|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response显示文摘Personalized immunotherapy targeting tumor-specific antigens(TSAs)could generate efficient and safe antitumor immune response without damaging normal tissues.Although neoantigen vaccines have shown therapeutic effect in clinic trials,precise prediction of neoantigens from tumor mutations is still challenging.The host antitumor immune response selects and activates T cells recognizing tumor antigens.Hence,T cells engineered with T-cell receptors(TCRs)from these naturally occurring tumor antigen-specific T(Tas)cells in a patient will target personal TSAs in his/her tumor.To establish such a personalized TCR-T cell therapy,we comprehensively characterized T cells in tumor and its adjacent tissues by single-cell mRNA sequencing(scRNA-seq),TCR sequencing(TCR-seq)and in vitro neoantigen stimulation.Compared to bystander T cells circulating among tissues,Tas cells were characterized by tumor enrichment,tumor-specific clonal expansion and neoantigen specificity.We found that CXCL13 is a unique marker for both CD4^(+)and CD8^(+)Tas cells.Importantly,TCR-T cells expressing TCRs from Tas cells showed significant therapeutic effects on autologous patient-derived xenograft(PDX)tumors.Intratumoral Tas cell levels measured by CXCL13 expression precisely predicted the response to immune checkpoint blockade,indicating a critical role of Tas cells in the antitumor immunity.We further identified CD200 and ENTPD1 as surface markers for CD4^(^(+))and CD8^(^(+))Tas cells respectively,which enabled the isolation of Tas cells from tumor by Fluorescence Activating Cell Sorter(FACS)sorting.Overall,our results suggest that TCR-T cells engineered with Tas TCRs are a promising agent for personalized immunotherapy,and intratumoral Tas cell levels determine the response to immunotherapy. | Jingjing He Xinxin Xiong Han Yang Dandan Li Xuefei Liu Shuo Li Shuangye Liao Siyu Chen Xizhi Wen Kuai Yu Lingyi Fu Xingjun Dong Kaiyu Zhu Xiaojun Xia Tiebang Kang Chaochao Bian Xiang Li Haiping Liu Peirong Ding Xiaoshi Zhang Zhenjiang Liu Wende Li Zhixiang Zuo Penghui Zhou | 2022 | Cell Research2022，32，6： | 10 |
| 2 | Van der Waals epitaxy of ultrathin crystalline PbTe nanosheets with high near-infrared photoelectric response显示文摘Lead telluride(PbTe)is one of the reliable candidates for infrared(IR)optoelectronics with optimum band-gap as well as excellent photoelectric properties.Great interests had been paid on the growth and device applications with PbTe for the development of high-performance IR photodetectors especially those working in the near-infrared regime.Although a great deal of effort had been made to prepare PbTe nanostructures for miniaturized detectors,it is difficult to synthesize high-quality two-dimensional(2D)PbTe crystals due to its rock-salt non-layered structure.Herein,a facile strategy for controllable synthesis of ultrathin crystalline PbTe nanosheets by van der Waals epitaxy is reported.With an optimized growth temperature,which determines the morphology transit from triangular pyramid islands to regular square 2D planars,PbTe nanosheets in lateral size of tens of microns with thickness down to~7 nm are achieved.Meanwhile,ultrasensitive near-infrared detectors(NIRDs)based on the as-grown 2D PbTe nanosheets have been demonstrated with an ultrahigh responsivity exceeding 3,847 A/W at the wavelength of 1,550 nm under room temperature.Our approach demonstrates that 2D PbTe nanosheets have great latent capacity of developing high-performance miniaturized IR optoelectronic devices. | Xinxin Zhao Qing Yin Hao Huang Qiang Yu Bo Liu Jie Yang Zhuo Dong Zhenjiang Shen Benpeng Zhu Lei Liao Kai Zhang | 2021 | Nano Research2021，14，6： | 3 |
| 3 | Super-plasticity of Zr_(64.80)Cu_(14.85)Ni_(10.35)Al_(10) bulk metallic glass at room temperature显示文摘Generally,bulk metallic glasses(BMGs)exhibit a very limited plastic deformation under a compression load at room temperature,often less than 2% before fracturing.In this letter,through an appropriate choice of BMGs' composition,an amorphous rod of Zr64.80Cu14.85Ni10.35Al10 with a diameter of 2 mm was prepared by using copper mold suction casting.X-ray diffraction and differential scanning calorimetry were utilized to determine its structure and thermal stability,and the uniaxial compression test was adopted to study its plastic deformation behavior at room temperature simultaneously.The results showed that the glass transition temperature and onset temperature of the exothermic reaction of the amorphous rod were 646 and 750 K,respectively,and its micro-hardness was 594.7 Hv.During com-pression,when the engineering strain and engineering stress arrived at 9.05% and 1732 MPa,respec-tively,i.e.,the true strain and true stress reached 9.42% and 1560 MPa,respectively,the amorphous rod started to yield.After yielding,with the increase of load,the strain increased and the glass rod ulti-mately were compressed into flake-like form.Although the maximum engineering strain was larger than 70%,i.e.,the maximum true strain exceeded by 120%,the amorphous specimen was not fractured,indicating that it has super-plasticity at room temperature.Through the appropriate choice of compo-sition and optimization of the technological process,flexible BMG with super-plasticity at room tem-perature could be produced. | TAO PingJun YANG YuanZheng BAI XiaoJun XIE ZhiWei CHEN XianCao DONG ZhenJiang Wen JianGuo | 2008 | Chinese Science Bulletin2008，53，3： | 3 |
| 4 | Key Technologies and Application of Edge Computing显示文摘Cloud computing faces a series of challenges,such as insufficient bandwidth,unsatisfactory real-time,privacy protection,and energy consumption.To overcome the challenges,edge computing emerges.Edge computing refers to a process where the open platform that converges the core capabilities of networks,computing,storage,and applications provides intelligent services at the network edge near the source of the objects or data to meet the critical requirements for agile connection,real-time services,data optimization,application intelligence,security and privacy protection of industry digitization.Edge computing consists of three elements:edge,computing,and intelligence.Edge computing and the Internet of Things(IoT)mutually create,and edge computing and cloud computing complement each other.In the architecture of edge computing,resources are distributed to the edge nodes,and therefore the storage system is near users while the computation function is near data.In this way,the stress on the backbone network can be lessened.With this architecture,the existing key technologies for computation,networks,and storage will change significantly.ZTE’s edge computing solutions can ensure the service quality of operators and greatly enhance the experience of mobile users. | TU Yaofeng DONG Zhenjiang YANG Hongzhang | 2017 | ZTE Communications2017，15，2： | 3 |
| 5 | Android Apps:Static Analysis Based on Permission Classification显示文摘Android has a strict permission management mechanism. Any applications that try to run on the Android system need to obtain permission. In this paper, we propose an efficient method of detecting malicious applications in the Android system. First, hundreds of permissions are classified into different groups. The application programming interfaces (APIs) associated with permissions that can interact with the outside environment are called sink functions. The APIs associated with other permissions are called taint functions. e construct association tables for block variables and function variables of each application. Malicious applications can then be detected by using the static taint-propagation method to analyze these tables. | Zhenjiang Dong Hui Ye Yan Wu Shaoyin Cheng Fan Jiang | 2013 | ZTE Communications2013，11，1： | 2 |
| 6 | Preparation and characterization of long chain branched polypropylene mediated by different heteroaromatic ring derivatives显示文摘 | Dong Wan Li Ma Haiping Xing Lu Wang Zhenjiang Zhang Jian Qiu Guangchun Zhang Tao Tang | 2012 | Polymer2012，，： | 1 |
| 7 | Synthesis and Structure-Property Relationships of Polypropylene-g-Poly (Ethylene-co-l-Butene) Graft Copolymers with Well-Defined Long Chain Branched Molecular Structures 显示文摘 | Wang Lu Wan Dong Zhang Zhenjiang | 2011 | Macromole- cules2011，44，11： | 1 |
| 8 | SeSoa: Security Enhancement System with Online Authentication for Android APK显示文摘Android OS provides such security mechanisms as application signature,,privilege limit and sandbox to protect the security of operational system.However,these methods are unable to protect the applications of Android against anti‘reverse engineering and the codes of such applications face the risk of being obtained or modified,which are always the first step for further attacks.In this paper;a security enhancement system with online authentication(SeSoa)for Android APK is proposed,in which the code of Android application package(APK)can be automatically encrypted.The encrypted code is loaded and run in the Android system after being successfully decrypted.Compared with the exiting software protecting systems,SeSoa uses online authentication mechanism to ensure the improvementof the APK security and good balance between security and | DONG Zhenjiang WANG Wei LI Hui ZHANG Yateng ZHANG Hongrui ZHAO Hanyu | 2016 | ZTE Communications2016，14，B06： | 1 |
| 9 | Improving Performance of Cloud Computing and Big Data Technologies and Applications显示文摘Cloud computing technology is changing the development and usage pat-terns of IT infrastructure and applications.Virtualized and distributedsystems as well as unified management and scheduling has greatly im-proved computing and storage.Management has become easier,andOAM costs have been significantly reduced.Cloud desktop technology is develop- | Zhenjiang Dong | 2014 | ZTE Communications2014，12，4： | 1 |
| 10 | MBGM: A Graph-Mining Tool Based on MapReduce and BSP显示文摘This paper proposes an analytical mining tool for big graph data based on Map Reduce and bulk synchronous parallel(BSP) com-puting model. The tool is named Mapreduce and BSP based Graph-mining tool(MBGM). The core of this mining system are foursets of parallel graph-mining algorithms programmed in the BSP parallel model and one set of data extraction-transformation-load-ing(ETL) algorithms implemented in Map Reduce. To invoke these algorithm sets, we designed a workflow engine which optimizedfor cloud computing. Finally, a well-designed data management function enables users to view, delete and input data in the Ha-doop distributed file system(HDFS). Experiments on artificial data show that the components of graph-mining algorithm in MBGMare efficient. | Zhenjiang Dong Lixia Liu Bin Wu Yang Liu | 2014 | ZTE Communications2014，12，4： | 1 |
| 11 | Technical Analysis of Network Plug-in Flannel for Containers显示文摘The development of cloud computing has made container tec-hnology a hot research issue in recent years. The container technology provides a basic support for micro service architecture, while container networking plays an important role in application of the container technology. In this paper, we study the technical implementation of the Flannel module, a network plug-in for Docker containers, including its func tions, implementation principle, utilization, and performance. The performance of Flannel in different modes is further tested and analyzed in real application scenarios. | YANG Yong DONG Xiugang DONG Zhenjiang | 2017 | ZTE Communications2017，15，4： | 1 |
| 12 | Mobile Internet WebRTC and Related Technologies显示文摘This paper describes an improved design for WebRTC technolo-gy. With this design, WebRTC communication at client side,server side, and between these two sides is improved. HTML5WebSocket, media negotiation and synthesis, network addresstranslator(NAT)/firewall traversal, Session Initiation Protocol(SIP) signaling interaction, and P2P communication security areall used in this improved design. This solution solves cross-browser running problem of WebRTC applications, reduces reli-ance on client-side processing capability, and reduces band-width consumption. With this design, WebRTC also becomemore scalable. | Zhenjiang Dong Congbing Li Wei Wang Da Lyu | 2014 | ZTE Communications2014，12，1： | 1 |
| 13 | Synthesis and Structure_Property Relationships of Polypropylene-g-Poly(Ethylene-co-1-Butene)Graft Copolymers with Well-Defi ned Long Chain Branched Molecular Structures显示文摘 | Wang Lu Wan Dong Zhang Zhenjiang | 2011 | Macromolecules2011，44，11： | 1 |
| 14 | A New Grafting Monomer for Synthesizing Long Chain Branched Polypropylene Through Melt Radical Reaction显示文摘 | Zhang Zhenjiang Wan Dong Xing Haiping | 2012 | Polymer2012，53，1： | 1 |
| 15 | Controlling Degradation and Branching Reactions of Polypropylene by Different Heteroaromatic Ring Derivatives 显示文摘 | Dong Wan Li Ma Zhenjiang Zhang | 2012 | Polymer Degradation and Stability2012，97，1： | 1 |
| 16 | Con- trolling degradation and branching reactions of polypropylene by different heteroaromatic ring derivatives显示文摘 | Wan Dong Ma Li Zhang Zhenjiang | 2012 | Polymer Degradation and Stabil- ity2012，97，1： | 1 |
| 17 | A new grafting monomer for synthesizing long chain branched polypropylene through melt radical reaction显示文摘 | Zhenjiang Zhang Dong Wan Haiping Xing Zhijie Zhang Haiying Tan Lu Wang Jun Zheng Yanjie An Tao Tang | 2011 | Polymer2011，，1： | 1 |
| 18 | A New Grafting Monomer for Synthesizing Long Chain Branched Polypropylene Through Melt Radical Reaction 显示文摘 | Zhang Zhenjiang Wan Dong Xing Haiping | 2012 | Polymer2012，53，1： | 1 |
| 19 | Open Access Standards for Telecom Service Capabilities显示文摘Among the open access standards for telecom service capabilities, Java Community Process (JCP) and Parlay series are two mainstream standards, which provide service capability opening standards at different levels for different user objects. The JCP specifications include Java Specification Request (JSR) 21, JSR 32, JSR 116 and JSR 289 especially for Java application developers, while Parlay brings out specifications including Parlay and ParlayX. The service capability open technologies feature different benefits and vitality due to their diversified implementations. As the community of service developers is continuously growing and the demands for integrated service development become more and more manifest, fast, effective and easy-to-use open access technologies for telecom service capabilities have become a very important research subject. | Yang Yong, Jia Xia, Dong Zhenjiang (ZTE Corporation, Shenzhen 518057, P. R. China) | 2009 | ZTE Communications2009，7，2： | 1 |
| 20 | Synthesis and Structure Property Relationships of Polypropylene-g- Poly(Ethylene-co-l-Butene) Graft Copolymers with Well- Defined Long Chain Branched Molecular Structures 显示文摘 | Wang Lu Wan Dong Zhang Zhenjiang | 2011 | Mac- romolecules2011，44，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员