, respectively. Addition of bulking agents to kitchen waste produced less leachate,higher moisture-removal rates, and lower consumption of volatile solids. The CS treatment had the highest biodrying index(4.07), and those for the WP and CK treatments were 3.67 and 1.97, respectively. Adding cornstalks or wood peat decreased NH3 emissions by 55.8%and 71.7%, respectively. Total sulfur losses were 3.6%–21.6% after 21 days biodrying, and H2 S and Me2 SS were the main(> 95%) sulfur compounds released. The smallest amounts of sulfur-containing odorous compounds were emitted when cornstalks were added, and adding cornstalks and wood peat decreased total sulfur losses by 50.6%–64.8%. | Jing Yuan Yun Li Hongyu Zhang Difang Zhang David Chadwick Guoxue Li Guoying Wang Menghao Chi Fan Yang | 2018 | Journal of Environmental Sciences2018，30，5： | 7 |
| 14 | A novel procedure for pollen-based quantitative paleoclimate reconstructions and its application in China显示文摘Traditionally, the evaluation of pollen-based quantitative paleoclimate reconstructions focuses on the ability of calibration sets to infer present climatic conditions and/or the similarity between fossil and modern assemblages. Objective criteria for choosing the most appropriate climate parameter(s) to be reconstructed at a specific site are thus lacking. Using a novel approach for testing the statistical significance of a quantitative reconstruction using random environmental data, in combination with the advantageous large environmental gradients, abundant vegetation types and comprehensive modern pollen databases in China, we describe a new procedure for pollen-based quantitative paleoclimatic reconstructions. First, the most significant environmental variable controlling the fossil pollen assemblage changes is identified. Second, a calibration set to infer changes in this targeted variable is built up, by limiting the modern ranges of other environmental variables. Finally, the pollen-based quantitative reconstruction is obtained and its statistical significance assessed. This novel procedure was used to reconstruct the mean annual precipitation(Pann) from Gonghai Lake in the Lvliang Mountains, and Tianchi Lake in the Liupan Mountains, on the eastern and western fringe of the Chinese Loess Plateau, respectively. Both Pann reconstructions are statistically significant(p<0.001), and a sound and stable correlation relationship exists in their common period, showing a rapid precipitation decrease since 3300 cal yr BP. Thus, we propose that this procedure has great potential for reducing the uncertainties associated with pollen-based quantitative paleoclimatic reconstructions in China. | CHEN JianHui LV FeiYa HUANG XiaoZhong H.John B.BIRKS Richard J.TELFORD ZHANG ShengRui XU QingHai ZHAO Yan WANG HaiPeng ZHOU AiFeng HUANG Wei LIU JianBao WEI GuoYing | 2017 | Science China Earth Sciences2017，60，11： | 6 |
| 15 | Gait analysis of goat at different slopes and study on biomimetic walking mechanism显示文摘To study the walking status of a goat on slope and the walking mechanics,a comparative analysis of the walking gait mode of a goat on different slopes was conducted.The uphill and downhill walking processes on different slopes(6°,18°and 36°)were recorded by a high speed video system.The experimental image results were processed and analyzed via SigmaScan software and MATLAB software.The characteristic parameters of locomotion gait on the different slopes and the angle change curves of each goat leg in the process of slope movement indicated that the goat performed tetrapod gait,static gait,ipsilateral gait and trot gait on different slopes.With the increase of gradient in the uphill process,the corresponding load factors of each leg were 0.65±0.15,0.75 and 0.645±0.205,whereas those in the downhill process were 0.70±0.08,0.66±0.06,and 0.685±0.125.Results showed that the load factors of each leg are higher than 0.5.The foreleg angle ofa(the angle of wrist joints),which ranges from 100°to 130°,is suitable for different slopes.However,the angle ofb(the angle between the thigh and the forward direction in the walking process of goat),which ranges from 99°to 109°,is suitable for the 6°slope,whereas the angle ranging from 46°to 91°is suitable for the 18°slope and 36°slope.For the hind leg,the angle ofa,which ranges from 105°to 153°,is suitable for the different slopes.The angle ofb,which ranges from 128°to 150°,is suitable for the different slopes.The research can provide a theoretical basis and experimental data for the design of biomimetic agricultural slope walking mechanism. | Zhang Fu Wang Wei Zhang Guoying Wang Jun Qiu Zhaomei Mao Pengjun | 2016 | International Journal of Agricultural and Biological Engineering2016，9，3： | 6 |
| 16 | Express,on of the novel adipokine ClqTNF-related protein 4 (CTRP4) suppresses colitis and colitis- associated colorectal cancer in mice显示文摘 | Yang Luo Xiaotong Wu Zhuang Ma Weifeng Tan Lanlan Wang Daxiang Na Guoying Zhang Ang Yin He Huang Dan Xia Yingmei Zhang Xueying Shi Lu Wang | 2016 | Cellular & Molecular Immunology2016，13，5： | 6 |
| 17 | The U6 Biogenesis-Like I Plays an Important Role in Maize Kernel and Seedling Development by Affecting the 3' End Processing of U6 snRNA显示文摘 | Jiankun Li Junjie Fu Yan Chen Kaijian Fan Cheng He Zhiqiang Zhang Li Li Yunjun Liu Jun Zheng Dongtao Ren Guoying Wang | 2017 | Molecular Plant2017，10，3： | 5 |
| 18 | Antibiotic Metabolites from the Coral-Associated Actinomycete Streptomyces sp. OUCMDZ-1703显示文摘从软联系珊瑚的放射菌类紧张的寡营养的文化, Streptomyces sp。 OUCMDZ-1703 ,我们孤立并且识别我们把 strepchloritides 称为 A 和 B ( 1 和 2 )的二新使氯化的 polyketides ,作为 watasemycin A ( 3 )知道的三 thiazole 衍生物, pulicatin G ( 4 )和 aerugine ( 5 )与 pyrrole-2-carboxamide 一起, furan-2-carboxamide 和1-( 3,5-dihydroxyphenyl ) ethanone 。1 和 2 的新结构被象 1D-NMR 和 2D-NMR 和 MS 分析那样的分光镜的研究决定,当已知的混合物被 NMR 数据的比较在文学与那些识别时。结果证明放射菌类种类 OUCMDZ-1703 能在寡营养的媒介使用氯的相对高比率综合使氯化的自然产品。新混合物 1 和 2 与 9.9 和 20.2 的 IC50 价值对 MCF-7 房间显示了 cytotoxicity ?? 愠杮' 讙贅 H 敮 ???????? 寓?? | Peng Fu Fandong Kong Yuanfei Wang Yi Wang Peipei Liu Guoying Zuo Weiming Zhu | 2013 | Chinese Journal of Chemistry2013，31，1： | 5 |
| 19 | Exosomal HOTAIR promotes proliferation, migration and invasion of lung cancer by sponging miR-203显示文摘Dear Editor,Lung cancer is one of the most common causes of cancerrelated deaths worldwide.Despite great progress in the development of lung cancer treatments,the prognoses of patients with advanced stage cancer remains poor(Torre et al.,2015). | Chengcheng Zhang Lisha Xu Guoying Deng Yajie Ding Ke Bi Hansong Jin Jixin Shu Jia Yang Haibin Deng Zhongqi Wang Yin Wang | 2020 | Science China(Life Sciences)2020，63，8： | 4 |
| 20 | Water quality criteria for 4-nonylphenol in protection of aquatic life显示文摘Here reproduction and death toxicity data were selected for 4-nonylphenol based on endocrine disrupting properties of the reproductive system. Assessment factor (AF) and species sensitivity distribution (SSD) curve were employed to derive criteria maximum concentration (CMC) and criteria continuous concentration (CCC) of three different 4-nonylphenols for protection of aquatic life. The results showed that the CMC and CCC based on SSD method and death toxicity data for three different 4-nonylphenols (CAS No: 104405, 25154523, 84852163) were 26.7, 13.6, 3.84 g L 1 and 8.86, 2.21, 0.97 g L 1, respectively. Based on SSD and reproductive toxicity data, the CCC values of different 4-nonylphenols (CAS No: 104405, 25154523) were 1.59 and 1.34 g L 1, respectively. The CCC values obtained by the AF for three different 4-nonylphenol (CAS No: 104405, 25154523, 84852163) were 0.165, 1.03, 0.74 g L 1 and 0.5, 0.5, 0.1 g L 1, respectively, based on death toxicity data and reproductive toxicity data. The CCC values obtained by AF were all lower than the corresponding criteria values obtained by SSD, and the CCC values based on reproductive toxicity data were less than those based on the death toxicity data. This study provides a useful method for deriving water quality criteria for endocrine disruptors. | LEI BingLi LIU Qian SUN YanFeng WANG YiPei YU ZhiQiang ZENG XiangYing FU JiaMo SHENG GuoYing | 2012 | Science China Earth Sciences2012，55，6： | 4 |
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