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| 1 | Functionalization of small black phosphorus nanoparticles for targeted imaging and photothermal therapy of cancer显示文摘Black phosphorus(BP) nanomaterials have attracted extensive attention due to their unique physical,chemical, and biological properties. In this study, small BP nanoparticles were synthesized and modified with dextran and poly(ethyleneimine) for functionalization with folic acid and cyanine 7. The functionalized BP nanoparticles exhibit excellent biocompatibility, stability, and near infrared optical properties for targeted imaging of tumors through photoacoustic imaging and near-infrared fluorescence imaging.They also display high photothermal conversion efficiency for photothermal therapy of cancer. This work demonstrates the potential of functionalized small BP nanoparticles as an emerging nanotheranostic agent for the diagnosis and treatment of cancer. | Lijuan Deng Yifan Xu Caixia Sun Baofeng Yun Qiao Sun Chongjun Zhao Zhen Li | 2018 | Science Bulletin2018，63，14： | 12 |
| 2 | Zebrafish model for assessing induced organ toxicity by Strychnos nux-vomica显示文摘OBJECTIVE:To assess the acute organ toxicity of Strychnos nux-vomica with zebrafish model visually.METHODS:To assess acute toxicity,we initially determined the lethal concentration after Strychnos nux-vomica treatment for 24 h.Zebrafish was treated with five concentrations Strychnos nux-≦vo LC10 for 24 h,and the effects ofmica on morphology,function of heart,central nervous system,liver,kidney and organ-specific cell death were assessed.Next,we assessed the reversibility of toxic effect.RESULTS:Strychnos nux-vomica has an effect on the different organs of zebrafish,including heart,central nervous system,liver,and kidney,and cadiotoxicity induced by Strychnos nux-vomica was reversible to some extent.CONCLUSION:Zebrafish model is suitable for confirming the toxic target organs for Chinese traditional medicine. | Zhao Chongjun Tian Jinghuan Wang Jinfeng Feng Yaru Ni Yuanyuan Fan Jiaojiao Wang Chunmei Cao Dan Zou Qinwen Ma Zhiqiang Lin Ruichao | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 9 |
| 3 | Bamboo charcoal addition enhanced the nitrogen removal of anammox granular sludge with COD:Performance,physicochemical characteristics and microbial community显示文摘The effects of different chemical oxygen demand(COD)concentrations on the anammox granular sludge with Bamboo Charcoal(BC)addition were evaluated in UASB reactor.The results showed that the average total nitrogen(TN)removal efficiency was reduced from 85.9%to 81.4%when COD concentration was increased from 50 to 150 mg/L.However,the TN removal efficiency of BC addition reactors was dramatically 3.1%-6.4%higher than that without BC under different COD concentrations.The average diameter of granular sludge was 0.13 mm higher than that without BC.The settling velocity was increased by elevated COD concentration,while the EPS and VSS/SS were increased with BC addition.The high-throughput Miseq sequencing analyses revealed that the bacterial diversity and richness were decreased under COD addition,and the Planctomycetes related to anammox bacteria were Candidatus Brocadia and Candidatus Kuenenia.The Metagenomic sequencing indicated that the abundance of denitrification related functional genes all increased with elevated COD,while the abundance of anammox related functional genes of decreased.The func-tional genes related to anammox was hydrazine synthase encoding genes(hzsA,hzsB and hzsB).The average relative abundance of hzs genes in the reactor with BC addition was higher than the control at COD concentrations of 50 mg/L and 150 mg/L.The functional genes of denitrification mediated by BC were higher than those without BC throughout the operation phase.It is interesting to note that BC addition greatly enriched the related func-tional genes of denitrification and anammox. | Menglei Guo Ying Jiang Junxiang Xie Qianfei Cao Qun Zhang Adams Mabruk Chongjun Chen | 2022 | Journal of Environmental Sciences2022，34，5： | 5 |
| 4 | Removal of nitrogen from wastewater with perennial ryegrass/artificial aquatic mats biofilm combined system显示文摘To develop a cost-effective combined phytoremediation and biological process,a combined perennial ryegrass/artificial aquatic mat biofilm reactor was used to treat synthetic wastewater.Influent ammonium loading,reflux ratio,hydraulic retention time(HRT) and temperature all had significant effects on the treatment efficiency.The results indicated that the effluent concentration of ammonium increased with increasing influent ammonium loading.The reactor temperature played an important role in the nitrification process.The ammonium removal efficiency significantly decreased from 80% to 30%-50% when the reactor temperature dropped to below 10°C.In addition,the optimal nitrogen removal condition was a reflux ratio of 2.The nitrate and ammonium concentration of the effluent were consistent with the HRT of the combined system.The chemical oxygen demand(COD) removal efficiency was at a high level during the whole experiment,being almost 80% after the start-up,and then mostly above 90%.The direct uptake of N by the perennial ryegrass accounted for 18.17% of the total N removal by the whole system.The perennial ryegrass absorption was a significant contributor to nitrogen removal in the combined system.The result illustrated that the combined perennial ryegrass/artificial aquatic mat biofilm reactor demonstrated good performance in ammonium,total N and COD removal. | Chongjun Chen Rui Zhang Liang Wang Weixiang Wu Yingxu Chen | 2013 | Journal of Environmental Sciences2013，25，4： | 5 |
| 5 | Loose architecture of multi-level massive geospatial data based on virtual quadtree显示文摘This paper proposed a virtual quadtree (VQT) based loose architecture of multi-level massive geospatial data for integrating massive geospatial data dispersed in the departments of different hierarchies in the same sector into a unified GIS (Geographic Information System) platform. By virtualizing the nodes of the quad-tree,the VQT separates the structure of data organization from data storage,and screens the difference between the data storage in local computer and in the re-mote computers in network environment. And by mounting,VQT easily integrates the data from the remote computers into the local VQT so as to implement seam-less integration of distributed multi-level massive geospatial data. Based on that mode,the paper built an application system with geospatial data over 1200 GB distributed in 12 servers deployed in 12 cities. The experiment showed that all data can be seamlessly rapidly traveled and performed zooming in and zooming out smoothly. | YANG ChongJun,WU Sheng,REN YingChao,FU Li,ZHANG FuQing,WANG Gang,TAN Jian,LIU DongLin,MA ChaoJi & LIANG Li State Key Laboratory of Remote Sensing Science,Jointly Sponsored by the Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University,Beijing 100101,China | 2008 | Science China(Technological Sciences)2008，51，S1： | 4 |
| 6 | A CFD model for gas uniform distribution in turbulent flow for the production of titanium pigment in chloride process显示文摘The fluid dynamic behavior of feeding gas(Ti Cl4) in an annular channel affects the combination of O2 and Ti Cl4 in an oxidation reactor, a key piece of equipment in titanium pigment production. The numerical procedure was validated by a 3-dimensional gas flow in the annular channel. Applying the validated model, the flow characteristics of Ti Cl4 in the oxidation reactor with a tangential inlet were simulated and characterized. The flow distribution with five rectifying rings of different structure was simulated and analyzed. The results showed that the rectifying ring improved the distribution uniformity of the pressure and outlet velocity. Compared to the original case without a rectifying ring, the non-uniformity of the pressure and outlet velocity could be reduced by up to91% and 69% respectively. The rectifying ring #5, which can be installed and adjusted easily, is more effective in realizing even distribution. In addition, installation of the rectifying ring effectively reduced the circulating flow in an annular channel as well as the total energy loss. | Yadong Li Gang Xie Ting Lei Chongjun Bao Lin Tian Yanqing Hou | 2016 | Chinese Journal of Chemical Engineering2016，24，6： | 4 |
| 7 | Parallel algorithm for viewshed analysis on a modern GPU显示文摘Spatial analysis,including viewshed analysis,is an important aspect of the Digital Earth system.Viewshed analysis is usually performed on a large scale,so efficiency is important in any Digital Earth application making these calculations.In this paper,a real-time algorithm for viewshed analysis in 3D scenes is presented by using the parallel computing capabilities of a graphics processing unit(GPU).In contrast to traditional algorithms based on line-of-sight,this algorithm runs completely within the programmable 3D visualization pipeline to render 3D terrains with viewshed analysis.The most important difference is its integration of the viewshed calculation with the rendering module.Invisible areas are rendered as shadows in the 3D scene.The algorithm process is paralleled by rasterizer units in the graphics card and by vertex and pixel shaders executed on the GPU.We have implemented this method in our 3D Digital Earth system with the DirectX 9.0c API and tested on some consumer-level PC platforms with interactive framerates and high image quality.Our algorithm has been widely used in related systems based on Digital Earth. | Fang Chao Yang Chongjun Chen Zhuo Yao Xiaojing Guo Hantao | 2011 | International Journal of Digital Earth2011，4，6： | 4 |
| 8 | Parallel algorithm for real-time contouring from grid DEM on modern GPUs显示文摘A real-time algorithm for constructing contour maps from grid DEM data is pre-sented.It runs completely within the programmable 3D visualization pipeline.The interpolation is paralleled by rasterizer units in the graphics card,and contour line extraction is paralleled by pixel shader.During each frame of the rendering,we first make an elevation gradient map out of original terrain vertex data,then figure out the final contour lines with image-space processing,and directly blend the results on the original scene to obtain a final scene with contour map using alpha-blending.We implement this method in our global 3D-digitalearth system with Direct3D?9.0c API and tested on some consumer level PC platforms.For arbitrary scene with certain LOD level,the process takes less than 10 ms,giving topologically correct,anti-aliased contour lines. | CHEN Zhuo,SHEN Lei,ZHAO YanQing & YANG ChongJun State Key Laboratory of Remote Sensing Science,Jointly Sponsored by the Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University,Beijing 100101,China | 2010 | Science China(Technological Sciences)2010，53，S1： | 3 |
| 9 | NEW FIXED POINT THEOREMS OF CONDENSING MAPPINGS SATISFYING THE INTERIOR CONDITION IN BANACH SPACES显示文摘In this paper, based on a basic result on condensing mappings satisfying the interior condition, some new fixed point theorems of the condensing mappings of this kind are obtained. As a result, the famous Altman’s theorem, Roth’s theorem and Petryshyn’s theorem are extended to condensing mappings satisfying the interior condition. | Shaoyuan Xu Chongjun Zhu Guanghui Zhou | 2010 | Analysis in Theory and Applications2010，26，1： | 3 |
| 10 | Sparse approximate solution of fitting surface to scattered points by MLASSO model显示文摘The goal of this paper is to achieve a computational model and corresponding efficient algorithm for obtaining a sparse representation of the fitting surface to the given scattered data. The basic idea of the model is to utilize the principal shift invariant(PSI) space and the l_1 norm minimization. In order to obtain different sparsity of the approximation solution, the problem is represented as a multilevel LASSO(MLASSO)model with different regularization parameters. The MLASSO model can be solved efficiently by the alternating direction method of multipliers. Numerical experiments indicate that compared to the AGLASSO model and the basic MBA algorithm, the MLASSO model can provide an acceptable compromise between the minimization of the data mismatch term and the sparsity of the solution. Moreover, the solution by the MLASSO model can reflect the regions of the underlying surface where high gradients occur. | Yongxia Hao Chongjun Li Renhong Wang | 2018 | Science China Mathematics2018，61，7： | 2 |
| 11 | Pd films on soft substrates:a visual,high-contrast and low-cost optical hydrogen sensor显示文摘For the rapid development of the hydrogen economy,a reliable and low-cost hydrogen sensor appears to be extremely important.Here,we first show that a palladium film deposited on polydimethylsiloxane(PDMS)can obtain an exceedingly high-reflectance contrast of 25.78 over the entire visible band upon exposure to 4 vol% hydrogen gas(H2)mixed with nitrogen gas.This high-reflectance contrast results from the surface deformation induced by the volume inflation after exposure to H2,leading to the transition of the near-specular surface to a diffusing surface.In addition,a change in brightness is readable by naked eye upon exposure to H2 with various concentrations from 0.6 to 1 vol% under the illumination of a fluorescent tube.Furthermore,this sensor possesses an excellent recyclability and quick response time of a few seconds.Compared with Pd nanostructure-based hydrogen sensors,this visual,high-contrast and low-cost sensor is of great potential for practical hydrogen sensing. | Xiaoyi She Yang Shen Jianfang Wang Chongjun Jin | 2019 | Light(Science & Applications)2019，8，1： | 2 |
| 12 | The interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP-2/HMGCR/SQLE/LSS pathway显示文摘Polyphyllin I(PPI)and polyphyllin II(PII)are the main active substances in the Paris polyphylla.However,liver toxicity of these compounds has impeded their clinical application and the potential hepatotoxicity mechanisms remain to be elucidated.In this work,we found that PPI and PII exposure could induce significant hepatotoxicity in human liver cell line L-02 and zebrafish in a dose-dependent manner.The results of the proteomic analysis in L-02 cells and transcriptome in zebrafish indicated that the hepatotoxicity of PPI and PII was associated with the cholesterol biosynthetic pathway disorders,which were alleviated by the cholesterol biosynthesis inhibitor lovastatin.Additionally,3-hydroxy-3-methy-lglutaryl CoA reductase(HMGCR)and squalene epoxidase(SQLE),the two rate-limiting enzymes in the cholesterol synthesis,selected as the potential targets,were confirmed by the molecular docking,the overexpression,and knockdown of HMGCR or SQLE with siRNA.Finally,the pull-down and surface plasmon resonance technology revealed that PPI could directly bind with SQLE but not with HMGCR.Collectively,these data demonstrated that PPI-induced hepatotoxicity resulted from the direct binding with SQLE protein and impaired the sterol-regulatory element binding protein 2/HMGCR/SQLE/lanosterol synthase pathways,thus disturbing the cholesterol biosynthesis pathway.The findings of this research can contribute to a better understanding of the key role of SQLE as a potential target in drug-induced hepatotoxicity and provide a therapeutic strategy for the prevention of drug toxic effects with similar structures in the future. | Zhiqi Li Qiqi Fan Meilin Chen Ying Dong Farong Li Mingshuang Wang Yulin Gu Simin Guo Xianwen Ye Jiarui Wu Shengyun Dai Ruichao Lin Chongjun Zhao | 2023 | Journal of Pharmaceutical Analysis2023，13，1： | 2 |
| 13 | Dynamic and steady control of quantum coherence in photonic crystals via the Zeeman effect显示文摘The dynamic evolution of a multi-level atom in the three-dimensional photonic crystal under an applied magnetic field is investigated.By combining the Zeeman effect with the photonic band gap effect,the dynamic quantum superposition states and steady quantum coherent trapping states of the atom can be flexibly controlled.This paves the way for coherent manipulation of quantum states in the solid-state system,which has important applications in quantum information processing. | CHEN LuZhou HUANG YongGang JIN ChongJun WANG XueHua | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，12： | 2 |
| 14 | Detection of Asymptomatic Carotid Artery Stenosis in High-Risk Individuals of Stroke Using a Machine-Learning Algorithm显示文摘Objective Asymptomatic carotid stenosis(ACS)is closely associated to the incidence of severe cerebrovascular diseases.Early identifying the individuals with ACS and its associated risk factors could be beneficial for primary prevention of stroke.This study aimed to investigate a machine-learning algorithm for the detection of ACS among high-risk population of stroke based on the associated risk factors.Methods A novel model of machine learning was utilized to screen the associated predictors of ACS based on 30 potential risk factors.The algorithm of this model adopted a random forest pattern based on the training data and then was verified using the testing data.All of the original data were retrieved from the China National Stroke Screening and Prevention Project(CNSSPP),including demographic,clinical and laboratory characteristics.The individuals with high risk of stroke were enrolled and randomly divided into a training group and a testing group at a ratio of 4:1.The identification of carotid stenosis by carotid artery duplex scans was set as the golden standard.The receiver operating characteristic(ROC)curve and the area under the curve(AUC)was used to evaluate the efficacy of the model in detecting ACS.Results Of 2841 high risk individual of stroke enrolled,326(11.6%)were diagnosed as ACS by ultrasonography.The top five risk fectors contributing to ACS in this model were identified as family history of dyslipidemia,high level of lowdensity lipoprotein cholesterol(LDL-c),low level of high-density lipoprotein cholesterol(HDL-c),aging,and low body. | Junxiong Yin Cheng Yu Lixia Wei Chuanyong Yu Hongxing Liu Mingyang Du Feng Sun Chongjun Wang Xiaoshan Wang | 2020 | Chinese Medical Sciences Journal2020，35，4： | 2 |
| 15 | Metal nanopartiele precipitation in periodic arrays in Au20-doped glass by two interfered femtosecond laser pulses 显示文摘 | Qu Shiliang QIU Jianrong ZHAO Chongjun | 2004 | Appl Phys Lett2004，84，12： | 1 |
| 16 | Some further results on the uniqueness range sets of meromorphic functions显示文摘 | Li Ping Yang Chongjun | 1995 | Kodai Mathematical Journal1995，18，： | 1 |
| 17 | Preparation and Optical Properties of Ag/PPy Composite Colloids显示文摘 | Chongjun Zhao Qitao Zhao Quanzhong Zhao | 2007 | Journal of Photochemistry and Photobiology A:Chemistry2007，187，23： | 1 |
| 18 | Synthesis of nano-sized Li4Ti5 O12/C composite anode material with excellent high-rate performance显示文摘 | Shaowei Zheng Yunlong Xu Chongjun Zhao | | 0，，： | 1 |
| 19 | The Bases of the Non-Uniform Cubic Spline Space S_(3)^(1,2)(Δ_(mn)^((2))显示文摘In this paper,the dimension of the nonuniform bivariate spline space S_(3)^(1,2)(Δ_(mn)^((2))is discussed based on the theory of multivariate spline space.Moreover,by means of the Conformality of Smoothing Cofactor Method,the basis ofS_(3)^(1,2)(Δ_(mn)^((2))composed of two sets of splines are worked out in the form of the values at ten domain points in each triangular cell,both of which possess distinct local supports.Furthermore,the explicit coefficients in terms of B-net are obtained for the two sets of splines respectively. | Jiang Qian Renhong Wang Chongjun Li | 2012 | Numerical Mathematics(Theory,Methods and Applications)2012，5，4： | 1 |
| 20 | A Web-mapping System for Real-time Visualization of the Global Terrain 显示文摘 | Zhang Liqiang Yang Chongjun Liu Donglin | 2005 | Computer & Geoscience2005，31，3： | 1 |
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