|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dual effects of α-synuclein on neurotoxicity induced by low dosage of rotenone are dependent on exposure time in dopaminergic neuroblastoma cells显示文摘This study was designed to investigate the effects of α-synuclein on toxicity induced by long-term exposure to relatively low concentrations of rotenone.Compared with the control groups,the inhibition of cell viability which overexpressed α-synuclein(SH-SY5Y-Syn) improved after 1 and 2 weeks of rotenone treatment.The complex I activity was greater and the mitochondrial membrane swelling intensity was reduced after 1 and 2 weeks of treatment,which indicated that α-synuclein,at least in part,resists the rotenone-induced oxidative stress.The results indicate that α-synuclein has a dual effect on toxicity of rotenone according to exposure time in human SH-SY5Y cells. | LU LingLing,GU Li,LIANG Yuan,SUN XiaoHong,DUAN ChunLi & YANG Hui Beijing Institute for Neuroscience,Capital Medical University,The Beijing Center of Neural Regeneration and Repairingr,Key Laboratory for Neurodegenerative Disease of the Ministry of Education,Beijing 100069,China | 2010 | Science China(Life Sciences)2010，53，5： | 3 |
| 2 | Salubrinal protects against Clostridium difficile toxin B-induced CT26 cell death显示文摘Clostridium 顽固(C。顽固) 被认为在动物和人是联系抗菌素的腹泻和 pseudomembranous 大肠炎的主要原因。C 的流行。自从 2000,顽固感染(CDI ) 一直在增加。C 的二外毒素。顽固,毒素 A (TcdA ) 和毒素 B (TcdB ) , CDI 的主要毒力因素,能在宿主 cytosol 导致 Rho GTPases 的 glucosylation,正在导致细胞词法变化,细胞 apoptosis,和细胞死亡。导致 TcdB 的房间死亡的机制被调查十年了,但是它仍然不完全被理解。TcdB 经由在 CT26 房间线(BALB/C 老鼠冒号肿瘤房间) 表明小径的 PERK-eIF2 导致 endoplasmic 蜂窝胃应力,这被报导了。在这研究,我们发现了那 salubrinal, eIF2 dephosphorylation 的一个选择禁止者,高效地保护 CT26 房间线免于导致 TcdB 的房间死亡并且试着探索在这保护的效果位于下面的机制。我们的结果证明那 salubrinal 保护 CT26 房间免受的伤害调停 TcdB 细胞毒素并且 cytopathic 效果,经由 caspase-9-dependent 小径, eIF2 发信号小径,和 autophagy 禁止暴露毒素的房间的 apoptosis 和死亡。这些调查结果将对 CDI 治疗的发展有用。 | Shuyi Chen Chunli Sun Huawei Gu Haiying Wang Shan Li Yi Ma Jufang Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，3： | 2 |
| 3 | Magnetosphere response to the IMF turning from north to south显示文摘In this paper, the Space Weather Modeling Framework(SWMF) is used to simulate the real-time response of the magnetosphere to a solar wind event on June 5, 1998, in which the interplanetary magnetic field shifted its direction from north to south.Since most current models do not take into account convective effects of the inner magnetosphere, we first study the importance of Rice Convection Model(RCM) in the global model.We then focus on the following four aspects of the magnetosphere's response: the magnetosphere's density distribution, the structure of its magnetic field lines, the area of the polar cap boundary, and the corresponding ionospheric current change.We find that(1) when the IMF changes from north to south in this event, high magnetosheath density is observed to flow downstream along the magnetopause with the solar wind; low-latitude reconnection at dayside occurs under the southward IMF, while the magnetic field lines in the tail lobe caudal, caused by the nightside high latitude reconnection, extend into the interplanetary space.Open magnetic field lines exist simultaneously at both high and low latitudes at the magnetopause;(2) the area of the polar cap is obviously increased if the IMF turns from the north to the south; this observation is highly consistent with empirical observations;(3) the ionospheric field align current in the northern hemisphere is stronger than in the southern hemisphere and also increases as the IMF changes from north to south.SWMF with the Rice Convection effect provides reliable modeling of the magnetospheric and ionospheric response to this solar wind variation. | JianYong Lu HanXiao Zhang Ming Wang ChunLi Gu HaiYan Guan | 2019 | Earth and Planetary Physics2019，3，1： | 2 |
| 4 | A MDM 2‐dependent positive‐feedback loop is involved in inhibition of mi R ‐375 and mi R ‐106b induced by H elicobacter pylori lipopolysaccharide显示文摘 | Feng Ye Chunli Tang Weijia Shi Juan Qian Shuping Xiao Min Gu Yini Dang Jianping Liu Yan Chen Ruihua Shi Guoxin Zhang | 2015 | Cancer2015，，9： | 1 |
| 5 | Electrochemical detection of BSA damage induced by Fenton reagents in room temperature ionic liquid显示文摘 | Chunli Bian Huayu Xiong Xiuhua Zhang Yong Ye Haoshuang Gu Shengfu Wang | 2012 | Sensors & Actuators: B Chemical2012，，： | 1 |
| 6 | Suggestion and Current Situation of Ordinary Cosmetics Label Management Under New Regulations显示文摘Sorted out the legal system of cosmetics registration and filing,mainly adopted on the Regulations on the Supervision and Administration of Cosmetics,Administrative Measures for Registration and Filing of Cosmetics,Regulations on the Administration of Cosmetics Registration and Filing Documents,analyzed and summarized the relevant laws and regulations related to the management of cosmetics label,and discussed the background and significance of Measures for the Management of Cosmetics Label in detail.On the basis of summarizing and analyzing the problems and current situation faced by the current label management,this paper put forward reasonable suggestions to the filer and regulatory authorities,so as to provide certain guiding significance for the declaration and evaluation of ordinary cosmetics labels. | Hu Chunli Gu Yu | 2022 | China Detergent & Cosmetics2022，7，1： | 0 |
| 7 | Three‐dimensional magnetic resonance elastography in chronic liver disease显示文摘Chronic liver disease(CLD)has become a major health problem worldwide owing to its increased morbidity and mortality.Evaluation of the degree of liver injury is crucial for the clinical management and treatment of CLD patients.In the current clinical practice,liver biopsy with histological analysis is the clinical standard for assessing the degree of CLD injury.However,liver biopsy is an invasive procedure that is limited by sampling errors and interobserver variability and is insufficient for screening and monitoring.Advanced three‐dimensional magnetic resonance elastography(3D MRE)is a simple,fast,safe,and noninvasive technology.This offers comprehensive insight into increased liver stiffness beyond stage‐specific fibrosis.This technology exhibits considerable potential for comprehensively and simultaneously assessing early necroinflammation,discriminating necroinflammation from fibrosis,detecting nonalcoholic steatohepatitis severity,predicting cirrhosis complications,and identifying tumor recurrence.Nevertheless,the clinical application and promotion of this technology are currently required in China.3D MRE should evolve towards better clinical convenience and satisfaction to provide an imaging basis to improve treatment selection in CLD patients and facilitate its widespread use. | Chunli Li He Zhu Yan Wang Ye Gu Yu Shi | 2023 | Portal Hypertension & Cirrhosis2023，2，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员