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| 1 | High matrix metalloproteinase-9 expression induces angiogenesis and basement membrane degradation in stroke-prone spontaneously hypertensive rats after cerebral infarction显示文摘Basement membrane degradation and blood-brain barrier damage appear after cerebral infarction, severely impacting neuronal and brain functioning; however, the underlying pathogenetic mechanisms remain poorly understood. In this study, we induced cerebral infarction in strokeprone spontaneously hypertensive rats by intragastric administration of high-sodium water(1.3% NaCl) for 7 consecutive weeks. Immunohistochemical and immunofluorescence assays demonstrated that, compared with the non-infarcted contralateral hemisphere, stroke-prone spontaneously hypertensive rats on normal sodium intake and Wistar-Kyoto rats, matrix metalloproteinase-9 expression, the number of blood vessels with discontinuous collagen IV expression and microvessel density were significantly higher, and the number of continuous collagen IV-positive blood vessels was lower in the infarct border zones of stroke-prone spontaneously hypertensive rats given high-sodium water. Linear correlation analysis showed matrix metalloproteinase-9 expression was positively correlated with the number of discontinuously collagen IV-labeled blood vessels and microvessel density in cerebral infarcts of stroke-prone spontaneously hypertensive rats. These results suggest that matrix metalloproteinase-9 upregulation is associated with increased regional angiogenesis and degradation of collagen IV, the major component of the basal lamina, in stroke-prone spontaneously hypertensive rats with high-sodium water-induced focal cerebral infarction. | Huilian Hou Guanjun Zhang Hongyan Wang Huilin Gong Chunbao Wang Xuebin Zhang | 2014 | Neural Regeneration Research2014，9，11： | 30 |
| 2 | A Brief Overview of Low CO_2 Emission Technologies forIron and Steel Making显示文摘The global steel production has been growing for the last 50 years,from 200Mt in 1950s to 1240Mt in 2006. Iron and steel making industry is one of the most energy-intensive industries,with an annual energy consumption of about 24 EJ,5% of the world's total energy consumption. The steel industry accounts for 3%-4% of total world greenhouse gas emissions. Enhancing energy efficiency and employing energy saving/recovering technologies such as coke dry quechning (CDQ) and top pressure recovery turbine (TRT) can be short-term approaches to the steel industry to reduce greenhouse gas emission. The long-term approaches to achieving a significant reduction in CO2 emissions from the steel industry would be through developing and applying CO2 breakthrough technologies for iron and steel making,and through increasing use of renewable energy for iron and steel making. Thus,an overview of new CO2 breakthrough technologies for iron and steel making was made. | Chunbao (Charles) XU CANG Da-qiang | 2010 | Journal of Iron and Steel Research(International)2010，17，3： | 22 |
| 3 | 高炉喷吹生物炭研究进展显示文摘高炉喷煤可以降低焦比,但同时加剧温室效应和环境污染。近年来人们开始探索可以替代煤粉的新型燃料,如生物炭、兰炭、城市有机废物等,其中生物质因其来源丰富、环境友好而受到广泛关注。生物炭中的碳含量与煤相近,具备替代煤粉用于高炉喷吹的基本条件。对高炉喷煤技术、生物炭的制备和高炉喷吹生物炭的国内外现状进行了论述,并将生物炭的理化性质、热值、燃烧特性等指标与煤粉进行了对比,分析了生物炭替代煤粉用于高炉喷吹的技术可行性,并对下一步实施高炉喷吹生物炭进行展望。 | 郑伟成 XU Chunbao Charles 魏汝飞 钱立新 龙红明 李家新 | 2021 | 钢铁研究学报2021，33，1： | 18 |
| 4 | Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19:a phase 1 clinical trial显示文摘No effective drug treatments are available for coronavirus disease 2019(COVID-19).Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage,death,or long-term functional disability in survivors require clinical evaluation.We performed a parallel assigned controlled,non-randomized,phase 1 clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells(UC-MSCs)infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.The study enrolled 18 hospitalized patients with COVID-19(n=9 for each group).The treatment group received three cycles of intravenous infusion of UC-MSCs(3×107 cells per infusion)on days 0,3,and 6.Both groups received standard COVID-treatment regimens.Adverse events,duration of clinical symptoms,laboratory parameters,length of hospitalization,serial chest computed tomography(CT)images,the PaO2/FiO2 ratio,dynamics of cytokines,and IgG and IgM anti-SARS-CoV-2 antibodies were analyzed.No serious UC-MSCs infusion-associated adverse events were observed.Two patients receiving UC-MSCs developed transient facial flushing and fever,and one patient developed transient hypoxia at 12 h post UC-MSCs transfusion.Mechanical ventilation was required in one patient in the treatment group compared with four in the control group.All patients recovered and were discharged.Our data show that intravenous UC-MSCs infusion in patients with moderate and severe COVID-19 is safe and well tolerated.Phase 2/3 randomized,controlled,double-blinded trials with long-term follow-up are needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve long-term treatment outcomes in patients with serious COVID-19. | Fanping Meng Ruonan Xu Siyu Wang Zhe Xu Chao Zhang Yuanyuan Li Tao Yang Lei Shi Junliang Fu Tianjun Jiang Lei Huang Peng Zhao Xin Yuan Xing Fan Ji-Yuan Zhang Jinwen Song Dawei Zhang Yanmei Jiao Limin Liu Chunbao Zhou Markus Maeurer Alimuddin Zumla Ming Shi Fu-Sheng Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 16 |
| 5 | NUMERICAL ANALYSIS ON THREE-DIMENSIONAL FLOW FIELD OF TURBINE IN TORQUE CONVERTER显示文摘Three-dimensional flow field of turbine in torque converter is simulated by numerical calculation in order to improve the performance of torque converter. Calculation model of a torque converter is presented based on the mixing-plane technology. In the calculation of flow field,the 3D N-S equations are separated by finite-volume method and solved by semi-implicit method for pressure-linked equations(SIMPLE). Based on flow field calculation,the flow field of turbine is simulated. The velocity and pressure in the flow field of turbine are analyzed. The external performance of the torque converter is also calculated. Results of flow simulation show that there are secondary flow,off flow and velocity gradient in turbine passage. The validity of numerical simulation is verified by comparing the results of numerical simulation with experiment data. | LIU Yue PAN Yuxue LIU Chunbao | 2007 | Chinese Journal of Mechanical Engineering2007，20，2： | 11 |
| 6 | Preparation of Cationic Chitosan-Polyacrylamide Flocculant and Its Properties in Wastewater Treatment显示文摘Chitosan derived from crab shells,was used to prepare the graft polymer in aqueous solution with acrylamide (AM) and methacrylatoethyl trimethyl ammonium chloride (DMC) as raw materials and ceric ammonium nitrate (CAN) as initiator.The floc-culation ability of the resulting polymer (PCAD) was studied in waste water treatment experiments.Its properties were determined on the basis of the transmittance of waste water after flocculation.The effects of chitosan and DMC content on PCAD’s flocculation ability were studied.Flocculation experiments were also undertaken under various pH conditions.According to the experimental data,the flocculation ability could be improved when chitosan content decreased in the raw material,but the monomer conversion would decrease obviously.When the chitosan’s content was more than 65%,AM and DMC groups were less on each chitosan molecule.So PCAD’s flocculation ability was poor.Similarly,high content of DMC would result in low monomer conversion and high floccula-tion ability.PCAD molecules with more DMC group had more positive charges.It was favorable to flocculation.However,monomer conversion would decrease with the increase of DMC content.The suitable conditions were that chitosan and DMC contents were 65% and 15-20%,respectively.The experiment data showed that PCAD had good flocculation ability under weak acidic condition.Its ability would be weakened by strong acidic or alkaline condition.The flocculation efficiency was the best at pH of 5.5 when PCAD’s dosage was 8mg?L-1.Compared with cationic polymer (the copolymer of AM and DMC,PAD),PCAD showed better floc-culation ability under acid and neutral conditions,but worse ability under alkaline condition. | WANG Ben ZHANG Yulian MIAO Chunbao | 2011 | Journal of Ocean University of China2011，10，1： | 9 |
| 7 | MODIFIED GENETIC ALGORITHM APPLIED TO SOLVE PRODUCT FAMILY OPTIMIZATION PROBLEM显示文摘形式公共并且当试着在优化过程期间在产品系列以内解决在公共和单个产品性能之间的折衷时,自动地越过为平台改变公共的层次寻找。由合并估计索引到问题明确的表达的公共, 2LCGA 在一个单个阶段优化产品站台和它产品的相应家庭,它能与二阶段的途径相比在产品系列的全面性能产出改进(第一个阶段涉及决定为平台变量和唯一的变量的值的最佳调节各被作出对有利的裁决在第二个阶段的产品)。算法的范围被介绍分类机制允许多重平台在产品系列优化期间被考虑也扩展,提供为由在公共和表演之间的更有效的折衷的优异全面设计的机会。2LCGA 的有效性对以前的结果通过通用电动机和比较的一个家庭的设计被表明。 | CHEN Chunbao WANG Liya | 2007 | Chinese Journal of Mechanical Engineering2007，20，4： | 8 |
| 8 | EFFECTS OF GAS TYPE AND TEMPERATURE ON FINE PARTICLE FLUIDIZATION显示文摘The influence of gas type (helium and argon) and bed temperature (77?473 K) on the fluidization behav- iour of Geldart groups C and A particles was investigated. For both types of particles tested, i.e., Al2O3 (4.8 μm) and glass beads (39 μm), the fluidization quality in different gases shows the following priority sequence: Ar > He. In the same gaseous atmosphere, the particles when fluidized at an elevated temperature usually show larger bed voidages, higher bed pressure drops, and a lower umf for the group A powder, all indicating an enhancement in fluidization quality. Possible mechanisms governing the operations of gas type and temperature in influencing the fluidization behaviours of fine par- ticles have been discussed with respect to the changes in both gas properties and interparticle forces (on the basis of the London-van der Waals theory). Gas viscosity (varying significantly with gas-type and temperature) proves to be the key parameter that influences the bed pressure drops and umf in fluidization of fine particles, while the interparticle forces (also varying with gas-type and temperature) may play an important role in fine-particle fluidization by affecting the ex- pansion behaviour of the particle-bed. | Chunbao Xu J.-X. Zhu | 2006 | China Particuology2006，4，3： | 6 |
| 9 | Parallel selection of distinct Tof5 alleles drove the adaptation of cultivated and wild soybean to high latitudes显示文摘Photoperiod responsiveness is a key factor limiting the geographic distribution of cultivated soybean and its wild ancestor.In particular,the genetic basis of the adaptation in wild soybean remains poorly understood.In this study,by combining whole-genome resequencing and genome-wide association studies we identified a novel locus,Time of Flowering 5(Tof5),which promotes flowering and enhances adaptation to high latitudes in both wild and cultivated soybean.By genomic,genetic and transgenic analyses we showed that Tof5 en-codes a homolog of Arabidopsis thaliana FRUITFULL(FUL).Importantly,further analyses suggested that different alleles of Tof5 have undergone parallel selection.The Tof5H1 allele was strongly selected by humans after the early domestication of cultivated soybean,while Tof5H2 allele was naturally selected in wild soybean,and in each case facilitating adaptation to high latitudes.Moreover,we found that the key flowering repressor E1 suppresses the transcription of Tof5 by binding to its promoter.In turn,Tof5 physically associates with the promoters of two important FLOWERING LOCUS T(FT),FT2a and FT5a,to upregulate their transcription and promote flowering under long photoperiods.Collectively,ourfindings provide insights into how wild soybean adapted to high latitudes through natural selection and indicate that cultivated soybean underwent changes in the same gene but evolved a distinct allele that was artificially selected after domestication. | Lidong Dong Qun Cheng Chao Fang Lingping Kong Hui Yang Zhihong Hou Yongli Li Haiyang Nan Yuhang Zhang Qingshan Chen Chunbao Zhang Kun Kou Tong Su Lingshuang Wang Shichen Li Haiyang Li Xiaoya Lin Yang Tang Xiaohui Zhao Sijia Lu Baohui Liu Fanjiang Kong | 2022 | Molecular Plant2022，15，2： | 5 |
| 10 | Design and Optimization of Bionic Janus Blade in Hydraulic Torque Converter for Drag Reduction显示文摘 | Chunbao Liu Chuang Sheng Hualong Yang Zhe Yuan | 2018 | Journal of Bionic Engineering2018，15，1： | 5 |
| 11 | MS1 is essential for male fertility by regulating the microsporocyte cell plate expansion in soybean显示文摘Male sterility is an essential trait in hybrid seed production,especially for monoclinous and autogamous food crops.Soybean male-sterile ms1 mutant has been known for more than 50 years and could be instrumental in making hybrid seeds.However,the gene responsible for the male-sterile phenotype has remained unknown.Here,we report the map-based cloning and characterization of the MS1 gene in soybean.MS1 encodes a kinesin protein and localizes to the nucleus,where it is required for the male meiotic cytokinesis after telophase Ⅱ.We further substantiated that MS1 colocalizes with microtubules and is essential for cell plate formation in soybean male gametogenesis through immunostaining.Both ms1 and CRISPR/Cas9 knockout mutants show complete male sterility but are otherwise phenotypically normal,making them perfect tools for producing hybrid seeds.The identification of MS1 has the practical potential for assembling the sterility system and speeding up hybrid soybean breeding. | Xiaolong Fang Xiaoyuan Sun Xiangdong Yang Qing Li Chunjing Lin Jie Xu Wenjun Gong Yifan Wang Lu Liu Limei Zhao Baohui Liu Jun Qin Mengchen Zhang Chunbao Zhang Fanjiang Kong Meina Li | 2021 | Science China(Life Sciences)2021，64，9： | 4 |
| 12 | A Review of Biological Fluid Power Systems and Their Potential Bionic Applications显示文摘Nature has always inspired human achievements in industry, and biomimetics is increasingly being applied in fluid power technology. Arachnida use hydraulic forces, rather than muscle, for leg extensions during locomotion. Many cold-blooded and soft-bodied organisms rely on a hydrostatic skeleton to transmit force, which involves a hydraulic mechanism. Biological hydraulic transmission differs from engineering hydraulic transmission in many aspects, such as in energy transfer and transformation, the movement mode, environmental friendliness, system pressure level, and energy supplement mode. The existence of a hydraulic mechanism in a biological drive requires 3 features: a power source, cavity, and working medium. The power source is similar to a hydraulic pump, and the cavity is similar to a hydraulic cylinder, both of which are necessary for producing deformation. The working medium is similar to a hydraulic fluid. Under these 3 conditions, a biological flow is generated inside or outside the body to meet the requirements of a biological drive. This paper reviews the biological organisms that employ hydraulic systems, identifies related studies on these biological hydraulic systems, and summarizes the mechanisms involved in using hydraulic pressure to achieve graceful and agile movements. This in-depth study and exploration of biological hydraulic systems can provide a good reference for solving the challenges of using hydraulic systems, such as increasing the energy efficiency, improving reliability, building smart components and systems, reducing the size and weight of components, reducing the environmental impact of systems, and improving and applying energy storage and redeployment capabilities. This paper also includes a detailed discussion of new ideas and innovative sources for the future development of hydraulic systems. In contrast with the bio-inspired designs used in other engineering fields, very few studies have reported on using bio-inspired methods for hydraulic transmission techniques. The aim of this work is to attract the attention of researchers to help address this gap and to promote the use of biologically-inspired methods to improve engineering fluid power systems. | Chunbao Liu Yingjie Wang Luquan Ren Lei Ren | 2019 | Journal of Bionic Engineering2019，16，3： | 3 |
| 13 | Generation of male-sterile soybean lines with the CRISPR/Cas9 system显示文摘Soybean [Glycine max(L.) Merr.] provides a rich source of plant protein and oil worldwide. The commercial use of transgenic technology in soybean has become a classical example of the application of biotechnology to crop improvement. Although genetically modified soybeans have achieved commercial success,hybrid soybean breeding is also a potential way to increase soybean yield. Soybean cytoplasmic malesterile(CMS) lines have been used in three-line hybrid breeding systems, but their application to exploiting soybean heterosis has been limited by rare germplasm resource of sterile lines. The generation of various genetic diversity male-sterile soybean lines will help to overcome the shortcoming. In this study,we used targeted editing of AMS homologs in soybean by CRISPR/Cas9 technology for the first time to generate stable male-sterile lines. Targeted editing of GmAMS1 resulted in a male-sterile phenotype,while editing of GmAMS2 failed to produce male-sterile lines. GmAMS1 functions not only in the formation of the pollen wall but also in the controlling the degradation of the soybean tapetum.CRISPR/Cas9 technology could be used to rapidly produce stable male-sterile lines, providing new sterile-line materials for soybean hybrid breeding systems. | Xiao Chen Suxin Yang Yaohua Zhang Xiaobin Zhu Xinjing Yang Chunbao Zhang Haiyan Li Xianzhong Feng | 2021 | The Crop Journal2021，9，6： | 3 |
| 14 | Investigation of microstructure modification of C-doped a-SiO_2/Si after Pb-ion irradiation显示文摘Thermally grown amorphous SiO 2 (a-SiO 2) films were implanted at room temperature (RT) with 100 keV C-ions to 5.0×10 17 ions/cm 2.These samples were irradiated at RT with 853 MeV Pb-ions to 1.0×10 12 and 5.0×10 12 ions/cm 2.Then the samples were investigated using Transmission Electron Microscopy (TEM) at RT.Significant microstructure modifications were observed in C-doped a-SiO 2/Si samples after high energy Pb-ion irradiations,and the formation of new structures depended strongly on the Pb-ion irradiation fluences.For example,tracks in high density were observed in a 1.0×10 12 Pb/cm 2 irradiated and C-doped sample.Additionally,the length of tracks grows,and a large number of 8H-SiC nanocrystals can be seen in the film when irradiation fluence is increased to 5.0×10 12 Pb/cm 2.Possible modification processes of C-doped a-SiO 2 under swift heavy ion irradiations are briefly discussed. | LIU ChunBao WEI KongFang YAO CunFeng WANG ZhiGuang JIN YunFan TOULEMONDE M | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，2： | 2 |
| 15 | Changes in meat quality of ovine longissimus dorsi muscle in response to repeated freeze and thaw显示文摘 | Jun Qi Chunbao Li Yinji Chen Feifei Gao Xinglian Xu Guanghong Zhou | 2012 | Meat Science2012，，4： | 2 |
| 16 | Bioinspired soft actuators with highly ordered skeletal muscle structures显示文摘Mammals such as humans develop skeletal muscles composed of muscle fibers and connective tissue,which have mechanical properties that enable power output with three-dimensional motion when activated.Artificial muscle-like actuators developed to date,such as the McKibben artificial muscle,often focus sole contractile elements and have rarely addressed the contribution of flexible connective tissue that forms an integral part of the structure and morphology of biological muscle.Herein,we present a class of pneumatic muscle-like actuators,termed highly mimetic skeletal muscle(HimiSK)actuator,that consist of parallelly arranged contractile units in a flexible matrix inspired by ultrasonic measurements on skeletal muscle.The contractile units act as a muscle fiber to produce active shortening force,and the flexible matrix functions as connective tissue to generate passive deformation.The application of positive pressure to the contractile units can produce a linear contraction and force.In this actuator,we assign different flexible materials as contractile units and a flexible matrix,thus forming five mold actuators.These actuators feature three-dimensional motion on activation and present both intrinsic force-velocity and force-length characteristics that closely resebmle those of a biological muscle.High output and tetanic force produced by harder contractile units improve the maximum output force by up to about 41.3%and the tetanic force by up to about 168%.Moreover,high displacement and velocity can be generated by a softer flexible matrix,with the improvement of maximum displacement up to about 33.3%and velocity up to about 73%.The results demonstrate that contractile units play a crucial role in force generation,while the flexible matrix has a significant impact on force transmission and deformation;the final force,velocity,displacement,and three-dimensional motion results from the interplay of contractile units,fluid and flexible matrix.Our approach introduces a model of the presented HimiSK actuators to better understand the mechanical behaviors,force generation,and transmission in bioinspired soft actuators,and highlights the importance of using flexible connective tissue to form a structure and configuration similar to that of skeletal muscle,which has potential usefulness in the design of effective artificial muscle. | Yingjie Wang Chunbao Liu Luquan Ren Lei Ren | 2022 | Bio-Design and Manufacturing2022，5，1： | 2 |
| 17 | Synthesis of phenol formaldehyde resol resins using organosolv pine lig- nins显示文摘 | Wang Mingcun Mathew Leitch Xu Chunbao | 2009 | Eur PoIyrn J2009，45，： | 1 |
| 18 | GPS系统建设及技术发展研究显示文摘The United States was the first country in the world to develop a satellite navigation system,with rich experience in system management,R&D,operation,and satellite applications industry.It started the construction of the Global Positioning System(GPS)in 1973 and deployed the first satellite in 1978.It has successfully developed and deployed three series of GPS satellites with a total of seven models.The United States is now focusing on the research and development of cutting edge navigation technologies and constellation modernization,replacing old ones with new GPS III series of satellites and actively exploring and verifying the frontier navigation technologies represented through the Navigation Technology Satellite 3(NTS-3).It is now upgrading the original ground-based operation and control system,actively developing and deploying the GPS Next Generation Operational Control System(GPS OCX),and upgrading the military user equipment supporting Military Code(M-Code).The U.S.attaches importance to multiple measures to improve the service performance of the GPS system and enhance the resilience of the system to provide positioning,navigation,and timing capabilities.In this context,the progress of the construction of GPS and the related technological innovations are separated out and analyzed,which will help the Global Navigation Satellite System(GNSS)solutions summarizing their experience and learning from each other’s development to better serve social progress and economic development. | WU Jun LIU Chunbao | 2020 | Aerospace China2020，21，4： | 1 |
| 19 | Microwave-prompted reaction of cinnamon-nitrile derivatives with 5,5- dimethyl-1,3-cyclohexanedione显示文摘 | Tu Shujiang Miao Chunbao Gao Yuan | 2002 | Chin J Chem2002，20，7： | 1 |
| 20 | <ce:link locator='fx1'/> Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients显示文摘 | Junliang Fu Dongping Xu Zhenwen Liu Ming Shi Ping Zhao Baoyun Fu Zheng Zhang Huiyin Yang Hui Zhang Chunbao Zhou Jinxia Yao Lei Jin Huifen Wang Yongping Yang Yang-Xing Fu Fu-Sheng Wang | 2007 | Gastroenterology2007，，7： | 1 |
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