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| 1 | Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria显示文摘AIM: To investigate the correlation between in vitro and in vivo immunomodulation potential of the probiotic strain and its ability to prevent experimental colitis in mice. METHODS: In vitro immunomodulation was assessed by measuring interleukin (IL)-12p70, IL-10, tumor necrosis factor alpha (TNFa) and interferon g (IFNg) release by human peripheral blood mononuclear cells (PBMCs) after 24 h stimulation with 13 live bacterial strains. A murine model of acute TNBS-colitis was next used to evaluate the prophylactic protective capacity of the same set of strains. RESULTS: A strain-specific in vivo protection was observed. The strains displaying an in vitro potential to induce higher levels of the anti-inflammatory cytokine IL-10 and lower levels of the inflammatory cytokine IL-12, offered the best protection in the in vivo colitis model. In contrast, strains leading to a low IL-10/IL-12 cytokine ratio could not significantly attenuate colitis symptoms. CONCLUSION: These results show that we could predict the in vivo protective capacity of the studied lactic acid bacteria (LAB) based on the cytokine profile we established in vitro. The PBMC-based assay we used may thus serve as a useful primary indicator to narrow down the number of candidate strains to be tested inmurine models for their anti-inflammatory potential. | Benoit Foligne Sophie Nutten Corinne Grangette Véronique Dennin Denise Goudercourt Sabine Poiret Joelle Dewulf Dominique Brassart Annick Mercenier Bruno Pot | 2007 | World Journal of Gastroenterology2007，13，2： | 22 |
| 2 | Partial Beclin 1 silencing aggravates doxorubicin-and Fasinduced apoptosis in HepG2 cells显示文摘瞄准:在 HepG2 房间的危险性上调查 Beclin 1 的角色在反船边交货抗体或 doxorubicin 治疗以后经历 apoptosis。方法:Beclin 1 silencing 用 RNA 干扰被完成。DNA 倍性, apoptotic 房间的百分比和 mitochondrial 膜电位被流动血细胞计数估计。多形核白细胞(自动数据处理核糖) 的 Beclin 1, Bcl-X (L) 和细胞色素 c,和劈开聚合酶(PARP ) 的层次是由使用西方的污点的 assayed。结果:Beclin 1 表示在 Beclin 1 siRNA transfection 以后由 75% 72 h 减少了。部分 Beclin 1 silencing 显著地增加了 subG1 房间的百分比有 doxorubicin 或反船边交货抗体的 24 和 40 h 术后疗法,分别地并且这 potentiation 被处理与一个 pan-caspase 禁止者废除。部分 Beclin 1 silencing 也增加了 PARP 劈开, mitochondrial 膜去极和 cytosolic 细胞色素 c。部分 Beclin 1 silencing 的 pro-apoptotic 后果没在 Bcl-X (L) 表示与衰落被联系。结论:部分 Beclin 1 silencing 在与反船边交货抗体或与 doxorubicin 对待的 HepG2 房间加重 mitochondrial permeabilization 和 apoptosis。 | Fanny Daniel Agnès Legrand Dominique Pessayre Nathalie Vadrot Véronique Descatoire Dominique Bernuau | 2006 | World Journal of Gastroenterology2006，12，18： | 11 |
| 3 | Mechanisms involved in the inhibition of myoblast proliferation and differentiation by myostatin显示文摘 | Dominique Joulia Henri Bernardi Véronique Garandel Fanjaniriana Rabenoelina Barbara Vernus Gérard Cabello | 2003 | Experimental Cell Research2003，，2： | 3 |
| 4 | Insulin resistance–associated hepatic iron overload显示文摘 | Michel-Henry Mendler Bruno Turlin Romain Moirand Anne-Marie Jouanolle Thierry Sapey Dominique Guyader Jean-Yves le Gall Pierre Brissot Véronique David Yves Deugnier | 1999 | Gastroenterology1999，，5： | 2 |
| 5 | Natural History of Pediatric Crohn’s Disease: A Population-Based Cohort Study显示文摘 | Gwenola Vernier–Massouille Mamadou Balde Julia Salleron Dominique Turck Jean Louis Dupas Olivier Mouterde Véronique Merle Jean Louis Salomez Julien Branche Raymond Marti éric Lerebours Antoine Cortot Corinne Gower–Rousseau Jean Frédéric Colombel | 2008 | Gastroenterology2008，，4： | 2 |
| 6 | Arterial and portal circulation and parenchymal changes in Budd-Chiari syndrome:a study in 17 explanted livers显示文摘 | Vilgrain V Genin P | 2003 | Hepatology2003，37，3： | 1 |
| 7 | Expression of three members of the ACC synthase gene family in deep water rice by submergence, wounding and hormonal treatments 显示文摘 | Dominique V D S Somboon A Wim V C | 1997 | Plant Science1997，124，： | 1 |
| 8 | Molecular nanoelectronics 显示文摘 | DOMINIQUE V | 2010 | Procee- dings of theIEEE2010，98，12： | 1 |
| 9 | Prediction of the PCDD/F and dl-PCB 2005-WHO-TEQ content based on the contribution of six congeners: Toward a new screening approach for fish samples?显示文摘 | Ronan Cariou Philippe Marchand Ana?s Vénisseau Aline Brosseaud Dominique Bertrand El Mostafa Qannari Jean-Philippe Antignac Bruno Le Bizec | 2009 | Environmental Pollution2009，，3： | 1 |
| 10 | Electroconductive adhesive for high density package and flip-chip interconnections 显示文摘 | DOMINIQUE W JAN V ELISABETH R | 2000 | Microelectron Reliab2000，40，： | 1 |
| 11 | Five hundred and fifty microsatellite markers for the study of the honeybee (Apis mellifera L) genome显示文摘 | Michel S Dominique V Anne L | 2003 | Molecular Ecology Notes2003，3，： | 1 |
| 12 | Sarcoidosis 显示文摘 | Dominique V Antje P Hilario N | 2014 | Lancet2014，383，9923： | 1 |
| 13 | Techni-cal improvements in two-dimensional electrophoresisincrease the level of genetic variation detected inwheat-seedling proteins显示文摘 | Catherine D Dominique D V Michel Z | 1986 | Electrophoresis1986，7，1： | 1 |
| 14 | AgNO3 spray tests: advantages, weaknesses, and various applications to quantify chloride ingress into concrete. Part 1: Non-steady-state diffusion tests and exposure to natural conditions显示文摘 | Véronique Baroghel-Bouny Patrick Belin Matthias Maultzsch Dominique Henry | 2007 | Materials and Structures2007，，8： | 1 |
| 15 | Expression of three members of the ACC synthase gene family in deepwater rice by submergence,wounding and hormonal treatments 显示文摘 | DOMINIQUE V D S SOMBOON A WIM V C | 1997 | Plant Science1997，124，： | 1 |
| 16 | Rest myocardial perfusion/metabolism imaging using simultaneous dual-isotope acquisition SPECT with 99mTc-MIBI/18F-FDG显示文摘 | Dominique D Searle V James A | 1995 | J Nucl Med1995，36，11： | 1 |
| 17 | AgNO3 spray tests: advantages, weaknesses, and various applications to quantify chloride ingress into concrete. Part 2: Non-steady-state migration tests and chloride diffusion coefficients显示文摘 | Véronique Baroghel-Bouny Patrick Belin Matthias Maultzsch Dominique Henry | 2007 | Materials and Structures2007，，8： | 1 |
| 18 | Formation of Pt silicide on doped Si: Kinetics and stress显示文摘 | Omar Abbes Khalid Hoummada Dominique Mangelinck Véronique Carron | 2013 | Thin Solid Films2013，，： | 1 |
| 19 | Five hundred and fifty microsatellite markers for the study of the honeybee (Apis mellifera L) genome 显示文摘 | Michel S Dominique V Anne L | 2003 | Molecular Ecology Notes2003，3，2： | 1 |
| 20 | hTRET expression correlates with MYC over-expression in human prostate cancer显示文摘 | Alain L Dominique V Antoine V | 2000 | Int J Cancer2000，89，2： | 1 |
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