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| 1 | Transmission Dynamics of an Outbreak of the COVID-19 Delta Variant B.1.617.2——Guangdong Province,China,May-June 2021显示文摘On May 21,2021,a local case of coronavirus disease 2019(COVID-19)was confirmed in a 75-year-old woman(experienced onset of symptoms on May 18)in Liwan District,Guangzhou City,Guangdong Province,China.The number of infections has increased in the following 10 days and led to 5 generations of transmission. | Meng Zhang Jianpeng Xiao Aiping Deng Yingtao Zhang Yali Zhuang Ting Hu Jiansen Li Hongwei Tu Bosheng Li Yan Zhou Jun Yuan Lei Luo Zimian Liang Youzhi Huang Guoqiang Ye Mingwei Cai Gongli Li Bo Yang Bin Xu Ximing Huang Yazun Cui Dongsheng Ren Yanping Zhang Min Kang Yan Li | 2021 | China CDC weekly2021，3，27： | 51 |
| 2 | The pharmacology, toxicology and therapeutic potential of anthraquinone derivative emodin显示文摘Emodin(1, 3, 8-trihydroxy-6-methylanthraquinone) is a derived anthraquinone compound extracted from roots and barks of pharmaceutical plants, including Rheum palmatum, Aloe vera, Giant knotweed, Polygonum multiflorum and Polygonum cuspidatum. The review aims to provide a scientific summary of emodin in pharmacological activities and toxicity in order to identify the therapeutic potential for its use in human specific organs as a new medicine. Based on the fundamental properties, such as anticancer, anti-inflammatory, antioxidant, antibacterial, antivirs, anti-diabetes, immunosuppressive and osteogenesis promotion, emodin is expected to become an effective preventive and therapeutic drug of cancer, myocardial infarction, atherosclerosis, diabetes, acute pancreatitis, asthma, periodontitis, fatty livers and neurodegenerative diseases. This article intends to provide a novel insight for further development of emodin, hoping to reveal the potential of emodin and necessity of further studies in this field. | CUI Ya CHEN Liu-Jing HUANG Tu YING Jian-Qiong LI Juan | 2020 | Chinese Journal of Natural Medicines2020，18，6： | 23 |
| 3 | The chromosome-level reference genome assembly for Panax notoginseng and insights into ginsenoside biosynthesis显示文摘Panax notoginseng,a perennial herb of the genus Panax in the family Araliaceae,has played an important role in clinical treatment in China for thousands of years because of its extensive pharmacological effects.Here,we report a high-quality reference genome of P.notoginseng,with a genome size up to 2.66 Gb and a contig N50 of 1.12 Mb,produced with third-generation PacBio sequencing technology.This is the first chromosome-level genome assembly for the genus Panax.Through genome evolution analysis,we explored phylogenetic and whole-genome duplication events and examined their impact on saponin biosynthesis.We performed a detailed transcriptional analysis of P.notoginseng and explored genelevel mechanisms that regulate the formation of characteristic tubercles.Next,we studied the biosynthesis and regulation of saponins at temporal and spatial levels.We combined multi-omics data to identify genes that encode key enzymes in the P.notoginseng terpenoid biosynthetic pathway.Finally,we identified five glycosyltransferase genes whose products catalyzed the formation of different ginsenosides in P.notoginseng.The genetic information obtained in this study provides a resource for further exploration of the growth characteristics,cultivation,breeding,and saponin biosynthesis of P.notoginseng. | Zhouqian Jiang Lichan Tu Weifei Yang Yifeng Zhang Tianyuan Hu Baowei Ma Yun Lu Xiuming Cui Jie Gao Xiaoyi Wu Yuru Tong Jiawei Zhou Yadi Song Yuan Liu Nan Liu Luqi Huang Wei Gao | 2021 | Plant Communications2021，2，1： | 11 |
| 4 | Optimization of Protein Extraction and Decoloration Conditions for Tea Residues显示文摘To optimize alkaline method for extracting proteins from tea residue(TR), the effect of extraction conditions on tea protein extraction rate(TPER) was investigated. Single factor experiment showed the extraction temperature 80 °C, extraction time 100 min, p H value 13 and liquid–solid ratio 40:1 as the optimal extraction conditions. The orthogonal test revealed that the maximum TPER reached 29.71% under the following optimal combination of conditions: extraction temperature 70 °C, extraction time 60 min, p H 12 and liquid–solid ratio 50:1. For optimizing the purification of tea residue proteins, isoelectric point precipitation(p I), ammonium sulfate precipitation(a S) and isoelectric point plus ammonium sulfate precipitation(i PAS) were compared. The result showed that the highest protein precipitation rate(PPR) was 89.70% which was generated by using i PAS. Furthermore, powdered activated carbon was chosen as the most suitable decolorant for the extracted proteins. | CUI Qiaoyun NI Xinghong ZENG Liang TU Zheng LI Jin SUN Kang CHEN Xuan LI Xinghui | 2017 | Horticultural Plant Journal2017，3，4： | 8 |
| 5 | Analysis of Pulse Signals Based on Array Pulse Volume显示文摘Objective: To collect and analyze multi-dimensional pulse diagram features with the array sensor of a pressure profile system(PPS) and study the characteristic parameters of the new multi-dimensional pulse diagram by pulse diagram analysis technology. Methods: The pulse signals at the Guan position of left wrist were acquired from 105 volunteers at the Shanghai University of Traditional Chinese Medicine. We obtained the pulse data using an array sensor with 3×4 channels. Three dimensional pulse diagrams were constructed for the validated pulse data, and the array pulse volume(APV) parameter was computed by a linear interpolation algorithm. The APV differences among normal pulse(NP), wiry pulse(WP) and slippery pulse(SP) were analyzed using one-way analysis of variance. The coefficients of variation(CV) were calculated for WP, SP and NP. Results: The APV difference between WP and NP in the 105 volunteers was statistically significant(6.26±0.28 vs. 6.04±0.36, P=0.048), as well as the difference between WP and SP(6.26±0.28 vs. 6.07±0.46, P=0.049). However, no statistically significant difference was found between NP and SP(P=0.75). WP showed a similar CV(4.47%) to those of NP(5.96%) and SP(7.58%). Conclusion: The new parameter APV could differentiate between NP or SP and WP. Accordingly, APV could be considered an useful parameter for the analysis of array pulse diagrams in Chinese medicine. | CUI Ji TU Li-ping ZHANG Jian-feng ZHANG Shao-liang ZHANG Zhi-feng XU Jia-tuo | 2019 | Chinese Journal of Integrative Medicine2019，25，2： | 8 |
| 6 | Salivary mycobiome dysbiosis and its potential impact on bacteriome shifts and host immunity in oral lichen planus显示文摘The biodiversity of the mycobiome,an important component of the oral microbial community,and the roles of fungal–bacterial and fungal–immune system interactions in the pathogenesis of oral lichen planus (OLP) remain largely uncharacterized.In this study,we sequenced the salivary mycobiome and bacteriome associated with OLP.First,we described the dysbiosis of the microbiome in OLP patients,which exhibits lower levels of fungi and higher levels of bacteria.Significantly higher abundances of the fungi Candida and Aspergillus in patients with reticular OLP and of Alternaria and Sclerotiniaceae_unidentified in patients with erosive OLP were observed compared to the healthy controls.Aspergillus was identified as an “OLP-associated” fungus because of its detection at a higher frequency than in the healthy controls.Second,the co-occurrence patterns of the salivary mycobiome–bacteriome demonstrated negative associations between specific fungal and bacterial taxa identified in the healthy controls,which diminished in the reticular OLP group and even became positive in the erosive OLP group.Moreover,the oral cavities of OLP patients were colonized by dysbiotic oral flora with lower ecological network complexity and decreased fungal–Firmicutes and increased fungal–Bacteroidetes sub-networks.Third,several keystone fungal genera (Bovista,Erysiphe,Psathyrella,etc.) demonstrated significant correlations with clinical scores and IL-17 levels.Thus,we established that fungal dysbiosis is associated with the aggravation of OLP.Fungal dysbiosis could alter the salivary bacteriome or may reflect a direct effect of host immunity,which participates in OLP pathogenesis. | Yan Li Kun Wang Bo Zhang Qichao Tu Yufei Yao Bomiao Cui Biao Ren Jinzhi He Xin Shen Joy D.Van Nostrand Jizhong Zhou Wenyuan Shi Liying Xiao Changqing Lu Xuedong Zhou | 2019 | International Journal of Oral Science2019，11，3： | 8 |
| 7 | First imaging observation of the gravity waves in the mesopause region in China显示文摘The first imaging observation experiment of the atmospheric gravity waves in the mesopause region with the all-sky OH Meinel band airglow CCD imager is made during 02:00 to 06:00 on January 5,2009,at Hancun (39.4°N,116.6°E),Langfang,Hebei in China.Quasi-monochromatic gravity waves (QMGWs) are found clearly in the observation data.Case studies show that their horizontal wavelengths,horizontal phase velocities,azimuth angles of horizontal propagation directions and periods of three QMGW examples are about 12.3 km,41 m/s,327°,5 min;25 km,35 m/s,68°,12 min;and 10 km,48 m/s,341°,3.5 min respectively. | TU Cui HU Xiong YAN ZhaoAi XU QingChen ZHAO MingLiang LIU Jia | 2010 | Chinese Science Bulletin2010，55，6： | 7 |
| 8 | Killing effects of cytosine deaminase gene mediated by adenovirus vector on human pancreatic cancer cell lines in vitro显示文摘OBJECTIVE: To evaluate the killing effects of the cytosine deaminase (CD) gene mediated byadenovirus vector on human pancreatic cancer cell lines in vitro.METHODS: The CD gene was cloned into pAdTrack-CMV-CD, and pAdTrack-CMV-CD and pAdEasy-lwere recombinated in bacteria. The newly recombinated Ad-CD containing green fluoreseent protein(GFP) was propagated in 293 cells and purified by cesium chloride gradient centrifugation. Humanpancreatic cancer cell lines Patu8988 and SW1990 were infected with this virus, then 5-FC was added.XTT assay was used to estimate relative numbers of viable cells.RESULTS: The positive clones were selected by using endonuclease to digest the combinatants and theconcentration of viral liquids containing the CD gene was 2×1O11 pfu/ml. It was found that significantcytotoxic activities were possesscd by 5-FC for the CD gene transduced pancreatic cell lines, but littleeffects exerted on the nontransduced pancreatic carcinoma cells.CONCLUSIONS: The CD gene mediated by adenovirus with a high infectivity is efficient for genetherapy of pancreatic carcinoma cell lines. These data demonstrate the therapeutic efficacy of an enzymeprodrug strategy in experimental pancreatic cancer. | Zhao-Shen Li Xue Pan Guo-Ming Xu Long Cui Guan-Rong Dai Yan-Fang Gong Zhen-Xing Tu the Department of Gastroenterology Department of General Surgery Changhai Hospital, Second Military Medical University, Shanghai 200433, China | 2003 | Hepatobiliary & Pancreatic Diseases International2003，2，1： | 5 |
| 9 | The modified bilobed flap for reconstructing sacral decubitus ulcers显示文摘Background:Sacral pressure ulcers are associated with high morbidity and,in some cases,result in mortality from severe sepsis.Local flaps are frequently used for reconstruction of stage III and IV pressure ulcers.An ideal flap should be simple to design,have a reliable vascular supply and minimal donor site morbidity.Our study evaluates the use of a bilobed flap based on the superficial branch of the superior gluteal artery or the posterior branch of the fourth lumbar artery to reconstruct the sacral pressure ulcer.Case presentation:We performed a retrospective analysis of paraplegic patients with sacral pressure ulcers treated with our bilobed flaps from January 2015 to December 2019.A description of our management,operative protocol,outcome and complications is outlined.Seven paraplegic patients(6 male,1 female;average age 53.1 years)with sacral pressure ulcers were treated with our bilobed flap based on the superficial branch of the superior gluteal artery or the posterior branch of the fourth lumbar artery.The average size of the pressure ulcers was 7×5 cm(range 6.2×4.5 cm to 11×10 cm).All 7 flaps survived.The patients were followed up for 12 months without significant complications,such as flap necrosis or recurrence.Conclusions:The superficial branch of the superior gluteal artery or the posterior branch of the fourth lumbar artery reliably supplies the bilobed flap.The superior cluneal nerve can be included in the design.The technique is simple and reliable.It should be included in the reconstructive algorithm for the management of sacral pressure ulcers. | Xiangong Jiao Chunxiao Cui Sally Kiu-Huen Ng Zhangjia Jiang Chihui Tu Jiemin Zhou Xiandong Lu Xianwen Ouyang Tong Luo Ke Li Yixin Zhang | 2020 | Burns & Trauma2020，8，1： | 4 |
| 10 | Isosibiricin inhibits microglial activation by targeting the dopamine D1/D2 receptor-dependent NLRP3/caspase-1 inflammasome pathway显示文摘Microglia-mediated neuroinflammation is a crucial risk factor for neurological disorders.Recently,dopamine receptors have been found to be involved in multiple immunopathological processes and considered as valuable therapeutic targets for inflammation-associated neurologic diseases.In this study we investigated the anti-neuroinflammation effect of isosibiricin,a natural coumarin compound isolated from medicinal plant Murraya exotica.We showed that isosibiricin(10?50μM)dose-dependently inhibited lipopolysaccharide(LPS)-induced BV-2 microglia activation,evidenced by the decreased expression of inflammatory mediators,including nitrite oxide(NO),tumour necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-1β(IL-1β)and interleukin-18(IL-18).By using transcriptomics coupled with bioinformatics analysis,we revealed that isosibiricin treatment mainly affect dopamine receptor signalling pathway.We further demonstrated that isosibiricin upregulated the expression of dopamine D1/2 receptors in LPS-treated BV-2 cells,resulting in inhibitory effect on nucleotide binding domain-like receptor protein 3(NLRP3)/caspase-1 inflammasome pathway.Treatment with dopamine D1/2 receptor antagonists SCH 23390(1μM)or sultopride(1μM)could reverse the inhibitory effects of isosibiricin on NLRP3 expression as well as the cleavages of caspase-1 and IL-1β.Collectively,this study demonstrates a promising therapeutic strategy for neuroinflammation by targeting dopamine D1/2 receptors. | Yan-hang Wang Hai-ning Lv Qing-hua Cui Peng-fei Tu Yong Jiang Ke-wu Zeng | 2020 | Acta Pharmacologica Sinica2020，41，2： | 4 |
| 11 | SUBTYPES OF B LYMPHOCYTES IN PATIENTS WITH AUTOIMMUNE HEMOCYTOPENIA显示文摘Objective To investigate the quantities of bone marrow CD5+ B lymphocytes in the patients with autoimmune hemocytopenia and the relationship between quantities of CD5+ B lymphocytes and clinical or laboratorial parameters. Methods Quantities of CD5+ B lymphocytes in the bone marrow of 14 patients with autoimmune hemolytic anemia (AIHA) or Evans syndrome, 22 immunorelated pancytopenia (IRP) patients, and 10 normal controls were assayed by flow cytometry. The correlation between their clinical or laboratorial parameters and CD5+ B lymphocytes was analyzed. Results The quantity of CD5+ B lymphocytes of AIHA/Evans syndrome (34.64%±19.81%) or IRP patients (35.81%±16.83%) was significantly higher than that of normal controls (12.00%±1.97%, P<0.05). However, there was no significant difference between AIHA/Evans syndrome and IRP patients (P>0.05). In all hemocytopenic patients, the quantity of bone marrow CD5+ B lymphocytes showed significantly negative correlation with serum complement C3 level (r=-0.416, P<0.05). In the patients with AIHA/Evans syndrome, the quantity of bone marrow CD5+ B lymphocytes showed significantly positive correlation with serum indirect bilirubin level (r=1.00, P<0.05). In Evans syndrome patients, the quantity of CD5+ B lymphocytes in bone marrow showed significantly positive correlation with platelet-associated immunoglobulin G (r=0.761, P<0.05) and platelet-associated immunoglobulin M (r=0.925, P<0.05). The quantity of CD5+ B lymphocytes in bone marrow of all hemocytopenic patients showed significantly negative correlation with treatment response (tau-b=-0.289, P<0.05), but had no correlation with colony forming unit-erythroid (r=-0.205, P>0.05) or colony forming unit-granulocyte-macrophage colonies (r=-0.214, P>0.05). Conclusions The quantity of bone marrow CD5+ B lymphocytes in the patients with autoimmune hemocytopenia significantly increases and is correlated with disease severity and clinical response, which suggest that CD5+ B lymphocytes might play an important role in the pathogenesis of autoimmune hemocytopenia. | Li-min Xing Zong-hong Shao Rong Fu Hong Liu Jun Shi Jie Bai Mei-feng Tu Hua-quan Wang Zhen-zhu Cui Hai-rong Jia Juan Sun Chong-li Yang | 2007 | Chinese Medical Sciences Journal2007，22，2： | 3 |
| 12 | Durable endothelium-mimicking coating for surface bioengineering cardiovascular stents显示文摘Mimicking the nitric oxide(NO)-release and glycocalyx functions of native vascular endothelium on cardiovascular stent surfaces has been demonstrated to reduce in-stent restenosis(ISR)effectively.However,the practical performance of such an endothelium-mimicking surfaces is strictly limited by the durability of both NO release and bioactivity of the glycocalyx component.Herein,we present a mussel-inspired amine-bearing adhesive coating able to firmly tether the NO-generating species(e.g.,Cu-DOTA coordination complex)and glycocalyx-like component(e.g.,heparin)to create a durable endothelium-mimicking surface.The stent surface was firstly coated with polydopamine(pDA),followed by a surface chemical cross-link with polyamine(pAM)to form a durable pAMDA coating.Using a stepwise grafting strategy,Cu-DOTA and heparin were covalently grafted on the pAMDA-coated stent based on carbodiimide chemistry.Owing to both the high chemical stability of the pAMDA coating and covalent immobilization manner of the molecules,this proposed strategy could provide 62.4%bioactivity retention ratio of heparin,meanwhile persistently generate NO at physiological level from 5.9±0.3 to 4.8±0.4×10^(-10) mol cm^(-2) min^(-1) in 1 month.As a result,the functionalized vascular stent showed long-term endothelium-mimicking physiological effects on inhibition of thrombosis,inflammation,and intimal hyperplasia,enhanced re-endothelialization,and hence efficiently reduced ISR. | Qing Ma Xiuying Shi Xing Tan Rui Wang Kaiqin Xiong Manfred F.Maitz Yuanyuan Cui Zhangmei Hu Qiufen Tu Nan Huang Li Shen Zhilu Yang | 2021 | Bioactive Materials2021，6，12： | 3 |
| 13 | Identification of diapause-associated proteins in migratory locust, Locusta migratoria L.(Orthoptera: Acridoidea) by label-free quantification analysis显示文摘Maternal photoperiodic response is a key factor that affects offspring diapause in migratory locust,Locusta migratoria L.(Orthoptera:Acridoidea).Although many aspects of insect diapause have been studied,little is known about the molecular mechanisms of maternal photoperiodic response that influence diapause regulation.To gain insight into the possible mechanisms of maternal photoperiod influence on diapause regulation,proteomics data by label-free quantification analysis were generated from non-diapause and diapause eggs.A total of 175 proteins were differentially expressed between diapause and non-diapause eggs.Among them,24 proteins were upregulated,and 151 proteins were downregulated.Gene Ontology(GO)analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichments were performed on all differentially expressed proteins(DEPs)and showed that peroxisome,insect hormone biosynthesis,and longevity regulating pathway may be related to diapause of migratory locust.Furthermore,we used qRT-PCR to verify some results of the proteomic analysis.Proteins such as hexamerin-like protein 4,juvenile hormone epoxide hydrolase 1(JHEH1),cytochrome P450 and heat shock protein(HSP)20.7 were predicted to be involved in diapause.This study provides an important reference for future research that will explore the mechanisms of diapause induced by maternal effects in migratory locust. | CUI Dong-nan TU Xiong-bing HAO Kun Aftab Raza CHEN Jun Mark McNeill ZHANG Ze-hua | 2019 | Journal of Integrative Agriculture2019，18，11： | 3 |
| 14 | VlbZIP30 of grapevine functions in dehydration tolerance via the abscisic acid core signaling pathway显示文摘Drought stress limits the growth and development of grapevines,thereby reducing productivity,but the mechanisms by which grapevines respond to drought stress remain largely uncharacterized.Here,we characterized a group A bZIP gene from“Kyoho”grapevine,VlbZIP30,which was shown to be induced by abscisic acid(ABA)and dehydration stress.Overexpression of VlbZIP30 in transgenic Arabidopsis thaliana enhanced dehydration tolerance.Transcriptome analysis revealed that a major proportion of ABA-responsive and/or drought-responsive genes are transcriptionally regulated by VlbZIP30 during ABA or mannitol treatment at the cotyledon greening stage.We identified an A.thaliana G-box motif(CACGTG)and a potential grapevine G-box motif(MCACGTGK)in the promoters of the 39 selected A.thaliana genes upregulated in the transgenic plants and in the 35 grapevine homologs,respectively.Subsequently,using two grapevine-related databases,we found that 74%(23/31)and 84%(21/25)of the detected grapevine genes were significantly upregulated by ABA and drought stress,respectively,suggesting that these genes are involved in ABA or dehydration stress and may be regulated by VlbZIP30 in grapevine.We propose that VlbZIP30 functions as a positive regulator of dehydration-responsive signaling in the ABA core signaling pathway. | Mingxing Tu Xianhang Wang Yanxun Zhu Dejun Wang Xuechuan Zhang Ye Cui Yajuan Li Min Gao Zhi Li Yuejin Wang Xiping Wang | 2018 | Horticulture Research2018，5，1： | 2 |
| 15 | The long-term denudation rate of granitic regolith in Qinhuangdao, North China determined from the in situ depth profile of the cosmogenic nuclides ^(26)Al and ^(10)Be显示文摘This study quantifies the surface denudation rate of granitic regolith via the application of the in situ cosmogenic26 Al and10Be depth profile in China. The concentration ranges of26 Al and10Be in the quartz along the*3-m granitic regolith profile in Qinhuangdao are(4.9–23.1) 9 105and(2.3–36.6) 9 104atoms/g, respectively. With the exception of the surface sample, both26 Al and10Be concentrations decrease exponentially with sample depth. The Chi-square best-fitting results revealed a total denudation rate of *9 m/Ma averaged over a 103–105a timescale, which is lower than the values observed in global granitic outcrops. Compared with global datasets, the flat terrain due to the lack of tectonic activities is most likely the dominant factor that controls the local denudation process.The surface sample offsets from the theoretical cosmogenic nuclide distribution implies that the denudation rate from river basin sediment could be overestimated because of the bioturbation in the surficial soil layer. | Lifeng Cui Congqiang Liu Sheng Xu Zhiqi Zhao Chenglong Tu Taoze Liu Hu Ding | 2014 | Chinese Science Bulletin2014，59，34： | 2 |
| 16 | Gather wisdom to overcome barriers:Well-designed nano-drug delivery systems for treating gliomas显示文摘Due to the special physiological and pathological characteristics of gliomas,most therapeutic drugs are prevented from entering the brain.To improve the poor prognosis of existing therapies,researchers have been continuously developing non-invasive methods to overcome barriers to gliomas therapy.Although these strategies can be used clinically to overcome the blood-brain barrier(BBB),the accurate delivery of drugs to the glioma lesions cannot be ensured.Nano-drug delivery systems(NDDS)have been widely used for precise drug delivery.In recent years,researchers have gathered their wisdom to overcome barriers,so many well-designed NDDS have performed prominently in preclinical studies.These meticulous designs mainly include cascade passing through BBB and targeting to glioma lesions,drug release in response to the glioma microenvironment,biomimetic delivery systems based on endogenous cells/extracellular vesicles/protein,and carriers created according to the active ingredients of traditional Chinese medicines.We reviewed these well-designed NDDS in detail.Furthermore,we discussed the current ongoing and completed clinical trials of NDDS for gliomas therapy,and analyzed the challenges and trends faced by clinical translation of these well-designed NDDS. | Jiwei Cui Yuanxin Xu Haiyan Tu Huacong Zhao Honglan Wang Liuqing Di Ruoning Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 2 |
| 17 | A bioinformatics method for predicting long noncoding RNAs associated with vascular disease显示文摘Long noncoding RNAs(lncRNAs)play important roles in human diseases including vascular disease.Given the large number of lncRNAs,however,whether the majority of them are associated with vascular disease remains unknown.For this purpose,here we present a genomic location based bioinformatics method to predict the lncRNAs associated with vascular disease.We applied the presented method to globally screen the human lncRNAs potentially involved in vascular disease.As a result,we predicted 3043 putative vascular disease associated lncRNAs.To test the accuracy of the method,we selected 10 lncRNAs predicted to be implicated in proliferation and migration of vascular smooth muscle cells(VSMCs)for further experimental validation.The results confirmed that eight of the 10 lncRNAs(80%)are validated.This result suggests that the presented method has a reliable prediction performance.Finally,the presented bioinformatics method and the predicted vascular disease associated lncRNAs together may provide helps for not only better understanding of the roles of lncRNAs in vascular disease but also the identification of novel molecules for the diagnosis and therapy of vascular disease. | LI JianWei GAO Cheng WANG YuChen MA Wei TU Jian WANG JunPei CHEN ZhenZhen KONG Wei CUI QingHua | 2014 | Science China(Life Sciences)2014，57，8： | 2 |
| 18 | A Novel Cholesterol Oxidase Biosensor Based on Pt-nanoparticle/Carbon Nanotube Modified Electrode显示文摘A Pt-nanoparticle/carbon nanotube modified graphite electrode immobilized with cholesterol oxidase/sol-gel layer was developed for monitoring cholesterol. Using this electrode, cholesterol concentration (4.0×10-6 to 1.0×10-4 mol/L) could be determined accurately in the presence of ascorbic or uric acid, and the response time was rapid (< 20 s). This biosensor has high sensitivity and selectivity. | Qiao Cui SHI Tu Zhi PENG | 2005 | Chinese Chemical Letters2005，16，8： | 2 |
| 19 | Antisense targeting protein kinase C alpha and betal inhibits gastric carcinogen- esis显示文摘 | Jiang XH Tu SP Cui JT | 2004 | Cancer Res2004，64，16： | 1 |
| 20 | Overexpression of interleukin- !beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppres- sor cells in mice 显示文摘 | Tu S Bhagat G Cui G | 2008 | Cancer Cell2008，14，5： | 1 |
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