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| 1 | Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver显示文摘Obesity is a major risk factor for cancers including hepatocellular carcinoma(HCC)that develops from a background of non-alcoholic fatty liver disease(NAFLD).Hypercholesterolemia is a common comorbidity of obesity.Although cholesterol biosynthesis mainly occurs in the liver,its role in HCC development of obese people remains obscure.Using high-fat high-carbohydrate diet-associated orthotopic and spontaneous NAFLD-HCC mouse models,we found that hepatic cholesterol accumulation in obesity selectively suppressed natural killer T(NKT)cell-mediated antitumor immunosurveillance.Transcriptome analysis of human liver revealed aberrant cholesterol metabolism and NKT cell dysfunction in NAFLD patients.Notably,cholesterol-lowering rosuvastatin restored NKT expansion and cytotoxicity to prevent obesogenic diet-promoted HCC development.Moreover,suppression of hepatic cholesterol biosynthesis by a mammalian target of rapamycin(mTOR)inhibitor vistusertib preceded tumor regression,which was abolished by NKT inactivation but not CD8^(+)T cell depletion.Mechanistically,sterol regulatory element-binding protein 2(SREBP2)-driven excessive cholesterol production from hepatocytes induced lipid peroxide accumulation and deficient cytotoxicity in NKT cells,which were supported by findings in people with obesity,NAFLD and NAFLD-HCC.This study highlights mTORC1/SREBP2/cholesterol-mediated NKT dysfunction in the tumor-promoting NAFLD liver microenvironment,providing intervention strategies that invigorating NKT cells to control HCC in the obesity epidemic. | Wenshu Tang Jingying Zhou Weiqin Yang Yu Feng Haoran Wu Myth T.S.Mok Lingyun Zhang Zhixian Liang Xiaoyu Liu Zhewen Xiong Xuezhen Zeng Jing Wang Jiahuan Lu Jingqing Li Hanyong Sun Xiaoyu Tian Philip Chun Yeung Yong Hou Heung Man Lee Candice C.H.Lam Howard H.W.Leung Anthony W.H.Chan Ka Fai To John Wong Paul B.S.Lai Kelvin K.C.Ng Simon K.H.Wong Vincent W.S.Wong Alice P.S.Kong Joseph J.Y.Sung Alfred S.L.Cheng | 2022 | Cellular & Molecular Immunology2022，19，7： | 3 |
| 2 | Experiment study on estimation of lever arm in GPS/ INS 显示文摘 | Hong Sinpyo Lee Man Hyung Chun Ho-Hwan | 2006 | IEEE Transactions on Vehicular Technology2006，55，2： | 1 |
| 3 | Long non-coding RNA expression profiles predict clinical phenotypes in glioma显示文摘 | Xiaoqin Zhang Stella Sun Jenny Kan Suen Pu Anderson Chun On Tsang Derek Lee Venus On Ying Man Wai Man Lui Stanley Thian Sze Wong Gilberto Ka Kit Leung | 2012 | Neurobiology of Disease2012，，1： | 1 |
| 4 | Observability of error states in GPS/INS integration显示文摘 | Sinpyo Hong Man Hyung Lee Ho-Hwan Chun et ac | 2005 | IEEE Transactions on Vehicular Technology2005，54，2： | 1 |
| 5 | Novel Efficient Blue Fluorophors with Small Singlet‐Triplet Splitting: Hosts for Highly Efficient Fluorescence and Phosphorescence Hybrid WOLEDs with Simplified Structure显示文摘 | Cai‐Jun Zheng Jing Wang Jun Ye Ming‐Fai Lo Xiao‐Ke Liu Man‐Keung Fung Xiao‐Hong Zhang Chun‐Sing Lee | 2013 | Adv Mater2013，，15： | 1 |
| 6 | The MicroRNA miR-139 Suppresses Metastasis and Progression of Hepatocellular Carcinoma by Down-regulating Rho-Kinase 2显示文摘 | Carmen Chak–Lui Wong Chun–Ming Wong Edmund Kwok–Kwun Tung Sandy Leung–Kuen Au Joyce Man–Fong Lee Ronnie Tung–Ping Poon Kwan Man Irene Oi–Lin Ng | 2011 | Gastroenterology2011，，1： | 1 |
| 7 | Management of Singlet and Triplet Excitons in a Single Emission Layer: A Simple Approach for a High‐Efficiency Fluorescence/Phosphorescence Hybrid White Organic Light‐Emitting Device显示文摘 | Jun Ye Cai‐Jun Zheng Xue‐Mei Ou Xiao‐Hong Zhang Man‐Keung Fung Chun‐Sing Lee | 2012 | Adv Mater2012，，25： | 1 |
| 8 | Fermented rice bran prevents atopic dermatitis in DNCB-treated NC/Nga mice显示文摘The fermentation of natural plants has a favorable effect on the functional and biological activities of living systems.These include anti-oxidative,anti-inflammatory,and anti-platelet aggregation activities.This is attributed to the chemical conversion of the parent plants to functional constituents,which show more potent biological activity.In our study,rice bran along with oriental medicinal plants(Angelicae gigantis,Cnidium officinale,Artemisia princeps,and Camellia sinensis) was fermented by Lactobacillus rhamnosus and Pichia deserticola(FRBE).We evaluated the effects of oral administration of FRBE on atopic dermatitis in l-chloro-2,4-dinitrobenzene(DNCB)-treated NC/Nga mice.FRBE significantly ameliorated the macroscopic and microscopic appearance of skin lesions in DNCB-induced atopic dermatitis and reduced levels of serum immunoglobulin E and the differential white blood cell count.In addition,it reduced skin thickness compared to that of atopic dermatitis-affected skin.FRBE treatment also reduced mast cell incorporation in skin lesions of atopic dermatitis.The total cell number in dorsal skin tissue and the axillary lymph node increased following DNCB application,and this was normalized by FRBE treatment.Moreover,it decreased the levels of CD8^+ helper T cells and Gr-1^+/CD11b^+ B cells in peripheral blood mononuclear cells and skin lesions in DNCB-induced atopic dermatitis.Using real-time polymerase chain reaction analysis,we demonstrated that FRBE significantly inhibited mRNA expression of cytokines(e.g.,interleukin-5 and interleukin-13) and cyclooxygenase-2 in AD skin lesions.These results suggest that FRBE could be a valuable herbal remedy for the treatment of atopic dermatitis. | Evelyn Saba Chun Hee Lee Da Hye Jeong Kija Lee Tae-Hwan Kim Seong-Soo Roh Seung-Hyung Kim Man Hee Rhee | 2016 | The Journal of Biomedical Research2016，30，4： | 1 |
| 9 | Reconstruction of inferior right hepatic veins in living donor liver transplantation using right liver grafts显示文摘 | Shin Hwang Tae‐Yong Ha Chul‐Soo Ahn Deok‐Bog Moon Ki‐Hun Kim Gi‐Won Song Dong‐Hwan Jung Gil‐Chun Park Jung‐Man Namgoong Sung‐Won Jung Sam‐Youl Yoon Kyu‐Bo Sung Gi‐Young Ko Byungchul Cho Kyoung Won Kim Sung‐Gyu Lee | 2012 | Liver Transpl2012，，2： | 1 |
| 10 | Hemodynamics‐compliant reconstruction of the right hepatic vein for adult living donor liver transplantation with a right liver graft显示文摘 | Shin Hwang Tae‐Yong Ha Chul‐Soo Ahn Deok‐Bog Moon Gi‐Won Song Ki‐Hun Kim Dong‐Hwan Jung Gil‐Chun Park Kyu‐Bo Sung Gi‐Young Ko Kyoung Won Kim Byungchul Cho Jung‐Man Namgoong Sung‐Won Jung Sam‐Youl Yoon Chun‐Soo Park Yo‐Han Park Hyeong‐Woo Park Hyo‐Jun Lee | 2012 | Liver Transpl2012，，7： | 1 |
| 11 | Usability of ringed polytetrafluoroethylene grafts for middle hepatic vein reconstruction during living donor liver transplantation显示文摘 | Shin Hwang Dong‐Hwan Jung Tae‐Yong Ha Chul‐Soo Ahn Deok‐Bog Moon Ki‐Hun Kim Gi‐Won Song Gil‐Chun Park Sung‐Won Jung Sam‐Youl Yoon Jung‐Man Namgoong Chun‐Soo Park Yo‐Han Park Hyeong‐Woo Park Hyo‐Jun Lee Sung‐Gyu Lee | 2012 | Liver Transpl2012，，8： | 1 |
| 12 | Self-expanding metallic stent as a bridge to surgery versus emergency resection for obstructing left-sided colorectal cancer: A case-matched study显示文摘 | Ka Chun Ng M.B.B.S. Wai Lun Law M.S. Yee Man Lee M.B.B.S. Hok Kwok Choi M.B.B.S. Chi Leung Seto M.B.B.S. Judy WC Ho M.B.B.S | 2006 | Journal of Gastrointestinal Surgery2006，，6： | 1 |
| 13 | Evaluation of leachate recirculation on nitrous oxide production in the likang landfill, China 显示文摘 | Chun Man Lee Xue Rui Lin Chong Yu Lan | 2002 | Journal of Environment Quality2002，31，： | 1 |
| 14 | Genetic epidemiology and heritability of AIS: A study of 415 Chinese female patients显示文摘 | Nelson L.S. Tang Hiu‐Yan Yeung Vivian W.Y. Hung Chen Di Liao Tsz‐Ping Lam Hau‐Man Yeung Kwong‐Man Lee Bobby Kin‐Wah Ng Jack Chun‐Yiu Cheng | 2012 | J. Orthop. Res2012，，9： | 1 |
| 15 | Prevalence,awareness and control of hypertension in Malaysia from 1980-2018:A systematic review and meta-analysis显示文摘BACKGROUND Hypertension is a common public health problem worldwide and is a well-known risk factor for increased risk of cardiovascular diseases,contributing to high morbidity and mortality.However,there has been no systematic review and meta-analysis of a multiethnic population such as that of Malaysia.AIM To determine the trend in prevalence,awareness and control rate of hypertension in Malaysia.METHODS Systematic searches were conducted in six databases(PubMed,Scopus,Ovid,CINAHL,Malaysian Medical Repository and Malaysia Citation Index)for articles published between 1980 and 2018.Two authors reviewed the studies and performed quality assessment and data extraction independently.Pooled estimates of hypertension prevalence,awareness and control rate were calculated using the DerSimonian-Laird random-effects model.Subgroup and sensitivity analyses were performed.RESULTS We included 56 studies involving a total of 241796 participants.The overall pooled prevalence of hypertension aged≥18 years was 29.7%.The prevalence of hypertension was the lowest in the 1980s(16.2%,95%confidence interval(CI):13.4,19.0),increasing up to 36.8%(95%CI:6.1,67.5)in the 1990s,then decreasing to 28.7%(95%CI:21.7,35.8)in the 2000s and 26.8%(95%CI:21.3,32.3)in the 2010s.The prevalence of awareness was 51.4%(95%CI:46.6,56.3),while 33.3%(95%CI:28.4,38.2)of those on treatment had achieved control of their blood pressure.CONCLUSION In Malaysia,three in ten adults aged≥18 years have hypertension,while four in ten adults aged≥30 years have hypertension.Five out of ten people are aware of their hypertension status and only one-third of those under treatment achieved control of their hypertension.Concerted efforts by policymakers and healthcare professionals to improve awareness and control of hypertension should be of high priority. | Man Jun Soo Zhen Yee Chow Siew Mooi Ching Chun Han Tan Kai Wei Lee Navin Kumar Devaraj Hani Syahida Salim Vasudevan Ramachandran Poh Ying Lim Dhashani Sivaratnam Fan Kee Hoo Ai Theng Cheong Yook Chin Chia | 2020 | World Journal of Meta-Analysis2020，8，4： | 0 |
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