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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | 氨氯地平和左旋氨氯地平对高血压患者血管内皮功能的影响显示文摘已证明氨氯地平可改善高血压患者的血管内皮功能,但左旋氨氯地平是否具有类似作用仍存在争议。该研究比较氨氯地平和左旋氨氯地平对高血压患者血管内皮功能的影响,应用体外细胞培养研究其相关作用机制。方法:该研究为一项随机、交叉试验。选取原发性高血压患者24例服用氨氯地平和左旋氨氯地平各6周, | He Y Si D Yang C Ni L Li B Ding M Yang P 罗冬梅 叶鹏 | 2014 | 中华高血压杂志2014，22，4： | 2 |
| 4 | B7H1-Ig fusion protein activates the CD4^+ IFN-gamma receptor^+ type 1 T regulatory subset through IFN gamma-secreting Th1 cells显示文摘 | Ding Q Lu L Wang B etal | 2006 | J Immunol2006，177，： | 1 |
| 5 | Insect resistant of transgenic tobacco expressing an insect chitinase gene显示文摘 | Ding X F Gopalakrishnana B Johnson L B | 1998 | Transgenic Res1998，7，： | 1 |
| 6 | Influence of chemical potential on the computer simulation of hydrogen storage in single - walled carbon nanotube array 显示文摘 | Cheng J R Zhang L B Ding R | 2008 | Comp Mater Sci2008，44，： | 1 |
| 7 | Converting ceria polyhedral nanoparticles into single-crystal nanospheres 显示文摘 | Feng X D Sayle D C Wang Z L Paras M S Santora B Sutorik A C Sayle T X T Yang Y Ding Y Wang X D Her Y S | 2006 | Science2006，312，5779： | 1 |
| 8 | Wind-blown origin of the Pliocene red clay formation in the central Loess Plateau 显示文摘 | Ding Z L Sun J M Liu T S Zhu R X Yang S L Guo B | 1998 | Earth and Planetary Science Letters1998，161，： | 1 |
| 9 | Syntheses and structures of 1D and 2D coordination polymers derived from pyridine-2,4,6-tricarboxylic acid显示文摘 | Gao H L Ding B Yi L | 2006 | Inorg Chem Commun2006，8，： | 1 |
| 10 | Temperature-Dependent Photoluminescence of ZnO Nanorods Prepared by a Simple Solution Route显示文摘 | Lv Y Z Zhang Y H Li C P Ren L R Guo L Xu H B Ding L Yang C L Ge W K and Yang S H | 2007 | Luminescence2007，，： | 1 |
| 11 | The role of protein kinase C in the opening of blood-brain barrier induced by electromagnetic pulse 显示文摘 | QIU L B DING G R LI K C | 2010 | Toxicology2010，273，13： | 1 |
| 12 | Simultaneous determination of flavonoid and alkaloid compounds in Citrus herbs by high-performance liquid chromatography-photodiode array detection-electrospray mass spectrometry 显示文摘 | Ding L Luo X B Tang F | 2007 | J Chromatogr B2007，857，2： | 1 |
| 13 | First 3D Pr(Ⅲ)-Ni(Ⅱ)-Na(I) polymer and a 3D Pr(Ⅲ) open network based on pyridine-2,4,6-tricarboxylic acid显示文摘 | Gao H L Yi L Ding B | 2006 | Inorg Chem2006，45，2： | 1 |
| 14 | Effects of sintering temperature on fine-grained tungsten heavy alloy produced by high-energy ball milling assisted spark plasma sintefing显示文摘 | DING L XIANG D P LI Y Y LI C LI J B | 2012 | International Journal of Refractory Metals and Hard Materials2012，33，： | 1 |
| 15 | Particle size influence to the microwave properties of iron based magnetic particulate composites 显示文摘 | Wu L Z Ding J Jiang-H B | 2005 | J Magn Magn Mater2005，285，： | 1 |
| 16 | TRAF1-C5 as a risk locus for rheumatoid arthritis:a genome-wide study显示文摘 | Plenge R M Seielstad M Padyukov L Lee A T Remmers E F Ding B | 2007 | N Engl J Med2007，357，： | 1 |
| 17 | Hepaittis B virus X protein and the estrogen receptor variant lacking exon 5 inhibit estrogen receptor signaling in hepatoma cells 显示文摘 | HanJ Ding L Yuan B | 2006 | Nucleic AcidsRes2006，34，10： | 1 |
| 18 | 查看详情显示文摘 | Yan L W Duan X R Ding X T Dong J Q Yang Q W Liu Y Zou X L Liu D Q Xuan W M Chen L Y Rao J Song X M Huang Y Mao W C Wang Q M Li Q Cao Z Li B Cao J Y Lei G J Zhang J H Li X D Chen W Cheng J Cui C H Cui Z Y Deng Z C Dong Y B Feng B B Gao Q D Han X Y Hong W Y | | 0，，： | 1 |
| 19 | Structure of severe fever with thrombocytopenia syndrome virus nucleocapsid protein in complex with suramin reveals therapeutic potential显示文摘 | Jiao L Y Ouyang S Y Liang M F Niu F F Shaw N Wu W Ding W Jin C Peng Y Zhu Y P Zhang F S Wang T Li C Zuo X B Luan C H Li D X Liu Z J | 2013 | J Virol2013，87，12： | 1 |
| 20 | Grand canonical Monte Carlo simulation of hydrogen physisorption in single-walled boron nitride nanotubes 显示文摘 | CHENG J R ZHANG L B DING R | 2007 | Int J Hydrogen Energ2007，32，： | 1 |
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