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| 1 | Safety and efficacy of ciprofol vs.propofol for sedation in intensive care unit patients with mechanical ventilation:a multi-center,open label,randomized,phase 2 trial显示文摘Background:Ciprofol(HSK3486;Haisco Pharmaceutical Group Co.,Ltd.,Chengdu,China),developed as a novel 2,6-disubstituted phenol derivative showed similar tolerability and efficacy characteristics as propofol when applicated as continuous intravenous infusion for 12 h maintenance sedation in a previous phase 1 trial.The phase 2 trial was designed to investigate the safety,efficacy,and pharmacokinetic characteristics of ciprofol for sedation of patients undergoing mechanical ventilation.Methods:In this multicenter,open label,randomized,propofol positive-controlled,phase 2 trial,39 Chinese intensive care unit patients receiving mechanical ventilation were enrolled and randomly assigned to a ciprofol or propofol group in a 2:1 ratio.The ciprofol infusion was started with a loading infusion of 0.1-0.2 mg/kg for 0.5-5.0 min,followed by an initial maintenance infusion rate of 0.30 mg·kg^(-1)·h^(-1),which could be adjusted to an infusion rate of 0.06 to 0.80 mg·kg^(-1)·h^(-1),whereas for propofol the loading infusion dose was 0.5-1.0 mg/kg for 0.5-5.0 min,followed by an initial maintenance infusion rate of 1.50 mg·kg^(-1)·h^(-1),which could be adjusted to 0.30-4.00 mg·kg^(-1)·h^(-1)to achieve-2 to+1 Richmond Agitation-Sedation Scale sedation within 6-24 h of drug administration.Results:Of the 39 enrolled patients,36 completed the trial.The median(min,max)of the average time to sedation compliance values for ciprofol and propofol were 60.0(52.6,60.0)min and 60.0(55.2,60.0)min,with median difference of 0.00(95%confidence interval:0.00,0.00).In total,29(74.4%)patients comprising 18(69.2%)in the ciprofol and 11(84.6%)in the propofol group experienced 86 treatment emergent adverse events(TEAEs),the majority being of severity grade 1 or 2.Drug-and sedation-related TEAEs were hypotension(7.7%vs.23.1%,P=0.310)and sinus bradycardia(3.8%vs.7.7%,P=1.000)in the ciprofol and propofol groups,respectively.The plasma concentration-time curves for ciprofol and propofol were similar.Conclusions:ciprofol is comparable to propofol with good tolerance and efficacy for sedation of Chinese intensive care unit patients undergoing mechanical ventilation in the present study setting.Trial registration:ClinicalTrials.gov,NCT04147416. | Yongjun Liu Xiangyou Yu Duming Zhu Jun Zeng Qinhan Lin Bin Zang Chuanxi Chen Ning Liu Xiao Liu Wei Gao Xiangdong Guan | 2022 | Chinese Medical Journal2022，，9： | 19 |
| 2 | Virus-Encoded microRNAs: Future Therapeutic Targets?显示文摘The discovery of microRNAs (miRNAs) is a remarkable breakthrough in the field of molecular genetics, as miRNAs are key actors which regulate gene expression in diverse cellular processes from unicellular yeast to human. The recent discovery of virus-encoded miRNAs indicates that viruses also use this fundamental mode of gene regulation. Research into viral miRNAs function demonstrates that some miRNAs play an important role in regulating both the viral life cycle and the interaction between viruses and their hosts. The first in vivo “antagomir” study provides an exciting first step towards miRNA therapy, and the potential for ultimately designing molecular medicines based on the modulation of miRNAs seems good. | Peng Qi Jinxiang Han Yanqin Lu Chuanxi Wang Fanfeng Bu | 2006 | Cellular & Molecular Immunology2006，3，6： | 12 |
| 3 | Nosocomial infection control in healthcare settings: Protection against emerging infectious diseases显示文摘The Middle East respiratory syndrome(MERS)outbreak in Korea in 2015 may be attributable to poor nosocomial infection control procedures implemented.Strict infection control measures were taken in the hospital where an imported case with MERS was treated in southern China and 53 health care workers were confirmed to be MERS-CoV negative.Infection control in healthcare settings,in which patients with emerging infectious diseases such as MERS,Ebola virus disease,and the severe acute respiratory syndrome(SARS)are diagnosed and treated,are often imperfect.When it comes to emerging or unknown infectious diseases,before the imported case was finally identified or community transmission was reported,cases have often occurred in clusters in healthcare settings.Nosocomial infection control measures should be further strengthened among the workers and inpatients in designated healthcare settings that accommodate suspected cases suffering from emerging or unknown infectious diseases. | Chuanxi Fu Shengyong Wang | 2016 | Infectious Diseases of Poverty2016，5，1： | 9 |
| 4 | Conformal isoparametric hypersurfaces with two distinct conformal principal curvatures in conformal space显示文摘The conformal geometry of regular hypersurfaces in the conformal space is studied.We classify all the conformal isoparametric hypersurfaces with two distinct conformal principal curvatures in the conformal space up to conformal equivalence. | NIE ChangXiong 1,2,LI TongZhu 3,HE YiJun 4 & WU ChuanXi 5 1 Faculty of Mathematics and Computer Sciences,Hubei University,Wuhan 430062,China 2 School of Mathematical Sciences,Peking University,Beijing 100871,China 3 Faculty of Sciences,Beijing Institute of Technology,Beijing 100081,China 4 School of Mathematical Sciences,Shanxi University,Taiyuan 030006,China 5 Institute of Mathematics,Hubei University,Wuhan 430062,China | 2010 | Science China Mathematics2010，53，4： | 9 |
| 5 | Regular Submanifolds in Conformal Space Q_p^n显示文摘The authors study the regular submanifolds in the conformal space Q_p^n and introduce the submanifold theory in the conformal space Q_p^n.The first variation formula of the Willmore volume functional of pseudo-Riemannian submanifolds in the conformal spaceQ_p^n is given.Finally,the conformal isotropic submanifolds in the conformal space Q_p^n are classified. | Changxiong NIE Chuanxi WU | 2012 | Chinese Annals of Mathematics,Series B2012，33，5： | 8 |
| 6 | In situ plasmonic optical fiber detection of the state of charge of supercapacitors for renewable energy storage显示文摘In situ and continuous monitoring of electrochemical activity is key to understanding and evaluating the operation mechanism and efficiency of energy storage devices.However,this task remains challenging.For example,the present methods are not capable of providing the real-time information about the state of charge(SOC)of the energy storage devices while in operation.To address this,a novel approach based on an electrochemical surface plasmon resonance(SPR)optical fiber sensor is proposed here.This approach offers the capability of in situ comprehensive monitoring of the electrochemical activity(the electrode potential and the SOC)of supercapacitors(used as an example).The sensor adopted is a tilted fiber Bragg grating imprinted in a commercial single-mode fiber and coated with a nanoscale gold film for high-efficiency SPR excitation.Unlike conventional“bulk”detection methods for electrode activity,our approach targets the“localized”(sub-μm-scale)charge state of the ions adjacent to the electrode interface of supercapacitors by monitoring the properties of the SPR wave on the fiber sensor surface located adjacent to the electrode.A stable and reproducible correlation between the real-time charge–discharge cycles of the supercapacitors and the optical transmission of the optical fiber has been found.Moreover,the method proposed is inherently immune to temperature cross-talk because of the presence of environmentally insensitive reference features in the optical transmission spectrum of the devices.Finally,this particular application is ideally suited to the fundamental qualities of optical fiber sensors,such as their compact size,flexible shape,and remote operation capability,thereby opening the way for other opportunities for electrochemical monitoring in various hard-to-reach spaces and remote environments. | Jiajie Lao Peng Sun Fu Liu Xuejun Zhang Chuanxi Zhao Wenjie Mai Tuan Guo Gaozhi Xiao Jacques Albert | 2018 | Light(Science & Applications)2018，7，1： | 8 |
| 7 | Recent advances in biological detection with magnetic nanoparticles as a useful tool显示文摘Magnetic nanoparticles have emerged as a powerful tool for magnetic resonance imaging, biodetection, drug delivery, and hyperthermia. This review focuses on the biological detection of magnetic nanoparticles as well as their physicochemical properties. Substantial progress in the sensitivity of detection has been made by developing variety of methods. Five applications of magnetic nanoparticles in biological detection are discussed in this review: magnetic separation, magnetic sensing, magnetic manipulation, magnetic catalysis, and signal enhancer for surface plasmon resonance(SPR). Finally, some future trends and perspectives in these research areas are outlined. | Liwei Lu Xiuyu Wang Chuanxi Xiong Li Yao | 2015 | Science China Chemistry2015，58，5： | 6 |
| 8 | Analysis of Power Consumption on Laser Solder Joints of Electric Connector显示文摘Laser soldering process was introduced in Universal serial bus(USB) 2.0 electric connector to improve the mechanical and electrical bonding reliability. While, the effects of laser soldering technology on electric connector solder joints need to be estimated completely, especially on power consumption. The combined method based on numerical simulation and the Accelerated temperature experiment(ATE) was developed to analyze the power consumption of USB 2.0 electric connector in this paper. The ATE contains thermal cycle and thermal shock tests, and the four-electrode method is used to obtain the conductivity of solder joints. Numerical modeling and analysis was used to quantify the power consumption and optimize the geometry of solder joints, because the electric experimental measurements of power consumption during ATE are time-costing and often intractable. Accurate knowledge of the power consumption is a prerequisite for the reliability of the electric connector. | ZENG Zhi LI Xunbo LI Miao HUANG Bo WANG Rui XIA Chuanxi | 2014 | Chinese Journal of Electronics2014，23，4： | 5 |
| 9 | Bushen Qiangjin capsule(补肾强筋胶囊) inhibits the Wnt/β-catenin pathway to ameliorate papain-induced knee osteoarthritis in rats显示文摘OBJECTIVE:To evaluate the molecular mechanism underlying the beneficial effect of Bushen Qiangjin capsule(补肾强筋胶囊,BSQJ),a Traditional Chinese Medicine,on knee osteoarthritis(KOA).METHODS:In the present study,32 female Sprague-Dawley rats were randomly divided into four groups:control,KOA,high-dose BSQJ(H-BSQJ),and low-dose BSQJ(L-BSQJ).After successfully establishing the KOA model by intra-articular injection of papain,H-BSQJ and L-BSQJ groups were intragastrically administered 0.243 and 0.122 g/kg BSQJ,respectively,daily for 6 weeks.At the end of the experiment,knee articular cartilage tissues of rats were collected for evaluation by hematoxylin and eosin staining,Safranin O-Fast Green staining,and terminal deoxynucleotidyl transferase-mediated d UTP nick-end labeling assay.Serum interleukin-1βand tumor necrosis factor-αlevels of rats were detected with an enzyme-linked immunosorbent assay method.Gene expression of Wnt-4,β-catenin,Frizzled-2,glycogen synthase kinase-3β(GSK-3β),cysteinyl aspartate-specific proteinases 3 and 9(caspases 3 and 9),collagen typeⅡalpha 1(Col2 a1),and matrix metalloproteinases 1 and 13(MMP-1 and MMP-3)of rat knee articular cartilage was quantified by reverse transcription-quantitative polymerase chain reaction analysis.Wnt-4,β-catenin,Frizzled-2,GSK-3β,cleaved caspase-3,and cleaved caspase-9 protein expression in rat knee articular cartilage was determined by western blot analysis.RESULTS:BSQJ obviously reduced pathological damage and matrix degradation of articular cartilage in KOA rats.Compared with the KOA group,H-BSQJ rats exhibited downregulated m RNA and protein expression of Wnt-4,β-catenin,Frizzled-2,and caspase-3,as well as upregulated m RNA and protein expression of GSK-3β.In addition,H-BSQJ significantly increased m RNA expression of Col2 a1 and decreased m RNA expression of MMP-1 and MMP-13.CONCLUSION:BSQJ exerted a beneficial effect on KOA by a mechanism involving downregulation of the Wnt/β-catenin pathway,which inhibited both cartilage extracellular matrix degradation and chondrocyte apoptosis to ameliorate KOA in rats. | YAO Nan CHEN Guocai LU Yanyan XU Xuemeng ZHAO Chuanxi HUANG Xuejun LIU Wengang PENG Sha WU Huai | 2021 | Journal of Traditional Chinese Medicine2021，41，6： | 5 |
| 10 | Assessment of outcomes of hearing and speech rehabilitation in children with cochlear implantation显示文摘Objectives:This study aimed to assess the effect of hearing and speech rehabilitation in patients with Nurotron■cochlear implants.Design:Ninety-eight paediatric patients with bilateral severe-to-profound sensorineural deafness who received cochlear implantation were divided into three groups according to age:group A(≤3 years),group B(4-7 years),and group C(8-16 years).All patients were followed up for one year for hearing and speech performance after the surgery.The comprehensive Auditory Perception Assessment,MAIS,CAP and SIR hearing and speech assessments and rating materials were used for assessment before the surgery and at 3,6,and 12 months after implant activation.Results:The scores of patients in the open-set speech assessment,Chinese Auditory Perception Assessment,MAIS,CAP and SIR significantly improved after cochlear implantation in all age groups.The younger the age at implantation,the better the results.Moreover,the hearing and speech performance of cochlear implant recipients gradually improved with the extension of rehabilitation time.Conclusions:Nurotron■Venus^TM cochlear implantation can improve the hearing and speech performance of patients with bilateral severe-to-profound sensorineural deafness. | Shaofeng Liu Fang Wang Peipei Chen Na Zuo Cheng Wu Jun Ma Jingjiang Huang Chuanxi Wang | 2019 | Journal of Otology2019，14，2： | 4 |
| 11 | Mechanical Behavior of a Partially Encased Composite Girder with Corrugated Steel Web: Interaction of Shear and Bending显示文摘 | Jun He Sihao Wang Yuqing Liu Zhan Lyu Chuanxi Li | 2017 | Engineering2017，3，6： | 4 |
| 12 | Pm67, a new powdery mildew resistance gene transferred from Dasypyrum villosum chromosome 1V to common wheat(Triticum aestivum L.)显示文摘Powdery mildew, caused by the biotrophic fungus Blumeria graminis f. sp. tritici(Bgt), is a global disease that poses a serious threat to wheat production. To explore additional resistance gene, a wheatDasypyrum villosum 1 V#5(1 D) disomic substitution line NAU1813(2 n = 42) with high level of seedling resistance to powdery mildew was used to generate the recombination between chromosomes 1 V#5 and1 D. Four introgression lines, including t1 VS#5 ditelosomic addition line NAU1815, t1 VL#5 ditelosomic addition line NAU1816, homozygous T1 DL·1 VS#5 translocation line NAU1817, and homozygous T1 DS·1 VL#5 translocation line NAU1818 were developed from the selfing progenies of 1 V#5 and 1 D double monosomic line that derived from F1 hybrids of NAU1813/NAU0686. All of them were characterized by fluorescence in situ hybridization, genomic in situ hybridization, 1 V-specific markers analysis, and powdery mildew tests at different developmental stages. A new powdery mildew resistance gene named Pm67 was physically located in the terminal bin(FL 0.70–1.00) of 1 VS#5. Lines with Pm67 exhibited seedling stage immunity and tissue-differentiated reactions at adult plant stage. The sheaths, stems, and spikes of the Pm67 line were still immune, but the leaves showed a low degree of susceptibility.Microscopic observation showed that most penetration attempts were stopped in association with papillae on the sheath, and colonies cannot form conidia on the susceptible leaf of Pm67 line at adult plant stage, suggesting that the defence layers of the Pm67 line is tissue-differentiated. Thus, the T1 DL·1 VS#5 translocation line NAU1817 provides a new germplasm in wheat breeding for improvement of powdery mildew resistance. | Ruiqi Zhang Chuanxi Xiong Huanqing Mu Ruonan Yao Xiangru Meng Lingna Kong Liping Xing Jizhong Wu Yigao Feng Aizhong Cao | 2021 | The Crop Journal2021，9，4： | 3 |
| 13 | Satellite Measurements of the Madden–Julian Oscillation in Wintertime Stratospheric Ozone over the Tibetan Plateau and East Asia显示文摘We investigate the Madden–Julian Oscillation(MJO) signal in wintertime stratospheric ozone over the Tibetan Plateau and East Asia using the harmonized dataset of satellite ozone profiles. Two different MJO indices — the all-season Real-Time multivariate MJO index(RMM) and outgoing longwave radiation-based MJO index(OMI) — are used to compare the MJOrelated ozone anomalies. The results show that there are pronounced eastward-propagating MJO-related stratospheric ozone anomalies(mainly within 20–200 h Pa) over the subtropics. The negative stratospheric ozone anomalies are over the Tibetan Plateau and East Asia in MJO phases 4–7, when MJO-related tropical deep convective anomalies move from the equatorial Indian Ocean towards the western Pacific Ocean. Compared with the results based on RMM, the MJO-related stratospheric column ozone anomalies based on OMI are stronger and one phase ahead. Further analysis suggests that different sampling errors, observation principles and retrieval algorithms may be responsible for the discrepancies among different satellite measurements. The MJO-related stratospheric ozone anomalies can be attributed to the MJO-related circulation anomalies,i.e., the uplifted tropopause and the northward shifted westerly jet in the upper troposphere. Compared to the result based on RMM, the upper tropospheric westerly jet may play a less important role in generating the stratospheric column ozone anomalies based on OMI. Our study indicates that the circulation-based MJO index(RMM) can better characterize the MJOrelated anomalies in tropopause pressure and thus the MJO influence on atmospheric trace gases in the upper troposphere and lower stratosphere, especially over subtropical East Asia. | ZHANG Yuli LIU Yi LIU Chuanxi V.F.SOFIEVA | 2015 | Advances in Atmospheric Sciences2015，32，11： | 3 |
| 14 | Mechanism and Kinetics of Phase Transformation in Two-phase TiAl-based Alloys显示文摘The aged and quenched microstructures of both alloys, Ti-42at-%Al and Ti-45at -%Al,homogenized in the disordered single phase field. were investigated And the results show that the quinched microstructure is a supersaturated single phase of ordered 22. When the supersaturated phase is aged in the two phase range at 1273 and 1373 K, it will transform to a lamellar microstructure of γ+α2. with a discontinuous decomposition mechanism in Ti-42at-%Al alloy and a semicontinuous decomposition mechanism in T1-45at-%Al alloy. With the methods of quantitative metallograph examination and X-ray diffraction analysis. the relationship between the amount of γ, phase precipitation and the time of isothermal transformation is | Shiming HAO+ and Wen tao WU(Dept. of Mater. Sci., Northeastern University, Shenyang, 110006, China)Chuanxi HAN(Northwest Institute for Nonferrous Metal Research, Bao ji, 721014, China) | 1994 | Journal of Materials Science & Technology1994，10，3： | 2 |
| 15 | Low‐intensity pulsed ultrasound ameliorates angiotensin II-induced cardiac fibrosis by alleviating inflammation via a caveolin-1-dependent pathway显示文摘Objective:Cardiac hypertrophy and fibrosis are major pathological manifestations observed in left ventricular remodeling induced by angiotensin II(AngII).Low-intensity pulsed ultrasound(LIPUS)has been reported to ameliorate cardiac dysfunction and myocardial fibrosis in myocardial infarction(MI)through mechano-transduction and its downstream pathways.In this study,we aimed to investigate whether LIPUS could exert a protective effect by ameliorating AngII-induced cardiac hypertrophy and fibrosis and if so,to further elucidate the underlying molecular mechanisms.Methods:We used AngII to mimic animal and cell culture models of cardiac hypertrophy and fibrosis.LIPUS irradiation was applied in vivo for 20 min every 2 d from one week before mini-pump implantation to four weeks after mini-pump implantation,and in vitro for 20 min on each of two occasions 6 h apart.Cardiac hypertrophy and fibrosis levels were then evaluated by echocardiographic,histopathological,and molecular biological methods.Results:Our results showed that LIPUS could ameliorate left ventricular remodeling in vivo and cardiac fibrosis in vitro by reducing AngII-induced release of inflammatory cytokines,but the protective effects on cardiac hypertrophy were limited in vitro.Given that LIPUS increased the expression of caveolin-1 in response to mechanical stimulation,we inhibited caveolin-1 activity with pyrazolopyrimidine 2(pp2)in vivo and in vitro.LIPUS-induced downregulation of inflammation was reversed and the anti-fibrotic effects of LIPUS were absent.Conclusions:These results indicated that LIPUS could ameliorate AngII-induced cardiac fibrosis by alleviating inflammation via a caveolin-1-dependent pathway,providing new insights for the development of novel therapeutic apparatus in clinical practice. | Kun ZHAO Jing ZHANG Tianhua XU Chuanxi YANG LiqingWENG TingtingWU XiaoguangWU Jiaming MIAO Xiasheng GUO Juan TU Dong ZHANG Bin ZHOU Wei SUN Xiangqing KONG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，10： | 2 |
| 16 | Some theorems of random operator equations 显示文摘 | Zhu Chuanxi Xu Zongben | 2002 | International Journal of Mathematics and Mathematical Sciences2002，30，9： | 2 |
| 17 | Perovskite-based color camera inspired by human visual cells显示文摘There are two primary types of photoreceptor cells in the human eye:cone cells and rod cells that enable color vision and night vision,respectively.Herein,inspired by the function of human visual cells,we develop a high-resolution perovskite-based color camera using a set of narrowband red,green,blue,and broadband white perovskite photodetectors as imaging sensors.The narrowband red,green,and blue perovskite photodetectors with color perceptions mimic long-,medium-,and short-wavelength cones cells to achieve color imaging ability.Also,the broadband white perovskite photodetector with better detectivity mimics rod cells to improve weak-light imaging ability.Our perovskite-based camera,combined with predesigned pattern illumination and image reconstruction technology,is demonstrated with high-resolution color images(up to 256 x 256 pixels)in diffuse mode.This is far beyond previously reported advanced perovskite array image sensors that only work in monochrome transmission mode.This work shows a new approach to bio-inspired cameras and their great potential to strongly mimic the ability of the natural eve. | Yujin Lu Zhong Ji Guobiao Cen Hengchao Sun Haibao Wang Chuanxi Zhao Zhong Lin Wang Wenjie Mai | 2023 | Light(Science & Applications)2023，12，2： | 2 |
| 18 | A FIRST-ORDER SPLITTING METHOD FOR SOLVING A LARGE-SCALE COMPOSITE CONVEX OPTIMIZATION PROBLEM显示文摘In this paper, we construct several efficient first-order splitting algorithms for solving a multi-block composite convex optimization problem. The objective function includes a smooth function with a Lipschitz continuous gradient, a proximable convex function that may be nonsmooth, and a finite sum composed of a proximable function and a bounded linear operator. To solve such an optimization problem, we transform it into the sum of three convex functions by defining an appropriate inner product space. Based on the dual forward-backward splitting algorithm and the primal-dual forward-backward splitting algorithm, we develop several iterative algorithms that involve only computing the gradient of the differentiable function and proximity operators of related convex functions. These iterative algorithms are matrix-inversion-free and completely splitting algorithms. Finally, we employ the proposed iterative algorithms to solve a regularized general prior image constrained compressed sensing model that is derived from computed tomography image reconstruction. Numerical results show that the proposed iterative algorithms outperform the compared algorithms including the alternating direction method of multipliers, the splitting primal-dual proximity algorithm, and the preconditioned splitting primal-dual proximity algorithm. | Yuchao Tang Guorong Wu Chuanxi Zhu | 2019 | Journal of Computational Mathematics2019，37，5： | 2 |
| 19 | Microstructure and pore structure of concrete mixed with superfine phosphorous slag and superplasticizer显示文摘 | Gao Peiwei Lu Xiaolin Yang Chuanxi | 2008 | Construction and Building Materials2008，，22： | 1 |
| 20 | A new deliverability prediction method of horizontal well in gas reservoir显示文摘 | Wang Shuping Yuan Xiangchun Liu Chuanxi | 2010 | Journal of Southwest Petroleum University Science & Technology Edition2010，32，2： | 1 |
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