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| 1 | Minimal invasive microscopic tooth preparation in esthetic restoration: a specialist consensus显示文摘By removing a part of the structure,the tooth preparation provides restorative space,bonding surface,and finish line for various restorations on abutment.Preparation technique plays critical role in achieving the optimal result of tooth preparation.With successful application of microscope in endodontics for>30 years,there is a full expectation of microscopic dentistry.However,as relatively little progress has been made in the application of microscopic dentistry in prosthodontics,the following assumptions have been proposed:Is it suitable to choose the tooth preparation technique under the naked eye in the microscopic vision?Is there a more accurate preparation technology intended for the microscope?To obtain long-term stable therapeutic effects,is it much easier to achieve maximum tooth preservation and retinal protection and maintain periodontal tissue and oral function health under microscopic vision?Whether the microscopic prosthodontics is a gimmick or a breakthrough in obtaining an ideal tooth preparation should be resolved in microscopic tooth preparation.This article attempts to illustrate the concept,core elements,and indications of microscopic minimally invasive tooth preparation,physiological basis of dental pulp,periodontium and functions involved in tool preparation,position ergonomics and visual basis for dentists,comparison of tooth preparation by naked eyes and a microscope,and comparison of different designs of microscopic minimally invasive tooth preparation techniques.Furthermore,a clinical protocol for microscopic minimally invasive tooth preparation based on target restorative space guide plate has been put forward and new insights on the quantity and shape of microscopic minimally invasive tooth preparation has been provided. | Haiyang Yu Yuwei Zhao Junying Li Tian Luo Jing Gao Hongchen Liu Weicai Liu Feng Liu Ke Zhao Fei Liu Chufan Ma Juergen MSetz Shanshan Liang Lin Fan Shanshan Gao Zhuoli Zhu Jiefei Shen Jian Wang Zhimin Zhu Xuedong Zhou | 2019 | International Journal of Oral Science2019，11，4： | 25 |
| 2 | Positioning error compensation of an industrial robot using neural networks and experimental study显示文摘Due to the characteristics of high efficiency,wide working range,and high flexibility,industrial robots are being increasingly used in the industries of automotive,machining,electrical and electronic,rubber and plastics,aerospace,food,etc.Whereas the low positioning accuracy,resulted from the serial configuration of industrial robots,has limited their further developments and applications in the field of high requirements for machining accuracy,e.g.,aircraft assembly.In this paper,a neural-network-based approach is proposed to improve the robots’positioning accuracy.Firstly,the neural network,optimized by a genetic particle swarm algorithm,is constructed to model and predict the positioning errors of an industrial robot.Next,the predicted errors are utilized to realize the compensation of the target points at the robot’s workspace.Finally,a series of experiments of the KUKA KR 500–3 industrial robot with no-load and drilling scenarios are implemented to validate the proposed method.The experimental results show that the positioning errors of the robot are reduced from 1.529 mm to 0.344 mm and from 1.879 mm to 0.227 mm for the no-load and drilling conditions,respectively,which means that the position accuracy of the robot is increased by 77.6%and 87.9%for the two experimental conditions,respectively. | Bo LI Wei TIAN Chufan ZHANG Fangfang HUA Guangyu CUI Yufei LI | 2022 | Chinese Journal of Aeronautics2022，35，2： | 9 |
| 3 | Two congenital coronary abnormalities affecting heart function: anomalous origin of the left coronary artery from the pulmonary artery and congenital left main coronary artery atresia显示文摘 | Xiao Yanyan Jin Mei Han Ling Ding Wenhong Zheng Jianyong Sun Chufan Lyu Zhenyu | 2014 | Chinese Medical Journal2014，，21： | 7 |
| 4 | Superconducting gap evolution of kagome metal CsV3Sb5 under pressure显示文摘Kagome superconductors AV3Sb5(A=Cs,V,Sb) have served as an ideal platform to unveil the intriguing competitions between charge-density-wave(CDW),superconductivity and possible nontrivial topological states.We report soft point-contact spectroscopy(SPCS) studies on CsV3Sb5under pressure up to 2.5 GPa.Its superconducting transition temperature Tcand gaps for SPCS at pressure P=0.1 GPa suggest the absence of the adverse local strain effect as observed in point-contacts at ambient pressure,while the SPCS-determined Tcunder hydrostatic pressure deviates from the reported double dome feature below 2.5 GPa.Three distinct gap values in CsV3Sb5are proposed to exist through the whole pressure range with 2Δ1/kBTc≤1,2Δ2/kBTc~2.3-3.0 and 2Δ3/kBTc>3.5.The two smaller gaps for 2Δ1/kBTc≤1 and 2Δ2/kBTc~2.3-3.0 are robust under pressure,while there is no trace of the largest gap 2Δ3/kBTc>3.5 for SPCS in the c direction with P≤P1=0.7 GPa and P≥ P2=2.0 GPa and it becomes observable in the pressure range of(P1,P2),suggesting a complex relation between CDW and superconductivity between(P1,P2). | Dongting Zhang Chufan Chen Lichang Yin Yan'En Huang Fengrui Shi Yi Liu Xiaofeng Xu Huiqiu Yuan Xin Lu | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，2： | 2 |
| 5 | PD173074, a selective FGFR inhibitor reverses ABCB1- mediated drug resistance in cancer cells 显示文摘 | Patel A Tiwari AK Chufan EE | 2013 | Cancer Chemother Pharmacol2013，72，1： | 1 |
| 6 | Anticonvulsant activity of analogues of acetazolamide显示文摘 | CHUFAN E E PEDREGOSA J C BADINI O N | 1999 | Farmaco1999，54，： | 1 |
| 7 | PD173074, a selective FG- FR inhibitor, reverses ABCB1 - mediated drug resistance in cancer cells显示文摘 | Patel A Tiwari AK Chufan EE | 2013 | Cancer Chemother Pharmacol2013，72，： | 1 |
| 8 | Electrically polarized micro-arc oxidized TiO 2 coatings with enhanced surface hydrophilicity显示文摘 | Chufan Ma Akiko Nagai Yuko Yamazaki Takeshi Toyama Yusuke Tsutsumi Takao Hanawa Wei Wang Kimihiro Yamashita | 2011 | Acta Biomaterialia2011，，2： | 1 |
| 9 | PD173074, a selective FGFR inhibitor, reverses ABCBl-mediated drug resistance in cancer ceils 显示文摘 | Patel A Tiwari AK Chufan EE | 2013 | Cancer Chemother Pharmaeol2013，72，1： | 1 |
| 10 | The effect of enhanced external counterpulsation on C‐reactive protein and flow‐mediated dilation in porcine model of hypercholesterolaemia显示文摘 | Yanqiu Liu Yan Xiong Donghong Liu Chufan Luo Yan Zhang Guifu Wu Qiang Xie Yugang Dong Zhensheng Zheng | 2012 | Clinical Physiology and Functional Imaging2012，，： | 1 |
| 11 | Thermodilution-Derived Coronary Microvascular Resistance and Flow Reserve in Patients With Cardiac Syndrome X显示文摘 | Chufan Luo Ming Long Xun Hu Zhibin Huang Chengheng Hu Xiuren Gao Zhimin Du | 2014 | Circulation: Cardiovascular Interventions2014，，1： | 1 |
| 12 | Molecular basis of the polyspeciflcity of P-Glycoprotein ( ABCB1 ) : recent biochemical and structural studies显示文摘 | Chufan EE Sim HM Ambudkar SV | 2015 | Adv Cancer Res2015，125，： | 1 |
| 13 | TCR–pMHC bond conformation controls TCR ligand discrimination显示文摘A major unanswered question is how a TCR discriminates between foreign and self-peptides presented on the APC surface.Here,we used in situ fluorescence resonance energy transfer(FRET)to measure the distances of single TCR–pMHC bonds and the conformations of individual TCR–CD3ζreceptors at the membranes of live primary T cells.We found that a TCR discriminates between closely related peptides by forming single TCR–pMHC bonds with different conformations,and the most potent pMHC forms the shortest bond.The bond conformation is an intrinsic property that is independent of the binding affinity and kinetics,TCR microcluster formation,and CD4 binding.The bond conformation dictates the degree of CD3ζdissociation from the inner leaflet of the plasma membrane via a positive calcium signaling feedback loop to precisely control the accessibility of CD3ζITAMs for phosphorylation.Our data revealed the mechanism by which a TCR deciphers the structural differences among peptides via the TCR–pMHC bond conformation. | Dibyendu KSasmal Wei Feng Sobhan Roy Peter Leung Yanran He Chufan Cai Guoshuai Cao Huada Lian Jian Qin Enfu Hui Hans Schreiber Erin JAdams Jun Huang | 2020 | Cellular & Molecular Immunology2020，17，3： | 0 |
| 14 | Laminin 332-functionalized coating to regulate the behavior of keratinocytes and gingival mesenchymal stem cells to enhance implant soft tissue sealing显示文摘Peri-implant epithelial sealing is the first line of defense against external pathogens or stimuli;hence,an essential process to prevent peri-implantitis.Laminin 332(LN332)is the main component of the internal basal lamina and participates in peri-implant epithelial sealing by forming hemidesmosomes(HDs)with integrinα6β4.In thiswork,poly(D,L-lactide)(PDLLA)-LN332 composite coating was successfully constructed by a method similar to layer-by-layer assembly,displaying staged LN332 release for as long as 28days.The PDLLA-LN332 composite coating can activate the intracellular PI3K-Akt pathway via binding to cellular integrinα6β4,which can promote adhesion,migration and proliferation of HaCaT cells and further enhance the expression of keratinocyte HD-related molecules,including integrinα6β4,LN332 and plectin.Furthermore,the PDLLA-LN332 composite coating can promote the adhesion,spreading and proliferation of gingival mesenchymal stem cells and accelerate their epithelial differentiation.Therefore,the PDLLA-LN332 composite coating can enhance implant soft tissue sealing,warranting further in vivo study. | Lipeng Liu Jing Wang Ying Li Bing Liu Wei Zhang Weikang An Qing Wang Boya Xu Lingzhou Zhao Chufan Ma | 2022 | Regenerative Biomaterials2022，9，1： | 0 |
| 15 | Fresh Processing Technology in Polygonatum odoratum Production Area and Its Comparison with Traditional Processing显示文摘[Objectives]To compare the effects of traditional processing and fresh processing on the quality of Polygonatum odoratum decoction piece.[Methods]The effects of fresh processing and traditional processing on the quality of P.odoratum decoction piece were compared and analyzed with appearance characteristics,total ash content,extract content,total polysaccharides content,and total flavonoids content as the evaluation indexes.[Results]Fresh processing method in different production areas has different effects on P.odoratum decoction piece.P.odoratum was dried in oven of 50℃.When moisture content was 41.44%-59.67%,it was cut.After complete drying at 50℃,the moisture content of dried P.odoratum was 8.94%-9.60%,and ethanol-soluble extract content was 77.29%-78.20%,and water-soluble extract was 77.7%-78.14%.At this time,the appearance characteristics of section of P.odoratum decoction piece were better than that of traditional processing,which was yellowish white.The total polysaccharide content was higher than that of traditional processing,and the content of total flavonoids was statistically significant different from that of traditional processing.[Conclusions]The quality of P.odoratum decoction piece by fresh processing is better than that of the traditional processing,and it is feasible to use fresh processing. | Miao YANG Chufan PENG Haixia LU Rufeng LIANG Hui TANG Zhongmei QIN Shengjiu GU | 2024 | Medicinal Plant2024，15，1： | 0 |
| 16 | Pulmonary endogenous progenitor stem cell subpopulation:Physiology,pathogenesis,and progress显示文摘Lungs are structurally and functionally complex organs consisting of diverse cell types from the proximal to distal axis.They have direct contact with the external environment and are constantly at risk of various injuries.Capable to proliferate and differentiate,pulmonary endogenous progenitor stem cells contribute to the maintenance of lung structure and function both under homeostasis and following injuries.Discovering candidate pulmonary endogenous progenitor stem cell types and underlying regenerative mechanisms provide insights into therapeutic strategy development for lung diseases.In this review,we reveal their compositions,roles in lung disease pathogenesis and injury repair,and the underlying mechanisms.We further underline the advanced progress in research approach and potential therapy for lung regeneration.We also demonstrate the feasibility and prospects of pulmonary endogenous stem cell transplantation for lung disease treatment. | Di Liu Chufan Xu Lai Jiang Xiaoyan Zhu | 2023 | Journal of Intensive Medicine2023，3，1： | 0 |
| 17 | Advances in the dynamic control of metabolic pathways in Saccharomyces cerevisiae显示文摘The metabolic engineering of Saccharomyces cerevisiae has great potential for enhancing the production of high-value chemicals and recombinant proteins.Recent studies have demonstrated the effectiveness of dynamic regu-lation as a strategy for optimizing metabolic flux and improving production efficiency.In this review,we provide an overview of recent advancements in the dynamic regulation of S.cerevisiae metabolism.Here,we focused on the successful utilization of transcription factor(TF)-based biosensors within the dynamic regulatory network of S.cerevisiae.These biosensors are responsive to a wide range of endogenous and exogenous signals,including chemical inducers,light,temperature,cell density,intracellular metabolites,and stress.Additionally,we ex-plored the potential of omics tools for the discovery of novel responsive promoters and their roles in fine-tuning metabolic networks.We also provide an outlook on the development trends in this field. | Chufan Xiao Yuyang Pan Mingtao Huang | 2023 | Engineering Microbiology2023，3，4： | 0 |
| 18 | Efficient replacement of long DNA fragments via non-homologous end joining at norrcoding regions显示文摘Targeted double-strand breaks(DSBs)in genomes can be introduced efficiently by endonucleases(Umov et al.,2010;Jinek et al.,2012;Joung and Sander,2013),including zinc-finger nucleases,tran scription activator-like effector nu cleases,and clustered regularly in terspaced palindromic repeats(CRISPR)/Cas9.After DSBs,DNA repair is mainly via homology-directed repair(HDR)and/or non-homologous end joining(NHEJ)(Hustedt and Durocher,2016).It was reported that genomic DNA replacement can be achieved via HDR at the site of DSBs in multiple organisms(Dickinson et al.,2013;Yang et al.,2013;Zu et al.,2013),but the efficiency is still not enough for general application,in particular for replacing long DNA fragment that is more than hundreds of base pairs(bps).As NHEJ is 10-fold more active than HDR at DSB sites(Mao et al.,2008),we speculated that NHEJ can be utilized to implement long genomic DNA replacement with high efficiency. | Shanye Gu Jia Li Siyuan Li Jianbin Cao Jiwen Bu Yonggang Ren Wenjie Du Zhecong Chen Chufan Xu Mingcang Wang Lai Jiang Cheng Huang Jiulin Du | 2021 | Journal of Molecular Cell Biology2021，13，1： | 0 |
| 19 | Polymeric nanoparticles developed by vitamin E-modified aliphatic polycarbonate polymer to promote oral absorption of oleanolic acid显示文摘Oleanolic acid (OA) exhibited good pharmacological activities in the clinical treatment of hypoglycemia, immune regulation, acute jaundice and chronic toxic hepatitis. However, the oral delivery of OA is greatly limited by its inferior water solubility and poor intestinal mucosa permeability. Herein, we developed a novel polymeric nanoparticle (NP) delivery system based on vitamin E modified aliphatic polycarbonate (mPEG-PCC-VE) to facilitate oral absorption of OA. OA encapsulated mPEG-PCC-VE NPs (OA/mPEG-PCC-VE NPs) showed uniform particle size of about 170 nm with high drug loading capability (8.9%). Furthermore, the polymeric mPEG-PCC-VE NPs, with good colloidal stability and pH-sensitive drug release characteristics, significantly enhanced the in vitro dissolution of OA in the alkaline medium. The in situ single pass intestinal perfusion (SPIP) studies performed on rats demonstrated that the OA/m PEG-PCC-VE NPs showed significantly improved permeability in the whole intestinal tract when compared to OA solution, especially for duodenum and colon. As a result, the in vivo pharmacokinetics study indicated that the bioavailability of OA/m PEG-PCC-VE NPs showed 1.5-fold higher than commercially available OA tablets. These results suggest that mPEGPCC-VE NPs are a promising platform to facilitate the oral delivery of OA. | Wenjuan Zhang Chufan Liang Hao Liu Zhenbao Li Rui Chen Mei Zhou Dan Li Qing Ye Cong Luo Jin Sun | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，6： | 0 |
| 20 | The Importance of Visual Identity Graphic Design in Cities显示文摘 | Zhang Chufan | 2016 | International Journal of Technology Management2016，，3： | 0 |
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