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| 1 | Long-term outcomes and prognostic factors of patients with obstructive colorectal cancer: A multicenter retrospective cohort study显示文摘AIM: To investigate the long-term oncologic outcomes and prognostic factors in patients with obstructive colorectal cancer(CRC) at multiple Japanese institutions.METHODS: We identified 362 patients diagnosed with obstructive colorectal cancer from January 1, 2002 to December 31, 2012 in Yokohama Clinical Oncology Group's department of gastroenterological surgery. Among them, 234 patients with stage Ⅱ/Ⅲ disease who had undergone surgical resection of their primary lesions were analyzed, retrospectively. We report the long-term outcomes, the risk factors for recurrence, and the prognostic factors.RESULTS: The five-year disease free survival and cancer-specific survival were 50.6% and 80.3%, respectively. A multivariate analysis showed the ASAPS(HR = 2.23, P = 0.026), serum Albumin ≤ 4.0 g/d L(HR = 2.96, P = 0.007), T4 tumor(HR = 2.73, P = 0.002) and R1 resection(HR = 6.56, P = 0.02) to be independent risk factors for recurrence. Furthermore, poorly differentiated cancers(HR = 6.28, P = 0.009), a T4 tumor(HR = 3.46, P = 0.011) and R1 resection(HR = 6.16, P = 0.006) were independent prognostic factors in patients with obstructive CRC.CONCLUSION: The outcomes of patients with obstructive CRC was poor. T4 tumor and R1 resection were found to be independent prognostic factors for both recurrence and survival in patients with obstructive CRC. | Ishibe Atsushi Ota Mitsuyoshi Yamaguchi Kazuya Kaida Syuhei Kamiya Noriyuki Momiyama Masashi Watanabe Akira Sekizawa Kentaro Kamimukai Nobuyuki Sugimasa Natsuko Watanabe Jun Ichikawa Yasushi Kunisaki Chikara Endo Itaru | 2016 | World Journal of Gastroenterology2016，22，22： | 9 |
| 2 | Narrow-band imaging observation of colorectal lesions using NICE classification to avoid discarding significant lesions显示文摘AIM: To assess the risk of failing to detect diminutive and small colorectal cancers with the 'resect and discard' policy.METHODS: Patients who received colonoscopy and polypectomy were recruited in the retrospective study. Probable histology of the polyps was predicted by six colonoscopists by the use of NICE classification. The incidence of diminutive and small colorectal cancersand their endoscopic features were assessed. RESULTS: In total, we found 681 cases of diminutive(1-5 mm) lesions in 402 patients and 197 cases of small(6-9 mm) lesions in 151 patients. Based on pathology of the diminutive and small polyps, 105 and 18 were non-neoplastic polyps, 557 and 154 were low-grade adenomas, 18 and 24 were high-grade adenomas or intramucosal/submucosal(SM) scanty invasive carcinomas, 1 and 1 were SM deeply invasive carcinoma, respectively. The endoscopic features of invasive cancer were classified as NICE type 3 endoscopically.CONCLUSION: The risk of failing to detect diminutive and small colorectal invasive cancer with the 'resect and discard' strategy might be avoided through the use of narrow-band imaging observation with the NICE classification scheme and magnifying endoscopy. | Santa Hattori Mineo Iwatate Wataru Sano Noriaki Hasuike Hidekazu Kosaka Taro Ikumoto Masahito Kotaka Akihiro Ichiyanagi Chikara Ebisutani Yasuko Hisano Takahiro Fujimori Yasushi Sano | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，12： | 5 |
| 3 | Bile duct hamartomas(von Mayenburg complexes) mimicking liver metastases from bile duct cancer:MRC findings显示文摘我们在场是的有胆总管癌症的一个 72 岁的人的一个盒子开始相信了吃多重肝转移基于计算断层摄影术调查结果,并且在磁性的回声胆管造影术(MRC ) 在谁揭示胆汁管 hamartomas 的诊断。在为 pancreaticoduodenectomy 的探索,肝触诊在肝的表面揭示了传播小瘤。这些小瘤在在两片肝脑叶的表面上散布的直径显示出大约 0.5 厘米的灰色白人的榴状的损害,它被看起来像从胆汁管癌的多重肝转移。肝活体检视的冰冻切片揭示了多重胆汁管,稍微扩大的腔在多重胆汁管 hamartomas (BDH ) 的成胶的基质特征嵌入。仅仅二份报告描述了胆汁管 hamartomas 的 MRC 特征。所有成像过程, MRC 为胆汁管 hamartomas 的成像诊断提供最相关的特征。 | Yasuhiko Nagano Kenichi Matsuo Katsuya Gorai Kazuya Sugimori Chikara Kunisaki Hideyuki Ike Katsuaki Tanaka Toshio Imada Hiroshi Shimada | 2006 | World Journal of Gastroenterology2006，12，8： | 4 |
| 4 | Efficacy of 1.2L polyethylene glycol plus ascorbic acid for bowel preparations显示文摘BACKGROUND A low-volume polyethylene glycol(PEG) solution that combines ascorbic acid with PEG-based electrolyte solution(PEG-ASC) is gaining mainstream acceptance for bowel preparation due to reduced volume and improved taste.Although several reports showed that bowel preparation with PEG-ASC volume lower than 2.0 L with laxative agents could be an alternative to traditional preparation regimen, the cleansing protocols have not been fully investigated.AIM To evaluate the cleansing efficacy of 1.2 L PEG-ASC solution comparing with 2.0 L PEG electrolyte(PEG-ELS) for bowel preparations.METHODS A randomized, single-blinded, open-label, single-center, non-inferiority study was conducted. In total, 312 Japanese adult patients(aged > 18 years) who underwent colonoscopy were enrolled. Patients were randomly allocated to bowel lavage with either 1.2 L of PEG-ASC solution with at least 0.6 L of an additional clear fluid(1.2 L PEG-ASC group) or 2.0 L of PEG-ELS(PEG-ELS group). Then, 48 mg of sennoside was administered at bedtime on the day before colonoscopy, and the designated drug solution was administered at the hospital on the day of colonoscopy. Bowel cleansing was evaluated using the Boston Bowel Preparation Scale(BBPS). The volume of fluid intake and required time for bowel preparation were evaluated. Furthermore, compliance, patient tolerance,and overall acceptability were evaluated using a patient questionnaire, which was assessed using a visual analog scale.RESULTS In total, 291 patients(1.2 L PEG-ASC group, 148; PEG-ELS group, 143) completed the study. There was no significant difference in successful cleansing, defined as a BBPS score ≥ 2 in each segment, between the two groups(1.2 L PEG-ASC group, 91.9%; PEG-ELS group, 90.2%; 95%CI:-0.03-0.09). The required time for bowel preparation was significantly shorter(164.95 min ± 68.95 min vs 202.16 min± 68.69 min, P < 0.001) and the total fluid intake volume was significantly lower(2.23 L ± 0.55 L vs 2.47 L ± 0.56 L, P < 0.001) in the 1.2 L PEG-ASC group than in the PEG-ELS group. Palatability, acceptability of the volume of solution, and overall acceptability evaluated using a patient questionnaire, which was assessed by the visual analog scale, were significantly better in the 1.2 L PEG-ASC group than in the PEG-ELS group(7.70 cm ± 2.57 cm vs 5.80 cm ± 3.24 cm, P < 0.001). No severe adverse event was observed in each group.CONCLUSION The 1.2 L PEG-ASC solution was non-inferior to the 2.0 L PEG-ELS solution in terms of cleansing efficacy and had better acceptability among Japanese patients. | Hiroyuki Tamaki Teruyo Noda Masahiro Morita Akina Omura Atsushi Kubo Chikara Ogawa Toshihiro Matsunaka Mitsushige Shibatoge | 2019 | World Journal of Clinical Cases2019，7，4： | 4 |
| 5 | Comparison of Surgical Results of D2 Versus D3 Gastrectomy (Para-Aortic Lymph Node Dissection) for Advanced Gastric Carcinoma: A Multi-Institutional Study显示文摘 | Chikara Kunisaki Hirotoshi Akiyama Masato Nomura Goro Matsuda Yuichi Otsuka Hidetaka Ono Yutaka Nagahori Hideo Hosoi Masazumi Takahashi Fumihiko Kito Hiroshi Shimada | 2006 | Annals of Surgical Oncology2006，，5： | 2 |
| 6 | Budd-Chiari syndrome: A case with a combination of hepatic vein and superior vena cava occlusion显示文摘We here report a recent, rare case of Budd-Chiari syndrome, associated with a combination of hepatic vein and superior vena cava occlusion. A young female, who had been ingood health, was admitted to our hospital because of massive ascites. The patient had used no oral contraceptives. Tests for coagulation disorders, hematological disorders, and antiphospholipid syndrome were all negative. BuddChiari syndrome was diagnosed by radiographic examination. The patient was suffering from a combination of hepatic vein and superior vena cava occlusion. In particular, the venous flow returned from the liver mainly through a right accessory hepatic vein, and stenosis was recognized at the orifice of this collateral vein into the vena cava.Subsequently, the patient underwent percutaneous balloon dilatation therapy for this stenosis. After this treatment, the massive ascites was gradually reduced, and she was discharged from our hospital. It has now been one year since discharge, and the patient has been doing well. If deteriorating liver function or intractable ascites occur again, a liver transplantation may be anticipated. This is the first case report of Budd-Chiari syndrome associated with a superior vena cava occlusion. | Yoshio Araki Chikara Sakaguchi Izumi Ishizuka Masaya Sasaki Tomoyuki Tsujikawa Shigeki Koyama Akira Furukawa Yoshihide Fujiyama | 2005 | World Journal of Gastroenterology2005，11，24： | 2 |
| 7 | Impact of lymphovascular invasion in patients with stage I gastric cancer显示文摘 | Chikara Kunisaki Hirochika Makino Jun Kimura Ryo Takagawa Takashi Kosaka Hidetaka A. Ono Hirotoshi Akiyama Tadao Fukushima Yutaka Nagahori Masazumiu Takahashi | 2010 | Surgery2010，，2： | 2 |
| 8 | A model to estimate available timber and forest biomass and reforestation expenses in a mountainous region in Japan显示文摘We developed a model to estimate supply potentials and available amounts of timber and forest biomass resources from profitable sub-compartments of thinning and final felling operations. Economic balances were estimated while considering not only harvesting expenses but also reforestation expenses after final felling, which should be considered for sustainable forest management. Harvesting expenses were estimated based on two types of timber harvesting systems and three types of forest biomass harvesting systems in each sub-compartment. Then, the model was applied to Nasushiobara city of Tochigi prefecture, Japan. Reforestation expenses had large negative impacts on the financial balances of final felling operations. Few sub-compartments were profitable after considering reforestation expenses. Most profitable sub-compartments were those with mechanized operation systems and landing sales. These accounted for 17.19% of all sub-compartments, while only 5.75% of the sub-compartments were profitable based on their current operation systems and landing sales. Although the overall supply potentials of timber and forest biomass resources were 380,000 m3 and 210,000 Mg, respectively, and 15 times the planned harvest of coniferous tree volume of 25,000 m3year-1 and 50 times the annual demand for the woody gasification power generation of 4,000 Mg year-1 in Nasushiobara, available amounts of timber and forest biomass resources were only49,429 m3 and 33,333 Mg, which were 13.0% and 15.7% of supply potentials for landing sales with mechanized operation systems. | Kazuhiro Aruga Ayami Murakami Chikara Nakahata Reiko Yamaguchi Masashi Saito Kanae Kanetsuki | 2013 | Journal of Forestry Research2013，24，2： | 2 |
| 9 | Omentum-preserving gastrectomy for advanced gastric cancer: a propensity-matched retrospective cohort study显示文摘 | Shinichi Hasegawa Chikara Kunisaki Hidetaka Ono Takashi Oshima Shoichi Fujii Masataka Taguri Satoshi Morita Tsutomu Sato Roppei Yamada Norio Yukawa Yasushi Rino Munetaka Masuda | 2013 | Gastric Cancer2013，，3： | 2 |
| 10 | Expression of circadian genes correlates with liver metastasis and outcomesin colorectal cancer显示文摘 | Takashi Oshima Seiich Takenoshita Makoto Akaike Chikara Kunisaki Shoich Fujii Akito Nozaki Kazushi Numata Manabu Shiozawa Yasushi Rino Katsuaki Tanaka Munetaka Masuda Toshio Imada | 2011 | Oncology Reports2011，，5： | 2 |
| 11 | Short-term results of a randomized study between laparoscopic and open surgery in elderly colorectal cancer patients显示文摘 | Shoichi Fujii Atsushi Ishibe Mitsuyoshi Ota Shigeru Yamagishi Kazuteru Watanabe Jun Watanabe Amane Kanazawa Yasushi Ichikawa Mari Oba Satoshi Morita Yojiro Hashiguchi Chikara Kunisaki Itaru Endo | 2014 | Surgical Endoscopy2014，，2： | 2 |
| 12 | Risk assessment of airborne fine particles and nanoparticles显示文摘 | Toshihiko Myojo Akira Ogami Takako Oyabu Yasuo Morimoto Masami Hirohashi Masahiro Murakami Kenichiro Nishi Chikara Kadoya Isamu Tanaka | 2010 | Advanced Powder Technology2010，，5： | 1 |
| 13 | Comparative results of conservative treatments for isolated anterior talofibular ligament (ATFL) injury and injury to both the ATFL and calcaneofibular ligament of the ankle as assessed by subtalar arthrography显示文摘 | Norihiro Samoto Kazuya Sugimoto Takanori Takaoka Tadashi Fujita Chikara Kitada Yoshinori Takakura | 2007 | Journal of Orthopaedic Science2007，，1： | 1 |
| 14 | Largescale purification of Japanese encephalitis virus from infected mouse brain for preparation of vaccine显示文摘 | Chikara Aizawa Shigeo Hasegawa Cheng Chih-yuan | | 0，，01： | 1 |
| 15 | Rheological and interracial properties of pickering emulsions prepared by fumed silica suspensions pre adsorbed poly(N-isopropylacrylamide) 显示文摘 | Chikara M Masami K | 2009 | Colloids and Surfaces A: Physicochem Eng Aspects2009，335，： | 1 |
| 16 | Molecular simulation on interaction of polychlorodibenzodioxin and cyclodextrins 显示文摘 | Chikara I Yasuji I | 2005 | Yarnaguchikenritsu Daigaku Seikatsu Kagakubu Kenkyu Hokoku2005，31，： | 1 |
| 17 | Effect of salt stress on plasma membrane permeability and lipid saturation in the salt-toler- ant yeast Zygosaccharomyces rouxii显示文摘 | YOSHIKAWA S MITSUI N CHIKARA K I | 1995 | J Ferment Bioeng1995，80，2： | 1 |
| 18 | Development of bioactive organic-inorganic hybrid for bone substitutes 显示文摘 | Chikara O Toshiki M Masao T | 2002 | Materials Science and Engineering: C2002，22，1： | 1 |
| 19 | Gramicidin-perIorated patchrecording revealed the oscillatory nature of secretory Clmovements in salivary acinar cells显示文摘 | Makoto S Chikara H Yoshiki S | 2004 | Journal of General Phys2004，124，1： | 1 |
| 20 | Transposon tagging in rice显示文摘 | Takeshi Izawa Tohru Ohnishi Toshitsugu Nakano Nobuhiro Ishida Hiroyuki Enoki Hisako Hashimoto Kimiko Itoh Rie Terada Chuanyn Wu Chikara Miyazaki Tomoko Endo Shigeru Iida Ko Shimamoto | 1997 | Plant Molecular Biology (-)1997，，1： | 1 |
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