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| 1 | Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response显示文摘Personalized immunotherapy targeting tumor-specific antigens(TSAs)could generate efficient and safe antitumor immune response without damaging normal tissues.Although neoantigen vaccines have shown therapeutic effect in clinic trials,precise prediction of neoantigens from tumor mutations is still challenging.The host antitumor immune response selects and activates T cells recognizing tumor antigens.Hence,T cells engineered with T-cell receptors(TCRs)from these naturally occurring tumor antigen-specific T(Tas)cells in a patient will target personal TSAs in his/her tumor.To establish such a personalized TCR-T cell therapy,we comprehensively characterized T cells in tumor and its adjacent tissues by single-cell mRNA sequencing(scRNA-seq),TCR sequencing(TCR-seq)and in vitro neoantigen stimulation.Compared to bystander T cells circulating among tissues,Tas cells were characterized by tumor enrichment,tumor-specific clonal expansion and neoantigen specificity.We found that CXCL13 is a unique marker for both CD4^(+)and CD8^(+)Tas cells.Importantly,TCR-T cells expressing TCRs from Tas cells showed significant therapeutic effects on autologous patient-derived xenograft(PDX)tumors.Intratumoral Tas cell levels measured by CXCL13 expression precisely predicted the response to immune checkpoint blockade,indicating a critical role of Tas cells in the antitumor immunity.We further identified CD200 and ENTPD1 as surface markers for CD4^(^(+))and CD8^(^(+))Tas cells respectively,which enabled the isolation of Tas cells from tumor by Fluorescence Activating Cell Sorter(FACS)sorting.Overall,our results suggest that TCR-T cells engineered with Tas TCRs are a promising agent for personalized immunotherapy,and intratumoral Tas cell levels determine the response to immunotherapy. | Jingjing He Xinxin Xiong Han Yang Dandan Li Xuefei Liu Shuo Li Shuangye Liao Siyu Chen Xizhi Wen Kuai Yu Lingyi Fu Xingjun Dong Kaiyu Zhu Xiaojun Xia Tiebang Kang Chaochao Bian Xiang Li Haiping Liu Peirong Ding Xiaoshi Zhang Zhenjiang Liu Wende Li Zhixiang Zuo Penghui Zhou | 2022 | Cell Research2022，32，6： | 10 |
| 2 | Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation显示文摘Cyclin 依赖的 kinase 1 (Cdk1 )/cyclin B1 建筑群是为有丝分裂的入口的驱动力,并且它的激活被 G2/M 检查点紧调整。我们原来报导了那新奇蛋白质 C53 (也作为 Cdk5rap3 和 LZAP 知道) 加强由 modulating 的 DNA 导致损坏的房间死亡 G2/M 检查点。更最近,王等。(2007 ) 发现 C53/LZAP 可以通过禁止 NF-魏 B 发信号作为肿瘤 suppressor 工作。我们这里作为 Cdk1 激活的一个新奇管理者报导 C53 蛋白质的鉴定。我们 C53 蛋白质原因发现那击倒推迟的 Cdk1 激活和有丝分裂的入口。在 DNA 损坏反应期间,检查点 kinase 的激活(Chk1 和 Chk2 ) 1 和 2 被 C53 overexpression 部分禁止。有趣地,我们发现 C53 与 Chk1 交往并且反对它的功能。而且, C53 蛋白质的部分 potently 在中心体,和指向中心体的 C53 是局部性的支持本地 Cdk1 激活。一起拿,我们的结果强烈建议 C53 是检查点反应的一个新奇否定管理者。由抵抗 Chk1, C53 在两不受搅乱的房间周期前进和 DNA 损坏反应支持 Cdk1 激活和有丝分裂的入口。 | Hai Jiang Jianchun Wu Chen He Wending Yang Honglin Li | 2009 | Cell Research2009，19，4： | 9 |
| 3 | Mathematical model study on the damage of the liquid phase to productivity in the gas reservoir with a bottom water zone显示文摘The production process in the gas reservoir with an aquifer is complex.With gas production,aquifer water could possibly flow into the production well and accumulate within the well bore,which leads to a lower production rate and may even block the producer.However,few studies in the literature investigate the damage caused by the liquid phase in this kind of reservoir or predict gas productivity using the relationship between reservoir pressure and water gas ratio(WGR).For this reason,it is important to know the effects of the formation of liquid phase behavior on production when an aquifer is present under a gas reservoir.From the results of published literature reviews,we found that studies focused on the production of a gas reservoir with bottom water.Nevertheless,for gas well damage from the liquid phase behavior,we found that there was no statistical data or mathematical model of the relationship between reservoir pressure and the gas oil ratio(GOR),which affects production.In this research,based on the theory of fluid flow in porous media,a new mathematical model of water and gas production and a new equation on gas well productivity is developed.To verify the model and equation,gas production data collected from the field are applied.By analyzing the typical gas reservoir with bottom water and the collected data,influences from the liquid phase behavior are shown.In this way,mathematical relationships between reservoir pressure and the WGR and between the GOR and production decline were obtained.The new gas productivity model is derived from the gas and water pseudo pressure functions,which can be applied to analyze well damage caused by the liquid phase.In order to verify the mathematical model,production data were collected from a typical gas reservoir with an aquifer located in the Changxing gas reservoir.The results indicate that a semi-logarithmic linear relationship is obtained between the WGR and productivity decrease.When the WGR increases from 0.5 to 15m3/104m3,damage caused by liquid phase decreases to 59%.The tendency of gas productivity in the Changxing gas reservoir was obtained so that it decreases as reservoir pressure decreases and increases as the WGR decreases.The gradient of the gas productivity deduction increases as the WGR increases.By the end of the data analysis,two linear equations indicating the relationship between gas productivity and reservoir pressure and the relationship between gas productivity and the water gas ratio are obtained:QAOF?A1lnWGRB1 and QAOF?A2lnPB2,respectively. | Xiaoliang Huang Xiao Guo Xinqian Lu Xiang Zhou Zhilin Qi Wende Yan Jiqiang Li | 2018 | Petroleum2018，4，2： | 4 |
| 4 | Pivoting plant immunity from theory to the field显示文摘Plants live in complex environments and are constantly exposed to potential pathogens with different lifestyles and infection strategies.The evolutionary arms race between plants and their attackers has provided plants with a highly sophisticated and multi-layered defense system,which recognizes pathogen molecules and responds by activating defense pathways in order to resist the invaders.Here,we discuss recent developments in plant immunity,summarize conserved anti-microbial defense outputs and pathways,and provide new insights into the edge-cutting theories and technologies applied in crop production to enhance disease resistance.In the near future,the wide application of plant immune activators and precious bio-edited disease resistant agronomic crops will bring green,economic,and sustainable agriculture to reality. | Fangfang Li Wende Liu Xueping Zhou | 2019 | Science China(Life Sciences)2019，62，11： | 4 |
| 5 | Identification of abnormal conditions in high-dimensional chemical process based on feature selection and deep learning显示文摘Identification of abnormal conditions is essential in the chemical process.With the rapid development of artificial intelligence technology,deep learning has attracted a lot of attention as a promising fault identification method in chemical process recently.In the high-dimensional data identification using deep neural networks,problems such as insufficient data and missing data,measurement noise,redundant variables,and high coupling of data are often encountered.To tackle these problems,a feature based deep belief networks(DBN)method is proposed in this paper.First,a generative adversarial network(GAN)is used to reconstruct the random and non-random missing data of chemical process.Second,the feature variables are selected by Spearman’s rank correlation coefficient(SRCC)from high-dimensional data to eliminate the noise and redundant variables and,as a consequence,compress data dimension of chemical process.Finally,the feature filtered data is deeply abstracted,learned and tuned by DBN for multi-case fault identification.The application in the Tennessee Eastman(TE)process demonstrates the fast convergence and high accuracy of this proposal in identifying abnormal conditions for chemical process,compared with the traditional fault identification algorithms. | Wende Tian Zijian Liu Lening Li Shifa Zhang Chuankun Li | 2020 | Chinese Journal of Chemical Engineering2020，28，7： | 3 |
| 6 | Q-switched fiber laser based on saturable absorption of ferroferric-oxide nanoparticles显示文摘We demonstrate that ferroferric-oxide(Fe_3O_4) nanoparticles exhibit nonlinear saturable absorption property at1.55 μm, and fabricate two filmy saturable absorbers by embedding the nanoparticles into a polyvinyl alcohol(PVA) film or polyimide(PI) film separately. In the Fe_3O_4-PVA(Fe_3O_4-PI) Q-switched fiber laser, the pulse repetition rate increases from 8.5 kHz(5.5 kHz) to 28 kHz(49 kHz) and the pulse duration decreases from 23.5 μs(47 μs) to 6 μs(3.5 μs) by varying the pump power from 25 m W(23 mW) to 150 m W(650 mW). Experiment results indicate that PI-based saturable absorbers can afford larger powers than PVA-based saturable absorbers, which can be attributed to the higher fusion point of the PI film. The Fe_3O_4-PI saturable absorber exhibits features of high damage threshold, low cost, and good flexibility, which could be applied in fields of near-infrared pulse generation and frequency conversions. | Dong Mao Xiaoqi Cui Wending Zhang Mingkun Li Tianxian Feng Bobo Du Hua Lu Jianlin Zhao | 2017 | Photonics Research2017，5，1： | 3 |
| 7 | A progressive method for the collapse of river representation considering geographical characteristics显示文摘During map generalization,the collapse of geometry,which is also called geometric dimension reduction,is a basic generalization operation.When the map scale decreases,rivers with long,shallow polygonal shapes,usually require their dual-line representation to be collapsed to a single line.This study presents a new algorithm called superpixel river collapse(SURC)to convert dual-line rivers to single-line rivers based on raster data.In this method,dual-line rivers are first segmented at different levels of detail using a superpixel method called simple linear iterative clustering.Then,by connecting the edge midpoints and centre of mass of each superpixel,single-line rivers are preliminarily generated from dual-line rivers.Finally,an interpolation algorithm called polynomial approximation with an exponential kernel is applied to maintain the uniform distribution of the feature points of single-line rivers at different levels of detail(LOD).The presented method can progressively collapse the river during scale transformation to support the LOD representation in a highly sensitive way.The results show that compared with three typical thinning algorithms,the SURC method can generate smooth single-line rivers from dual-line rivers considering different river widths while effectively avoiding burrs and fractured intersections. | Yilang Shen Tinghua Ai Jingzhong Li Lina Huang Wende Li | 2020 | International Journal of Digital Earth2020，13，12： | 3 |
| 8 | Plasmonic tip internally excited via an azimuthal vector beam for surface enhanced Raman spectroscopy显示文摘The synergy of a plasmonic tip and fiber-based structure light field excitation can provide a powerful tool for Raman examination. Here, we present a method of Raman spectrum enhancement with an Ag-nanoparticles(Ag-NPs)-coated fiber probe internally excited via an azimuthal vector beam(AVB), which is directly generated in a few-mode fiber by using an acoustically induced fiber grating. Theoretical analysis shows that gap mode can be effectively generated on the surface of the Ag-NPs-coated fiber probe excited via an AVB. The experimental result shows that the intensity of Raman signal obtained with analyte molecules of malachite green by exciting the Ag-NPs-coated fiber probe via an AVB is approximately eight times as strong as that via the linear polarization beam(LPB), and the activity of the AVB-excited fiber probe can reach 10^-11 mol∕L, which cannot be achieved by LPB excitation.Moreover, the time stability and reliability are also examined, respectively. | Min Liu Wending Zhang Fan fan Lu Tianyang Xue Xin Li Lu Zhang Dong Mao Ligang Huang Feng Gao Ting Mei Jianlin Zhao | 2019 | Photonics Research2019，7，5： | 3 |
| 9 | Azimuthal vector beam exciting silver triangular nanoprisms for increasing the performance of surface-enhanced Raman spectroscopy显示文摘Surface-enhanced Raman spectroscopy(SERS)with high-sensitivity performance is a very necessary detection technology.Here,we present a method for increasing the performance of SERS based on silver triangular nanoprism arrays(ATNAs)vertically excited via a focused azimuthal vector beam(AVB).The ATNA substrates with different structural parameters are prepared based on the traditional self-assembled and modified film lift-off technique.Based on a theoretical model established adopting the structural parameters of the ATNA substrates,theoretical simulation results show that AVB excitation can achieve greater electric-field enhancement than linearly polarized beam(LPB)excitation.Experimental result indicates that SERS sensitivity obtained via AVB excitation is 10^-13M(1 M=1 mol/L)using rhodamine 6 G(R6 G)as the target analyte,which is 2 orders of magnitude lower than that of LPB excitation(10^-11M).Meanwhile,the uniformity and reproducibility of the ATNA substrates are examined using Raman mapping and batch-to-batch measurement,respectively,and the Raman enhancement factor is calculated to be^3.3×10^7.This method of vector light field excitation may be used to improve the SERS performance of the substrates in fields of ultra-sensitive Raman detection. | LU ZHANG WENDING ZHANG FANFAN LU ZHIQIANG YANG TIANYANG XUE MIN LIU CHAO MENG PENG LI DONG MAO TING MEI JIANLIN ZHAO | 2019 | Photonics Research2019，7，12： | 3 |
| 10 | Identification of New Resistance Loci Against Sheath Blight Disease in Rice Through Genome-Wide Association Study显示文摘Sheath blight(SB) caused by the soil borne pathogen Rhizoctonia solani is one of the most serious global rice diseases. Breeding resistant cultivar is the most economical and effective strategy to control the disease. However, no rice varieties are completely resistant to SB, and only a few reliable quantitative trait loci(QTLs) linked with SB resistance have been identified to date. In this study, we conducted a genome-wide association study(GWAS) of SB resistance using 299 varieties from the rice diversity panel 1(RDP1) that were genotyped using 44 000 high-density single nucleotide polymorphism(SNP) markers. Through artificial inoculation, we found that only 36.5% of the tested varieties displayed resistance or moderate resistance to SB. In particular, the aromatic and aus sub-populations displayed higher SB resistance than the tropical japonica(TRJ), indica and temperate japonica sub-populations. Seven varieties showed similar resistance levels to the resistant control YSBR1. GWAS identified at least 11 SNP loci significantly associated with SB resistance in the three independent trials, leading to the identification of two reliable QTLs, qSB-3 and qSB-6, on chromosomes 3 and 6. Using favorable alleles or haplotypes of significantly associated SNP loci, we estimated that both QTLs had obvious effects on reducing SB disease severity and can be used for enhancing SB resistance, especially in improving SB resistance of TRJ sub-population rice varieties. These results provided important information and genetic materials for developing SB resistant varieties through breeding. | CHEN Zongxiang FENG Zhiming KANG Houxiang ZHAO Jianhua CHEN Tianxiao LI Qianqian GONG Hongbing ZHANG Yafang CHEN Xijun PAN Xuebiao LIU Wende WANG Guoliang ZUO Shimin | 2019 | Rice science2019，26，1： | 3 |
| 11 | Defect Engineering of Carbons for Energy Conversion and Storage Applications显示文摘Sustainable energy conversion and storage technologies are a vital prerequisite for neutral future carbon.To this end,carbon materials with attractive features,such as tunable pore architecture,good electrical conductivity,outstanding physicochemical stability,abundant resource,and low cost,have used as promising electrode materials for energy conversion and storage.Defect engineering could modulate the structures of carbon materials,thereby affecting their electronic properties.The presence of defects on carbons may lead to asymmetric charge distribution,change in geometrical configuration,and distortion of the electronic structure that may result in unexpected electrochemical performances.In this review,recent advances in defects of carbons used for energy conversion and storage were examined in terms of types,regulation strategies,and fine characterization means of defects.The applications of such carbons in supercapacitors,rechargeable batteries,and electrocatalysis were also discussed.The perspectives toward the development of defect engineering carbons were proposed.In all,novel insights related to improvement in high-performance carbon materials for future energy conversion and storage applications were provided. | Xianyou Luo Heng Zheng Wende Lai Ping Yuan Shengwei Li De Li Yong Chen | 2023 | Energy & Environmental Materials2023，6，3： | 2 |
| 12 | Protein characteristics of Chinese black-grained wheat显示文摘 | Wende Li Trust Beta Shancheng Sun Harold Corke | 2005 | Food Chemistry2005，，3： | 1 |
| 13 | Spotlight on Shanxi very mature vinegar显示文摘 | Shan Fang Wang Lixia Li Wende | 2005 | Agricultural Science & Technology2005，6，2： | 1 |
| 14 | Weakened interlayer coupling in two-dimensional MoSe2 flakes with screw dislocations显示文摘The screw dislocations are intriguing defects that are often observed in natural and artificial materials. The dislocation spirals break the reflection and inversion symmetries of the lattices and modify the interlayer coupling in layer-structured materials, inducing additional complexity in layer stacking and thus novel properties in materials. Here, we report on the interlayer coupling of two-dimensional (2D) MoSe2 flakes with screw dislocations by atomic force microscopy (AFM), Raman spectra and photoluminescence (PL) spectra. By controlling the supersaturation conditions, 2D MoSe2 flakes with screw dislocations are grown on amorphous SiO2 substrates by chemical vapor deposition (CVD). AFM measurements reveal that the interlayer spacing in such 2D MoSe2 flakes with screw dislocation is slightly widened with respect to the normal AA- or AB-stacked ones due to the presence of the screw dislocations. Raman and PL spectra show that the interlayer coupling is weaker and thus the band gap is wider than that in the normal AA- or AB-stacked ones. Our work demonstrates that the interlayer coupling of 2D transition metal dichalcogenides (TMDCs) flakes can be tuned by the induction of screw dislocations, which is very helpful for developing novel catalysts and electronic devices. | Xiangzhuo Wang Huixia Yang Rong Yang Qinsheng Wang Jingchuan Zheng Lu Qiao Xianglin Peng Yongkai Li Dongyun Chen Xiaolu Xiong Junxi Duan Guangyu Zhang Jie Ma Junfeng Han Wende Xiao Yugui Yao | 2019 | Nano Research2019，12，8： | 1 |
| 15 | Genistein Inhibit Cytokines or Growth Factor-Induced Proliferation and Transformation Phenotype in Fibroblast-Like Synoviocytes of Rheumatoid Arthritis显示文摘 | Yujun Zhang Jianqiang Dong Peiying He Wende Li Qi Zhang Na Li Tiezheng Sun | 2012 | Inflammation2012，，1： | 1 |
| 16 | Kinetics of hydrolysis and changes in amylose content during preparation of microcrystalline starch from high-amylose maize starches 显示文摘 | Wende Li Harold corke Trust Beta | 2007 | Carbohydrate Polymers2007，，69： | 1 |
| 17 | Kinetics of hetero- geneous oxidation of concentrated ammonium sulfite 显示文摘 | Jinghong Zhou Wei Li Wende Xiao | 2000 | Chem Eng Sci2000，，55： | 1 |
| 18 | Physicochemical properties of common and tartary buckwheat starch显示文摘 | Li Wende Lin Rufa Corke H | 1997 | Cereal Chem- istry1997，74，1： | 1 |
| 19 | A pure quantum mechanical theory of parity effect in tunneling and evolution of spins显示文摘 | Bozang Li Jianhua Wu Wending Zhong Fucho Pu | 1998 | Science in China Series A: Mathematics1998，，3： | 1 |
| 20 | A nonhuman primate model of Alzheimer’s disease generated by intracranial injection of amyloid-beta42 and thiorphan显示文摘 | Wende Li Yu’e Wu Fangui Min Zhuo Li Jiayuan Huang Ren Huang | 2010 | Metabolic Brain Disease2010，，3： | 1 |
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