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| 1 | Uplift, climate and biotic changes at the Eocene-Oligocene transition in south-eastern Tibet显示文摘The uplift history of south-eastern Tibet is crucial to understanding processes driving the tectonic evolution of the Tibetan Plateau and surrounding areas.Underpinning existing palaeoaltimetric studies has been regional mapping based in large part on biostratigraphy that assumes a Neogene modernization of the highly diverse,but threatened,Asian biota.Here,with new radiometric dating and newly collected plant-fossil archives,we quantify the surface height of part of the south-eastern margin of Tibet in the latest Eocene(~34 Ma)to be^3 km and rising,possibly attaining its present elevation(3.9 km)in the early Oligocene.We also find that the Eocene–Oligocene transition in south-eastern Tibet witnessed leaf-size diminution and a floral composition change from sub-tropical/warm temperate to cool temperate,likely reflective of both uplift and secular climate change,and that,by the latest Eocene,floral modernization on Tibet had already taken place,implying modernization was deeply rooted in the Palaeogene. | Tao Su Robert A. Spicer Shi-Hu Li He Xu Jian Huang Sarah Sherlock Yong-Jiang Huang Shu-Feng Li Li Wang Lin-Bo Jia Wei-Yu-Dong Deng Jia Liu Cheng-Long Deng Shi-Tao Zhang Paul J. Valdes Zhe-Kun Zhou | 2019 | National Science Review2019，6，3： | 16 |
| 2 | Genome of Wild Mandarin and Domestication History of Mandarin显示文摘官员(柠檬 reticulata ) 是世界范围的最重要的柠檬庄稼之一。它的驯服被相信发生在华南,它是四几千年的官员耕作的中心之一。我们在 Nanling 区域附近收集了官员的自然野人口并且在附近栽培了 landraces。我们发现柠檬性的酸水平戏剧性地在栽培官员被减少。理解 ? 官员驯服的基因基础,我们 de novo 装配了野官员的一个草稿染色体并且分析了一套 104 个柠檬染色体。我们发现 Mangshan 官员是一种原始类型并且二个独立驯服事件发生了,分别地导致在北方和南方 Nanling 山的二组栽培官员(MD1 和 MD2 ) 。二个瓶颈和有效人口尺寸的二扩大为栽培官员的 MD1 组被识别。然而,在 MD2 组织 ? 在人口尺寸有长、连续的减少。MD1 和 MD2 官员从栽培 pummelo 种类显示出种间的基因渗入的不同模式。我们在官员的驯服期间在选择下面可能在基因在柠檬酸盐内容的规定包含了的 aconitate hydratase (ACO ) 识别了高分叉的一个区域,它是。这研究为现存野官员人口的地理起源提供具体基因证据并且使驯服和官员的进化历史清楚些。 | Lun Wang Fa He Yue Huang Jiaxian He Shuizhi Yang Jiwu Zeng Chongling Deng Xiaolin Jiang Yiwen Fang Shaohua Wen Rangwei Xu Huiwen Yu Xiaoming Yang Guangyan Zhong Chuanwu Chen Xiang Yan Changfu Zhou Hongyan Zhang Zongzhou Xie Robert M. Larkin Xiuxin Deng Qiang Xu | 2018 | Molecular Plant2018，11，8： | 14 |
| 3 | CCA-secure unidirectional proxy re-encryption in the adaptive corruption model without random oracles显示文摘Up to now, it is still an open question of how to construct a chosen-ciphertext secure unidirectional proxy re-encryption scheme in the adaptive corruption model. To address this problem, we propose a new unidirectional proxy re-encryption scheme, and prove its chosen-ciphertext security in the adaptive corruption model without random oracles. Compared with the best known unidirectional proxy re-encryption scheme proposed by Libert and Vergnaud in PKC'08, our scheme enjoys the advantages of both higher efficiency and stronger security. | WENG Jian CHEN MinRong ANG YanJiang DENG Robert CHEN KeFei BAO Feng | 2010 | Science China(Information Sciences)2010，53，3： | 12 |
| 4 | Lake geochemistry reveals marked environmental change in Southwest China during the Mid Miocene Climatic Optimum显示文摘中间中新世的气候的最佳(MMCO;~ 15-17 ? 妈) 是标点的短期的气候的温暖的事件之一新生代长期的冷却趋势。因为有这个事件的很少的陆上的记录,大多数我们的理解来自海洋的核心。在这份报告,我们首先介绍修订标明日期的新 palaeomagnetic 数据我们的 400 ? 在 Wenshan (云南) 的 m 厚的湖的节,以前想了晚中新世。这些新数据建议老年, ca。15.2-16.5 ? 妈,与 MMCO 与一致。我们测量了 13 体积有机物上的 C (13 C 器官的碳(TOC ) ,全部的氮(TN ) 和在高度的 C/N 比率取样的 org ), 总数分辨率:(1 ) 重建在湖集水区域的 palaeoenvironmental 变化,并且(2 ) 推断为这些变化负责的机制。我们的结果证明所有四个 geochemical 参数证明一个强壮的环境变化发生在节的中间附近,立即在在 15.97 点的 C5Cn/C5Br 地磁气的颠倒和早 / 中间中新世的边界以后 ? 妈。我们建议环境移动可能由于在气候的一个变化的联合,它变得更凉爽,和在有机物在湖以内骑车的一个变化。这研究提供新卓见进 MMCO 并且证明尽管 MMCO 通常是一个温暖的事件,它也是气候的不稳定性和突然的环境变化的一倍。 | Julie Lebreton-Anberree Shihu Li Shu-Feng Li Robert A. Spicer Shi-Tao Zhang Tao Su Chenglong Deng Zhe-Kun Zhou | 2016 | Science Bulletin2016，61，11： | 8 |
| 5 | Extinct genus Lagokarpos reveals a biogeographic connection between Tibet and other regions in the Northern Hemisphere during the Paleogene显示文摘The biodiversity history on the Qinghai-Tibetan Plateau(QTP)has remained unclear for a long time.Recent paleobotanical investigations provide opportunities for revealing the phytogeographic history on the QTP in deep time and for testing phylogeographic hypotheses.Lagokarpos is an extinct genus with unknown modern affinities.It is easily distinguished by its fruits,which have two long wings and an elliptical fruit body.Previously,Lagokarpos fossils have only been found from North America and Germany,ranging from the latest Paleogene to early middle Eocene.Recently,we found fossil fruits of this genus from the Niubao Formation,near Bangoin County in the central QTP.A new species,namely Lagokarpos tibetensis H.Tang,T.Su&Z.K.Zhou sp.nov.,is described.This is the first fossil record of the genus in Asia.The occurrence of L tibetensis indicates a close floristic linkage between the QTP and other floras in the Northern Hemisphere during the Paleogene.According to the floristic assemblages,we suggest the central QTP experienced a tropical or subtropical humid climate during that period. | He Tang Jia Liu Fei-Xiang Wu Teresa Spicer Robert A.Spicer Wei-Yu-Dong Deng Cong-Li Xu Fan Zhao Jian Huang Shu-Feng Li Tao Su Zhe-Kun Zhou | 2019 | Journal of Systematics and Evolution2019，57，6： | 7 |
| 6 | Tartrate-resistant acid phosphatase 5b is a potential biomarker for rheumatoid arthritis: a pilot study in Han Chinese显示文摘 | Cheng Tao Wang Mingjun Chen Zhiwei Robert A Eisenberg Zhang Yu Zou Yaohong Deng Yingsu Wang Mian Zhou Ling | 2014 | Chinese Medical Journal2014，，16： | 7 |
| 7 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 8 | Glycosylation-independent binding to extracellular domains 11-13 of mannose-6-phosphate/insulin-like growth factor-2 receptor mediates the effects of soluble CREG on the phenotypic proliferation of vascular smooth muscle cells显示文摘Background The present study aimed to investigate the detailed mode and specific sites for their binding as well as the functional relevance of this binding in the phenotypic proliferation of vascular smooth muscle cells(SMCs). Methods CREG knocked-down SMCs were employed to evaluate the biological activity of wtCREG and mCREG.Expressions of SMC differentiation markers SM myosin heavy chain(SM-MHC),SM-actin,heavy caldesmon and myocardin were determined by Western blotting using specific antibodies. Cellular growth of SMCs was assessed by bromide dewuridine (BrdU) incorporation and cell cycle analysis on fluorescence-activated cell sorting(FACS).A solid-phase binding assay was used to study the binding of CREG to extracellular domains of M6P/IGF2R.The cellular co-localization of the two recombinant CREGs with M6P/IGF2R was detected on SMC surface by immunoprecipitation and immunofluorescence analysis.Results The molecular weight of wtCREG was around 30 kD while that of the mCREG was~25 kD.Treatment of wtCREG with PNGase F reduced its molecular weight from~30 kD to~25 kD,whereas PNGase F treatment had no effect on the molecular weight of mCREG.Both wtCREG and mCREG proteins enhanced SMC differentiation,inhibited BrdU incorporation,and arrested cell cycle progression when added to the culture medium.In CREG knocked-down SMCs,the amount of CREG detected by immunoblotting in M6P/IGF2R immunoprecipitates was significantly reduced when compared to normal cells.Both recombinant CREGs co-immunoprecipitated with M6P/IGF2R, although slightly reduced amount of the mutant CREG was detected in M6P/IGF2R immunoprecipitates.Immunostaining revealed that His-tagged CREGs co-localized with IGF2R on the cell surface in a glycosylation-independent manner.In vitro binding assay showed that CREGs bound to M6P/ IGF2R extracellular domains 7-10 and 11-13 in a glycosylation -dependent and -independent manner,respectively.Further blocking experiments using soluble M6P/IGF2R fragments and M6P/IGF2R neutralizing antibody indicated that the biological activities of recombinant CREGs in SMC growth and the up-regulation of SMC differentiation markers were all abolished by treatment with the M6P/IGF2R neutralizing antibody. However,although the growth inhibitory effect of wtCREG was nearly abolished by D7-10 or D11-13,the effect of mCREG was only reversed by Dll-13,indicating that the binding to domains 11-13 is required for CREG to modulate the proliferation of SMCs.Conclusions These data suggest that solubleCREG proteins can exert their biological function via binding to the extracellular domains 7-10 and 11-13 of cell surface M6P/IGF2R in both a glycosylation-dependent and -independent manner. | LUAN Bo~1,HAN Ya-ling~1,SUN Ming-yu~1,GUO Liang~1,GUO Peng~1,TAO Jie~1,DENG Jie~1,WU Guang-zhe~1,YAN Cheng-hui~1, LI Shao-hua~2 (1.Department of Cardiology,Shenyang Northern Hospital, Shenyang,China 2.Division of Vascular Surgery,Robert Wood Johnson Medical School-UMDNJ,New Jersey,USA) | 2011 | 岭南心血管病杂志2011，17，S1： | 5 |
| 9 | Design and baseline data of a populationbased metabonomics study of eye diseases in eastern China: the Yueqing Ocular Diseases Investigation显示文摘Background:China is undergoing a massive transition toward an urban and industrial economy.These changes will restructure the demographics and economy which will eventually influence the future patterns of disease.The risk factors of vision-impairing eye diseases remain ambiguous and poorly understood.Metabolomics is an ideal tool to understand and shed light on the ocular disease mechanisms for earlier treatment.This article aims to describe the design,methodology and baseline data of the Yueqing Ocular Diseases Investigation(YODI),a developed county population-based study to determine the prevalence and primary causes of visual impairment;also with metabonomics analysis we aimed to identify,predict and suggest some preventive biomarkers that cause blindness.Methods:A population-based,cross-sectional study.Randomized clustering sampling was used to identify adults aged 50 years and older in Xiangyang Town,Yueqing county-level City.The interviews covered demographic,behavioral,ocular risk factors and mental health state.The ocular examination included visual acuity,autorefraction,intraocular pressure,anterior and posterior segment examinations,fundus photography,retinal tomography and angiography,and visual field testing.Anthropometric measurements included height and weight,waist and hip circumference,blood pressure,pulse rate,electrocardiogram,and abdominal ultrasound scan.A venous blood sample was collected for laboratory tests and metabonomics studies.Results:Of the 5319 individuals recruited for the YODI,4769(89.7%)subjects were enrolled for analyses.The median age was 62.0 years,and 45.6%were male.The educational level of illiteracy or semi-illiteracy,primary,middle and high school or above was 29.8%,45.5%,20.1%,and 3.3%,respectively.Majority of the participants were female,younger,and less educated when compared with nonparticipants.The average body mass index and waist-hip ratios were 24.4±3.4 kg/m^(2) and 0.9±0.1 respectively.Blood sample collection reached a sample size of 1909(479 from subjects with selfreported diabetes and 1430 from one-third of the 4290 subjects without self-reported diabetes).Conclusions:The YODI provides population-based data with a high response rate(89.7%)on the prevalence and primary causes of major vision-impairing eye diseases in developed county areas in eastern China.Metabonomics analysis from YODI will provide further association of metabolic characteristics with the visual impairment eye diseases.The risk prediction model could be created and has the potential to be generalized to developed eastern areas in China for prevention. | Yuxuan Deng Yuanbo Liang Sigeng Lin Liang Wen Jin Li Yue Zhou Meixiao Shen Jingwei Zheng Kemi Feng Yanting Sun Kwapong Willaim Robert Jia Qu Fan Lu | 2020 | Eye and Vision2020，7，1： | 4 |
| 10 | 基于粉体流动测试仪的水泥流动性能分析显示文摘以CEMⅡ/A-LL 32.5R型波特兰石灰石水泥为研究对象,基于Jenike理论与粉体流动测试仪,分析其流动函数与时间固结效应,并采用304/2B不锈钢、Tivar塑料、低碳钢、橡胶与聚四氟乙烯胶带共5种材料进行壁摩擦测试。结果表明:时间固结效应使得物料的流动性能变差;以304/2B不锈钢为壁面材料时水泥壁摩擦角最小;结合流动因子图与整体流料斗半顶角函数图,得出低碳钢制圆锥料斗、楔形料斗最大半顶角分别为5、15°,相应的最小开口尺寸即出口直径、出口缝宽分别为0.112、0.057 m。 | 蔡国华 Robert James BERRY Tong DENG | 2016 | 中国粉体技术2016，0，1： | 2 |
| 11 | Study of the retina algorithm on FPGA for fast tracking显示文摘Real-time track reconstruction in high-energy physics experiments at colliders running at high luminosity is very challenging for trigger systems. To perform pattern recognition and track fitting, artificial retina or Hough transformation algorithms have been introduced to the field typically implemented on state-of-the-art field programmable gate array(FPGA) devices. In this paper, we report on two FPGA implementations of the retina algorithm: one using a mixed Floating-Point core and the other using Fixed-Point and Look-Up Table, and detailed measurements of the retina performance are investigated and compared. So far, the retina has mainly been used in a detector configuration comprising parallel planes, and the goal of our work is to study the hardware implementation of the retina algorithm and estimate the possibility of using such a method in a real experiment. | Zi-Xuan Song Wen-Di Deng Gilles De Lentdecker Guang-Ming Huang Hua Pei Yi-Fan Yang Dong Wang Frederic Robert | 2019 | Nuclear Science and Techniques2019，30，8： | 2 |
| 12 | Down regulated expression of S_(2)-RNase attenuates self-incompatibility in “Guiyou No.1”pummelo显示文摘Self-incompatibility(SI)substantially restricts the yield and quality of citrus.Therefore,breeding and analyzing selfcompatible germplasm is of great theoretical and practical signi ficance for citrus.Here,we focus on the mechanism of a self-compatibility mutation in‘Guiyou No.1'pummelo(Citrus maxima),which is a spontaneous mutant of‘Shatian’pummelo(Citrus maxima,self-incompatibility).The rate of fruit set and the growth of pollen tubes in the pistil con firmed that a spontaneous mutation in the pistil is responsible for the self-compatibility of‘Guiyou No.1'.Segregation ratios of the S genotype in progeny,expression analysis,and western blotting validated that the reduced levels of S_(2)-RNase mRNA contribute to the loss of SI in‘Guiyou No.1'.Furthermore,we report a phased assembly of the‘Guiyou No.1'pummelo genome and obtained two complete and well-annotated S haplotypes.Coupled with an analysis of SV variations,methylation levels,and gene expression,we identi fied a candidate gene(CgHB40),that may in fluence the regulation of the S/^RNase promoter.Our data provide evidence that a mutation that affects the pistilled to the loss of SI in‘Guiyou No.1'by in fluencing a poorly understood mechanism that affects transcriptional regulation.This work signi ficantly advances our understanding of the genetic basis of the SI system in citrus and provides information on the regulation of S-RNase genes. | ianbing Hu Qiang Xu Chenchen Liu Binghao Liu Chongling Deng Chuanwu Chen Zhuangmin Wei Muhammad Husnain Ahmad Kang Peng Hao Wen Xiangling Chen Peng Chen Robert MLarkin Junli Ye Xiuxin Deng Lijun Chai | 2021 | Horticulture Research2021，8，1： | 2 |
| 13 | Earth orientation parameters from VLBI determined with a Kalman filter显示文摘This paper introduces the reader to our Kalman filter developed for geodetic VLBI(very long baseline interferometry) data analysis. The focus lies on the EOP(Earth Orientation Parameter) determination based on the Continuous VLBI Campaign 2014(CONT14) data, but also earlier CONT campaigns are analyzed. For validation and comparison purposes we use EOP determined with the classical LSM(least squares method) estimated from the same VLBI data set as the Kalman solution with a daily resolution. To gain higher resolved EOP from LSM we run solutions which yield hourly estimates for polar motion and dUTl = Universal Time(UT1)-Coordinated Universal Time(UTC). As an external validation data set we use a GPS(Global Positioning System) solution providing hourly polar motion results.Further, we describe our approach for determining the noise driving the Kalman filter. It has to be chosen carefully, since it can lead to a significant degradation of the results. We illustrate this issue in context with the de-correlation of polar motion and nutation.Finally, we find that the agreement with respect to GPS can be improved by up to 50% using our filter compared to the LSM approach, reaching a similar precision than the GPS solution. Especially the power of erroneous high-frequency signals can be reduced dramatically, opening up new possibilities for highfrequency EOP studies and investigations of the models involved in VLBI data analysis.We prove that the Kalman filter is more than on par with the classical least squares method and that it is a valuable alternative, especially on the advent of the VLBI2010 Global Observing System and within the GGOS frame work. | Maria Karbon Benedikt Soja Tobias Nilsson Zhiguo Deng Robert Heinkelmann Harald Schuh | 2017 | Geodesy and Geodynamics2017，8，6： | 2 |
| 14 | Contribution of genotype and ethnicity to bone mineral density variation in Caucasians and Chinese: a test for five candidate genes for bone mass显示文摘Background Ethnicity is shown to be one of important factors affacting bone mineral density (BMD). The present study was performed to compare the association of six markers for five candidate genes with BMD variation in two populations of different ethnicity, Caucasian and Chinese, and the contribution of genotype and ethnicity to this variation in the populations.Methods The studied restriction fragment length polymorphisms were Bsa H Ⅰ of the calcium-sensing receptor gene, Sac Ⅰ of the α2HS-glycoprotein (AHSG) gene, Pvu Ⅱ and Xba Ⅰ of the oestrogen receptor α gene, Apa Ⅰ of the vitamin D receptor (VDR) gene and BstB Ⅰ of the parathyroid hormone gene. The association of these markers with BMD was analysed by one-way and two-way ANOVA with adjustment for covariates. Results Two polymorphisms, AHSG- Sac Ⅰ and VDR- Apa Ⅰ, showed no association with BMD, while the others were associated with BMD variation at some skeletal sites in either males or females. The polymorphisms indicated clear distinctions between the associations depending on ethnicity, gender and skeletal site. Similar patterns were observed in their contribution to the total population BMD variation. Ethnicity appears to have a larger effect on the total population BMD variation in females than in males. It may account, on the average, for about 2% total population BMD variation at the spine of females and about 1% at the hip of males and females. Conclusion The results of the present study suggest that significant interethnic differentiation at some loci may contribute to the significant interethnic difference in BMD. However, this contribution apparently is not large. | Volodymyr Dvornyk LIU Peng-yuan LONG Ji-rong ZHANG Yuan-yuan LEI Shu-feng Robert R Recker DENG Hong-wen | 2005 | Chinese Medical Journal2005，，15： | 2 |
| 15 | Inter- company comparison using modified TOPSIS with objective weights 显示文摘 | Deng Hepu Yeh Chung- Hsing Willis Robert J | 2000 | Computers and Operations Research2000，27，10： | 1 |
| 16 | Mutation Patterns at Dinucleotide Microsatellite Loci in Humans显示文摘 | Qing-Yang Huang Fu-Hua Xu Hui Shen Hong-Yi Deng Yong-Jun Liu Yao-Zhong Liu Jin-Long Li Robert R. Recker Hong-Wen Deng | 2002 | The American Journal of Human Genetics2002，，3： | 1 |
| 17 | Allele-spe- cific methylation is prevalent and is contributed by CpG- SNPs in the human genome 显示文摘 | SHOEMAKER ROBERT DENG Jie | 2010 | Genome Research2010，20，7： | 1 |
| 18 | Practical protocols for certified electronic mail显示文摘 | Deng L G | 1996 | Journal of Network Systems Management1996，4，3： | 1 |
| 19 | Mortgage Terminations,Heterogeneity and the Exercise of Mortgage Options显示文摘 | Yongheng Deng John M.Quigley Robert Van Order | | 0，，02： | 1 |
| 20 | Practical protocols for certified electronic mail显示文摘 | Robert H Deng Li Gong Aurel A Lazar WeiguoWang | 1996 | Journal of Network System Manager1996，4，3： | 1 |
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