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| 1 | Immunopathogenesis of inflammatory bowel disease显示文摘Crohn’s disease and ulcerative colitis are chronic relapsing immune mediated disorders that results from an aberrant response to gut luminal antigen in genetically susceptible host. The adaptive immune response that is then triggered was widely considered to be a T-helper-1 mediated condition in Crohn’s disease and T-helper-2 mediated condition in ulcerative colitis. Recent studies in animal models, genome wide association, and basic science has provided important insights in in the immunopathogenesis of inflammatory bowel disease, one of which was the characterization of the interleukin-23/Th-17 axis. | David Q Shih Stephan R Targan | 2008 | World Journal of Gastroenterology2008，14，3： | 44 |
| 2 | Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade显示文摘 | Clifford R Jack David S Knopman William J Jagust Leslie M Shaw Paul S Aisen Michael W Weiner Ronald C Petersen John Q Trojanowski | 2010 | Lancet Neurology2010，，1： | 4 |
| 3 | A case of steroid-dependent myeloid granulocytic sarcoma masquerading as Crohn's disease显示文摘Small bowel tumors and Crohn's disease are common causes of small bowel obstruction.Early stage neoplasms can easily be mistaken for Crohn's disease.Therefore,thorough work-ups including imaging studies and endoscopic evaluation with biopsies are critical for accurate diagnosis.Here we report a case of an otherwise healthy female with progressive onset of multiple,recurrent obstructive symptoms secondary to terminal ileal narrowing who was referred for management of steroid-dependent Crohn's disease.After thorough evaluation,the diagnosis was revised to myeloid granulocytic sarcoma involving the terminal ileum.In this case,a delay in diagnosis can be detrimental for prognosis,as myeloid granulocytic sarcoma is highly predictive of underlying acute myeloid leukemia and needs urgent referral for chemotherapy and/or resection. | Lola Y Kwan Stephan R Targan David Q Shih | 2011 | World Journal of Gastroenterology2011，17，19： | 3 |
| 4 | MAP kinase signaling specificity 显示文摘 | Claire R David Q Roger J | 2002 | Science2002，296，： | 1 |
| 5 | Relation of ischemia modifiedalhumin(IMA)levels following elective angioplasty for stable angina pectoristo duration of halloon-indured myocardial ischemia显示文摘 | Juan Q Dehashis R David | 2003 | Am J Cardiol2003，92，3： | 1 |
| 6 | A view of cloud computing显示文摘 | MICHAEL A ARMANDO F REAN Q ANTHONY D J RANDY K ANDY K GUNHO L DAVID P ARIEL R ION S MATEI Z | 2010 | Communications of the ACM2010，53，4： | 1 |
| 7 | Processing Effects on the Stability of Amorphous Indium Gallium Zinc Oxide Thin-Film Transistors 显示文摘 | Hai Q Chiang Brian R McFarlane David hong | 2008 | Journal of Non-Crystalline Solids2008，354，： | 1 |
| 8 | Relation of ischemia modified albumin (IMA) levels following elective angloplasty for stable angina peetoris to duration of balloon-induced myocardial ischemia显示文摘 | JUAN Q DEBASHIS R DAVID G | 2003 | Am J Cardiol2003，92，3： | 1 |
| 9 | Vitamin D deficiency and associated factors in adolescent girls in Beijing显示文摘 | Du X Q Heather G David R F | 2001 | Am J Clin Nutr2001，74，： | 1 |
| 10 | In vitro production of huperzine A, a promis- ing drug candidate for Alzheimer' s disease 显示文摘 | Ma X Q David R | 2008 | Phytochemistry2008，69，： | 1 |
| 11 | Relation of isehemia-modifled albumin (IMA) levels following elective angioplasty for stable angina pectoris to duration of balloon-induced myocardial ischemia显示文摘 | Juan Q Debashis R David G | 2003 | Am J Cardiol2003，92，3： | 1 |
| 12 | Safe awareness and workload in driving while using adaptive cruise control and a cell phone显示文摘 | Ma R Q David B K | | 0，，： | 1 |
| 13 | Adsorp- tion of Organophosphates Into Microporous and Meso- porous Nax Zeolites and Subsequent Chemistry显示文摘 | Meng Q G David C D Apostolos K R | 2011 | En- vironmental Science Technoloy2011，45，7： | 1 |
| 14 | Recent Improvements in Survival in Primary Systemic Amyloidosis and the Importance of an Early Mortality Risk Score显示文摘 | Kumar Shaji K Gertz Morie A Lacy Martha Q Dingli David Hayman Suzanne R Buadi Francis K Short-Detweiler Kristen Zeldenrust Steven R Leung Nelson Greipp Philip R Lust John A Russell Stephen J Kyle Robert A Rajkumar S Vincent Dispenzieri Ange | 2011 | Mayo Clinic Proceedings2011，，1： | 1 |
| 15 | Non adhesive lotus and other hydropho- bie Materials显示文摘 | David Q Mathilde R | 2008 | Phil Trans R Soc A2008，366，1870： | 1 |
| 16 | Open reduction and internal fixation of fractures of the radial head 显示文摘 | DAVID R JAIME Q JESSE B J | 2002 | J Bone Joint Surg Am2002，84，： | 1 |
| 17 | Tetrathioethylenes显示文摘 | Coffen David L Chambers James Q Williams Denis R | 1971 | Journal of the American Chemical Society1971，93，9： | 1 |
| 18 | Simple approaches to quality large-scale tungsten oxide nanoneedles显示文摘 | JIN Y Z ZHU Y Q WHITBY R L D YAO N MA R WATTS P C P KROTO H W DAVID R M | 2004 | The Journal of Physical Chemistry B2004，108，15： | 1 |
| 19 | Water deficit alters differentially metabolic pathways affecting important flavor and quality traits in grape berries of Cabernet Sauvignon and Chardonnay显示文摘 | LAURENT G D DAVID R Q ALAIN D JEROME G MATTEW D W KAREN A S JEAN-MICHEL M JOHN C C GRANT R C | 2009 | BMC Genomics2009，10，1： | 1 |
| 20 | Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline显示文摘 | Talbot Konrad Wang Hoau-Yan Kazi Hala Han Li-Ying Bakshi Kalindi P Stucky Andres Fuino Robert L Kawaguchi Krista R Samoyedny Andrew J Wilson Robert S Arvanitakis Zoe Schneider Julie A Wolf Bryan A Bennett David A Trojanowski John Q Arnold | 2012 | EN2012，，4： | 1 |
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