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| 1 | EZH2-, CHD4-, and IDH-linked epigenetic perturbation and its association with survival in glioma patients显示文摘Glioma 是有有限治疗选择的复杂疾病。最近的进展在多达 80% 更低的等级 gliomas (LGG ) 并且在 76% 第二等的 glioblastomas (GBM ) 识别了 isocitrate 脱氢酶(IDH ) 变化。IDH 变化也在尖锐 myeloid 白血病(AML ) 的 10%-20% 被看见。在 AML,包含 epigenetic 规定的 IDH 和另外的基因的变化是早事件,这被决定,出现在 pre 白血病的干细胞(最低有效字符前) 上演,而在宣传 oncogenic 信号的基因的变化是在白血病的迟了的事件。IDH 变化也是在 glioma 的早事件,发生在 TP53 变化前, 1p/19q 删除,等等。尽管有在 glioma 研究的这些进展,进另外的分子的改变的研究更加落后。在这研究,我们分析了当前可得到的数据库。我们除了已知的基因 IDH1/2 在 glioma 识别了 EZH2, KMT2C,和 CHD4 同样重要的基因。我们也证明 PIK3CA, CDKN2A, CDK4, FIP1L1,或 FUBP1 的 genomic 改变与 IDH 变化协作否定地在 LGG 影响病人幸存。在有 TP53 变化或 IDH1/2 变化的 LGG 病人,没有如此的改变, EZH2, KMC2C,和 CHD4 的另外的 genomic 改变个别地或在联合比病人与显著地减少的没有疾病的幸存被联系。在基因水平或蛋白质水平的 EZH2, KMT2C,和 CHD4 的改变能使不安 epigenetic 节目,在 glioma 导致恶意的转变。由在可得到的数据集上在 AML 和 glioma 和表现生物信息学分析上考察当前的文学,我们从 premalignant 干细胞在 tumorigenesis 上开发了一个假想模型到 glioma。 | Le Zhang Ying Liu Mengning Wang Zhenhai Wu Na Li Jinsong Zhang Chuanwei Yang | 2017 | Journal of Molecular Cell Biology2017，9，6： | 11 |
| 2 | Electrochemical corrosion behavior of composite coatings of sealed MAO film on magnesium alloy AZ91D显示文摘 | Hongping Duan Keqin Du Chuanwei Yan Fuhui Wang | 2005 | Electrochimica Acta2005，，14： | 3 |
| 3 | Growth process of plasma electrolytic oxidation films formed on magnesium alloy AZ91D in silicate solution显示文摘 | Hongping Duan Chuanwei Yan Fuhui Wang | 2007 | Electrochimica Acta2007，，15： | 2 |
| 4 | Three‐Dimensional Co3O4@MnO2 Hierarchical Nanoneedle Arrays: Morphology Control and Electrochemical Energy Storage显示文摘 | Dezhi Kong Jingshan Luo Yanlong Wang Weina Ren Ting Yu Yongsong Luo Yaping Yang Chuanwei Cheng | 2014 | Adv. Funct. Mater2014，，24： | 2 |
| 5 | Learning cross-modal interaction for RGB-T tracking显示文摘Dear editor,Visual object tracking, which has attracted increasing attention in the field of general visual understanding, aims to track each temporally changing object in a video sequence, with the target specified only in the first frame.Although most tracking algorithms have facilitated significant advances in RGB video sequences, object tracking using only RGB information is unreliable under extreme lighting conditions(e.g., dark night, rain, and foggy). | Chunyan XU Zhen CUI Chaoqun WANG Chuanwei ZHOU Jian YANG | 2023 | Science China(Information Sciences)2023，66，1： | 1 |
| 6 | Growth process of plasma electrolytic oxidation films formed on magnesium alloy AZ91D in silicate solution显示文摘 | Duan Hongping Yan Chuanwei Wang Fuhui | 2007 | Electrochimica Acta2007，52，： | 1 |
| 7 | Rice FLOURY ENDOSPERM22, encoding a pentatricopeptide repeat protein, is involved in both mitochondrial RNA splicing and editing and is crucial for endosperm development显示文摘Most of the reported P-type pentatricopeptide repeat(PPR) proteins play roles in organelle RNA stabilization and splicing. However, P-type PPRs involved in both RNA splicing and editing have rarely been reported, and their underlying mechanism remains largely unknown. Here, we report a rice floury endosperm22(flo22) mutant with delayed amyloplast development in endosperm cells. Map-based cloning and complementation tests demonstrated that FLO22 encodes a mitochondrion-localized P-type PPR protein.Mutation of FLO22 resulting in defective transsplicing of mitochondrial nad1 intron 1 and perhaps causing instability of mature transcripts affected assembly and activity of complex Ⅰ, and mitochondrial morphology and function. RNA-seq analysis showed that expression levels of many genes involved in starch and sucrose metabolism were significantly down-regulated in the flo22mutant compared with the wild type, whereas genes related to oxidative phosphorylation and the tricarboxylic acid cycle were significantly upregulated. In addition to involvement in splicing as a P-type PPR protein, we found that FLO22 interacted with DYW3, a DYW-type PPR protein, and they may function synergistically in mitochondrial RNA editing. The present work indicated that FLO22 plays an important role in endosperm development and plant growth by participating in nad1 maturation and multi-site editing of mitochondrial messager RNA. | Hang Yang Yunlong Wang Yunlu Tian Xuan Teng Zehui Lv Jie Lei Erchao Duan Hui Dong Xue Yang Yuanyan Zhang Yinglun Sun Xiaoli Chen Xiuhao Bao Rongbo Chen Chuanwei Gu Yipeng Zhang Xiaokang Jiang Wenyu Ma Pengcheng Zhang Yi Ji Yu Zhang Yihua Wang Jianmin Wan | 2023 | Journal of Integrative Plant Biology2023，65，3： | 1 |
| 8 | Influence of Al Content on the Atmospheric Corrosion Behaviour of Magnesium-Aluminum Alloys显示文摘The influence of Al content on the Mg-Al alloys corrosion performance during sodium chloride induced at- mospheric corrosion has been studied. It was found that the corrosion rate of three Mg-Al alloys was accelerated with increasing Al content. The poor corrosion resistance was attributed to the galvanic coupling between the β phase and eutectic phase or α phase and the formation of porous corrosion products. | Ruiling Jia Chuanwei Yan Fuhui Wang | 2009 | Journal of Materials Science & Technology2009，25，2： | 1 |
| 9 | Study on the Enviromentally Friendly Anodizing of AZ91D Magnesium Alloy 显示文摘 | Zhang Yongjun Yan Chuanwei Wang Fuhui | 2002 | Surface and Coating Technology2002，161，： | 1 |
| 10 | Effect of thermal fatigue on the wear resistance of graphite cast iron with bionic units processed by laser cladding WC显示文摘 | Zhengjun Jing Hong Zhou Peng Zhang Chuanwei Wang Chao Meng Dalong Cong | 2013 | Applied Surface Science2013，，： | 1 |
| 11 | Tensile property of a hot work tool steel prepared by bi- omimetic coupled laser remelting process with difference laser input energies显示文摘 | WANG Chuanwei ZHOU Heng ZHANG Zhihui | 2012 | Applied Surface Science2012，258，： | 1 |
| 12 | Study on theenvironmentally friendly anodizing of AZ91D magnesium alloy 显示文摘 | Yongjun Zhang Chuanwei Yan Fuhui wang | 2002 | Surface and Coatings Technology2002，161，1： | 1 |
| 13 | The mechanical properties of H13 die steel repaired by a biomimetic laser technique显示文摘 | Dalong Cong Hong Zhou Miaoqiang Yang Zhihui Zhang Peng Zhang Chao Meng Chuanwei Wang | 2013 | Optics and Laser Technology2013，，： | 1 |
| 14 | Study on the environmentally friendly anodizing of AZ91D magnesium alloy 显示文摘 | Zhang Yongjun Yan Chuanwei Wang Fuhui | 2002 | Surface and Coatings Technology2002，161，1： | 1 |
| 15 | Coupled-ridge waveguide quantum cascade laser array lasing at λ~5μm显示文摘In this work,we demonstrated high-power quantum cascade laser(QCL)arrays lasing at λ~5μm by employing an optimized coupled-ridge waveguide(CRW)structure.Five-element QCL arrays were simulated and fabricated through a two-step etching method to extend the CRW structure to a mid-wave infrared regime.A lateral far-field with the main peak near a diffraction-limited intensity curve of about 10°was observed by properly designing a geometric shape of the ridges and interspaces.By introducing a buried 2nd-order distributed feedback(DFB)grating,substrate emission with a radiation power above 1 W at 25℃ is achieved.Single longitudinal mode operation is obtained by changing the temperature of the heatsink with a good linear wavelength tuning coefficient of -0.2 cm^(-1)/K. | Pengchang Yang Jinchuan Zhang Zenghui Gu Chuanwei Liu Yue Zhao Fengmin Cheng Shenqiang Zhai Ning Zhuo Junqi Liu Lijun Wang Shuman Liu Fengqi Liu | 2021 | Journal of Semiconductors2021，42，9： | 1 |
| 16 | Growth process of plasma electrolytic oxidation films formed on magnesium alloy AZ91D in silicate solution显示文摘 | Hongping Duan Chuanwei Yan Fuhui Wang | 2007 | Electrochimica Acta2007，52，： | 1 |
| 17 | Effect of electrolyte additives on performance of plasma electrolytic oxidation films formed on magnesium alloy AZglD显示文摘 | Hongping Duan Chuanwei Yan Fuhui Wang | 2007 | Electrochimica Acta2007，52，11： | 1 |
| 18 | Visualization of microstructural factors resisting the crack propagation in mesosegregated high-strength low-alloy steel显示文摘While relationship between fracture mechanism and homogeneous microstructures has been fully understood,relationship between fracture mechanism and inhomogeneous microstructures such as the mesosegregation receives less attention as it deserves.Fracture mechanism of the high-strength low-alloy(HSLA)steel considering the mesosegregation was investigated and its corre s ponding micro structure was characterized in this paper.Mesosegregation re fers to the inhomogeneous distribution of alloy elements during casting solidification,and leads to the formation of positive segregation zones(PSZ)and negative segregation zones(NSZ)in ingots.The fracture surface of impact sample exhibits the quasi-cleavage fracture at-21℃,and is divided into ductile and brittle fracture zone.Meanwhile,the PSZ and NSZ spread across ductile and brittle fracture zone randomly.In ductile fracture zone,micro-voids fracture mechanism covers the PSZ and NSZ,and higher deformation degree is shown in the PSZ.In brittle fracture zone,secondary cleavage cracks are observed in both PSZ and NSZ,but present bigger size and higher quantity in the NSZ.However,some regions of the PSZ still present micro-voids fracture mechanism in brittle fracture zone.It reveals that the microstructures in the PSZ exhibit a higher resistance ability to crack propagation than that in the NSZ.All observations above provide a better visualization of the microstructural factors that resist the crack propagation.It is important to map all information regarding the fracture mechanism and mesosegregation to allow for further acceptance and industrial use. | Shuxia Wang Chuanwei Li Lizhan Han Haozhang Zhong Jianfeng Gu | 2020 | Journal of Materials Science & Technology2020，42，7： | 1 |
| 19 | Growth process of plasma electrolytic oxidation films formed on magnesium alloy AZ91D in silicate solution 显示文摘 | Duan Hongping Yan Chuanwei Wang Fuhui | 2007 | Electrochemical Acta2007，52，： | 1 |
| 20 | On the sensitivity improvement of CMOS capacitive accelerometer显示文摘 | Sun Chiming Wang Chuanwei Fang Weileun | 2008 | Sensors and Actuators A2008，，141： | 1 |
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