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| 1 | Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma显示文摘AIM: To determine the genomic changes in hepatitis B virus(HBV) and evaluate their role in the development of hepatocellular carcinoma(HCC) in patients chronically infected with genotype C HBV.METHODS: Two hundred and forty chronic hepatitis B(CHB) patients were subjected and followed for a median of 105 mo. HCC was diagnosed in accordance with AASLD guidelines. The whole X, S, basal core promoter(BCP), and precore regions of HBV were sequenced using the direct sequencing method.RESULTS: All of the subjects were infected with genotype C HBV. Out of 240 CHB patients, 25(10%) had C1653 T and 33(14%) had T1753 V mutation in X region; 157(65%) had A1762T/G1764 A mutations in BCP region, 50(21%) had G1896 A mutation in precore region and 67(28%) had pre-S deletions. HCC occurred in 6 patients(3%). The prevalence of T1753 V mutation was significantly higher in patients who developed HCC than in those without HCC. The cumulative occurrence rates of HCC were 5% and 19% at 10 and 15 years, respectively, in patients with T1753 V mutant, which were significantly higher than 1% and 1% in those with wild type HBV(P < 0.001).CONCLUSION: The presence of T1753 V mutation in HBV X-gene significantly increases the risk of HCC development in patients chronically infected with genotype C HBV. | Danbi Lee Heather Lyu Young-Hwa Chung Jeong A Kim Priya Mathews Elizabeth Jaffee Lei Zheng Eunsil Yu Young Joo Lee Soo Hyung Ryu | 2016 | World Journal of Gastroenterology2016，22，23： | 9 |
| 2 | Predictors of poor outcomes in patients with wild mushroom-induced acute liver injury显示文摘AIM To identify early predictive markers of poor outcomes in patients with acute liver injury from wild mushroom intoxication.METHODS This observational, retrospective record review involved adults aged ≥ 18 years admitted to emergency department with mushroom intoxication from January 2005 to December 2015. The diagnosis of mushroom intoxication was based on the following:(1) a positive history of recent wild mushroom intake(either raw or cooked);(2) the onset of gastrointestinal symptoms, such as watery diarrhea, vomiting, and/or abdominal pain, after ingestion; and(3) the exclusion of other possible causes of acute liver injury. Acute liver injury was defined by a > 5-fold elevation of liver enzymes or moderate coagulopathy [international normalized ratio(INR) > 2.0]. Clinical and laboratory findings were compared in survivors and non-survivors.RESULTS Of 93 patients with mushroom intoxication, 23, 11 men(47.8%) and 12 women(52.2%), of median age 61 years, developed acute liver injury. The overall inhospital mortality rate was 43.5%(10/23). Among thelaboratory variables, mean serum alkaline phosphatase(73.38 ± 10.89 mg/dL vs 180.40 ± 65.39 mg/dL, P < 0.01), total bilirubin(2.312 ± 1.16 mg/dL vs 7.16 ± 2.94 mg/d L, P < 0.01) concentrations and indirect/direct bilirubin(2.45 ± 1.39 mg/dL vs 0.99 ± 0.45 mg/dL, P < 0.01) ratio as well as prothrombin time(1.88 ± 0.83 mg/dL vs 10.43 ± 4.81 mg/dL, P < 0.01), and activated partial thromboplastin time(a PTT; 32.48 ± 7.64 s vs 72.58 ± 41.29 s, P = 0.01), were significantly higher in non-survivors than in survivors. Logistic regression analysis showed that total bilirubin concentration(OR = 3.58, 95%CI: 1.25-10.22), indirect/direct bilirubin ratio(OR = 0.14, 95%CI: 0.02-0.94) and aP TT(OR = 1.30, 95%CI: 1.04-1.63) were significantly associated with mortality. All patients with total bilirubin > 5 mg/dL or aP TT > 50 s on day 3 died.CONCLUSION Monitoring of bilirubin concentrations and a PTT may help in predicting clinical outcomes in patients with acute liver injury from wild mushroom intoxication. | Taerim Kim Danbi Lee Jae Ho Lee Yoon-Seon Lee Bum Jin Oh Kyoung Soo Lim Won Young Kim | 2017 | World Journal of Gastroenterology2017，23，7： | 7 |
| 3 | Predisposing Factors of Hepatocellular Carcinoma Recurrence Following Complete Remission in Response to Transarterial Chemoembolization显示文摘 | Young-Joo Jin Young-Hwa Chung Jeong A. Kim Wonhyeong Park Don Lee Ju Hyun Shim Danbi Lee Kang Mo Kim Young-Suk Lim Han Chu Lee Yung Sang Lee Pyo Nyun Kim Kyu Bo Sung | 2013 | Digestive Diseases and Sciences2013，，6： | 2 |
| 4 | Comparison of Chemoembolization with and without Radiation Therapy and Sorafenib for Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis: A Propensity Score Analysis显示文摘 | Gi-Ae Kim Ju Hyun Shim Sang Min Yoon Jinhong Jung Jong Hoon Kim Min-Hee Ryu Baek-Yeol Ryoo Yoon-Koo Kang Danbi Lee Kang Mo Kim Young-Suk Lim Han Chu Lee Young-Hwa Chung Yung Sang Lee | 2014 | Journal of Vascular and Interventional Radiology2014，，： | 2 |
| 5 | Reappraisal of serum alpha‐foetoprotein as a surveillance test for hepatocellular carcinoma during entecavir treatment显示文摘 | Gi‐Ae Kim Chang Hyeon Seock Jang Won Park Jihyun An Kwang‐Sun Lee Jee Eun Yang Young‐Suk Lim Kang Mo Kim Ju Hyun Shim Danbi Lee Han Chu Lee | 2015 | Liver Int2015，，1： | 2 |
| 6 | Genetic predisposition of hand‐foot skin reaction after sorafenib therapy in patients with hepatocellular carcinoma显示文摘 | Joo Ho Lee Young‐Hwa Chung Jeong A. Kim Ju Hyun Shim Danbi Lee Han Chu Lee Eun‐Soon Shin Jung Hwan Yoon Byung Ik Kim Si Hyun Bae Kwang Cheol Koh Neung‐Hwa Park | 2012 | Cancer2012，，1： | 1 |
| 7 | Genetic predisposition of hand‐foot skin reaction after sorafenib therapy in patients with hepatocellular carcinoma显示文摘 | Joo Ho Lee Young‐Hwa Chung Jeong A. Kim Ju Hyun Shim Danbi Lee Han Chu Lee Eun‐Soon Shin Jung Hwan Yoon Byung Ik Kim Si Hyun Bae Kwang Cheol Koh Neung‐Hwa Park | 2012 | Cancer2012，，1： | 1 |
| 8 | Factors Predisposing Metastatic Tumor Antigen 1 Overexpression in Hepatitis B Virus Associated Hepatocellular Carcinoma显示文摘 | Young-Joo Jin Young-Hwa Chung Jeong A. Kim Won Hyung Park Danbi Lee Dong Dae Seo Soo Hyung Ryu Myoung Kuk Jang Eunsil Yu Young Joo Lee | 2012 | Digestive Diseases and Sciences2012，，11： | 1 |
| 9 | Factors Predisposing Metastatic Tumor Antigen 1 Overexpression in Hepatitis B Virus Associated Hepatocellular Carcinoma显示文摘 | Young-Joo Jin Young-Hwa Chung Jeong A. Kim Won Hyung Park Danbi Lee Dong Dae Seo Soo Hyung Ryu Myoung Kuk Jang Eunsil Yu Young Joo Lee | 2012 | Digestive Diseases and Sciences2012，，11： | 1 |
| 10 | Genetic predisposition of hand‐foot skin reaction after sorafenib therapy in patients with hepatocellular carcinoma显示文摘 | Joo Ho Lee Young‐Hwa Chung Jeong A. Kim Ju Hyun Shim Danbi Lee Han Chu Lee Eun‐Soon Shin Jung Hwan Yoon Byung Ik Kim Si Hyun Bae Kwang Cheol Koh Neung‐Hwa Park | 2012 | Cancer2012，，1： | 1 |
| 11 | Safety and efficacy of adjuvant pegylated interferon therapy for metastatic tumor antigen 1‐positive hepatocellular carcinoma显示文摘 | Danbi Lee Young‐Hwa Chung Jeong A. Kim Won Hyung Park Young‐Joo Jin Ju Hyun Shim Soo Hyung Ryu Myoung Kuk Jang Eunsil Yu Young Joo Lee | 2013 | Cancer2013，，12： | 1 |
| 12 | Two-photon interference between continuous-wave coherent photons temporally separated by a day显示文摘An understanding of the phenomenon of light interference forms the kernel underlying the discovery of the nature of light from the viewpoints of both classical physics and quantum physics.Here we report on two-photon interference with temporally separated continuous-wave coherent photons by using a temporal post-selection method with an arbitrary time delay.Although the temporal separation of a day between the photons is considerably longer than the coherence time of the light source,we observe the Hong–Ou–Mandel(HOM)interference of the pairwise two-photon state.Furthermore,we experimentally demonstrate the HOM interference observed in one of the interferometer-output modes by using only one single-photon detector for a large temporal separation. | DANBI KIM JIHO PARK TAEK JEONG HEONOH KIM HAN SEB MOON | 2020 | Photonics Research2020，8，3： | 0 |
| 13 | Hong–Ou–Mandel interference of two independent continuous-wave coherent photons显示文摘Interference between two completely independent photons lies at the heart of many photonic quantum information applications such as quantum repeaters,teleportation,and quantum key distribution.Here,we report the observation of Hong–Ou–Mandel(HOM)interference with two independent continuous-wave coherent light sources that are neither synchronized nor share any common reference.To prepare indistinguishable photons from two independent laser sources,we employ high-precision frequency-stabilization techniques using the 5 S1∕2(F=3)-5P1∕2(F'=3)transition line of 85 Rb atoms.We successfully observe an HOM interference fringe with two independent continuous-wave coherent photons originating from either the frequency-locked or the frequency-modulated lasers.An interference fringe involving two-photon beating is also observed when the frequency difference between the two interfering photons is beyond the spectral bandwidth of the individual coherent photons.We carry out further experiments to verify the robustness of the source preparation regardless of the separation distance between the two independent photon sources. | HEONOH KIM DANBI KIM JIHO PARK AND HAN SEB MOON | 2020 | Photonics Research2020，8，9： | 0 |
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