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| 1 | Boundary-processing-technique in EMD method and Hilbert transform显示文摘By virtue of neural network, a series of signals is extended forward and backward, as a result, two additional maxima and two additional minima are obtained at both ends of the original data set, with which the EMD decomposition can be exactly achieved with cubic spline interpolation. Meanwhile, by using of neural network every IMF component can also be extended forward and backward, which effectively restrains the end effect, thus the veracious Hilbert spectra are achieved. Verifications of the sample signals and the actual surface elevation of sea waves show that the present extension method is relatively accurate. | DENG Yongjun, WANG Wei, QIAN Chengchun, WANG Zhong & DAI DejunNetwork Center, Ocean University of Qingdao. Qingdao 266003, China Physical Oceanography Laboratory, Ocean Universily of Qingdao, Qingdao 266003, China | 2001 | Chinese Science Bulletin2001，46，11： | 91 |
| 2 | Extracorporeal shock-wave versus pneumatic ureteroscopic lithotripsy in treatment of lower ureteral calculi显示文摘Aim:To compae the efficacy and complications of extracorporeal shock-wave lithotripsy (SWL) and pneumatic ureteroscopic lithotripsy(URS) in the treatment of lower ureteral calculi.Methods:From August 1997 to June 1999,210 patients with calculi in the distal third of the ureter were treated with SWL and other 180 with URS.The stones were fragmented with either HB-ESWL-V lithotripter or JML-93 pneumatic lithotripter through Wolf 7.5-9.0 Fr ureteroscope.The outcome was assessed in terms of stone clearance rate,re-treatment rate and complication incidence.Results:the stone clearance rate was 78.1% with SWL and 93.3% with URS (p<0.05).SWL had a re-treatment rate of 11.9%,vs 2.2% in the URS group (P<0.05).URS caused ureteral perforation in 3.3% of patients,while it was o with SWL (P<0.05).The differences in the incidence of other complications such as infection and stricture between the two groups were insignificant.conclusion:Though the selection of these two options depends on equipments available and the expertise of the operator,we recomment URS as the optimal treatment for distal ureteral calculi. | Zeng, GQ Zhong, WD Cai, YB Dai, QS Hu, JB Wei, HA | 2002 | Asian Journal of Andrology2002，4，4： | 17 |
| 3 | Irritable bowel syndrome and functional constipation management with integrative medicine: A systematic review显示文摘BACKGROUND Irritable bowel syndrome(IBS)and functional constipation(FC)are two commonly encountered functional gastrointestinal disorders in clinical practice and are usually managed with Western medicines in cooperation with traditional Chinese medicine(TCM)interventions.Although clinical practice guidelines(CPGs)have been developed to assist clinicians with their decisions,there are still gaps in management with regard to integrative medicine(IM)recommendations.AIM To comprehensively review the currently available CPGs and to provide a reference for addressing the gaps in IBS and FC management.METHODS We searched mainstream English and Chinese databases and collected data from January 1990 to January 2019.The search was additionally enriched by manual searches and the use of publicly available resources.Based on the development method,the guidelines were classified into evidence-based(EB)guidelines,consensus-based(CB)guidelines,and consensus-based guidelines with no comprehensive consideration of the EB(CB-EB)guidelines.With regard to the recommendations,the strength of the interventions was uniformly converted to a 4-point grading scale.RESULTS Thirty CPGs met the inclusion criteria and were captured as data extraction sources.Most Western medicine(WM)CPGs were developed as EB guidelines.All TCM CPGs and most IM CPGs were identified as CB guidelines.Only the 2011 IBS and IM CPG was a CB-EB set of guidelines.Antispasmodics and peppermint oil for pain,loperamide for diarrhea,and linaclotide for constipation polyethylene glycol and lactulose as osmotic laxatives,bisacodyl and sodium picosulfate as stimulant laxatives,lubiprostone and linaclotide as prosecretory agents,and prucalopride were strongly recommended or recommended in FC.TCM interventions were suggested based on pattern differentiation,while the recommendation level was considered to be weak or insufficient.CONCLUSION WM CPGs generally provide a comprehensive management algorithm,although there are still some gaps that could be addressed with TCM.Specific high-quality trials are needed to enrich the evidence. | Liang Dai Linda LD Zhong Guang Ji | 2019 | World Journal of Clinical Cases2019，7，21： | 14 |
| 4 | Preoperative blood oxygen level-dependent functional magnetic resonance imaging in patients with gliomas involving the motor cortical areas显示文摘背景:功能的磁性的回声成像(fMRI ) 玩的血氧水平依赖者(粗体) 在识别大脑的功能的皮层区的一个重要角色,特别在有 gliomas 的病人。这研究试图在 presurgical 在马达皮层区与 gliomas 计划和病人的功能的结果估计 fMRI 的价值。方法:有在马达外皮的 gliomas 的 26 个病人在学习被招募。在操作前, fMRI 在每个病人被执行获得在主要感觉运动的外皮上印射双边的手区域。这考试与一个双边的手运动范例在一台 3.0T 扫描仪上被执行。在微外科在下面期间唤醒麻醉,运动区用直接电的刺激并且与外科手术前的印射相比被识别。最后肿瘤是 resected 像一样与在每个病人保存的马达外皮可能。Karnofsky 表演地位(KPS ) 在手术前后在所有病人被评估。结果:23 个病人显示出印射的成功的 fMRI。在他们之中, 19 是是等级 III 的 calssified;4,等级 II;3,等级我。操作时间是在 23 个病人,的大约 7 个小时在其它的 8.5 个小时 3。在前和手术后的 KPS 分数是 82.3 +/- 8.6 和 94.2 +/- 8.1 分别地。结论:手运动区的外科手术前的 fMRI 与 intraoperative 显示出高一致性外皮的电子刺激。二个方法的联合使用在外科疗法显示出一个最大的好处。 | XIE Jian CHEN Xu-zhu JIANG Tao LI Shou-wei LI Zi-xiao ZHANG Zhong DAI Jian-ping WANG Zhong-cheng | 2008 | Chinese Medical Journal2008，，7： | 14 |
| 5 | Effects of Naoxintong on atherosclerosis and inducible nitric oxide synthase expression in atherosclerotic rabbit显示文摘 | ZHONG Xiao-nan WANG Hong-hao LU Zheng-qi DAI Yong-qiang HUANG Jian-hua QIU Wei SHU Ya-qing XU Wen CHENG Chen HU Xue-qiang | 2013 | Chinese Medical Journal2013，，6： | 14 |
| 6 | Drug-resistant genes carried by Acinetobacter baumanii isolated from patients with lower respiratory tract infection显示文摘 | DAI Ning LI De-zhi CHEN Ji-chao CHEN Yu-sheng GENG Rong HU Ying-hui YANG Jing-ping DU Juan HU Cheng-ping ZHANG Wei LI Jia-shu YU Qin WAN Huan-ying MU Lan ZHONG Xiao-ning WEI Li-ping MA Jian-jun WANG Qiu-yue HU Ke TIAN Gui-zhen CAI Shao-xi WANG Rui-qin HE Bei WANG Si-qin WANG Zhan-wei ZHAO Su-rui GAO Zhan-cheng | 2010 | Chinese Medical Journal2010，，18： | 13 |
| 7 | Effects of Laser Shock Processing on Mechanical Properties of Laser Welded ANSI 304 Stainless Steel Joint显示文摘With the rapid development of engineering component with integration,high-speed and multi-parameter,traditional techniques haven't met practical needs in extreme service environment.Laser welding,a new welding technology,has been widely used.However,it would generate the drop of mechanical properties for laser welded joint due to its thermal effect.Laser shock processing(LSP) is one of the most effective methods to improve the mechanical properties of laser welded ANSI 304 stainless steel joint.In this paper,the effects of LSP on the mechanical properties of laser welded ANSI 304 stainless steel joint have been investigated.The welded joint on the front of the tensile samples is treated by LSP impacts,and the overlapping rate of the laser spot is 50%.The tensile test of the laser welded joint with and without LSP impacts is carried out,and the fracture morphology of the tensile samples is analyzed by scanning electron microscope(SEM).Compared with the yield strength of 11.70 kN,the tensile strength of 37.66 kN,the yield-to-tensile strength ratio of 0.310 7,the elongation of 25.20%,the area reduction of 32.68% and the elastic modulus of 13 063.876 MPa,the corresponding values after LSP impacts are 14.25 kN,38.74 kN,0.367 8,26.58%,42.29% and 14 754.394 MPa,respectively.Through LSP impacts,the increasing ratio of the yield strength and tensile strength are 121.79% and 102.87%,respectively;the elongation and area reduction are improved by 5.48% and 29.38%,respectively.By comparing with coarse fracture surface of the welded joint,the delamination splitting with some cracks in the sharp corner of the welded joint and asymmetric dimples,LSP can cause brighter fracture surface,and finer and more uniform dimples.Finally,the schematic illustration of dimple formation with LSP is clearly described.The proposed research ensures that the LSP technology can clearly improve the yield strength,tensile strength,yield-to-tensile strength ratio,elongation,area reduction and elastic modulus of the welded joint.The enhancement mechanism of LSP on laser welded ANSI 304 stainless steel joint is mainly due to the fact that the refined and uniform dimples effectively delay the fracture of laser welded joints. | ZHANG Yongkang ZHANG Lei LUO Kaiyu SUN Guifang LU Jinzhong DAI Fengze ZHONG Junwei | 2012 | Chinese Journal of Mechanical Engineering2012，25，2： | 11 |
| 8 | A mini-review on rare-earth down-conversion nanoparticles for NIR-II imaging of biological systems显示文摘Rare-earth(RE)based luminescent probes exhibit rich optical properties including upconversion and down-conversion luminescence spanning a broad spectral range from 300 to 3,000 nm,and have generated great scientific and practical interest from telecommunication to biological imaging.While upconversion nanoparticles have been investigated for decades,down-conversion luminescence of RE-based probes in the second near-infrared(NIR-II,1,000-1,700 nm)window for in vivo biological imaging with sub-centimeter tissue penetration and micrometer image resolution has come into light only recently.In this review,we present recent progress on RE-based NIR-II probes for in vivo vasculature and molecular imaging with a focus on Er3+-based nanoparticles due to the down-conversion luminescence at the long-wavelength end of the NIR-II window(NIR-IIb,1,500-1,700 nm).Imaging in NIR-IIb is superior to imaging with organic probes such as ICG and IRDye800 in the^800 nm NIR range and the 1,000-1,300 nm short end of NIR-II range,owing to minimized light scattering and autofluorescence background.Doping by cerium and other ions and phase engineering of Er^3+-based nanoparticles,combined with surface hydrophilic coating optimization can afford ultrabright,biocompatible NIR-IIb probe towards clinical translation for human use.The Nd^3+-based probes with NIR-II emission at 1,050 and 1,330 nm are also discussed,including Nd^3+doped nanocrystals and Nd^3+-organic ligand complexes.This review also points out future directions for further development of multi-functional RE NIR-II probes for biological imaging. | Yeteng Zhong Hongjie Dai | 2020 | Nano Research2020，13，5： | 11 |
| 9 | Preoperative 3T high field blood oxygen level dependent functional magnetic resonance imaging for glioma involving sensory cortical areas显示文摘感觉外皮的区域的背景本地化在操作期间是必要的直接保存感觉 function.Intraoperative electrostimulation 在下面醒着麻醉是金色的标准但是费时间。我们高使用了 3T 地血氧水平依赖者(粗体)功能的磁性的回声成像( fMRI )为有感觉外皮参与由或靠着损害的五个 glioma 病人有的快、精确的 localization.Methods 指导 electrostimulation 外科手术前地识别在 glioma 和外皮的感觉区域之间的关系并且指导 intraoperative 外科手术前的粗体 fMRI 将决定外皮的感觉区域的空间关系到瘤。双边的手反面运动被这些病人为 fMRI 执行。Precentral 和 postcentral gyri 被电的刺激在操作期间识别。病人的 pre- 的 Karnofsky 表演地位分数并且手术后并且大胆 fMRI 的角色是 evaluated.Results 外皮的感觉区域都在与双边的手反面运动由 BOLDf MRI 包含 postcentral 回转区域的五个 glioma 病人被激活。检测激活区域从外皮的电的 stimulation.Conclusions 与结果相应在外皮的感觉区域和瘤之间的关系以前能被大胆 fMRI 精确地显示出操作。并且过去常做瘤切除术的信息能获得好临床的结果。 | LI Shao-wu WANG Jiang-fei JIANG Tao LI Shou-wei ZHANG Wen-bo LI Zi-xiao ZHANG Zhong DAI Jian-ping WANG Zhong-cheng | 2010 | Chinese Medical Journal2010，，8： | 11 |
| 10 | Review on the decomposition and influence factors of coarse woody debris in forest ecosystem显示文摘Coarse woody debris (CWD) is an important and particular component of forest ecosystems and is extremely important to forest health. This review describes the decomposition process, decomposition model and influence factors. CWD decomposition is a complex and continuous process and characterizes many biological and physical processes, including biological respiration, leaching, and fragmentation. All these processes have closed relationships between each other and work synergistically. During decomposition, there are many controlling factors mainly including site conditions (temperature, humidity, and O2/CO2 concentration), woody substrate quality (diameter, species and compound) and organism in CWD. The decomposition rate is generally expresses through a constant k which indicate the percent mass, volume or density loss over time, and can be determined by long-term monitoring, chronosequence approach and the radio between input and the total mass. Now using mathematical models to simulate decomposition patterns and estimate the decomposition rate is widely applied, especially the exponential model. We brought forward that managing and utilizing for the CWD in forest was a primary objective on all forest lands. And it is should be intensified to integrate many related research subjects and to carry a comprehensive, long-term and multi-scale research which mainly focus on seven sections. | ZHOU Li DAI Li-min GU Hui-yan ZHONG Lei | 2007 | Journal of Forestry Research2007，18，1： | 10 |
| 11 | A Preliminary Study on the Soft–Sediment Deformation Structures in the Late Quaternary Lacustrine Sediments at Tashkorgan, Northeastern Pamir, China显示文摘This study identified soft–sediment deformation structures(SSDS) of seismic origin from lacustrine sediments in the late Quaternary paleo–dammed lake at Tashkorgan, northeastern Pamir. The observed deformation structures include sand dykes, liquefied diapir and convolute structures, gravity induced SSDS, and thixotropic pillar and tabular structures. We conducted a preliminary study on the morphology, formation and trigger mechanisms of pillar and tabular structures formed by liquefaction of underlying coarse sand and thixotropy of the upper silty clay. The regional tectonic setting and distribution of lacustrine strata indicate that the most probable trigger for the SSDS in lacustrine sediments was seismic activity, with an approximate earthquake magnitude of M>6.0; the potential seismogenic fault is the southern part of the Kongur normal fault extensional system. AMS 14 C dating results indicate that the SSDS were formed by seismic events occurring between 26050±100 yr BP and 22710±80 yr BP, implying intense fault activity in this region during the late Pleistocene. This study provides new evidence for understanding tectonic activity and regional geodynamics in western China. | LIANG Lianji DAI Fuchu JIANG Hanchao ZHONG Ning | 2018 | Acta Geologica Sinica(English Edition)2018，92，4： | 10 |
| 12 | Fourth C hinese National Consensus Report on the management of H elicobacter pylori infection显示文摘 | Wen Zhong Liu Yong Xie Hong Cheng Nong Hua Lu Fu Lian Hu Wan Dai Zhang Li Ya Zhou Ye Chen Zhi Rong Zeng Chong Wen Wang Shu Dong Xiao Guo Zong Pan Pin Jin Hu | 2013 | Journal of Digestive Diseases2013，，5： | 9 |
| 13 | Exosomes:key players in cancer and potential therapeutic strategy显示文摘Exosomes are extracellular vesicles secreted by most eukaryotic cells and participate in intercellular communication.The components of exosomes,including proteins,DNA,mRNA,microRNA,long noncoding RNA,circular RNA,etc.,which play a crucial role in regulating tumor growth,metastasis,and angiogenesis in the process of cancer development,and can be used as a prognostic marker and/or grading basis for tumor patients.Hereby,we mainly summarized as followed:the role of exosome contents in cancer,focusing on proteins and noncoding RNA;the interaction between exosomes and tumor microenvironment;the mechanisms that epithelial-mesenchymal transition,invasion and migration of tumor affected by exosomes;and tumor suppression strategies based on exosomes.Finally,the application potential of exosomes in clinical tumor diagnosis and therapy is prospected,which providing theoretical supports for using exosomes to serve precise tumor treatment in the clinic. | Jie Dai Yangzhou Su Suye Zhong Li Cong Bang Liu Junjun Yang Yongguang Tao Zuping He Chao Chen Yiqun Jiang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 8 |
| 14 | Inhibitory effects of genistein on metastasis of human hepatocellular carcinoma显示文摘AIM:To investigate the inhibitory effects of genistein on metastasis of MHCC97-H hepatocellular carcinoma cells and to explore the underlying mechanism.METHODS:MHCC97-H hepatocellular carcinoma cells were exposed to genistein.A cell attachment assay was carried out in a microculture well pre-coated with fibronectin.The invasive activity of tumor cells was assayed in a transwell cell culture chamber,and cell cycle and apoptosis were evaluated by a functional assay.In addition,the expression and phosphorylation of FAK were detected by Western blotting.In situ xenograft transplantation of hepatocellular carcinoma was performed in 12 nude mice and lung metastasis of hepatocellular carcinoma was observed.RESULTS:Genistein signifi cantly inhibited the growth of MHCC97-H cells in vitro.Adhesion and invasiveness of MHCC97-H cells were inhibited in a concentration-dependent fashion,and the inhibitory effect of genistein was more potent in the 10 μg/mL and 20 μg/ mL genistein-treated groups.Genistein caused G0/G1 cell cycle arrest,an S phase decrease,and increased apoptosis.The expression and phosphorylation of FAK in MHCC-97H cells were signifi cantly decreased.In situ xenograft transplantation of hepatocellular carcinoma was also significantly suppressed by genistein.The number of pulmonary micrometastatic foci in the genistein group was signifi cantly lower compared with the control group(12.3±1.8 vs 16.6±2.6,P<0.05).CONCLUSION:Genistein appears to be a promising agent in the inhibition of metastasis of hepatocellular carcinoma. | Yan Gu Cheng-Fang Zhu Ya-Lei Dai Qiang Zhong Bo Sun | 2009 | World Journal of Gastroenterology2009，15，39： | 8 |
| 15 | Myelin protein zero and its antibody in serum as biomarkers of n-hexane-induced peripheral neuropathy and neurotoxicity effects显示文摘 | Jia Xiaowei Liu Qingjun Zhang Yanshu Dai Yufei Duan Huawei Bin Ping Niu Yong Liu Jie Zhong Liuzhen Guo Jisheng Liu Xiaofeng Zheng Yuxin | 2014 | Chinese Medical Journal2014，，8： | 8 |
| 16 | Novel functional proteins interact with midkine in hepatic cancer cells显示文摘BACKGROUND: Midkine is a heparin-binding growth factor that promotes the proliferation, survival, migration and differentiation of various target cells. Midkine plays an important role in tumorigenesis and tumor progression, and is overexpressed in many human malignant tumors. Patients with high tumor midkine expression frequently have a worse prognosis than those with low expression. The present study was designed to investigate the interaction network of midkine in hepatic cancer cells, and to elucidate its role in hepatocellular carcinoma. METHODS: DNA encoding full-length midkine was cloned into pDBLeu vector to serve as bait in yeast two-hybrid screening to identify interacting proteins. Candidate proteins were examined on SC-Leu-Trp-His+3-AT (20 mmol/L) plates and assayed for X-gal activity, then sequenced and classified according to the GenBank. Finally, identified proteins were expressed by the in vitro expression system pCMVTnT, and protein interactions were confirmed by co-immunoprecipitation. RESULTS: Using the yeast two-hybrid system, we found 6 proteins that interacted with midkine: NK-kappa-B inhibitor alpha (I-κ-B-α), Dvl-binding protein naked cuticle 2, granulin, latent active TGF-β binding protein 3, latent active TGF-β binding protein 4, and phospholipid scramblase 1. In vitro co-immunoprecipitation demonstrated that all identified proteins directly interacted with midkine.CONCLUSION: The identification of midkine-interacting proteins in hepatic cancer cells indicates that midkine is a multifunctional factor that may participate in cell migration, differentiation, and proliferation, and is also associated with the multicellular response feedback during the development of hepatocellular carcinoma. | Qiang Yan, Hui-Lian Huang, Xing Yao, Jing Li, Li-Qin Li, Jing Zhong, Li-Shan Min, Li-Cheng Dai and Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery, Huzhou Central Hospital (Yan Q and Yao X) Huzhou Key Laboratory of Molecular Medicine, Affiliated Central Hospital of Huzhou Teachers College (Huang HL, Li J, Li LQ, Zhong J, Min LS and Dai LC), Huzhou 313000, China Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China (Yan Q and Zheng SS) | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 7 |
| 17 | Thermo-sensitive polymer nanospheres as a smart plugging agent for shale gas drilling operations显示文摘Emulsifier-free poly(methyl methacrylate–styrene) [P(MMA–St)] nanospheres with an average particle size of 100 nm were synthesized in an isopropyl alcohol–water medium by a solvothermal method. Then, through radical graft copolymerization of thermo-sensitive monomer N-isopropylacrylamide(NIPAm) and hydrophilic monomer acrylic acid(AA) onto the surface of P(MMA–St) nanospheres at 80 °C, a series of thermo-sensitive polymer nanospheres, named SD-SEAL with different lower critical solution temperatures(LCST), were prepared by adjusting the mole ratio of NIPAm to AA. The products were characterized by Fourier transform infrared spectroscopy, transmission electron microscopy, thermogravimetric analysis, particle size distribution, and specific surface area analysis. The temperature-sensitive behavior was studied by light transmittance tests, while the sealing performance was investigated by pressure transmission tests with Lungmachi Formation shales. The experimental results showed that the synthesized nanoparticles are sensitive to temperature and had apparent LCST values which increased with an increase in hydrophilic monomer AA.When the temperature was higher than its LCST value, SDSEAL played a dual role of physical plugging and chemical inhibition, slowed down pressure transmission, and reduced shale permeability remarkably. The plugged layer of shale was changed to being hydrophobic, which greatly improved the shale | Wei-Ji Wang Zheng-Song Qiu Han-Yi Zhong Wei-An Huang Wen-Hao Dai | 2017 | Petroleum Science2017，14，1： | 7 |
| 18 | Improvement of Fracture Toughness Lanthanum Zirconate显示文摘La2Zr2O7 (LZ) is a promising thermal barrier coating material for the high temperature applications. The fracture toughness and microhardness of nanocrystalline LZ (n-LZ), microcrystalline LZ (m-LZ) and LZ-5mol%8YSZ (LZ-5-8YSZ) composite (8YSZ for zirconia stabilized by 8 mol% ytrria) were studied. The n-LZ had a thermal expansion coefficient of (9.6±0.4)×10 -6 K -1 (200~1000℃) and fracture toughness of (1.98±0.07) MPa·m 1/2 which are obviously higher than those of the m-LZ ( (9.1±0.4)×10 -6 K -1 and (1.40±0.23) MPa·m 1/2, respectively), indicating that nanofication was an efficient way to increase the toughness and thermal expansion coefficient of LZ. The composite LZ-5-8YSZ had a higher fracture toughness ((1.88±0.30) MPa·m 1/2) than LZ, which was close to that of 8YSZ densified by superhigh pressure (SHP). | LI J DAI H LI Q ZHONG X H CAO X Q | 2006 | 材料工程2006，34，5： | 7 |
| 19 | Novel hydrophobic associated polymer based nano-silica composite with core–shell structure for intelligent drilling fluid under ultra-high temperature and ultra-high pressure显示文摘Micro-nano-based drilling fluid has attracted a strong interest due to its attractive properties, and micro-nano composite materials have great potential for developing intelligent drilling fluid. In this study a novel hydrophobic associated polymer based nano-silica composite with core–shell structure was prepared and characterized by PSD, SEM, TEM and ESEM. The results showed that the composite, as a micro-nano drilling fluid additive, possessed excellent properties such as thermal stability, rheology, fluid loss and lubricity. Especially, it could plug the formation effectively and improve the pressure bearing capability of formation significantly. | Hui Mao Zhengsong Qiu Zhonghou Shen Weian Huang Hanyi Zhong Wenhao Dai | 2015 | Progress in Natural Science:Materials International2015，25，1： | 7 |
| 20 | Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)显示文摘There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world situations.In this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May 2021.The primary endpoint was progression-free survival(PFS)according to modified RECIST.The secondary outcomes included overall survival(OS),objective response rate(ORR),and safety.We performed propensity score matching approaches to reduce bias between two groups.After matching,228 pairs were included with a predominantly advanced disease population.Median PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,respectively.Our results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile. | Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei Zhao Jian-Bing Wu Song Wang Xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-Wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 7 |
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