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| 1 | Hepatic portal venous gas: Physiopathology, etiology, prognosis and treatment显示文摘Hepatic portal venous gas (HPVG), an ominous radiologic sign, is associated in some cases with a severe underlying abdominal disease requiring urgent operative intervention. HPVG has been reported with increasing frequency in medical literature and usually accompanies severe or lethal conditions. The diagnosis of HPVG is usually made by plain abdominal radiography, sonography, color Doppler flow imaging or computed tomography (CT) scan. Currently, the increased use of CT scan and ultrasound in the inpatient setting allows early and highly sensitive detection of such severe illnesses and also the recognition of an increasing number of benign and non-life threatening causes of HPVG. HPVG is not by itself a surgical indication and the treatment depends mainly on the underlying disease. The prognosis is related to the pathology itself and is not influenced by the presence of HPVG. Based on a review of the literature, we discuss in this paper the pathophysiology, risk factors, radiographic findings, management, and prognosis of pathologies associated with HPVG. | Bassam Abboud Jad El Hachem Thierry Yazbeck Corinne Doumit | 2009 | World Journal of Gastroenterology2009，15，29： | 25 |
| 2 | Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria显示文摘AIM: To investigate the correlation between in vitro and in vivo immunomodulation potential of the probiotic strain and its ability to prevent experimental colitis in mice. METHODS: In vitro immunomodulation was assessed by measuring interleukin (IL)-12p70, IL-10, tumor necrosis factor alpha (TNFa) and interferon g (IFNg) release by human peripheral blood mononuclear cells (PBMCs) after 24 h stimulation with 13 live bacterial strains. A murine model of acute TNBS-colitis was next used to evaluate the prophylactic protective capacity of the same set of strains. RESULTS: A strain-specific in vivo protection was observed. The strains displaying an in vitro potential to induce higher levels of the anti-inflammatory cytokine IL-10 and lower levels of the inflammatory cytokine IL-12, offered the best protection in the in vivo colitis model. In contrast, strains leading to a low IL-10/IL-12 cytokine ratio could not significantly attenuate colitis symptoms. CONCLUSION: These results show that we could predict the in vivo protective capacity of the studied lactic acid bacteria (LAB) based on the cytokine profile we established in vitro. The PBMC-based assay we used may thus serve as a useful primary indicator to narrow down the number of candidate strains to be tested inmurine models for their anti-inflammatory potential. | Benoit Foligne Sophie Nutten Corinne Grangette Véronique Dennin Denise Goudercourt Sabine Poiret Joelle Dewulf Dominique Brassart Annick Mercenier Bruno Pot | 2007 | World Journal of Gastroenterology2007，13，2： | 22 |
| 3 | TRPM2: a candidate therapeutic target for treating neurological diseases显示文摘短暂受体潜力 melastatin (TRPM2 ) 2 是钙(Ca 2+)-permeable 属于 TRP 离子隧道家庭的非选择的阳离子隧道。氧化导致压力的 TRPM2 激活在许多房间类型挑起异常细胞内部的 Ca 2+ 累积和房间死亡,包括神经原。异常 TRPM2 功能包括局部缺血 / 击, Alzheimers 疾病,神经病的疼痛, Parkinsons 疾病和双极的混乱在几神经病学的混乱被含有。除了在疾病为 TRPM2 识别一个角色的研究,进步在大脑在 TRPM2 的生理的功能的鉴定被取得了,包括 TRPM2 为 N-methyl-D-aspartate ( NMDA )受体依赖者的正式就职是必要的最近的证据长期的消沉,在 glutamate 触处的 synaptic 粘性的一种重要形式。这里,我们处于健康和疾病在中央神经系统(CNS ) 在 TRPM2 的角色上总结最近的证据并且讨论指向 TRPM2 的潜在的治疗学的含意。一起,这些研究建议 TRPM2 为神经病学的混乱代表一个未来的新奇治疗学的目标。 | Jillian Corinne BELROSE Michael Frederick JACKSON | 2018 | Acta Pharmacologica Sinica2018，39，5： | 12 |
| 4 | 城市儿童乘车安全措施使用情况调查显示文摘目的观察汕头市城区儿童乘车安全措施使用情况,了解家长对乘车安全的认知态度,探讨提高儿童乘车安全的干预措施。方法采用横断面调查方法,对汕头市城区车载17岁以下儿童的乘车情况进行现场观察记录,同时对驾驶员进行现场问卷调查,调查地点包括22所中学、31所小学、24所幼儿园以及4所医院门口。结果本次研究共观察到3 333名乘车儿童,其中男童1 691人(50.7%),女童1 439人(43.2%),另有203(6.1%)名婴幼儿分辨不出性别。超过90.0%的儿童乘车时没有使用任何安全措施,26.5%的儿童乘坐于汽车副驾驶座。儿童年龄越大,佩戴安全带的比例越高。收集到驾驶员有效问卷1 069份,其中934(87.4%)位受访者为车载儿童的父母,62.0%的驾驶员认为儿童乘车时有必要使用安全座椅。结论儿童乘车安全措施使用率低,不正确乘坐方式普遍,受调查家长对汽车安全座椅的认识程度不高,提示对儿童父母实施乘车安全的健康教育干预措施有利于提高儿童乘车安全措施的使用率,促进儿童乘车安全。 | 陈晓军 杨静珍 Corinne Peek-Asa Daniel V.McGehee 李丽萍 | 2013 | 中华疾病控制杂志2013，17，10： | 12 |
| 5 | Epidemiology and Natural History of Inflammatory Bowel Diseases显示文摘 | Jacques Cosnes Corinne Gower–Rousseau Philippe Seksik Antoine Cortot | 2011 | Gastroenterology2011，，6： | 11 |
| 6 | Induced pluripotent stem cell-derived neural stem cell therapies for spinal cord injury显示文摘The greatest challenge to successful treatment of spinal cord injury is the limited regenerative capacity of the central nervous system and its inability to replace lost neurons and severed axons following injury. Neural stem cell grafts derived from fetal central nervous system tissue or embryonic stem cells have shown therapeutic promise by differentiation into neurons and glia that have the potential to form functional neuronal relays across injured spinal cord segments. However, implementation of fetal-derived or embryonic stem cell-derived neural stem cell therapies for patients with spinal cord injury raises ethical concerns. Induced pluripotent stem cells can be generated from adult somatic cells and differentiated into neural stem cells suitable for therapeutic use, thereby providing an ethical source of implantable cells that can be made in an autologous fashion to avoid problems of immune rejection. This review discusses the therapeutic potential of human induced pluripotent stem cell-derived neural stem cell transplantation for treatment of spinal cord injury, as well as addressing potential mechanisms, future perspectives and challenges. | Corinne A.Lee-Kubli Paul Lu | 2015 | Neural Regeneration Research2015，10，1： | 9 |
| 7 | Cancer treatment and survivorship statistics, 2012显示文摘 | Rebecca Siegel Carol DeSantis Katherine Virgo Kevin Stein Angela Mariotto Tenbroeck Smith Dexter Cooper Ted Gansler Catherine Lerro Stacey Fedewa Chunchieh Lin Corinne Leach Rachel Spillers Cannady Hyunsoon Cho Steve Scoppa Mark Hachey Rebecca Kirch Ahmed | 2012 | CA: A Cancer Journal for Clinicians2012，，4： | 6 |
| 8 | NTR/NRX Define a New Thioredoxin System in the Nucleus of Arabidopsis thaliana Cells显示文摘Thioredoxins (TRX ) 是细胞的氧化还原作用平衡的关键部件,调整通过 thiol/disulfide 交换反应的许多目标蛋白质。在更高的植物, TRX 组成其成员在几乎所有细胞的分隔空间被发现了的一个复杂 multigenic 家庭。尽管 chloroplastic 和 cytosolic TRX 系统大部分被学习了,一个原子 TRX 系统的存在很长时间是逃犯的。Nucleoredoxins (NRX ) 是在很真核细胞的有机体发现的潜在的原子 TRX。与哺乳动物,它怀有唯一的 NRX 相对照,被子植物通常拥有在三个亚科组织的多重 NRX。这里,我们证明分别地, Arabidopsis thaliana 有二 NRX 基因(AtNRX1 和 AtNRX2 ) 属于亚群我和 III。当 NRX1 怀有典型 TRX 时活跃地点(WCG/PPC ) , NRX2 有不正常的活跃地点(WCRPC 和 WCPPF ) 。不过, NRX1 和 NRX2 有二硫化物减小能力,尽管 NRX1 能被 thioredoxin reductase NTRA 独自减少。我们也证明 NRX1 和 NRX2 有双 nuclear/cytosolic 本地化。有趣地,我们发现了那 NTRA,以前作为 cytosolic 蛋白质识别了,在原子核部分也是局部性的,建议一个完全的 TRX 系统在原子核是功能的。我们证明 NRX1 是主要被发现一在 vivo 更暗淡。nrx1 和 nrx2 大美人异种植物不在标准生长条件下面展出 phenotypic 不安。然而, nrx1 异种显示出减少的花粉富饶显型,建议在 haploid 阶段的 NRX1 的一个特定的角色。 | Corinne Marchal Valerie Delorme-Hinoux Laetitia Bariat Wafi Siala Christophe Belin Julio Saez-Vasquez Christophe Riondet Jean-Philippe Reichheld | 2014 | Molecular Plant2014，7，1： | 5 |
| 9 | Impact of peginterferon and ribavirin therapy on hepatocellular carcinoma: Incidence and survival in hepatitis C patients with advanced fibrosis显示文摘 | Ana-Carolina Cardoso Rami Moucari Claudio Figueiredo-Mendes Marie-Pierre Ripault Nathalie Giuily Corinne Castelnau Nathalie Boyer Tarik Asselah Michelle Martinot-Peignoux Sarah Maylin Roberto J. Carvalho-Filho Dominique Valla Pierre Bedossa Patrick Marcel | 2010 | Journal of Hepatology2010，，5： | 3 |
| 10 | Thromboembolic events and cardiovascular mortality in inflammatory bowel diseases: A meta-analysis of observational studies显示文摘 | Mathurin Fumery Cao Xiaocang Luc Dauchet Corinne Gower-Rousseau Laurent Peyrin-Biroulet Jean-Frédéric Colombel | 2013 | Journal of Crohn’s and Colitis2013，，： | 3 |
| 11 | Endoscopy-based management decreases the risk of postoperative recurrences in Crohn's disease显示文摘AIM: To investigate whether an endoscopy-based management could prevent the long-term risk of postoperative recurrence.METHODS: From the pathology department database, we retrospectively retrieved the data of all the patients operated on for Crohn's disease(CD) in our center(1986-2015). Endoscopy-based management was defined as systematic postoperative colonoscopy(median time after surgery = 9.5 mo) in patients with no clinical postoperative recurrence at the time of endoscopy. RESULTS: From 205 patients who underwent surgery, 161 patients(follow-up > 6 mo) were included. Endoscopic postoperative recurrence occurred in 67.6%, 79.7%, and 95.5% of the patients, respectively 5, 10 and 20 years after surgery. The rate of clinical postoperative recurrence was 61.4%, 75.9%, and 92.5% at 5, 10 and 20 years, respectively. The rate of surgical postoperative recurrence was 19.0%, 38.9% and 64.7%, respectively, 5, 10 and 20 years after surgery. In multivariate analysis, previous intestinal resection, prior exposure to anti-TNF therapy before surgery, and fistulizing phenotype(B3) were postoperative risk factors. Previous perianal abscess/fistula(other perianal lesions excluded), were predictive of only symptomatic recurrence. In multivariate analysis, an endoscopy-based management(n = 49/161) prevented clinical(HR = 0.4, 95%CI: 0.25-0.66, P < 0.001) and surgical postoperative recurrence(HR = 0.30, 95%CI: 0.13-0.70, P = 0.006).CONCLUSION: Endoscopy-based management should be recommended in all CD patients within the first year after surgery as it highly decreases the long-term risk of clinical recurrence and reoperation. | Anne-Laure Boucher Bruno Pereira Stéphanie Decousus Marion Goutte Felix Goutorbe Anne Dubois Johan Gagniere Corinne Borderon Juliette Joubert Denis Pezet Michel Dapoigny Pierre J Déchelotte Gilles Bommelaer Anthony Buisson | 2016 | World Journal of Gastroenterology2016，22，21： | 3 |
| 12 | Epidemiology of inflammatory bowel diseases: New insights from a French population-based registry (EPIMAD)显示文摘 | Corinne Gower-Rousseau Francis Vasseur Mathurin Fumery Guillaume Savoye Julia Salleron Luc Dauchet Dominique Turck Antoine Cortot Laurent Peyrin-Biroulet Jean Frédéric Colombel | 2012 | Digestive and Liver Disease2012，，： | 3 |
| 13 | Relationship between the severity of hepatitis C virus-related liver disease and the presence of Helicobacter species in the liver: A prospective study显示文摘AIM: To determine the presence of Helicobacter species DNA in the liver of chronic hepatitis C (CHC) patients with and without cirrhosis as compared to controls, and to identify the bacterial species involved. METHODS: Seventy-nine consecutive patients (HBV and HIV negative) with a liver sample obtained after liver biopsy or hepatic resection were studied: 41 with CHC without cirrhosis, 12 with CHC and cirrhosis, and 26 controls (HCV negative). Polymerase chain reactions (PCRs) targeting Helicobacter 16S rDNA and species- specific were performed on DNA extracted from the liver. A gastric infection with H pylori was determined by serology and confirmed by 13C-urea breath test. RESULTS: Overall, Helicobacter 16S rDNA was found in 16 patients (20.2%). Although positive cases tended to be higher in CHC patients with cirrhosis (41.6%) than in those without cirrhosis (17.0%) or in controls (15.4%), the difference was not statistically significant (P =0.08). H pylori-like DNA was identified in 12 cases and H. pullorum DNA in 2, while 2 cases remained unidenti- fied. Gastric infection with H pylori was found in only 2 of these patients. CONCLUSION: Our results do not confirm the associ- ation of Helicobacter species DNA in the liver of CHC patients with advanced liver disease. The lack of correlation between positive H pylori serology and the presence of H pylori-like DNA in the liver may indicate the presence of a variant of this species. | Laurent Castéra Anne Pedeboscq Marcia Rocha Brigitte Le Bail Corinne Asencio Victor de Lédinghen Pierre-Henri Bernard Christophe Laurent Marie-Edith Lafon Maylis Capdepont Patrice Couzigou Paulette Bioulac-Sage Charles Balabaud FrancisMégraud Armelle Ménard | 2006 | World Journal of Gastroenterology2006，12，45： | 3 |
| 14 | 温度和养护条件对砂浆和混凝土强度增长的影响 | Barbara Lothenbac Corinne Alder Frank Winnefeld Dübendorf/Schweiz und Peter Lunk Zürich/Schweiz 杨先坤 | 2007 | 商品混凝土2007，0，2： | 3 |
| 15 | 《未来的光防护:挑战与机遇》共识解读:国际防晒化妆品发展趋势及对中国的启示显示文摘目前对防晒化妆品的认识还存在一些误区,如防晒系数越高越好,防晒剂可以引起使用者缺钙等。防晒化妆品也存在诸如防晒系数测定和标识方法不统一、防护波长范围不足、对人体及环境的安全性不明等许多问题和挑战。本文阐述国际上防晒化妆品面临的问题、发展趋势及对中国防晒化妆品研发的启示等,供临床医师参考。 | 赖维 郑跃 Granger Corinne Trullas Carles Krutmann Jean 刘玮 | 2020 | 中华皮肤科杂志2020，53，12： | 3 |
| 16 | Small bowel capsule endoscopy for management of Crohn’s disease: A retrospective tertiary care centre experience显示文摘 | Catherine Dussault Corinne Gower-Rousseau Julia Salleron Gwénola Vernier-Massouille Julien Branche Jean-Frédéric Colombel Vincent Maunoury | 2013 | Digestive and Liver Disease2013，，7： | 3 |
| 17 | 2011-2015年美国初高中生的烟草使用情况显示文摘烟草使用是美国可预防性疾病和死亡的首要原因。如果维持目前的吸烟率,那么预计有560万现今小于18岁的美国人将因吸烟相关的疾病而过早死亡。大部分烟草使用和成瘾始于青少年期和青年期。 | Tushar Singh RenéA.Arrazola Catherine G.Corey Corinne G.Husten Linda J.Neff David M.Homa Brian A.King 汪源(译) 金克峙(审校) 蔡颖(审校) | 2017 | 上海预防医学2017，29，9： | 3 |
| 18 | Hemostasis testing in patients with liver dysfunction: Advantages and caveats显示文摘Due to concomitant changes in pro-and anti-coagulant mechanisms,patients with liver dysfunction have a“rebalanced hemostasis”,which can easily be tipped toward either a hypo-or a hypercoagulable phenotype.Clinicians are often faced with the question whether patients with chronic liver disease undergoing invasive procedures or surgery and those having active bleeding require correction of the hemostasis abnormalities.Conventional coagulation screening tests,such as the prothrombin time/international normalized ratio and the activated partial thromboplastin time have been demonstrated to have numerous limitations in these patients and do not predict the risk of bleeding prior to high-risk procedures.The introduction of global coagulation assays,such as viscoelastic testing(VET),has been an important step forward in the assessment of the overall hemostasis profile.A growing body of evidence now suggests that the use of VET might be of significant clinical utility to prevent unnecessary infusion of blood products and to improve outcomes in numerous settings.The present review discusses the advantages and caveats of both conventional and global coagulation assays to assess the risk of bleeding in patients with chronic liver disease as well as the current role of transfusion and hemostatic agents to prevent or manage bleeding. | Guillaume Nguyen Manon Lejeune Benjamin Crichi Corinne Frere | 2021 | World Journal of Gastroenterology2021，27，42： | 2 |
| 19 | Xenobiotics shape the physiology and gene expression of the active human gut microbiome显示文摘 | Corinne Ferrier Maurice Henry Joseph Haiser Peter James Turnbaugh | 2012 | Cell2012，，： | 2 |
| 20 | Plasticity of Human Adipose Lineage Cells Toward Endothelial Cells: Physiological and Therapeutic Perspectives显示文摘 | Valérie Planat-Benard Jean-Sébastien Silvestre Béatrice Cousin Mireille André Maryse Nibbelink Radia Tamarat Michel Clergue Carole Manneville Corinne Saillan-Barreau Micheline Duriez Alain Tedgui Bernard Levy Luc Pénicaud Louis Casteilla | 2004 | Circulation: Journal of the American Heart Association2004，，5： | 2 |
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