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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | Metabolic profiling analysis of a D-galactosamine/lipopolysaccharide- induced mouse model of fulminant hepatic failure显示文摘 | Feng, B Wu, SM Lv, S Liu, F Chen, HS Yan, XZ Li, Y Dong, FT Wei, L | 2007 | 中国生物学文摘2007，21，11： | 23 |
| 3 | The precipitation strengthening behavior of Cu-rich phase in Nb contained advanced Fe-Cr-Ni type austenitic heat resistant steel for USC power plant application | Cheng-yu Chi a, Hong-yao Yu b, Jian-xin Dong b, Wen-qing Liu c, Shi-chang Cheng d, Zheng-dong Liu d, Xi-shan Xie b a School of Metallurgical and Ecological Engineering, University of Science & Technology Beijing, Beijing 100083, China b School of Materials Science and Engineering, University of Science & Technology Beijing, Beijing 100083, China c Instrumental Analysis & Research Center, Shanghai University, Shanghai 200444, China d Central Iron and Steel Research Institute, Beijing 100081, China | 2012 | Progress in Natural Science:Materials International2012，22，3： | 20 |
| 4 | Preparation of nano-sized Bi_2Te_3 thermoelectric material powders by cryogenic grinding | Xiaozong Chen a, Leifeng Liu b, Yuan Dong a, Lianjun Wang a, Lidong Chen c, Wan Jiang a, a State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, 2999 people of North Road, Shanghai 201620, PR China b Department of Materials and Environmental Chemistry, Stockholm University, SE-106 91 Stockholm, Sweden c Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, PR China | 2012 | Progress in Natural Science:Materials International2012，22，3： | 8 |
| 5 | Effect of nitrogen fertilization on yield, N content, and nitrogen fixation of alfalfa and smooth bromegrass grown alone or in mixture in greenhouse pots显示文摘Planting grass and legume mixtures on improved grasslands has the potential advantage of realizing both higher yields and lower environmental pollution by optimizing the balance between applied N fertilizer and the natural process of legume biological nitrogen fixation. However, the optimal level of N fertilization for grass-legume mixtures, to obtain the highest yield, quality, and contribution of N2 fixation, varies with species. A greenhouse pot experiment was conducted to study the temporal dynamics of N2 fixation of alfalfa(Medicago sativa L.) grown alone and in mixture with smooth bromegrass(Bromus inermis Leyss.) in response to the addition of fertilizer N. Three levels of N(0, 75, and 150 kg ha–1) were examined using 15N-labeled urea to evaluate N2 fixation via the 15 N isotope dilution method. Treatments were designated N0(0.001 g per pot), N75(1.07 g per pot) and N150(2.14 g per pot). Alfalfa grown alone did not benefit from the addition of fertilizer N; dry matter was not significantly increased. In contrast, dry weight and N content of smooth bromegrass grown alone was increased significantly by N application. When grown as a mixture, smooth bromegrass biomass was increased significantly by N application, resulted in a decrease in alfalfa biomass. In addition, individual alfalfa plant dry weight(shoots+roots) was significantly lower in the mixture than when grown alone at all N levels. Smooth bromegrass shoot and root dry weight were significantly higher when grown with alfalfa than when grown alone, regardless of N application level. When grown alone, alfalfa's N2 fixation was reduced with N fertilization(R2=0.9376, P=0.0057). When grown in a mixture with smooth bromegrass, with 75 kg ha–1 of N fertilizer, the percentage of atmospheric N2 fixation contribution to total N in alfalfa(%Ndfa) had a maximum of 84.07 and 83.05% in the 2nd and 3rd harvests, respectively. Total 3-harvest %Ndfa was higher when alfalfa was grown in a mixture than when grown alone(shoots: |t|=3.39, P=0.0096; root: |t|=3.57, P=0.0073). We believe this was due to smooth bromegrass being better able to absorb available soil N(due to its fibrous root system), resulting inlower soil N availability and allowing alfalfa to develop an effective N2 fixing symbiosis prior to the 1st harvest. Once soil N levels were depleted, alfalfa was able to fix N2, resulting in the majority of its tissue N being derived from biological nitrogen fixation(BNF) in the 2nd and 3rd harvests. When grown in a mixture, with added N, alfalfa established an effective symbiosis earlier than when grown alone; in monoculture BNF did not contribute a significant portion of plant N in the N75 and N150 treatments, whereas in the mixture, BNF contributed 17.90 and 16.28% for these treatments respectively. Alfalfa has a higher BNF efficiency when grown in a mixture, initiating BNF earlier, and having higher N2 fixation due to less inhibition by soil-available N. For the greatest N-use-efficiency and sustainable production, grass-legume mixtures are recommended for improving grasslands, using a moderate amount of N fertilizer(75 kg N ha–1) to provide optimum benefits. | XIE Kai-yun LI Xiang-lin HE Feng ZHANG Ying-jun WAN Li-qiang David B Hannaway WANG Dong QIN Yan Gamal M A Fadul | 2015 | Journal of Integrative Agriculture2015，14，9： | 5 |
| 6 | Report on Childhood Obesity in China(8):Effects and Sustainability of Physical Activity Intervention on Body Composition of Chinese Youth显示文摘Objectives To determine whether a large-scale physical activity intervention could affect body composition in primary school students in Beijing,China.Methods The study design was one-year cluster randomized controlled trial of physical activity intervention(20 min of daily exercise in the classroom) with an additional year of follow-up among 4 700 students aged 8-11 years at baseline.Results After the one-year intervention,BMI increased by 0.56 kg/m^2(SD 1.15) in the intervention group and by 0.72 kg/m^2(SD 1.20) in the control group,with a mean difference of-0.15 kg/m^2(95%CI:-0.28 to-0.02).BMI z score decreased by-0.05(SD 0.44) in the intervention group,but increased by 0.01(SD 0.46) in the control group,with a mean difference of-0.07(-0.13 to-0.01).After another year of follow up,compared to the control group,children in the intervention group had significantly lower BMI(-0.13,-0.25 to-0.01),BMI z score(-0.05,-0.10 to-0.01),fat mass(-0.27 kg,-0.53 to-0.02) and percent body fat(-0.53,-1.00 to-0.05).The intervention had a more pronounced effect on weight,height,BMI,BMI z score,and body composition among obese children than among normal weight or overweight children.Compared to the control group,the intervention group had a significantly higher percentage of children who maintained or reduced their BMI z score at year 1(P=0.008) and year 2(P=0.04).Conclusions These findings suggest that 20 min of daily moderate to vigorous physical activity during the school year is a feasible and effective way to prevent excessive gain of body weight,BMI,and body fatness in primary school students. | YAN-PING LI XIAO=QI HU EVERT G. SCHOUTEN AI-LING LIU SONG-MING DU LIN-ZHONG LI ZHAO-HuI CUI DONG WANG FRANS J KOK FRANK B HU GUAN-SHENG MA | 2010 | Biomedical and Environmental Sciences2010，23，3： | 5 |
| 7 | Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial显示文摘 | Craig S Anderson Yining Huang Ji Guang Wang Hisatomi Arima Bruce Neal Bin Peng Emma Heeley Christian Skulina Mark W Parsons Jong Sung Kim Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Stephane Heritier Lewis B Morgenste | 2008 | Lancet Neurology2008，，5： | 4 |
| 8 | ^137Cs tracing dynamics of soil erosion,organic carbon,and total nitrogen in terraced fields and forestland in the Middle Mountains of Nepal显示文摘The Middle Mountains is one of the regions of Nepal most vulnerable to water erosion, where fragile geology, steep topography, anomalous climatic conditions, and intensive human activity have resulted in serious soil erosion and enhanced land degradation. Based on the 137 Cs tracing method, spatial variations in soil erosion, organic carbon, and total nitrogen(TN) in terraced fields lacking field banks and forestland were determined. Soil samples were collected at approximately 5 m and 20 m intervals along terraced field series and forestland transects respectively. Mean 137 Cs inventories of the four soil cores from the reference site was estimated at 574.33 ± 126.22 Bq m-2(1 Bq(i.e., one Becquerel) is equal to 1 disintegration per second(1 dps)). For each terrace, the 137 Cs inventory generally increased fromupper to lower slope positions, accompanied by a decrease in the soil erosion rate. Along the entire terraced toposequence, 137 Cs data showed that abrupt changes in soil erosion rates could occur between the lower part of the upper terrace and the upper part of the immediate terrace within a small distance. This result indicated that tillage erosion is also a dominant erosion type in the sloping farmland of this area. At the same time, we observed a fluctuant decrease in soil erosion rates for the whole terraced toposequence as well as a net deposition at the toe terrace. Although steep terraces(lacking banks and hedgerows) to some extent could act to limit soil sediment accumulation in catchments, soil erosion in the terraced field was determined to be serious. For forestland, with the exception of serious soil erosion that had taken place at the top of slopes due to concentrated flows from a country road situated above the forestland site, spatialvariation in soil erosion was similar to the 'standard' water erosion model. Soil organic carbon(SOC) and TN inventories showed similar spatial patterns to the 137 Cs inventory for both toposequences investigated. However, due to the different dominant erosion processes between the two, we found similar patterns between the <0.002 mm soil particle size fraction(clay sized) and 137 Cs inventories in terraced fields, while different patterns could be found between 137 Cs inventories and the <0.002 mm soil particle size fraction in the forestland site. Such results confirm that 137 Cs can successfully trace soil erosion, SOC and soil nitrogen dynamics in steep terraced fields and forestland in the Middle Mountains of Nepal. | SU Zheng-an XIONG Dong-hong DENG Wei DONG Yi-fan MA Jing PADMA C Poudel GURUNG B Sher | 2016 | Journal of Mountain Science2016，13，10： | 4 |
| 9 | A novel method for Co(Ⅱ) and Cu(Ⅱ) analysis by capillary electrophoresis with chemiluminescence detection显示文摘Based on the fact that some metal ions can catalyze the chemiluminescence(CL)reaction of luminol with K3Fe(CN)6,a novel capillary electrophoresis CL method was developed for the determination of Co(Ⅱ)and Cu(Ⅱ).The separation was carried out with a 10 mmol/L sodium acetate solution containing 0.8 mmol/L luminol and 2.0 mmol/Lα-HIBA(adjusted to pH 4.8 by HAc solution).The post-capillary reagent was 2.0 mmol/L K3Fe(CN)6 which was adjusted to pH 13.0 by NaOH solution.Under the optimum conditions,the detection limits(S/N=3)for Co(Ⅱ)and Cu(Ⅱ)were 7.5×10-11mol/L and 7.5×10-9mol/L,with the linear range of 7.5×10-9mol/L to 1.0×10-6mol/L and 7.5×10-8mol/L to 5.0×10-5mol/L, respectively. | Xiao Ming Guo~a Xiang Dong Xu~(a,b) Hui Jing Zhang~a Yong Gang Hu~(a,*) Jie Zhang~a a Institute of Environmental Science & Engineering,Huazhong University of Science and Technology,Wuhan 430074,China b Department of Chemistry,Huazhong University of Science and Technology,Wuhan 430074,China | 2007 | Chinese Chemical Letters2007，18，9： | 3 |
| 10 | Steady and unsteady flow field at pump and turbine exits of a torque converter显示文摘 | DONG Y LAKSHMINARAYANA B MADDOCK D | 1998 | ASME1998，120，： | 2 |
| 11 | A new Upper Carboniferous stem-orthopteran (Insecta) from Ningxia (China)显示文摘 | Olivier Béthoux Jun-Jie Gu Dong Ren | 2012 | Insect Science2012，19，2： | 2 |
| 12 | The relationships between urban-rural temperature difference and vegetation in eight cities of the Great Plains显示文摘Interpreting the relationship between urban heat island (UHI) and urban vegetation is a basis for understanding the impacts of underlying surfaces on UHL The calculation of UHI intensity (UHII) requires observations from paired stations in both urban and rural areas.Due to the limited number of paired meteorological stations,many studies have used remotely sensed land surface temperature,but these time-series land surface temperature data are often heavily affected by cloud cover and other factors.These factors,together with the algorithm for inversion of land surface temperature,lead to accuracy problems in detecting the UHII,especially in cities with weak UHII.Based on meteorological observations from the Oklahoma Mesonet,a world-class network,we quantified the UHII and trends in eight cities of the Great Plains,USA,where data from at least one pair of urban and rural meteorological stations were available.We examined the changes and variability in urban temperature,UHII,vegetation condition (as measured by enhanced vegetation index,EVI),and evapotranspiration (ET).We found that both UHI and urban cold islands (UCI) occurred among the eight cities during 2000-2014 (as measured by impervious surface area).Unlike what is generally considered,UHII in only three cities significantly decreased as EVI and ET increased (p < 0.1),indicating that the UHI or UCI cannot be completely explained simply from the perspective of the underlying surface.Increased vegetative cover (signaled by EVI) can increase ET,and thereby effectively mitigate the UHI.Each study station clearly showed that the underlying surface or vegetation affects urban-rural temperature,and that these factors should be considered during analysis of the UHI effect over time. | Yaoping CUI Xiangming XIAO Russell B DOUGHTY Yaochen QIN Sujie LIU Nan LI Guosong ZHAO Jinwei DONG | 2019 | Frontiers of Earth Science2019，13，2： | 2 |
| 13 | Unsatisfying antiviral therapeutic effect in patients with mother-tochild transmissed chronic hepatitis B virus infection: a prospective multi-center clinical study显示文摘Background:Few data are available regarding the progression of liver disease and therapeutic efficacy in chronic hepatitis B(HBV)carriers infected by mother-to-child transmission(MTCT).This study aimed to investigate these two aspects by comparing the adult chronic HBV carriers in MTCT group with those in horizontal transmission group.Methods:The 683 adult chronic HBV patients qualified for liver biopsy including 191 with MTCT and 492 with horizontal transmission entered the multi-center prospective study from October 2013 to May 2016.Biopsy results from 217 patients at baseline and 78 weeks post antiviral therapy were collected.Results:Patients infected by MTCT were more likely to have e antigen positive(68.6%vs.58.2%,x^2=-2.491,P=0.012)than those with horizontal transmission.However,in patients with MTCT,levels of alkaline phosphatase(ALP)(P=0.031),Fibroscan(P=0.013),N-terminal propeptide of Type III procollagen(PIIINP)(P=0.014),and Laminin(LN)(P=0.006)were high,in contrast to the patients with horizontal transmission for whom the levels of albumin(ALB)(P=0.041),matrix metalloproteinase-3(MMP-3)(P=0.001)were high.The 47.2% of patients with MTCT and 36.8%of those with horizontal transmission had significant liver fibrosis(P=0.013).Following antiviral therapy for 78 weeks,21.2%and 38.0%patients with MTCT and horizontal transmission acquired hepatitis B e antigen(HBeAg)clearance,respectively(P=0.043),and the virological response rates were 54.7%and 74.1%in the MTCT and horizontal groups,respectively(P=0.005).MTCT was a risk factor for HBeAg clearance and virological response.Conclusion:Adult patients with MTCT were more prone to severe liver diseases,and the therapeutic efficacy was relatively poor,which underlined the importance of earlier,long-term treatment and interrupting perinatal transmission. | Jun Li Xiao-Qin Dong Zhao Wu An-Lin Ma Shi-Bin Xie Xu-Qing Zhang Zhan-Qing Zhang Da-Zhi Zhang Wei-Feng Zhao Guo Zhang Jun Cheng Qing Xie Jun Li Zhi-Qiang Zou Ying-Xia Liu Gui-Qiang Wang Hong Zhao China Hepatitis B Related Fibrosis Assessment Research Group | 2019 | Chinese Medical Journal2019，，22： | 2 |
| 14 | Reflectivity behavior of two dimensional ordered array of metallodielectric composite particles at large incidence angles 显示文摘 | ZHAN P LIU J B DONG W | 2005 | Appl Phys Lett2005，86，05： | 1 |
| 15 | Costimulation,coinhibition and cancer显示文摘 | Inman B A Frigola X Dong H | 2007 | Curr Cancer Drug Targets2007，7，1： | 1 |
| 16 | Seed-mediated synthesis of branched gold nanoparticles with the assistance of citrate and their surface-enhanced Raman scattering properties显示文摘 | Zou X Q Ying E B Dong S J | 2006 | Nanotechnol2006，17，： | 1 |
| 17 | Variations of horizontal and vertical velocities over two-dimensional transverse dunes: A wind tunnel simulation of the effect of windward slope显示文摘 | Qian G Q Dong Z B Luo W Y | 2009 | Journal of AridEnvironments2009，73，： | 1 |
| 18 | A Tribocatalysis Reaction in Boundary Lubrication-An antiwear Synergism between Borates and Copper Oleate 显示文摘 | Yao J B Dong J X | 1995 | Lubrication Engineering1995，51，3： | 1 |
| 19 | Hippocampal neruogenesis follows kainic acid-induced apoptosis in neonatal rats显示文摘 | Dong H Csernansky CA Goico B | 2003 | J Neurosci2003，23，： | 1 |
| 20 | Aerodynamic roughness of fixed sandy beds显示文摘 | Dong Z B Wang X M Zhao A G | 2001 | Journal of Geophysical Research2001，106，11： | 1 |
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