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| 1 | Clinical research linking Traditional Chinese Medicine constitution types with diseases:a literature review of 1639 observational studies显示文摘OBJECTIVE:To analyze clinical studies on correlations between Traditional Chinese Medicine(TCM)body constitution types and diseases published in the past 10 years,and to provide an evidence base to support the use of such correlations for health maintenance and disease prevention.METHODS:We searched five databases for the period April 2009 to December 2019:China National Knowledge Infrastructure Database,Wanfang Database,China Science and Technology Journal Database,PubMed and Embase.Three types of observational studies on correlation between constitution types and diseases were included:cross-sectional,case-control and cohort studies.Descriptive statistical methods were employed for data analysis.RESULTS:A total of 1639 clinical studies were identified:1452(88.59%)cross-sectional studies,115(7.02%)case-control studies and 72(4.39%)cohort studies covering 30 regions of China and five other countries(Malaysia,South Korea,Singapore,Thailand and France).The collection of studies comprised 19 disease categories and 333 different diseases.The 10 most commonly studied diseases were hypertension,diabetes,stroke,coronary atherosclerotic heart disease(CAHD),sleep disorders,neoplasm of the breast,dysmenorrhea,fatty liver disease,chronic viral hepatitis B and dyslipidemia.We found high distributions for each biased constitution type in different patient populations as follows:Qi-deficiency constitution in stroke,diabetes,chronic obstructive pulmonary disease,acquired immunodeficiency syndrome and hypertension;Yang-deficiency constitution in female infertility,osteoporosis,irritable bowel syndrome,gonarthrosis and dysmenorrhea;Yin-deficiency constitution in hypertension,diabetes,constipation,female climacteric states and osteoporosis;phlegm-dampness constitution in hypertension,stroke,fatty liver disease,diabetes and metabolic syndrome;damp-heat constitution in acne,chronic gastritis,chronic viral hepatitis B,human papillomavirus infection and hyperuricemia;blood-stasis constitution in CAHD,endometriosis and stroke;Qi-stagnation constitution in hyperplasia and neoplasms of the breast,insomnia,depression and thyroid nodules;and inherited-special constitution in asthma and allergic rhinitis.CONCLUSION:Eight biased TCM constitutions were closely related to specific diseases,and could be used to guide individualized prevention and treatment.More rigorously designed studies are recommended to further verify the constitution-disease relationship. | Liang Xue Wang Qi Jiang Zeqiang Li Zhuqing Zhang Mengxing Yang Peiying Wang Xin Wang Yanqiu Qin Yuehua Li Tianxing Zhang Tianyi Wang Yi Sun Jianxiang Li Yusi Luo Hui Li Lingru | 2020 | Journal of Traditional Chinese Medicine2020，40，4： | 29 |
| 2 | Expression of pro-inflammatory and anti-inflammatory cytokines in brain of atherosclerotic rats and effects of Ginkgo biloba extract显示文摘Aim: To study the protein and mRNA expressions of pro-inflammatory and antiinflammatory cytokines in the brain of rats with atherosclerosis (AS) and the effects of Ginkgo biloba extract (GbE) on expressions of cytokines. Methods:The experimental model of AS in rats were established by intraperitioneal injection of vitamin D3 with high fat/cholesterol diet. GbE 100 mg/kg was administered to rats by ig. After 8 weeks, the expressions of IL-1β, TNF-α, IL- 10, and IL-10R in the brain tissues of AS rats were detected by enzyme-linked immunosorbant assay, immunohistochemistry, Western blotting, and reverse transcriptase polymerase chain reaction. Results: The protein and mRNA expressions of IL-1β, TNF-α, and IL-10 in the brains were markedly higher in AS groups than that in control groups (6.11+0.15, 1.55±0.14, 0.54±0.04 ng/g wet weight vs 0.80±0.14, 0.33±0.09, and 0.33±0.02 ng/g wet weight, respectively). The protein and mRNA expressions of IL-1β and TNF-α in the brains were markedly lower in GbE groups (3.82±0.54, 0.95±0.08 ng/g wet weight) than that in AS groups, the protein and mRNA expressions of IL-10 and IL- 10R in the brains were markedly higher in GbE groups (0.85±0.06 ng/g wet weight) than that in AS groups. Conclusion: GbE inhibited production of pro-inflammatory cytokines IL-1β and TNF-α, but upregulated the production of anti-inflammatory cytokines, IL-10 and IL-1 OR in brain, which might be related with its anti-AS actions. | Ya-binJIAO Yao-chengRUI Tie-junLI Peng-yuanYANG YanQIU | 2005 | Acta Pharmacologica Sinica2005，26，7： | 23 |
| 3 | Deregulation of brain insulin signaling in Alzheimer's disease显示文摘Contrary to the previous belief that insulin does not act in the brain, studies in the last three decades have demonstrated important roles of insulin and insulin signal transduction in various functions of the central nervous system. Deregulated brain insulin signaling and its role in molecular pathogenesis have recently been reported in Alzheimer's disease(AD). In this article, we review the roles of brain insulin signaling in memory and cognition, the metabolism of amyloid β precursor protein, and tau phosphorylation. We further discuss defi ciencies of brain insulin signaling and glucose metabolism, their roles in the development of AD, and recent studies that target the brain insulin signaling pathway for the treatment of AD. It is clear now that deregulation of brain insulin signaling plays an important role in the development of sporadic AD. The brain insulin signaling pathway also offers a promising therapeutic target for treating AD and probably other neurodegenerative disorders. | Yanxing Chen Yanqiu Deng Baorong Zhang Cheng-Xin Gong | 2014 | Neuroscience Bulletin2014，30，2： | 15 |
| 4 | DISCUSSING ON SOLID ABRASIVE LAPPING PATH显示文摘DISCUSSINGONSOLIDABRASIVELAPPINGPATHYangJiandong,WenXuehengChangchunInstituteofOpticsandFineMechanicsZhuYanqiu,WangLijiangJil... | Yang Jiandong ,Wen XuehengChangchun Institute of Optics and Fine MechanicsZhu Yanqiu, Wang Lijiang Jilin University of Technology | 1997 | Chinese Journal of Mechanical Engineering1997，10，2： | 11 |
| 5 | Effect of Cl^- on the Properties of the Passive Films Formed on 316L Stainless Steel in Acidic Solution显示文摘The corrosion behavior of 316L stainless steel(316L SS) has been investigated in solutions containing various concentrations of chloride ions by using potentiodynamic polarization, capacitance measurement and Motte Schottky relationship analysis(Me S). The result indicates that passive currents change slightly with the addition of chloride ions. The pitting potential(Epit) decreases linearly with log[Cl ]. Correspondingly, the point defect diffusion coefficient(Do) of the passive film increases linearly with increasing log[Cl ]. The results also indicate that the pitting corrosion of 316L SS follows the adsorption mechanism in NaCl solution. | Guozhe Meng Yuan Li Yawei Shao Tao Zhang Yanqiu Wang Fuhui Wang | 2014 | Journal of Materials Science & Technology2014，30，3： | 10 |
| 6 | Tribological properties of conductive lubricating greases显示文摘Three kinds of new conductive lubricating greases were prepared using lithium ionic liquids as the base oil and the polytetrafluoroethylene(PTFE)as the thickener.These lithium ionic liquids([Li(PEG)X])were obtained by blending lithium salts(LiBF4,LiPF6 and LiNTf2)with poly(ethylene glycol)(PEG)because lithium salts have an extremely high solubility in PEG.The conductivities and contact resistances of the prepared lubricating greases were investigated using the DDSJ‐308A conductivity meter and the reciprocating ball‐on‐disk UMT‐2MT sliding tester.In addition,their tribological properties were investigated in detail.Scanning electron microscopy and X‐ray photoelectron spectroscopy were employed to explore the friction mechanisms.The results suggest that the prepared lubricating greases have high conductivities and excellent tribological properties.The high conductivities are attributed to ion diffusion or migration of the lithium ionic liquids with an external electric field,and the excellent tribological properties depend on the formation of boundary protective films. | Xiaoqiang FAN Yanqiu XIA Liping WANG | 2014 | Friction2014，2，4： | 10 |
| 7 | Leaf-surface wax of desert plants as a potential lubricant additive显示文摘Using an MFT-R4000 tester at room temperature,the leaf-surface wax of two desert plants,Ammopiptanthus mongolicus(AM)and Reaumuria soongorica(RS),was extracted and evaluated for its potential as a lubricant additive in polyalphaolefin(PAO)for steel-steel contact.Gas chromatography-mass spectrometry analysis was performed to identify the composition of the AM leaf-surface wax,and scanning electron microscopy and X-ray photoelectron spectroscopy were used to investigate its friction mechanisms.The results suggest that the leaf-surface wax could successfully reduce the friction and wear of steel-steel sliding pairs compared with PAO containing molybdenum dithiocarbamate additives.AM,in particular,showed high-performance wear resistance and friction-reducing properties.Its excellent tribological properties were attributed to the wax composition of leaf-surface fatty acids,alcohol,and esters. | Yanqiu XIA Xiaochun XU Xin FENG Guoxiong CHEN | 2015 | Friction2015，3，3： | 9 |
| 8 | The Mesozoic Basin-Mountain Coupling Process of the Southern East China Sea Shelf Basin and its Adjacent Land Area显示文摘Objective Basin-mountain coupling is a key issue for basin formation and evolution.The analysis of basin-mountain coupling process,as well as quantitative or semiquantitative restoration of prototype basin and the evolution of continental margin,can be used to | YANG Changqing YANG Yanqiu LI Gang YANG Chuansheng YANG Jinyu | 2016 | Acta Geologica Sinica(English Edition)2016，90，3： | 9 |
| 9 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 10 | Toripalimab plus chemotherapy as second-line treatment in previously EGFR-TKI treated patients with EGFR-mutant-advanced NSCLC:a multicenter phase-II trial显示文摘This multicenter phase-II trial aimed to investigate the efficacy,safety,and predictive biomarkers of toripalimab plus chemotherapy as second-line treatment in patients with EGFR-mutant-advanced NSCLC.Patients who failed from first-line EGFR-TKIs and did not harbor T790M mutation were enrolled.Toripalimab plus carboplatin and pemetrexed were administrated every three weeks for up to six cycles,followed by the maintenance of toripalimab and pemetrexed.The primary endpoint was objective-response rate(ORR).Integrated biomarker analysis of PD-L1 expression,tumor mutational burden(TMB),CD8+tumor-infiltrating lymphocyte(TIL)density,whole-exome,and transcriptome sequencing on tumor biopsies were also conducted.Forty patients were enrolled with an overall ORR of 50.0%and disease-control rate(DCR)of 87.5%.The median progression free survival(PFS)and overall survival were 7.0 and 23.5 months,respectively.The most common treatment-related adverse effects were leukopenia,neutropenia,anemia,ALT/AST elevation,and nausea.Biomarker analysis showed that none of PD-L1 expression,TMB level,and CD8+TIL density could serve as a predictive biomarker.Integrated analysis of whole-exome and transcriptome sequencing data revealed that patients with DSPP mutation had a decreased M2 macrophage infiltration and associated with longer PFS than those of wild type.Toripalimab plus chemotherapy showed a promising anti-tumor activity with acceptable safety profiles as the second-line setting in patients with EGFR-mutant NSCLC.DSPP mutation might serve as a potential biomarker for this combination.A phase-III trial to compare toripalimab versus placebo in combination with chemotherapy in this setting is ongoing(NCT03924050). | Tao Jiang Pingyang Wang Jie Zhang Yanqiu Zhao Jianying Zhou Yun Fan Yongqian Shu Xiaoqing Liu Helong Zhang Jianxing He Guanghui Gao Xiaoqian Mu Zhang Bao Yanjun Xu Renhua Guo Hong Wang Lin Deng Ningqiang Ma Yalei Zhang Hui Feng Sheng Yao Jiarui Wu Luonan Chen Caicun Zhou Shengxiang Ren | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 8 |
| 11 | Analyses of thermodynamic performance for the endoreversible Otto cycle with the concepts of entropy generation and entransy显示文摘In this paper,power the the and endoreversible the Otto cycle is analyzed with the entropy generation minimization objectives,and the the entransy theory.of The output power,the heat-work conversion efficiency are taken as the optimization rate,and relationships the output heat-work conversion efficiency,entransy the entropy generation and the entropy generation rate numbers,the work entransy are loss rate,The entransy loss of coefficient,the dissipation rate the entransy variation associated with discussed.applicability entropy the entropy generation minimization and the entransy theory while to the analyses is also analyzed.It is found do that smaller generation rate does not always lead to larger output our power,smaller entropy entransy generation loss numbers and not always lead to larger heat-work conversion efficiency,either.larger the In calculations,power,both larger larger rate larger entransy variation heat-work rate associated with work correspond also to that output while entransy is loss coefficient suitable results the in larger conversion developed efficiency.It is found concept of entransy dissipation not always for analyses because it was for heat transfer. | WU YanQiu | 2017 | Science China(Technological Sciences)2017，60，5： | 7 |
| 12 | A synergetic strategy based on laser surface texturing and lubricating grease for improving the tribological and electrical properties of Ag coating under current-carrying friction显示文摘Herein,a series of Ag coatings with different micro‐dimples were fabricated on copper surfaces by laser surface texturing(LST)and magnetron sputtering.Multilayer graphene lubricating grease(MGLG)was prepared using multilayer graphene as an additive.The textured Ag coatings and MGLG were characterized.Moreover,the tribological and electrical performances of the textured Ag coatings under MGLG lubrication were investigated in detail.Results demonstrated that the textured Ag coating with an appropriate dimple diameter could exhibit improved tribological and electrical properties when compared to the non‐textured Ag coating under MGLG lubrication.The characterization and analysis of the worn surfaces suggest that the synergetic effect of LST and MGLG contributes to these excellent tribological and electrical properties. | Zhengfeng CAO Yanqiu XIA Chuan CHEN Kai ZHENG Yi ZHANG | 2021 | Friction2021，9，5： | 7 |
| 13 | Multivalent m^6A motifs promote phase separation of YTHDF proteins显示文摘Dear Editor,Posttranscriptional modifications of coding and non-coding RNAs are prevale nt in cells.N6-methylade no sine (m6A) is the most abundant type of modification on eukaryotic messenger RNAs (mRNAs).1 This modification plays important roles in multiple fundamental biological processes, for example, cell differentiation, tissue development and tumorigenesis. | Yifei Gao Gaofeng Pei Dongxue Li Ru Li Yanqiu Shao Qiangfeng Cliff Zhang Pilong Li | 2019 | Cell Research2019，29，9： | 7 |
| 14 | Numerical investigation on freeze-drying of aqueous material frozen with pre-built pores显示文摘Freeze-drying of the initially porous frozen material with pre-built pores from liquid material was found experimentally to save drying time by over 30% with an initial saturation being 0.28 compared with the conventional operation with the initial saturation being 1, using mannitol as the solid material. In order to understand the mass and heat transfer phenomena of this novel process, a two-dimensional mathematical model of coupled mass and heat transfer was derived with reference to the cylindrical coordinate system. Three adsorption–desorption equilibrium relationships between the vapour pressure and saturation value namely, power-law, Redhead's style and Kelvin's style equation, were tested. Kelvin's style in exponential form of adsorption equilibrium relation gave an excellent agreement between the model prediction and experimental measurement when the equation parameter, γ, of 5000 was applied. Analyses of temperature and ice saturation profiles show that additional heat needs to be supplied to increase the sample temperature in order to promote the desorption process. Simulation also shows that there is a threshold initial porosity after which the drying time decreased with the increase in the initial porosity. Enhanced freeze-drying is expected to be achieved by simultaneously enhancing mass and heat transfer of the process. | Wei Wang Dapeng Hu Yanqiu Pan Guohua Chen | 2016 | Chinese Journal of Chemical Engineering2016，24，1： | 7 |
| 15 | Conductive grease synthesized using nanometer ATO as an additive显示文摘A new conductive grease was synthesized using a nanometer powder,i.e.,Sb doped SnO2(ATO),as an additive.The typical properties of this new conductive grease were investigated in detail.The results indicate that ATO can dramatically improve the dropping point and reduce contact resistance.The tribological properties of the new conductive grease were investigated using the MFT-R4000 reciprocating friction and wear tester.The tribol-test results indicate that ATO can dramatically improve the tribological properties of the grease.When the ATO concentration is 0.1wt%,the grease demonstrates the best friction reduction properties;when the concentration is 0.5wt%,the grease demonstrates the best anti-wear properties.The worn surfaces were observed and analyzed by scanning electron microscopy and energy-dispersive X-ray spectroscopy,and the friction mechanisms for the new conductive grease are proposed.The excellent tribological properties of the new conductive grease are attributed to the mechanical effect of ATO,and the film formed by Sn and Sb elements or metallic oxide deposited on worn surfaces during the friction process. | Xiangyu GE Yanqiu XIA Zongying SHU Xiaopei ZHAO | 2015 | Friction2015，3，1： | 6 |
| 16 | Initial gut microbiota structure affects sensitivity to DSS-induced colitis in a mouse model显示文摘The dextran sulfate sodium (DSS)-induced colitis model is a widely applied mouse model, but controversial results have been obtained from experiments using the same mouse strain under the same conditions. Because the gut microbiota play an important role in DSS-induced colitis, it is essential to evaluate the influence of the initial gut microbiota in this model. Here, we identified significant variations in the initial gut microbiota of different batches of mice and found that the initial intestinal microbiota had a profound influence on DSS-induced colitis. We performed three independent trials using the same C57BL/6J mouse model with DSS treatment and used high-throughput 16S rRNA gene sequencing to analyze the gut microbiota. We found that the structure and composition of the gut microbiota in mice with severe colitis, as compared with mice with milder colon damage, had unique features, such as an increase in Akkermansia bacteria and a decrease in Barnesiella spp. Moreover, these varied gut bacteria in the different trials also showed different responses to DSS treatment. Our work suggests that, in studies using mouse models, the gut microbiota must be considered when examining mechanisms of diseases, to ensure that comparable results are obtained. | Min Li Yanqiu Wu Yingxin Hu Liping Zhao Chenhong Zhang | 2018 | Science China(Life Sciences)2018，61，7： | 6 |
| 17 | Inhibition mechanism of compound ethanol extracts from Wuweizi(Fructus Schisandrae Chinensis) on renal interstitial fibrosis in diabetic nephropathy model mice显示文摘OBJECTIVE:To evaluate inhibition effect and mechanism of compound ethanol extracts from Wuweizi(Fructus Schisandrae Chinensis),Chuanxiong(Rhizoma Chuanxiong) and Muli(Cocha Ostreae)(FRC) on glomerular and tubular interstitial fibrosis in streptozocin(STZ)-induced diabetic nephropathy(ND) model mice.METHODS:Twenty-seven male C57BL/6 mice were divided randomly into 3 groups:nondibetic(ND),STZ-induced diabetic(D),and STZ-induced diabetic that were treated with 5 g · kg-1 · day-1 of FRC by oral gavage(D FRC),with 9 in each group.The protein expressions of E-cadherin,α-smooth muscle actin(α-SMA),Plasminogen Activator Inhibitor-1(PAI-1) in renal tissues were investigated by Western blotting.The expressions of fibronectin(FN) and α-SMA were detected by immunohistochemical method.The morphological changes of renal tissues were observed under a microscope.RESULTS:Renal tissues in the D FRC group showed a lessened degree of fibrosis.Meanwhile,the expressions of FN,α-SMA and PAI-1were significantly lower in the D FRC group than those in the D group(all P<0.05).CONCLUSION:FRC can ameliorate the DN in the C57BL/6 mice,and its mechanism may relate to inhibition on the epithelial to mesenchymal transdifferentiation,endothelial-myofibroblast transition and PAI-1 expression. | Yanqiu Zhang Daning Zhang Mianzhi Zhang | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 6 |
| 18 | Baicalin and rutin are major constituents in Shuanghuanglian injection involving anaphylactoid reaction显示文摘OBJECTIVE: To identify the constituents in Shuanghuanglian injection(SHLI) that correlate with anaphylactoid reaction.METHODS: Chemical fingerprints of 10 batches SHLI samples were determined by High Performance Liquid Chromatography(HPLC), and further investigated by similarity analysis. Combined with optical microscopy, both anaphylactoid experiments and confirmatory assay were displayed in Rat basophil leukemia cells(RBL-2H3) to obtain the histamine release inducing by SHLI. The content of histamine was tested by Enzyme-Linked Immuno Sorbent As-say method. Partial least squares regression(PLSR)method and HPLC-DAD-ESI-MSntechnology were conducted to analyze constituents in SHLI involving anaphylactoid reaction.RESULTS: The results of spectrum and effect relationships showed that the eight constituents were positively correlated with anaphylactoid reaction.Among which, nearly 90% of them were identified as baicalin and rutin with PLSR and HPLC-DAD-ESI-MSn. This result was in accordance with confirmatory assay on RBL-2H3 cells.CONCLUSION: Baicalin and rutin from SHLI were the main constituents involving anaphylactoid reaction. | Zhang Qi Cai Chengke Li Jian Wang Penglong Si Yinchu Ding Nan Gao Jing Zhang Yanqiu Ma Zhiqiang Lei Haimin Li Qiang | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 6 |
| 19 | A novel imidazoline derivative as corrosion inhibitor for P110 carbon steel in hydrochloric acid environment显示文摘novel imidazoline derivative,2-methyl-4-phenyl-1-tosyl-4,5-dihydro-1H-imidazole(IMI),was prepared and investigated as corrosion inhibitor for P110 carbon steel in 1.0 M HCl solution by weight loss measurements,potentiodynamic polarization and electrochemical impedance spectroscopy(EIS)tests.The inhibition efficiency increased with the rising concentration of IMI inhibitor.The test results and fitting data indicated that the IMI behaved as a mixed-type inhibitor and obeys the Langmuir adsorption isotherm.Scanning electron microscopy(SEM)was carried out to investigate the surface of carbon steel specimens,showing great protection from aggressive solution.Finally,inhibition mechanism of IMI on metal surface was further discussed. | Lei Zhang Yi He Yanqiu Zhou Ranran Yang Qiangbin Yang Dayong Qing Qianhe Niu | 2015 | Petroleum2015，1，3： | 5 |
| 20 | Inhibitory effect of extracts of Ginkgo biloba leaveson VEGF-induced hyperpermeability of bovine coronary endothelial cells in vitro显示文摘AIM: To study whether extract of Ginkgo biloba (EGb) can protect against atherosclerosis. METHODS: Confluent monolayers of bovine coronary endothelial cells (BCECs), bovine coronary smooth muscle cells (BCSMCs), and cocultures of the two were incubated with medium containing VEGF and/or EGb, and flux of ^125I-labeled oxidized low density lipoprotein (ox-LDL) across the monolayers was measured. RESULTS: Incubation with VEGF significantly increased the permeability of BCEC monolayers to ^125I-ox-LDL in a time- and concentration-dependent manner, but had no effect on permeability of BCSMCs or endothelial cells-smooth muscle cells cocultures. EGb significantly inhibited the VEGF-induced hyperpermeability of BCECs. CONCLUSION: VEGF was important in the formation and development of atherosclerosis. The inhibition of VEGF-induced permeability by EGb suggests that extracts of Ginkgo biloba leaves may have important clinical applications in the treatment of cardiovascular diseases. | YanQIU Yao-chengRUI Tie-junLI LiZHANG Peng-yuanYANG | 2004 | Acta Pharmacologica Sinica2004，25，10： | 5 |
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