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| 1 | USP47-mediated deubiquitination and stabilization of YAP contributes to the progression of colorectal cancer显示文摘Dear Editor,The Hippo tumor suppressor pathway plays an important role in development and tumorigenesis.Yes-associated protein(YAP)is a major effector of the Hippo pathway regulating the expression of genes involved in cell proliferation,cell death,and cell differentiation(Pan,2010;Johnson and Haider,2014;Piccolo etal.,2014;Yu etal.,2015).In intestine,YAP is mainly expressed in leucine rich repeat containing G protein-coupled receptor 5(LGR5)marked stem cells,and is required for regeneration following tissue damage and the development of colon cancer in mice(Cai etal.,2010;Barry etal.,2013;Wang etal.,2017).Moreover,in colorectal cancer(CRC)specimens,elevated YAP expression and activity is frequently observed(Steinhardt et al.,2008).It has been shown that high YAP expression is associated with cancer metastasis,poor prognosis,resistance to chemotherapy,and greater possibility of relapse(Johnson and Haider,2014;Yu etal.,2015). | Beiqing Pan Yi Yang Jian Li Yu Wang Chuantao Fang Fa-Xing Yu Yanhui Xu | 2020 | Protein & Cell2020，11，2： | 4 |
| 2 | A ratiometric benzothiazole-based fluorescence probe for selectively recognizing HClO and its practical applications显示文摘A ratiometric probe(HBT-HBZ)bearing 2-hydrazino benzothiazole and 3-(benzo[d]thiazol-2-yl)-2-hydroxy-5-methylbenzaldehyde for sensing hypochlorous acid(HClO)with high selectivity and sensitivity is reported in this article.The fluorescence intensity ratios(I470nm/I572nm)of the probe with different concentrations of analyte showed excellent selectivity and a linear response to minor changes in HClO.The detection limit of 24 nmol/L suggests that the sensor is very sensitive to HClO.According to the series of performed experiments,HBT-HBZ has practical applications,such as the detection of HClO residues in tap water,which has been rarely reported.In addition,confocal laser microscopy experiments confirmed that HBT-HBZ can selectively recognize HClO in HeLa cells.A ratiometric probe(HBT-HBZ)for sensing HClO with high selectivity and sensitivity is reported in this article.The probe exhibited high selectivity for HClO among other ROS,RNS and anions.In addition,HBTHBZ has some practical applications such as the analysis of the HClO content in tap water.Furthermore,confocal fluorescence microscopy imaging showed that HBT-HBZ can be applied for detecting HClO in living cells. | Kaijie Wang Dazhou Xi Chuantao Liu Yahui Chen Hao Gu Long Jiang Xiaoqiang Chen Fang Wang | 2020 | Chinese Chemical Letters2020，31，11： | 2 |
| 3 | Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma显示文摘Dear Editor,Signet-ring cell carcinoma(SRCC)is a rare subtype of colorectal cancer(CRC)characterized histologically by the accumulation of mucins in the cytoplasm and displacement of nuclei to the cellular periphery,accounting for about 1%CRC(Fig.S1A)(Borger et al.,2007).Compare to common subtypes of CRC,such as adenocarcinoma(AC)and mucinous adenocarcinoma(MAC),SRCC is associated with aggressive behaviors and younger age at presentation(Kang et al.,2005;Sung et al.,2008;Nitsche et al.,2013;Hugen et al.,2014;Inamura et al.,2015).A retrospective analysis of CRC patient's data at Fudan University Shanghai Cancer Center(FUSCC)also indicated a worse overall and disease-free survival of SRCC patients(Fig.S1B and S1C,Table S1). | Yaqi Li Jian Li Renjie Wang Long Zhang Guoxiang Fu Xueying Wang Yebin Wang Chuantao Fang Dandan Zhang Duo Du Xiaoji Ma Mengxue Pan Qiang Guo Xiaoya Xu Xiang Hu Yi Zhou Shaobo Mo Huijun Wang Jianjun Gao Shenglin Huang Yun Liu Sanjun Cai Guoqiang Hua Junjie Peng Fa-Xing Yu | 2020 | Protein & Cell2020，11，4： | 2 |
| 4 | Three-dimensional lithospheric density distribution of China and surrounding regions显示文摘In this paper,we analyze lithospheric density distribution of China and surrounding regions on the basis of 300300gravity data and 1 1 P-wave velocity data.Firstly,we used the empirical equation between the density and the P-wave velocity difference as the base of the initial model of the Asian lithospheric density.Secondly,we calculated the gravity anomaly,caused by the Moho discontinuity and the sedimentary layer discontinuity,by the Parker formula.Thirdly,the gravity anomaly of the spherical harmonics with 2e40 order for the anomalous body below the lithosphere is calculated based on the model of EGM96.Finally,by using Algebra Reconstruction Techniques(ART),the inversion of 300300residual lithospheric Bouguer gravity anomaly caused by the lithosphere yields a rather detailed structural model.The results show that the lithospheric density distribution of China and surrounding regions has a certain connection with the tectonic structure.The density is relatively high in the Philippine Sea plate,Japan Sea,the Indian plate,the Kazakhstan shield and the Western Siberia plain,whereas the Tibetan Plateau has low-density characteristics.The minimum value of density lies in the north of Philippines,in the Taiwan province and in the Ryukyu island arc. | Chuantao Li Guibin Zhang Xinsheng Wang Zhengkai Wang Jian Fang | 2014 | Geoscience Frontiers2014，5，1： | 0 |
| 5 | Slow-light-enhanced on-chip 1D and 2D photonic crystal waveguide gas sensing in near-IR with an ultrahigh interaction factor显示文摘Nanophotonic waveguides hold great promise to achieve chip-scale gas sensors. However, their performance is limited by a short light path and small light–analyte overlap. To address this challenge, silicon-based, slow-lightenhanced gas-sensing techniques offer a promising approach. In this study, we experimentally investigated the slow light characteristics and gas-sensing performance of 1D and 2D photonic crystal waveguides(PCWs) in the near-IR(NIR) region. The proposed 2D PCW exhibited a high group index of up to 114, albeit with a high propagation loss. The limit of detection(LoD) for acetylene(C_(2)H_(2)) was 277 parts per million(ppm) for a1 mm waveguide length and an averaging time of 0.4 s. The 1D PCW shows greater application potential compared to the 2D PCW waveguide, with an interaction factor reaching up to 288%, a comparably low propagation loss of 10 dB/cm, and an LoD of 706 ppm at 0.4 s. The measured group indices of the 2D and 1D waveguides are104 and 16, respectively, which agree well with the simulation results. | ZIHANG PENG YIJUN HUANG KAIYUAN ZHENG CHUANTAO ZHENG MINGQUAN PI HUAN ZHAO JIALIN JI YUTING MIN LEI LIANG FANG SONG YU ZHANG YIDING WANG FRANK K.TITTEL | 2023 | Photonics Research2023，11，10： | 0 |
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