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| 1 | Biochemically curative surgery for gastrinoma in multiple endocrine neoplasia type 1 patients显示文摘AIM: To search for the optimal surgery for gastrinoma and duodenopancreatic neuroendocrine tumors in patients with multiple endocrine neoplasia type 1. METHODS: Sixteen patients with genetically confirmed multiple endocrine neoplasia type 1 (MEN 1) and Zollinger-Ellison syndrome (ZES) underwent resection of both gastrinomas and duodenopancreatic neuroendocrine tumors (NETs) between 1991 and 2009. For localization of gastrinoma, selective arterial secretagogue injection test (SASI test) with secretin or calcium solution was performed as well as somatostatin receptor scintigraphy (SRS) and other imaging methods such as computed tomography (CT) or magnetic resonance imaging (MRI). The modus of surgery for gastrinoma has been changed over time, searching for the optimal surgery: pancreaticoduodenectomy (PD) was first performed guided by localization with the SAST test, then local resection of duodenal gastrinomas with dissection of regional lymph nodes (LR), and recently pancreas-preserving total duodenectomy (PPTD) has been performed for multiple duodenal gastrinomas. RESULTS: Among various types of preoperative localizing methods for gastrinoma, the SASI test was the most useful method. Imaging methods such as SRS or CT made it essentially impossible to differentiate functioning gastrinoma among various kinds of NETs. However, recent imaging methods including SRS or CT were useful for detecting both distant metastases and ectopic NETs; therefore they are indispensable for staging of NETs. Biochemical cure of gastrinoma was achieved in 14 of 16 patients (87.5%); that is, 100% in 3 patients who underwent PD, 100% in 6 patients who underwent LR (although in 2 patients (33.3%) second LR was performed for recurrence of duodenal gastrinoma), and 71.4% in 7 patients who underwent PPTD. Pancreatic NETs more than 1 cm in diameter were resected either by distal pancreatectomy or enucleations, and no hepatic metastases have developed postoperatively. Pathological study of the resected specimens revealed co-existence of pancreatic gastrinoma with duodenal gastrinoma in 2 of 16 patients (13%), and G cell hyperplasia and/or microgastrinoma in the duodenal Brunner's gland was revealed in all of 7 duodenal specimens after PPTD. CONCLUSION: Aggressive resection surgery based on accurate localization with the SASI test was useful for biochemical cure of gastrinoma in patients with MEN 1. | Masayuki Imamura Izumi Komoto Shuichi Ota Takuya Hiratsuka Shinji Kosugi Ryuichiro Doi Masaaki Awane Naoya Inoue | 2011 | World Journal of Gastroenterology2011，17，10： | 5 |
| 2 | Special effects on wood-liquefaction in polyhydric alcohols显示文摘 | Yasuji Kurimoto Shuichi Doi Yasuo Tamura | 1999 | Holzforschung1999，53，6： | 1 |
| 3 | Changes in contents of free amino acids and soluble carbohydrates during fruit-body development of Hypsizygus marmoreus 显示文摘 | Akira Harada Shozo Yoneyama Shuichi Doi | 2003 | Food Chemistry2003，83，3： | 1 |
| 4 | Changes of decay and termite durability of Japanese larch (larix leptolepis) wood due to high-temperature kiln drying process显示文摘 | Shuichi Doi Masakazu Aoyama Shigeru Yamauchi | 2005 | Journal of wood Science2005，，51： | 1 |
| 5 | Species Effects on Wood -liquefaction in Ployhydric Alcohols显示文摘 | KURIMOTO Yasuji DOI Shuichi | 1999 | Holzforschung1999，，53： | 1 |
| 6 | Adsorption of mercury by sugi wood carbonized at 1000°C显示文摘 | Lilibeth Pulido-Novicio Yasuji Kurimoto Masakazu Aoyama Kazuto Seki Shuichi Doi Toshimitsu Hata Shigehisa Ishihara Yuji Imamura | 2001 | Journal of Wood Science2001，，2： | 1 |
| 7 | Adsorption capacities and related characteristics of wood charcoals carbonized using a one-step or two-step process显示文摘 | Lilibeth Pulido-Novicio Toshimitsu Hata Yasuji Kurimoto Shuichi Doi Shigehisa Ishihara Yuji Imamura | 2001 | Journal of Wood Science2001，，1： | 1 |
| 8 | Effects of high temperature kiln drying on the practical performances of Japanese cedar wood (Cryptomeria japonica) I: changes in hygroscopicity due to heating显示文摘 | Eiichi Obataya Sakae Shibutani Kensuke Hanata Shuichi Doi | 2006 | Journal of Wood Science2006，，1： | 1 |
| 9 | Changes of decay and termite durability of Japanese larch (larix leptolepis) wood due to high-temperature kiln drying process 显示文摘 | SHUICHI DOI MASAKAZU AOYAMA SHIGERU YAMAUCHI | 2005 | Journal of wood Science2005，51，5： | 1 |
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