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| 1 | Preoperative diagnosis of malignant pulmonary nodules in lung cancer screening with a radiomics nomogram显示文摘Background:Lung cancer is the most commonly diagnosed cancer worldwide.Its survival rate can be significantly improved by early screening.Biomarkers based on radiomics features have been found to provide important physiological information on tumors and considered as having the potential to be used in the early screening of lung cancer.In this study,we aim to establish a radiomics model and develop a tool to improve the discrimination between benign and malignant pulmonary nodules.Methods:A retrospective study was conducted on 875 patients with benign or malignant pulmonary nodules who underwent computed tomography(CT)examinations between June 2013 and June 2018.We assigned 612 patients to a training cohort and 263 patients to a validation cohort.Radiomics features were extracted from the CT images of each patient.Least absolute shrinkage and selection operator(LASSO)was used for radiomics feature selection and radiomics score calculation.Multivariate logistic regression analysis was used to develop a classification model and radiomics nomogram.Radiomics score and clinical variables were used to distinguish benign and malignant pulmonary nodules in logistic model.The performance of the radiomics nomogram was evaluated by the area under the curve(AUC),calibration curve and Hosmer-Lemeshow test in both the training and validation cohorts.Results:A radiomics score was built and consisted of 20 features selected by LASSO from 1288 radiomics features in the training cohort.The multivariate logistic model and radiomics nomogram were constructed using the radiomics score and patients’age.Good discrimination of benign and malignant pulmonary nodules was obtained from the training cohort(AUC,0.836;95%confidence interval[CI]:0.793-0.879)and validation cohort(AUC,0.809;95%CI:0.745-0.872).The Hosmer-Lemeshow test also showed good performance for the logistic regression model in the training cohort(P=0.765)and validation cohort(P=0.064).Good alignment with the calibration curve indicated the good performance of the nomogram.Conclusions:The established radiomics nomogram is a noninvasive preoperative prediction tool for malignant pulmonary nodule diagnosis.Validation revealed that this nomogram exhibited excellent discrimination and calibration capacities,suggesting its clinical utility in the early screening of lung cancer. | Ailing Liu Zhiheng Wang Yachao Yang Jingtao Wang Xiaoyu Dai Lijie Wang Yuan Lu Fuzhong Xue | 2020 | Cancer Communications2020，40，1： | 22 |
| 2 | Tunable and multichannel terahertz perfect absorber due to Tamm surface plasmons with graphene显示文摘In this paper, we have shown that perfect absorption at terahertz frequencies can be achieved by using a composite structure where graphene is coated on one-dimensional photonic crystal(1 DPC) separated by a dielectric. Due to the excitation of optical Tamm states(OTSs) at the interface between the graphene and 1 DPC, a strong absorption phenomenon occurs induced by the coupling of the incident light and OTSs. Although the perfect absorption produced by a metal–distributed Bragg reflector structure has been researched extensively, it is generally at a fixed frequency and not tunable. Here, we show that the perfect absorption at terahertz frequency not only can be tuned to different frequencies but also exhibits a high absorption over a wide angle range. In addition,the absorption of the proposed structure is insensitive to the polarization, and multichannel absorption can berealized by controlling the thickness of the top layer. | XI WANG XING JIANG QI YOU JUN GUO XIAOYU DAI YUANJIANG XIANG | 2017 | Photonics Research2017，5，6： | 7 |
| 3 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 4 | Ultrasensitive biosensors based on long-range surface plasmon polariton and dielectric waveguide modes显示文摘An ultrasensitive biosensor based on hybrid structure and composed of long-range surface plasmon polariton(LRSPP) and dielectric planar waveguide(PWG) modes is proposed. Both PWG and LRSPP modes have strong resonances to form strong coupling between the two modes, and the two modes can couple to enhance sensitivity of sensors. In the hybrid structure, PWG is composed of cytop–Si–cytop multilayers and the LRSPP configuration is composed of cytop–metal–sensing medium multilayer slabs. The highest imaging sensitivities of 2264 and3619 RIU-1were realized in the proposed sensors based on Au and Al-monolayer graphene, respectively, which are nearly 1.2 and 1.9 times larger than the 1910 RIU-1sensitivity of the conventional LRSPR sensor(LRSPP sensor). Moreover, it is demonstrated that the PWG-coupled LRSPP biosensor is applicable to the sensing medium,with refractive index in the vicinity of 1.34. | Leiming Wu Jun Guo Hailin Xu Xiaoyu Dai Yuanjiang Xiang | 2016 | Photonics Research2016，4，6： | 4 |
| 5 | Effects of Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum on chemotactic migration of alveolar macrophages and inters regions macrophages in rats显示文摘OBJECTIVE: To observe the effects of serum containing Mahuang(Herba Ephedra Sinica) or Wuweizi(Fructus Schisandrae Chinensis) on the migration of alveolar macrophages(AM) and interstitial macrophages(IM) from normal rats, and to analyze and compare the mechanisms leading to cell migration differences.METHODS: Rats were randomly divided into three groups: Mahuang(Herba Ephedra Sinica), Wuweizi(Fructus Schisandrae Chinensis), and blank serum. After treatment with the herbs, serum was extracted from the rats. AM and IM were isolated from normal rats and cultured. The effects of Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum on normal rat AM and IM chemotactic migration were determined by transwell assays. The CC chemokine receptor(CCR) 2, CCR5, voltage-gated Kvl. 3 K^+channel(Kv1. 3), and voltage-gated Kvl. 5 K^+channel(Kv1. 5) protein levels were analyzed by western blotting.RESULTS: The migration quantities of AM and IM in the Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum groups were significantly higher than those in the blank serum group(P < 0.01). Compared with the Wuweizi(Fructus Schisandrae Chinensis) medicated serum group, the migration quantity of cultured rat AM in the Mahuang(Herba Ephedra Sinica) medicated serum group was significantly increased(P <0.01). Meanwhile, compared with the Mahuang(Herba Ephedra Sinica) medicated serum group, the migration quantity of cultured rat IM in the Wuweizi(Fructus Schisandrae Chinensis) medicated serum group was significantly increased(P < 0.01).CCR2, CCR5, Kv1. 3, and Kv1. 5 proteins were expressed on the AM cell surface, and showed significantly higher expression in the Mahuang(Herba Ephedra Sinica) medicated serum group compared with the Wuweizi(Fructus Schisandrae Chinensis)medicated serum group. In contrast, CCR5, Kv1.3,and Kv1.5 proteins were expressed on the IM cell surface, and showed significantly higher expression in the Wuweizi(Fructus Schisandrae Chinensis)medicated serum group compared with the Mahuang(Herba Ephedra Sinica) medicated serum group.CONCLUSION: Mahuang(Herba Ephedra Sinica)and Wuweizi(Fructus Schisandrae Chinensis) can promote AM and IM migration ability, with Mahuang(Herba Ephedra Sinica) targeting AM more apparently and Wuweizi(Fructus Schisandrae Chinensis) targeting IM more apparently. The mechanism may be that, by stimulating cells, Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) promote expression of CCR2 and CCR5 receptors on the AM and IM cell surface,which pass signals to Kvl.3 and Kvl.5 ion channels,leading to changes in the cytoskeleton, and ultimately promoting chemotactic cell migration. | Yuan Yiping Zhai Huaqiang Zhang Tian Guo Zhaojuan Kong Liting Jia Xiaoyu Wang Ningning Dai Ying Liu Guoxiu Wang Yanping | 2017 | Journal of Traditional Chinese Medicine2017，37，5： | 3 |
| 6 | A stringent dual control system overseeing transcription and activity of the Cre recombinase for the liver-specific conditional gene knock-out mouse model显示文摘Liver cancer is one of the most threatening diseases in Chinese population. Just like in other tissues, tumor initiation and development in liver involve multiple steps of genetic and epigenetic alterations with several unknown details. However, unlike in other tissues, a tis-sue specific inducible Cre recombinase system that allows temporal and spatial deletion of a target DNA fragment is still not available for in vivo functional gene annotation in hepatocytes. In our pursuit to establish such a mouse model, we designed a dual inducible Cre transgene system and tested it in cultured cells. By combining a CCAAT/enhancer binding protein β (C/EBP β) promoter derived Tet-off expression system and the estrogen receptor (ER) mediated functional control, we show a desirable profile of both hepatocyte-specificity and regulability of the Cre expression in a series of critical assessments in the cell culture system, which provides confidence in continua-tion of our ongoing pursuit in mouse. | Yu Wu Yinghua He Hongyu Zhang Xinlan Dai Xiaoyu Zhou Jun Gu Guan Wang Jingde Zhu | 2008 | Journal of Genetics and Genomics2008，35，7： | 3 |
| 7 | Ultrafast Synthesis of Metal-Layered Hydroxides in a Dozen Seconds for High-Performance Aqueous Zn(Micro-)Battery显示文摘Efficient synthesis of transition metal hydroxides on conductive substrate is essential for enhancing their merits in industrialization of energy storage field.However,most of the synthetic routes at present mainly rely on traditional bottom-up method,which involves tedious steps,time-consuming treatments,or additional alkaline media,and is unfavorable for high-efficiency production.Herein,we present a facile,ultrafast and general avenue to synthesize transition metal hydroxides on carbon substrate within 13 s by Joule-heating method.With high reaction kinetics caused by the instantaneous high temperature,seven kinds of transition metal-layered hydroxides(TM-LDHs)are formed on carbon cloth.Therein,the fastest synthesis rate reaches~0.46 cm^(2)s^(-1).Density functional theory calculations further demonstrate the nucleation energy barriers and potential mechanism for the formation of metal-based hydroxides on carbon substrates.This efficient approach avoids the use of extra agents,multiple steps,and long production time and endows the LDHs@carbon cloth with outstanding flexibility and machinability,showing practical advantages in both common and micro-zinc ion-based energy storage devices.To prove its utility,as a cathode in rechargeable aqueous alkaline Zn(micro-)battery,the NiCo LDH@carbon cloth exhibits a high energy density,superior to most transition metal LDH materials reported so far. | Xiangyang Li Fangshuai Chen Bo Zhao Shaohua Zhang Xiaoyu Zheng Ying Wang Xuting Jin Chunlong Dai Jiaqi Wang Jing Xie Zhipan Zhang Yang Zhao | 2023 | Nano-Micro Letters2023，15，3： | 2 |
| 8 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART. | Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu | 2021 | Cell Research2021，31，8： | 2 |
| 9 | Single-cell RNA sequencing reveals Nestin+active neural stem cells outside the central canal after spinal cord injury显示文摘Neural stem cells(NSCs)in the spinal cord hold great potential for repair after spinal cord injury(SCI).The ependyma in the central canal(CC)region has been considered as the NSCs source in the spinal cord.However,the ependyma function as NSCs after SCI is still under debate.We used Nestin as a marker to isolate potential NSCs and their immediate progeny,and characterized the cells before and after SCI by single-cell RNA-sequencing(scRNA-seq).We identified two subgroups of NSCs:the subgroup located within the CC cannot prime to active NSCs after SCI,while the subgroup located outside the CC were activated and exhibited the active NSCs properties after SCI.We demonstrated the comprehensive dynamic transcriptome of NSCs from quiescent to active NSCs after SCI.This study reveals that Nestin+cells outside CC were NSCs that activated upon SCI and may thus serve as endogenous NSCs for regenerative treatment of SCI in the future. | Muya Shu Xiaoyu Xue Hu Nie Xianming Wu Minghan Sun Lianyong Qiao Xing Li Bai Xu Zhifeng Xiao Yannan Zhao Yongheng Fan Bing Chen Jixiang Zhang Ya Shi Yaming Yang Falong Lu Jianwu Dai | 2022 | Science China(Life Sciences)2022，65，2： | 2 |
| 10 | Effect of Image Noise on the Classification of Skin Lesions Using Deep Convolutional Neural Networks显示文摘Skin lesions are in a category of disease that is both common in humans and a major cause of death.The classification accuracy of skin lesions is a crucial determinant of the success rate of curing lethal diseases.Deep Convolutional Neural Networks(CNNs)are now the most prevalent computer algorithms for the purpose of disease classification.As with all algorithms,CNNs are sensitive to noise from imaging devices,which often contaminates the quality of the images that are fed into them.In this paper,a deep CNN(Inception-v3)is used to study the effect of image noise on the classification of skin lesions.Gaussian noise,impulse noise,and noise made up of a compound of the two are added to an image dataset,namely the Dermofit Image Library from the University of Edinburgh.Evaluations,based on t-distributed Stochastic Neighbor Embedding(t-SNE)visualization,Receiver Operating Characteristic(ROC)analysis,and saliency maps,demonstrate the reliability of the Inception-v3 deep CNN in classifying noisy skin lesion images. | Xiaoyu Fan Muzhi Dai Chenxi Liu Fan Wu Xiangda Yan Ye Feng Yongqiang Feng Baiquan Su | 2020 | Tsinghua Science and Technology2020，25，3： | 2 |
| 11 | Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy显示文摘Recent studies have demonstrated the potential of natural killer(NK)cells in immunotherapy to treat multiple types of cancer.NK cells are innate lymphoid cells that play essential roles in tumor surveillance and control that efficiently kill the tumor and do not require the major histocompatibility complex.The discovery of the NK’s potential as a promising therapeutic target for cancer is a relief to oncologists as they face the challenge of increased chemo-resistant cancers.NK cells show great potential against solid and hematologic tumors and have progressively shown promise as a therapeutic target for cancer immunotherapy.The effector role of these cells is reliant on the balance of inhibitory and activating signals.Understanding the role of various immune checkpoint molecules in the exhaustion and impairment of NK cells when their inhibitory receptors are excessively expressed is particularly important in cancer immunotherapy studies and clinical implementation.Emerging immune checkpoint receptors and molecules have been found to mediate NK cell dysfunction in the tumor microenvironment;this has brought up the need to explore further additional NK cell-related immune checkpoints that may be exploited to enhance the immune response to refractory cancers.Accordingly,this review will focus on the recent findings concerning the roles of immune checkpoint molecules and receptors in the regulation of NK cell function,as well as their potential application in tumor immunotherapy. | Yuqing Cao Xiaoyu Wang Tianqiang Jin Yu Tian Chaoliu Dai Crystal Widarma Rui Song Feng Xu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 12 | Lineage tracing reveals the origin of Nestin-positive cells are heterogeneous and rarely from ependymal cells after spinal cord injury显示文摘Nestin is expressed extensively in neural stem/progenitor cells during neural development, but its expression is mainly restricted to the ependymal cells in the adult spinal cord. After spinal cord injury(SCI), Nestin expression is reactivated and Nestinpositive(Nestin;) cells aggregate at the injury site. However, the derivation of Nestin;cells is not clearly defined. Here, we found that Nestin expression was substantially increased in the lesion edge and lesion core after SCI. Using a tamoxifen inducible CreER(T2)-loxP system, we verified that ependymal cells contribute few Nestin;cells either to the lesion core or the lesion edge after SCI. In the lesion edge, GFAP+astrocytes were the main cell type that expressed Nestin;they then formed an astrocyte scar.In the lesion core, Nestin;cells expressed αSMA or Desmin, indicating that they might be derived from pericytes. Our results reveal that Nestin;cells in the lesion core and edge came from various cell types and rarely from ependymal cells after complete transected SCI, which may provide new insights into SCI repair. | Xiaoyu Xue Muya Shu Zhifeng Xiao Yannan Zhao Xing Li Haipeng Zhang Yongheng Fan Xianming Wu Bing Chen Bai Xu Yaming Yang Weiyuan Liu Sumei Liu Jianwu Dai | 2022 | Science China(Life Sciences)2022，65，4： | 2 |
| 13 | COLD1 Confers Chilling Tolerance in Rice显示文摘 | Yun Ma Xiaoyan Dai Yunyuan Xu Wei Luo Xiaoming Zheng Dali Zeng Yajun Pan Xiaoli Lin Huanhuan Liu Dajian Zhang Jun Xiao Xiaoyu Guo Shujuan Xu Yuda Niu Jingbo Jin Hui Zhang Xun Xu Legong Li Wen Wang Qian Qian Song Ge Kang Chong | 2015 | Cell2015，，6： | 1 |
| 14 | Functional carbon materials for high-performance Zn metal anodes显示文摘The realization of“carbon peak”and“carbon neutralization”highly depends on the efficient utilization of renewable energy sources.Exploring reliable and low-cost electrochemical energy storage systems is an ever-growing demand for renewable energy integration.Among available candidates,aqueous zinc-ion batteries(AZIBs)receive extensive researchers'attention because of their material abundance,high capacity,high safety,and environmental friendliness.However,the irreversible issues of Zn anode in terms of notorious dendric Zn growth,Zn corrosion/hydrogen evolution,and passivation significantly impede the commercialization of high-performance AZIBs.Carbon materials have advantages of large specific surface area,low cost,high electrical conductivity,controllable structure,and good stability.Their application provides remedies for improving the comprehensive performance of Zn anodes.In this review,the fundamentals and issues of Zn anodes,and the research progress with functional carbon materials for Zn anodes in recent years are presented.Three major strategies are described in detail,including the use of carbon materials(carbon nanotubes,graphene,carbon fiber,metal-organic framework(MOF)derived host,etc.)as Zn plating/stripping substrates,as protective coating layers on Zn,and as electrolyte additives.Finally,the remaining challenges and perspectives of carbon materials in high-performance AZIBs are outlined. | Caiwang Mao Yuxin Chang Xuanting Zhao Xiaoyu Dong Yifei Geng Ning Zhang Lei Dai Xianwen Wu Ling Wang Zhangxing He | 2022 | Journal of Energy Chemistry2022，，12： | 1 |
| 15 | Theoretical models for ultrashort electromagnetic beam propagation in nonlinear metamaterials显示文摘 | Wen Shuangchun Xiang Yuanjiang Dai Xiaoyu | 2007 | Phys Rev A2007，75，03： | 1 |
| 16 | Broadband nonlinear optical resonance and all-optical switching of liquid phase exfoliated tungsten diselenide显示文摘As a kind of two-dimensional transition metal dichalcogenide material, tungsten diselenide(WSe_2) has attracted increasing attention, owing to its gapped electronic structure, relatively high carrier mobility, and valley pseudospin, all of which show its valuable nonlinear optical properties. There are few studies on the nonlinear optical properties of WSe_2 and correlation with its electronic structure. In this paper, the effects of spatial self-phase modulation(SSPM) and distortion influence of WSe_2 ethanol suspensions are systematically studied, namely,the nonlinear refractive index and third-order nonlinear optical effect. We obtained the WSe_2 dispersions SSPM distortion formation mechanism, and through it, we calculated the nonlinear refractive index n_2,nonlinear susceptibility χ^(3), and their wavelength dependence under the excitation of 457 nm, 532 nm, and671 nm lasers. Moreover, by use of its strong and broadband nonlinear optical response, all-optical switching of two different laser beams due to spatial cross-phase modulation has been realized experimentally. Our results are useful for future optical devices, such as all-optical switching and all-optical information conversion. | YUE JIA YOUXIAN SHAN LEIMING WU XIAOYU DAI DIANYUAN FAN YUANJIANG XIANG | 2018 | Photonics Research2018，，11： | 1 |
| 17 | Modulation instability induced by nonlinear dispersion in nonlinear metamaterials显示文摘 | Xiang Yuanjiang Wen Shuangchun Dai Xiaoyu | 2007 | J Opt Soc Am B2007，24，12： | 1 |
| 18 | Solidification microstructure and phase constitution of Fe-7.5%Mo-16.5%Si ternary quasiperitectic alloy显示文摘Solidification of Fe-7.5%Mo-16.5%Si ternary quasiperitectic alloy is investigated by using differential scanning calorimetry (DSC) and drop tube containerless processing techniques.The primary phase is identified as R (Fe5Mo3Si2) and the quasiperitectic phases are τ1 (Fe5MoSi4) and Fe3Si.With the decrease of droplet diameter, the cooling rate and undercooling of the droplets in-crease rapidly.The experiment result indicates that the solidification microstructure is composed of remnant primary phase, qua-siperitectic phases and ternary eutectic when the droplet diameter exceeds 400 μm, whereas the ternary eutectic is suppressed when the droplet is smaller than 400 μm in diameter. | LI Li LU XiaoYu CAO ChongDe DAI FuPing | 2010 | Chinese Science Bulletin2010，55，16： | 1 |
| 19 | Modulation instability in metamaterials with saturable nonlinearity显示文摘 | Xiang Yuanjiang Dai Xiaoyu Wen Shuangchun | 2011 | J Opt Soc Am B2011，28，4： | 1 |
| 20 | 3D bioprinting of cell-laden nano-attapulgite/gelatin methacrylate composite hydrogel scaffolds for bone tissue repair显示文摘Bone tissue engineering(BTE)has proven to be a promising strategy for bone defect repair.Due to its excellent biological properties,gelatin methacrylate(GelMA)hydrogels have been used as bioinks for 3D bioprinting in some BTE studies to produce scaffolds for bone regeneration.However,applications for load-bearing defects are limited by poor mechanical properties and a lack of bioactivity.In this study,3D printing technology was used to create nano-attapulgite(nano-ATP)/GelMA composite hydrogels loaded into mouse bone mesenchymal stem cells(BMSCs)and mouse umbilical vein endothelial cells(MUVECs).The bioprintability,physicochemical properties,and mechanical properties were all thoroughly evaluated.Our findings showed that nano-ATP groups outperform the control group in terms of printability,indicating that nano-ATP is beneficial for printability.Additionally,after incorporation with nano-ATP,the mechanical strength of the composite hydrogels was significantly improved,resulting in adequate mechanical properties for bone regeneration.The presence of nano-ATP in the scaffolds has also been stud-ied for cell-material interactions.The findings show that cells within the scaffold not only have high viability but also a clear proclivity to promote osteogenic differentiation of BMSCs.Besides,the MUVECs-loaded composite hydrogels demonstrated increased angiogenic activity.A cranial defect model was also developed to evaluate the bone repair capability of scaffolds loaded with rat BMSCs.According to histo-logical analysis,cell-laden nano-ATP composite hydrogels can effectively im prove bone regeneration and promote angiogenesis.This study demonstrated the potential of nano-ATP for bone tissue engineering,which should also increase the clinical practicality of nano-ATP. | Chun Liu Ting Dai Xiaoyu Wu Jiayi Ma Jun Liu Siyu Wu Lei Yang Hongbin Zhao | 2023 | Journal of Materials Science & Technology2023，，4： | 1 |
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