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| 1 | Effect of hepatocyte apoptosis induced by TNF-α on acute severe hepatitis in mouse models显示文摘AIM To study the effect of hepatocyteapoptosis and necrosis induced by TNF-α on thepathogenesis of acute severe hepatitis(ASH).METHODS The model of ASH was prepared inD-galactosamine(GAIN)sensitized BALB/c miceby injection of either endotoxin(ET)or tumornecrosis factor-α(TNF-α).Morphologicalchanges of apoptotic hepatocytes were studiedby both light and electron microscope and in siteend labeling method(ISEL).Molecular biologicalchanges of DNA ladder were observed byelectrophoresis of extract from liver tissues.Biochemical changes were measured by alanineaminotransferase(ALT),asparticaminotransferase(AST)and TNF-α.The relationbetween apoptosis and necrosis was evaluatedsimultaneously.RESULTS The sequence of hepatocyteapoptosis,necrosis,and final death from ASHwas observed both in GAIN/ET and GAIN/TNF-agroup.Apoptosis was prominent at 3.5 h and 5 hafter injection of inducer,while necrosis becamedominant at 9 h after challenge.The appearanceof apoptosis was earlier in GAIN/TNF-α groupthan that in GAIN/ ET group.Pretreatment ofmice with antiTNF IgG1 may completely preventthe liver injury induced by GalN/ET.CONCLUSION TNF-α can cause liver damageby inducing hepatic apoptosis and necrosis inmice with endotoxemia. | Guo Qing Zang Xia Qiu Zhou Hong Yu Qing Xie Guo Ming Zhao Bin Wang Qing Guo Yue Qin Xiang Dan Liao Department of Infectious Diseases,Rujin Hospital,Shanghai Second Medical University,Shanghai 200025,China | 2000 | World Journal of Gastroenterology2000，6，5： | 30 |
| 2 | Delivery of Tapasin-modified CTL epitope peptide via cytoplasmic transduction peptide induces CTLs by JAK/STAT signaling pathway in vivo显示文摘特定的细胞毒素的 T 淋巴细胞(CTL ) 玩的肝炎 B 病毒(HBV ) 在病毒的控制和清理的一个重要角色。最近的研究阐明了那 Tapasin, endoplasmic 蜂窝胃女伴,是看起来在装载肽的过程必要的一个著名分子。Janus kinase/signal 变换器和小径玩的抄写(JAK/STAT ) 的使活跃之物在有免疫力的反应的一个重要角色规定和 cytokines 分泌物。我们以前证实了熔化蛋白质 CTP-HBcAg 18-27-Tapasin 能便于骨头髓的成熟导出的树枝状的房间并且在 vitro 提高特定的 CTL 回答,它可能与 JAK/STAT 发信号的激活被联系小径。为了进一步探索 JAK/STAT 发信号小径是否参予了特定的有免疫力的回答,由我们压制了的 CTP-HBcAg 18-27-Tapasin, 调停了有在 vivo 的药理学禁止者(AG490 ) 的 JAK/STAT 小径。我们的研究证明 IFN-+-CD8+ T 房间的数字在被 AG490 堵住以后与另外的组相比显著地被减少。IFN-+-CD4+ T 房间和 IL-2-CD4 + T 房间的百分比也被减少。而且, Jak2, Tyk2, STAT1,和 STAT4 的更低的表示层次在 AG490 被检测组。另外,象 Th1 一样 cytokines 的分泌物层次被减少,更弱的特定的 T 房间回答在 AG490 组被观察。而且,在这条小径在 HBV 转基因的老鼠被禁止以后,在浆液的 HBV DNA 和 HBsAg 的层次和在肝纸巾的 HBsAg 和 HBcAg 的表示层次被提高。这些结果证明表明小径的 JAK/STAT 参予 CTP-HBcAg 18-27-Tapasin 导致的 Th1 面向的有免疫力的反应,这可能为 HBV 免疫疗法提供一个理论基础。 | Shanshan Wu Xiaohua Chen Yuyan Tang Yi Zhang Dan Li Jie Chen Jieling Wang Zhenghao Tang Guoqing Zang Yongsheng Yu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，2： | 6 |
| 3 | Cyclospora cayetanensis infections among diarrheal outpatients in Shanghai: a retrospective case study显示文摘Cyclospora cayetanensis 是引起世界范围的地方性、流行的人的腹泻的 foodborne 和水运的病原体。关于 C 的一些流行病学的研究。在中国的 cayetanensis 感染被进行了。在 2013 期间, 291 个凳子标本的一个总数在城市的上海在一所医院与腹泻从病人被收集。C。, cayetanensis 没被传统的显微镜学在任何凳子标本检测五个凳子标本(1.72% , 5/291 ) 由 PCR 是积极的。分子的技术证实的这些积极盒子都在成年的组(吝啬的年龄 27.8 年;2.94% , 5/170 ) 与水的腹泻。显著感染发生在 5 月和 7 月的雨季。顺序和 C 的部分 18S rRNA 基因的种系发生的分析。cayetanensis 孤立这个寄生虫的显示出的 intra 种类差异。第一次,这研究显示出那 C。cayetanensis 是在有在上海的腹泻的门诊病人的病原体,在底层的虽然。然而,在这些病人的这个寄生虫的传播动力学仍然保持不明确。 | Yanyan Jiang Zhongying Yuan Guoqing Zang Dan Li Ying Wang Yi Zhang Hua Liu Jianping Cao Yujuan Shen | 2018 | Frontiers of Medicine2018，12，1： | 5 |
| 4 | Gut microbiota mediates the absorption of FLZ,a new drug for Parkinson’s disease treatment显示文摘The gut microbiota plays an important role in regulating the pharmacokinetics and pharmacodynamics of many drugs.FLZ,a novel squamosamide derivative,has been shown to have neuroprotective effects on experimental Parkinson’s disease(PD)models.FLZ is under phase I clinical trial now,while the underlying mechanisms contributing to the absorption of FLZ are still not fully elucidated.Due to the main metabolite of FLZ was abundant in feces but rare in urine and bile of mice,we focused on the gut microbiota to address how FLZ was metabolized and absorbed.In vitro studies revealed that FLZ could be exclusively metabolized to its major metabolite M1 by the lanosterol 14 alpha-demethylase(CYP51)in the gut microbiota,but was almost not metabolized by any other metabolism-related organs,such as liver,kidney,and small intestine.M1 was quickly absorbed into the blood and then remethylated to FLZ by catechol O-methyltransferase(COMT).Notably,dysbacteriosis reduced the therapeutic efficacy of FLZ on the PD mouse model by inhibiting its absorption.The results show that the gut microbiota mediate the absorption of FLZ through a FLZ-M1-FLZ circulation.Our research elucidates the vital role of the gut microbiota in the absorption of FLZ and provides a theoretical basis for clinical pharmacokinetic studies and clinical application of FLZ in the treatment of PD. | Junmei Shang Shurong Ma Caixia Zang Xiuqi Bao Yan Wang Dan Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 3 |
| 5 | Determination of triazine herbicide residues in water samples by on-line sweeping concentration in micellar electrokinetic chromatography显示文摘为在由在 micellar electrokinetic 层析(MEKC ) 的联机大规模集中技术的水样品的 atrazine, simazine 和 prometryn 的决心的一个新方法被开发。影响样品丰富和分离效率的各种各样的参数系统地被学习。与常规 MEKC 方法相比,直到在集中的 60200 褶层改进,敏感被使用这种大规模注射技术以山峰高度完成。复合士的宁为试验性的重制度的改进被用作内部标准。为 atrazine, simazine 和 prometryn 的察觉(S/N = 3:1 ) 的限制是 9, 10 和 0.5 ng mL ? 1 分别地。这个方法成功地在湖被用于 atrazine, simazine 和 prometryn 的分析,冒热气并且扎根水。 | Shuai Hua Zhang Yuan Yuan Yang Dan Dan Han Chun Wang Xin Zhou Xiao Huan Zang Zhi Wang | 2008 | Chinese Chemical Letters2008，19，12： | 2 |
| 6 | On-line Sweeping Sample Concentration in Micellar Electrokinetic Chromatography with Enhanced Sensitivity for the Deter-mination of Carbamazepine in Human Serum显示文摘A sensitive and simple micellar electrokinetic chromatography (MEKC) method was developed for the determination of antiepileptic drug,carbamazepine (CBZ),using sweeping on-line concentration method with photodiode array detection. Under the optimal conditions,the calibration curve was linear over a range of 0.5-40 μg·mL-1 for CBZ with a correlation coefficient of 0.998. The detection limit (S/N = 3:1) of CBZ was 0.10 μg·mL-1. The sweeping-MEKC method has been successfully applied to the analysis of CBZ in human serum. | Dan Dan HAN Chun WANG Zhi WANG Qiu Hua WU Xiao Huan ZANG | 2006 | Chinese Chemical Letters2006，17，7： | 1 |
| 7 | Electrical and thermal properties of a carbon nanotube/polycrystalline Bi Fe O3/Pt photovoltaic heterojunction with Cd Se quantum dots sensitization显示文摘 | ZANG Yong-yun XIE Dan CHEN Yu | 2012 | Nanoscale2012，4，9： | 1 |
| 8 | New progress of research on nonlinear optical crystals显示文摘 | CHANG Xinan CHEN Dan ZANG Hegui | 2007 | J Syn Cryst2007，36，2： | 1 |
| 9 | Investigation of the improved perfomanee in a graphene/polyerystal line BiFeO3/Pt photovoltaic heterojunction: experiment, modeling, and application显示文摘 | Zang Yongyuan Xie Dan Chen Yu | 2012 | Journal of Applied Phys- ics2012，112，05： | 1 |
| 10 | Mechanism of discoloration in processed garlic and onion显示文摘 | Jiachen Zang Dan Wang Guanghua Zhao | 2013 | Trends in Food Science & Technology2013，，2： | 1 |
| 11 | An uncertain energy planning model under carbon taxes显示文摘 | Hongkuan ZANG Yi XU Wei LI Guohe HUANG Dan LIU | 2012 | Frontiers of Environmental Science & Engineering2012，6，4： | 0 |
| 12 | A targeted QTL analysis for fiber length using a genetic population between two introgressed backcrossed inbred lines in upland cotton(Gossypium hirsutum)显示文摘Cotton fiber is the most important natural raw material for the textile industry, and fiber length(FL) is one of the most important traits in cotton.Quantitative trait locus(QTL)mapping based on high-density genetic maps is an efficient approach to identify genetic regions for FL.In our study, two backcrossed inbred lines(BILs) were chosen as parents to construct a high-density genetic map in F2 which was used to fine map FL QTL in F2:3 population.The genetic map had a total size of 3462.8 cM, containing 9182 singlenucleotide polymorphisms(SNPs) based on genotyping-by-sequencing.Two FL related stable QTL were identified on two chromosomes(qFL-A08–1 on A08 and qFL-D03–1 on D03),and qFL-A08–1 was confirmed by a meta-analysis.Utilizing previously obtained RNA-seq data for the two BILs and qRT-PCR analysis, two candidate genes annotated as cytochrome b5(CB5, Gh_A08 G1729) and microtubule end-binding 1 C(EB1C, Gh_D03 G0232) that may regulate FL during the fiber elongation stage were identified.In addition, nine recombination hotspots in this population were found.The results of this study will provide an important foundation for further studies on the molecular and genetic regulation of fiber elongation. | Guoyuan Liua Wenfeng Pei Dan Li Jianjiang Ma Yupeng Cui Nuohan Wang Jikun Song Man Wu Libei Li Xinshan Zang Shuxun Yu Jinfa Zhang Jiwen Yu | 2019 | The Crop Journal2019，7，3： | 0 |
| 13 | Combination of hollow fiber-based liquid-phase microextraction with sweeping techniques in micellar electrokinetic chromatography for the determination of Strychnos alkaloids in human urine显示文摘A new method for the enrichment of Strychnos alkaloids in biological samples via liquid-phase microextraction (LPME) based on porous polypropylene hollow fibers in combination with on-line sweeping in micellar electrokinetic chromatography was developed. The calibration curve was linear over the range of 20-200 ng mL-1 for both strychnine and brucine in human urine sample. The detection limits (S/N=3:1) for strychnine and brucine were 1 ng mL-1 and 2 ng mL-1, respectively. The LPME-sweeping method has been successfully applied to the analysis of strychnine and brucine in real urine samples. | Xiao Huan Zang Cai Rui Li Qiu Hua Wu Chun Wang Dan Dan Han Zhi Wang | 2007 | Chinese Chemical Letters2007，18，3： | 0 |
| 14 | Structural, magnetic behaviors and temperature-dependent Raman scattering spectra of Y and Zr codoped BiFeO_(3) ceramics显示文摘Multiferroic BiFeO_(3)(BFO)and Y,Zr codoped BFO(Bi_(1-x)Y_(x)Fe_(0.95)Zr_(0.05)O_(3)ceramics were prepared and the influence of codoping on the crystal structure and magnetic properties were investigated in this work.Confirmed by the evolution of X-ray diffraction and Raman modes,the codoping has changed the crystal structure from rhombohedral to tetragonal in bulk BFO ceramics.The enhancement of magnetic behaviors is demonstrated by the damage of space-modulated spiral spin structure,and it can be attributed to the crystal structure change and size effects.Meanwhile,Raman spectra from 300 to 800K demonstrates that lower frequency phonon modes show rapid softening near the Neel temperature. | Cheng Zhang Dan Xie Jianlong Xu Yilin Sun Yongyuan Zang Xiaowen Zhang Xingsen Gao | 2015 | Journal of Advanced Dielectrics2015，5，3： | 0 |
| 15 | Financial decision‑making behaviors of Ethnic Tibetan Households based on mental accounting显示文摘Ethnic Tibetans(ETs)typically reside in the remote plateaus of China and possess strong cultural and spiritual values.Their financial decision-making is influenced by economic and physical factors,unique culture,social norms,and psychological motivators.We conducted an in-person survey of 480 randomly selected ET households across four provinces in rural China.The survey data was analyzed using three different econometric models—probit,ordered probit,and ranked ordered logit—to examine the choice of borrowing from formal or informal credit sources,the number of sources borrowed from,and repayment priority.Our findings indicate that mental accounting plays a significant role in the financial decision-making process of ET households.Additionally,we find that the informal credit source is strongly associated with the financial decisions of ET households.The majority of loans from formal financial institutions are used to meet daily needs,as opposed to purchasing productive inputs.Our results also suggest that strong social relationships and religious beliefs prevent households from defaulting,and that loans from formal financial sources receive repayment priority.China would benefit from promoting inclusive finance and encouraging the adoption of improved agricultural practices to support the prosperity of ET and other minority communities. | DunGang Zang Krishna P.Paudel Yan Liu Dan Liu Yating He | 2023 | Financial Innovation2023，9，1： | 0 |
| 16 | The F5 gene predicts poor prognosis of patients with gastric cancer by promoting cell migration identified using a weighted gene co-expression network analysis显示文摘Distal gastric cancer(DGC)is a subgroup of gastric cancer(GC),which has different molecular characteristics from proximal gastric cancer(PGC).These differences result in different overall survival(OS)rates;however,data pertaining to the survival rate in PGC or DGC are contradictory.This suggests that the location of GC is not the unique cause of the different survival rates,while the molecular characteristics might be more important factors determining the prognosis of DGC.Therefore,the aim of this study was to discover key prognostic factors in DGC using bioinformatic methods and to explore the potential molecular mechanism.The Cancer Genome Atlas(TCGA)public database was employed to screen data relating to DGC,and we conducted a weighted gene co-expression network analysis(WGCNA)on DGC patient samples to establish co-expression modules.High-weight genes(hub genes)in a dominant color module were identified.In vitro experiments and gene set enrichment analyses(GSEA)were carried out to elucidate the potential molecular mechanism.In this study,139 DGC samples were enrolled to perform a co-expression analysis.According to the correlation between gene modules and clinical characteristics,the royal blue module related to stage M of DGC was screened,and a survival analysis was conducted to show that highcoagulation-factor V(F5)expression was related to the short OS of patients with GC.In vitro experiments confirmed that F5 could promote the migration of GC cells.GSEA suggested that F5 might have affected the prognosis of GC by modulating the activities of the Wnt and/or the TGF-βsignaling pathways.Our results indicated that high F5 expression predicts poor prognosis of patients with DGC,and it functions probably by promoting cell migration through the Wnt and/or the TGF-βsignaling pathways. | MENGYI TANG BOWEN YANG CHUANG ZHANG CHAOXU ZHANG DAN ZANG LIBAO GONG YUNPENG LIU ZHI LI XIUJUAN QU | 2021 | BIOCELL2021，45，4： | 0 |
| 17 | Zfp281 is essential for epiblast maturation through a cell autonomous effect显示文摘Pluripotency is recognized as a spectrum of cellular states spanning the na?ve pluripotency established in the preimplantation blastocyst and its transition into primed pluripotency in the postimplantation epiblast cells. The exit from pluripotency is followed by the initiation of gastrulation(Brennan et al., 2001;Nichols and Smith, 2009). | Ruge Zang Xin Huang Dan Li Hongwei Zhou Shaorong Gao Jianlong Wang | 2022 | Journal of Genetics and Genomics2022，49，1： | 0 |
| 18 | An Earth-mass planet in a time of COVID-19:KMT-2020-BLG-0414Lb显示文摘We report the discovery of KMT-2020-BLG-0414 Lb,with a planet-to-host mass ratio q2=0.9-1.2×10-5=3-4 q⊕at 1σ,which is the lowest mass-ratio microlensing planet to date.Together with two other recent discoveries(4?q/q⊕?6),it fills out the previous empty sector at the bottom of the triangular(log s,log q)diagram,where s is the planet-host separation in units of the angular Einstein radiusθE.Hence,these discoveries call into question the existence,or at least the strength,of the break in the mass-ratio function that was previously suggested to account for the paucity of very low-q planets.Due to the extreme magnification of the event,Amax~1450 for the underlying single-lens event,its light curve revealed a second companion with q3~0.05 and|log s3|~1,i.e.,a factor~10 closer to or farther from the host in projection.The measurements of the microlens parallaxπE and the angular Einstein radiusθE allow estimates of the host,planet and second companion masses,(M1,M2,M3)~(0.3 M⊙,1.0 M⊕,17 MJ),the planet and second companion projected separations,(a⊥,2,a⊥,3)~(1.5,0.15 or 15)au,and system distance DL~1 kpc.The lens could account for most or all of the blended light(I~19.3)and so can be studied immediately with high-resolution photometric and spectroscopic observations that can further clarify the nature of the system.The planet was found as part of a new program of high-cadence follow-up observations of high-magnification events.The detection of this planet,despite the considerable difficulties imposed by COVID-19(two KMT sites and OGLE were shut down),illustrates the potential utility of this program. | Weicheng Zang Cheongho Han Iona Kondo Jennifer C.Yee Chung-Uk Lee Andrew Gould Shude Mao Leandro de Almeida Yossi Shvartzvald Xiangyu Zhang Michael D.Albrow Sun-Ju Chung Kyu-Ha Hwang Youn Kil Jung Yoon-Hyun Ryu In-Gu Shin Sang-Mok Cha Dong-Jin Kim Hyoun-Woo Kim Seung-Lee Kim Dong-Joo Lee Yongseok Lee Byeong-Gon Park Richard W.Pogge John Drummond Thiam-Guan Tan JoséDias do Nascimento Júnior Dan Maoz Matthew T.Penny Wei Zhu Ian A.Bond Fumio Abe Richard Barry David P.Bennett Aparna Bhattacharya Martin Donachie Hirosane Fujii Akihiko Fukui Yuki Hirao Yoshitaka Itow Rintaro Kirikawa Naoki Koshimoto Man Cheung Alex Li Yutaka Matsubara Yasushi Muraki Shota Miyazaki Greg Olmschenk Clément Ranc Nicholas J.Rattenbury Yuki Satoh Hikaru Shoji Stela Ishitani Silva Takahiro Sumi Daisuke Suzuki Yuzuru Tanaka Paul J.Tristram Tsubasa Yamawaki Atsunori Yonehara Andreea Petric Todd Burdullis Pascal Fouqué | 2021 | Research in Astronomy and Astrophysics2021，21，9： | 0 |
| 19 | Maternal aging increases offspring adult body size via transmission of donut-shaped mitochondria显示文摘Maternal age at childbearing has continued to increase in recent decades.However,whether and how it influences offspring adult traits are largely unknown.Here,using adult body size as the primary readout,we reveal that maternal rather than paternal age has an evolutionarily conserved effect on offspring adult traits in humans,Drosophila,and Caenorhabditis elegans.Elucidating the mechanisms of such effects in humans and other long-lived animals remains challenging due to their long life course and difficulties in conducting in vivo studies.We thus employ the short-lived and genetically tractable nematode C.elegans to explore the mechanisms underlying the regulation of offspring adult trait by maternal aging.By microscopic analysis,we find that old worms transmit aged mitochondria with a donut-like shape to offspring.These mitochondria are rejuvenated in the offspring’s early life,with their morphology fully restored before adulthood in an AMPK-dependent manner.Mechanistically,we demonstrate that early-life mitochondrial dysfunction activates AMPK,which in turn not only alleviates mitochondrial abnormalities but also activates TGFβsignaling to increase offspring adult size.Together,our findings provide mechanistic insight into the ancient role of maternal aging in shaping the traits of adult offspring. | Runshuai Zhang Jinan Fang Ting Qi Shihao Zhu Luxia Yao Guicun Fang Yunsheng Li Xiao Zang Weina Xu Wanyu Hao Shouye Liu Dan Yang Di Chen Jian Yang Xianjue Ma Lianfeng Wu | 2023 | Cell Research2023，33，11： | 0 |
| 20 | FUS-mediated HypEVs: Neuroprotective effects against ischemic stroke显示文摘Few studies have investigated the properties and protein composition of small extracellular vesicles (sEVs) derived from neurons under hypoxic conditions. Presently, the extent of the involvement of these plentiful sEVs in the onset and progression of ischemic stroke remains an unresolved question. Our study systematically identified the characteristics of sEVs derived from neurons under hypoxic conditions (HypEVs) by physical characterization, sEV absorption, proteomics and transcriptomics analysis. The effects of HypEVs on neurites, cell survival, and neuron structure were assessed in vitro and in vivo by neural complexity tests, magnetic resonance imaging (MRI), Golgi staining, and Western blotting of synaptic plasticity-related proteins and apoptotic proteins. Knockdown of Fused in Sarcoma (FUS) small interfering RNA (siRNA) was used to validate FUS-mediated HypEV neuroprotection and mitochondrial mRNA release. Hypoxia promoted the secretion of sEVs, and HypEVs were more easily taken up and utilized by recipient cells. The MRI results illustrated that the cerebral infarction volume was reduced by 45% with the application of HypEVs, in comparison to the non- HypEV treatment group. Mechanistically, the FUS protein is necessary for the uptake and neuroprotection of HypEVs against ischemic stroke as well as carrying a large amount of mitochondrial mRNA in HypEVs. However, FUS knockdown attenuated the neuroprotective rescue capabilities of HypEVs. Our comprehensive dataset clearly illustrates that FUS-mediated HypEVs deliver exceptional neuroprotective effects against ischemic stroke, primarily through the maintenance of neurite integrity and the reduction of mitochondria-associated apoptosis. | Yousheng Wu Xiaoxiong Huang Zefeng Tan Jiankun Zang Min Peng Niu He Tao Zhang Hongcheng Mai Anding Xu Dan Lu | 2023 | Bioactive Materials2023，，11： | 0 |
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