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| 1 | On the Application of PCA Technique to Fault Diagnosis显示文摘In this paper, we briefly address the application of the standard principal component analysis (PCA) technique to fault detection and identification. Based on an analysis of the existing test statistic, we propose a new test statistic, which is similar to the Hawkin’s TH 2 statistic but without the numerical drawback. In comparison with the SPE index, the threshold setting associated with the new statistic is computationally simpler. Our further study is dedicated to the analysis of fault sensitivity. We consider the off-set and scaling faults, and evaluate the test statistic by viewing its sensitivity to the faults. Our final study focuses on identifying off-set and scaling faults. To this end, two algorithms are proposed. This paper also includes some critical remarks on the application of the PCA technique to fault diagnosis. | DING S ZHANG P DING E YIN S Naik A DENG P GUI W | 2010 | Tsinghua Science and Technology2010，15，2： | 31 |
| 2 | Relationship of Helicobacterpylori eradication with gastric cancer and gastric mucosal histological changes: a 10-year follow-up study显示文摘 | Zhou Liya Lin Sanren Ding Shigang Huang Xuebiao Jin Zhu Cui Rongli Meng Lingmei Li Yuan Zhang Li Guo Changji Xue Yan Yan Xiu'e Zhang Jing | 2014 | Chinese Medical Journal2014，，8： | 28 |
| 3 | Expression of calreticulin is associated with infiltration of T-cells in stage ⅢB colon cancer显示文摘AIM: To investigate the correlation between expression of calreticulin and infiltration of lymphocytes in stage ⅢB colon cancer. METHODS: Sixty-eight pathologically-confirmed speci-mens were obtained from stage ⅢB (T3N1M0) colon cancer patients who underwent radical resection between January 1999 and May 2002 at the Cancer Center of Sun Yat-Sen University, Guangzhou, China. Immuno-histochemical analysis was performed to show infiltration of lymphocytes and expression of calreticulin in colon cancer. Association between calreticulin expression, infiltration of lymphocytes, and 5-year survival rate of patients was assessed. RESULTS: The expression level of calreticulin was lower in cancer nest than in its adjacent normal epithelium since 61.8% (42/68) of the samples were stained with calreticulin in colon cancer. The expression of calreticulin in colon cancer was associated with the infi ltration of CD45RO+ cells rather than with that of CD3+ cells. In addition, the stronger expression of calreticulin and the higher infiltration of CD3+ and CD45RO+ cells in colon cancer were associated with the higher 5-year survival rate of patients. CONCLUSION: Expression of calreticulin is associated with infiltration of T-cells, which implies that a low expression level of molecular marker may represent a new mechanism underlying immune escape in colon cancer. | Rui-Qing Peng, Ya Ding, Xing Zhang, Yi-Xin Zeng, Xiao- Shi Zhang, State Key Laboratory of Oncology in South China, Biotherapy Center, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China Ying-Bo Chen, Zhi-Wei Zhou, State Key Laboratory of Oncology in South China, Department of Gastric and Pancreatic Oncology, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China Rong Zhang, State Key Laboratory of Oncology in South China, Department of Endoscopy, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China Xing-Juan Yu, Yi-Xin Zeng, State Key Laboratory of Oncology in South China, Department of Experimental Research, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China | 2010 | World Journal of Gastroenterology2010，16，19： | 16 |
| 4 | Impact of CYP3A4*1G Polymorphism on Fentanyl Analgesia Assessed by Analgesia Nociception Index in Chinese Patients Undergoing Hysteroscopy显示文摘Background:The clinical efficacy of fentanyl for pain control differs greatly across individuals.The purpose of this study was to investigate the impact of CYP3A4*1G polymorphism including wild-type homozygote (CYP3A4*1/*1,GG),mutant heterozygote (CYP3A4*1/*1G,GA),and mutant homozygote (CYP3A4*1G/*1G,AA)on fentanyl analgesia in Chinese patients undergoing hysteroscopy by the assessment of analgesia nociception index (ANI). Methods:A total of 200 gynecologic patients scheduled for elective hysteroscopy under general anesthesia at Peking University People's Hospital from May to December in 2017 were enrolled in this study.Venous blood was withdrawn for genotyping of CYP3A4*1G before operation.Fentanyl 1μg/kg was administered preoperatively followed by target-controlled infusion of propofol for induction and maintenance.Intraoperative analgesic efficacy of fentanyl was assessed by ANI monitoring at T0(entering room),T1(cervical dilation), T2(start of cervical aspiration),and T3(end of cervical aspiration)time points.The duration of propofol infusion and total dosage of propofol were recorded as well. Results:The patients were divided into three groups according to CYP3A4*1G polymorphism,including 143 in GG group,47in GA group, and 10 in AA group.There was no significant difference in clinical demographics among three groups.The frequency of CYP3A4*1G variant alleles accounted for 16.8%and the distribution of variant alleles was consistent with Hardy-Weinberg equilibrium.Using a multilevel model,ANI values at T1(63.81±19.61),T2(63.63±17.82),and T3(65.68±17.79)were significantly lower than that at T0 (77.16±12.93)in the study population (F =23.50,P <0.001),suggesting that higher levels of pain at T 1,T2,and T3 than T0.Patients with GG genotype showed significantly lower ANI than those with GA or AA genotypes during hysteroscopy under the same dose of fentanyl. Conclusion:CYP3A4*1G polymorphism associated with the analgesic efficacy of intraoperative fentanyl in the patients undergoing hysteroscopy under general anesthesia. | Qi Yan Yi Su Lan Gao Nan Ding Hong-Ying Zhang Wen E Yue Wang Yi Feng Hai-Yan An | 2018 | Chinese Medical Journal2018，，22： | 8 |
| 5 | Inside-out Ostwald ripening: A facile process towards synthesizing anatase TiO2 microspheres for high- efficiency dye-sensitized solar cells显示文摘一灵巧在内外面,到 TiO 2 microspheres 的控制形态学的准备的 Ostwald 成熟线路被开发。这里, TiO 2 空 microspheres (HM ) 和稳固的 microspheres (SM ) 被在 solvothermal 过程以 acetylacetone (Acac ) 调整 isopropanol (国际语音学协会) 的体积比率准备。在 HM,稳固的核心的降水,核心的表面上的外部壳的随后的免职,和同时的核心的形成过程期间,溶解和壳再结晶被观察,它验证在内外面 Ostwald 成熟机制。TiO 2 microspheres 的性质(毛孔尺寸,表面区域,和陷井状态) 的设计和优化对 dyesensitized 太阳能电池(DSSC ) 的高效重要。优化 TiO 2 microspheres (rHM 和 rSM ) 在再结晶上由 processing 以后获得了,拥有大毛孔尺寸,高表面区域和减少的陷井状态(Ti 3+ 和氧空缺) ,并且因此是为光电的设备的理想的材料。用 rHM photoanode 制作的 DSSC 的力量变换效率是 11.22% ,它显著地与基于 rSM 的 DSSC 的 10.54% 效率相比被改进。我们的工作为综合提供策略 TiO 2 microspheres 同时提供不同物理性质以表面区域, crystallinity,形态学,和 mesoporosity。 | Yong Ding Xin Xia Wangchao Chen Linhua Hu Li'e Mo Yang Huang Songyuan Dai | 2016 | Nano Research2016，9，7： | 7 |
| 6 | Detecting prostate cancer and prostatic calcifications using advanced magnetic resonance imaging显示文摘前列腺癌症和 prostatic 石灰化在老人有高发生。我们试图在检测前列腺癌症和 prostatic 石灰化调查危险性加权的成像的诊断能力。156 个人的一个全部的数字,与前列腺癌症包括 34 并且 122 在这研究与良性的前列腺被注册。计算断层摄影术,常规磁性的回声成像,散开加权的成像,和危险性加权的成像在所有病人上被执行。112 prostatic 石灰化在 87 个病人被检测。常规磁性的回声成像,明显的散开系数,和在检测前列腺癌症和 prostatic 石灰化的过滤危险性的阶段图象的敏感和特性是计算的。McNemars Chi 平方测试被用来在在这些技术之间的敏感和特性比较差别。结果证明在检测 prostatic 癌症的过滤危险性的阶段图象的敏感和特性比常规磁性的回声成像和明显的散开系数的大(P < 0.05 ) 。另外,在检测 prostatic 石灰化的过滤危险性的阶段图象的敏感和特性比得上计算断层摄影术的并且比常规磁性的回声成像和明显的散开系数的大(P < 0.05 ) 。在前列腺癌症给危险性加权的成像(SWI ) 的高发生反常,我们断定危险性加权的成像在检测前列腺癌症比常规磁性的回声成像,散开加权的成像,和计算断层摄影术更敏感、特定。而且,危险性加权的成像能识别类似于计算断层摄影术的 prostatic 石灰化,并且它比常规磁性的回声成像和散开加权的成像好一些。 | Shewei Dou Yan Bai Ankit Shandil Degang Ding Dapeng Shi E Mark Haacke Meiyun Wang | 2017 | Asian Journal of Andrology2017，19，4： | 7 |
| 7 | Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial显示文摘 | Eric Lawitz Fred F Poordad Phillip S Pang Robert H Hyland Xiao Ding Hongmei Mo William T Symonds John G McHutchison Fernando E Membreno | 2013 | The Lancet2013，，： | 5 |
| 8 | Transportation Development Transition in China显示文摘Scientific development is an invaluable asset to a country.Policies and development modes should be carried out based on scientific findings not only in industry,but also in transportation infrastructure construction.Building an integrated transportation system,which is in line with the national requirements of China and supports sustainable socio-economic development,is a key strategic issue related to building a moderately prosperous society and achieving realistic goals of a medium-level developed country.Based on a systematic review of the advances in China's transportation infrastructure over the last 60 years,this paper explores the main drivers of transportation development,including national policy,transportation structure,investment efficiency,and technological innovation.Analysis shows that China's comprehensive transportation infrastructure construction since 1949 can be divided into five stages initiated by these drivers,which correspond to four transition modes:policy transition,structural transition,efficiency transition,and technology transition.The transition path of China's transportation development shows that the dominant factors have changed,and the interval for each transition has shortened.With the implementation of the '12th Five-Year Plan',China's transportation infrastructure construction is showing some new characteristics and facing a new development transition.Finally,this paper analyzes the trends in transportation development in China and concludes that technological innovation will be the main driving force to increase the transportation supply and service area in the future. | JIN Fengjun DING Jinxue WANG Jiao'e LIU Dong WANG Chengjin | 2012 | Chinese Geographical Science2012，22，3： | 4 |
| 9 | Development of a rapid and sensitivity magnetic chemiluminescence immunoassay for DNA methyltransferase 1 in human serum显示文摘DNA methyltransferase 1(DNMT1)is a useful biomarker for lung cancer in early clinical diagnosis.A rapid magnetic chemiluminescence immunoassay(MCLIA)for DNMT1 in human serum has been developed.Horseradish peroxidase(HRP)-second-Ab was used to labeled polyclonal antibodies of anti-DNMT1.DNMT1 in sample integrates with specific immunomagnetic beads and can constitute a supersandwiched immunoreaction.In magnetic field,nonspecific materials can be separated.After luminescent substrate luminol-H2O2-BIP was added,the relative light unit(RLU)of HRP was detected and was discovered to be directly proportional to the content of DNMT1 in sample.The correlative variables involved in the MCLIA value were optimized and the methodological evaluation was carried out.After optimization,in the range of0.5–128 ng/mL,the linear regression equation was y=0.5014 x+1.769(x was logCDNMT1,y was relative luminescence units(RLU)/RLU0),and the limit of detection was 0.01 ng/mL.The RSD of intra-and interassays were 15.8%–16.9%and 14.3%–18.1%,respectively.The recovery was from 70.0%to 106.2%.Furthermore,paralleled with purchasable enzyme-linked immunosorbent assay(ELISA)kits,MCLEIA had lower detection limit,wider linear range and shorter detection time.Therefore,the MCLEIA established in this study could be used for the sensitive detection of DNMT1 in serum sample. | Sitian He Leiliang He Beibei Liu Songcheng Yu Li'e Liu Yongmei Tian Jia Wang Lihua Ding Yilin Wang Lingbo Qu Fei Yu Yongjun Wu | 2019 | Chinese Chemical Letters2019，30，5： | 4 |
| 10 | CCAR1 5' UTR as a natural miRancer of miR-1254 overrides tamoxifen resistance显示文摘 | Gaopeng Li Xiaoli Wu Wenchang Qian Huayong Cai Xinbao Sun Weijie Zhang Sheng Tan Zhengsheng Wu Pengxu Qian Keshuo Ding Xuefei Lu Xiao Zhang Hong Yan Haifeng Song Shouhong Guang Qingfa Wu Peter E Lobie Ge Shan Tao Zhu | 2016 | Cell Research2016，26，6： | 3 |
| 11 | Surface states in TiO2 submicrosphere films and their effect on electron transport显示文摘 | Li'e Mo Wangchao Chen Ling Jiang Yong Ding Zhaoqian Li Linhua Hu Songyuan Dai | 2017 | Nano Research2017，10，11： | 3 |
| 12 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) in the Liver – Update 2012显示文摘 | M. Claudon C. Dietrich B. Choi D. Cosgrove M. Kudo C. Nols?e F. Piscaglia S. Wilson R. Barr M. Chammas N. Chaubal M.-H. Chen D. Clevert J. Correas H. Ding F. Forsberg J. Fowlkes R. Gibson B. Goldberg N. Lassau E. Leen R. Mattrey F. Moriyasu L. Solbiati H. | 2013 | Ultraschall in Med2013，，01： | 3 |
| 13 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) in the Liver – Update 2012显示文摘 | M. Claudon C. Dietrich B. Choi D. Cosgrove M. Kudo C. Nols?e F. Piscaglia S. Wilson R. Barr M. Chammas N. Chaubal M.-H. Chen D. Clevert J. Correas H. Ding F. Forsberg J. Fowlkes R. Gibson B. Goldberg N. Lassau E. Leen R. Mattrey F. Moriyasu L. Solbiati H. | 2013 | Ultraschall in Med2013，，01： | 3 |
| 14 | Enhanced Efficiency of Human Pluripotent Stem Cell Genome Editing through Replacing TALENs with CRISPRs显示文摘 | Qiurong Ding Stephanie N. Regan Yulei Xia Leoníe A. Oostrom Chad A. Cowan Kiran Musunuru | 2013 | Cell Stem Cell2013，，4： | 2 |
| 15 | Single machine scheduling with deadlines and increasing rates of processing times显示文摘 | Cheng T C E Ding Q | 2000 | Acta Informatica2000，36，910： | 2 |
| 16 | Analysis of transportation carbon emissions and its potential for reduction in China显示文摘The transportation industry is an essential sector for carbon emissions mitigation.This paper firstly used the LMDI(Logarithmic Mean Divisia Index)decomposition method to establish factors decomposition model on China's transportation carbon emission.Then,a quantitative analysis was performed to study the factors influencing China's transportation carbon emissions from 1991 to 2008,which are identified as transportation energy efficiency,transportation structure and transportation development.The results showed that:(1)The impact of transportation development on transportation carbon emissions showed pulling function.Its contribution value to carbon emissions remained at high growth since 1991 and showed an exponential growth trend.(2)The impact of transportation structure on transportation carbon emissions showed promoting function in general,but its role in promoting carbon emissions decreased year by year.And with the continuous optimization of transportation structure,the promoting effect decreased gradually and showed the inversed'U'trend.(3)The impact of transportation energy efficiency on transportation carbon emissions showed a function of inhibition before pulling.In order to predict the potential of carbon emission reduction,three scenarios were set.Analysis of the scenarios showed that if greater intensity emission reduction measures are taken,the carbon emissions will reduce by 31.01 million tons by 2015 and by 48.81 million tons by 2020. | Jinxue Ding Fengjun Jin Yuejiao Li Jiao'e Wang | 2013 | Chinese Journal of Population,Resources and Environment2013，11，1： | 2 |
| 17 | Generalized nonlinear variational inequalities with nonmonotone set-valued mappings显示文摘 | Ding X P Tarafdar E | 1994 | Appl Math Lett1994，7，4： | 2 |
| 18 | Existence and uniqueness of solutions for a general nonlinear variational inequality显示文摘 | Ding X P Tarafdar E | 1995 | Appl Math Lett1995，8，1： | 2 |
| 19 | Integrated Therapy for Invasive Pulmonary Aspergillosis in a Patient with Asthma and Chronic Obstructive Pulmonary Disease Overlap Syndrome显示文摘To the Editor:We here present a case of invasive pulmonary aspergillosis (IPA) with asthma and chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS).The patient recently took a high dose of systemic corticosteroids.Additionally,pneumothorax occurred,prompting right upper lobectomy,which contained the majority of the Aspergillus lesion.Full recovery occurred utilizing a combination of surgical resection and systemic antifungal therapy.This case supports a surgical approach to clear the infection when antifungal agents are inadequate. | Ya-Qin Shi Pei Li Ting Wu Yuan Ding Yi Shi Mark E Wylam Xin Su | 2015 | Chinese Medical Journal2015，，16： | 2 |
| 20 | Pit-and trench-forming osteoclasts:a distinction that matters显示文摘Osteoclasts(OCs)seeded on bone slices either drill round pits or dig long trenches.Whereas pits correspond to intermittent resorption,trenches correspond to continuous and faster resorption and require a distinct assembly of the resorption apparatus.It is unknown whether the distinction between pits and trenches has any biological relevance.Using OCs prepared from different blood donors,we found that female OCs achieved increased resorption mainly through pit formation,whereas male OCs did so through trench formation.Trench formation went along with high collagenolytic activity and high cathepsin K(CatK)expression,thereby allowing deeper demineralization.A specific CatK inhibitor abrogated the generation of trenches,while still allowing the generation of pits.OCs obtained from bone marrow were more prone to generate trenches than those obtained from blood.Scanning electron microscopy of bone surfaces eroded in vivo showed trenches and pits of similar size as those made by OCs in culture.We conclude that the distinction between trench-and pit-forming OCs is relevant to the differences among OCs from different skeletal sites,different individuals,including gender,and results from differences in colIagenolytic power.This indicates a biological relevance and highlights the importance of discriminating between pits and trenches when assessing resorption. | Ditte MH Merrild Dinisha C Pirapaharan Christina M Andreasen Per Kjxrsgaard-Andersen Anas MJ Mùller Ming Ding Jean-Marie Delaissé Kent Sùe | 2015 | Bone Research2015，3，4： | 2 |
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