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| 1 | Colonoscopy surveillance for high risk polyps does not always prevent colorectal cancer显示文摘AIM To determine the frequency and risk factors for colorectal cancer(CRC) development among individuals with resected advanced adenoma(AA)/traditional serrated adenoma(TSA)/advanced sessile serrated adenoma(ASSA). METHODS Data was collected from medical records of 14663 subjects found to have AA, TSA, or ASSA at screening or surveillance colonoscopy. Patients with inflammatory bowel disease or known genetic predisposition for CRC were excluded from the study. Factors associated with CRC developing after endoscopic management of high risk polyps were calculated in 4610 such patients who had at least one surveillance colonoscopy within 10 years following the original polypectomy of the incident advanced polyp. RESULTS84/4610(1.8%) patients developed CRC at the polypectomy site within a median of 4.2 years(mean 4.89 years), and 1.2%(54/4610) developed CRC in a region distinct from the AA/TSA/ASSA resection site within a median of 5.1 years(mean 6.67 years). Approximately, 30%(25/84) of patients who developed CRC at the AA/TSA/ASSA site and 27.8%(15/54) of patients who developed CRC at another site had colonoscopy at recommended surveillance intervals. Increasing age; polyp size; male sex; right-sided location; high degree of dysplasia; higher number of polyps resected; and piecemeal removal were associated with an increased risk for CRC developmentat the same site as the index polyp. Increasing age; right-sided location; higher number of polyps resected and sessile endoscopic appearance of the index AA/TSA/ASSA were significantly associated with an increased risk for CRC development at a different site. CONCLUSION Recognition that CRC may develop following AA/TSA/ASSA removal is one step toward improving our practice efficiency and preventing a portion of CRC related morbidity and mortality. | Mohamad A Mouchli Lidia Ouk Marianne R Scheitel Alisha P Chaudhry Donna Felmlee-Devine Diane E Grill Shahrooz Rashtak Panwen Wang Junwen Wang Rajeev Chaudhry Thomas C Smyrk Ann L Oberg Brooke R Druliner Lisa A Boardman | 2018 | World Journal of Gastroenterology2018，24，8： | 5 |
| 2 | Staining for p53 and Ki-67 increases the sensitivity of EUS-FNA to detect pancreatic malignancy显示文摘AIM:To investigate whether tumor marker staining can improve the sensitivity of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)to diagnose pancreatic malignancy. METHODS:Patients who underwent EUS-FNA were retrospectively identified.Each EUS-FNA specimen was evaluated by routine cytology and stained for tumor markers p53,Ki-67,carcinoembryonic antigen(CEA) and CA19-9.Sensitivity,specificity,positive and negative predictive values(PPV and NPV),and positive and negative likelihood ratios(PLR and NLR)were calculated in order to evaluate the performance of each test to detect malignancy. RESULTS:Sixty-one specimens had complete sets of stains,yielding 49 and 12 specimens from pancreatic adenocarcinomas and benign pancreatic lesions due to pancreatitis,respectively.Cytology alone had sensitivity and specificity of 41%and 100%to detect malignancy, respectively.In 46%of the specimens,routine cytology alone was deemed indeterminate.The addition of either p53 or Ki-67 increased the sensitivity to 51%and 53%,respectively,with perfect specificity,PPV and PLR (100%,100%and infinite).Both stains in combination increased the sensitivity to 57%.While additional staining with CEA and CA19-9 further increased the sensitivity to 86%,the specificity,PPV and PLR were significantly reduced(at minimum 42%,84%and 1,respectively).Markers in all combinations performed poorly as a negative test(NPV 26%to 47%,and NLR 0.27 and 0.70).CONCLUSION:Immunohistochemical staining for p53 and Ki-67 can improve the sensitivity of EUS-FNA to diagnose pancreatic adenocarcinoma. | Alexander W Jahng Sonya Reicher David Chung Donna Varela Rahul Chhablani Anil Dev Binh Pham Jose Nieto Rose J Venegas Samuel W French Bruce E Stabile Viktor E Eysselein | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，11： | 3 |
| 3 | Neuropsychological assessment of learning and memory显示文摘 | Donna E Kalyna Z Buter J | 2003 | Jclin psychinatry2003，64，： | 1 |
| 4 | CDC2/CDK1 Expression in Esophageal Adenocarcinoma and Precursor Lesions Serves as a Diagnostic and Cancer Progression Marker and Potential Novel Drug Target显示文摘 | Donna E Hansel Surajit Dhara RuChih C Huang Raheela Ashfaq Mari Deasel Yutaka Shimada Harold S Bernstein John Harmon Malcolm Brock Arlene Forastiere M Kay Washington Anirban Maitra Elizabeth Montgomery | 2005 | The American Journal of Surgical Pathology2005，，3： | 1 |
| 5 | Silica aerogels with enhanced durability, 30-nm mean pore-size, and improved immersibility in liquids 显示文摘 | Erik M L Michael S D Donna M E | 2004 | Non-CrystaUine Solids2004，350，： | 1 |
| 6 | Do we have a knowledge transfer and translation plan at Teratogen Information Services显示文摘 | Adrienne E Donna L | | 0，，22： | 1 |
| 7 | Mutations in filamin 1 Prevent Migration of Cerebral Cortical Neurons in Human Periventricular Heterotopia显示文摘 | Jeremy W Fox Edward D Lamperti Yaman Z Ek?io?lu Susan E Hong Yuanyi Feng Donna A Graham Ingrid E Scheffer William B Dobyns Betsy A Hirsch Rodney A Radtke Samuel F Berkovic Peter R Huttenlocher Christopher A Walsh | 1998 | Neuron1998，，6： | 1 |
| 8 | Gender Differences in Depression and Chronic Pain Conditions in a National Epidemiologic Survey显示文摘 | Sarah EP Munce Donna E Stewart | 2007 | Psychosomatics2007，48，： | 1 |
| 9 | Foregut duplication cyst of the stomach 显示文摘 | Steven C Cunningham Donna E | 2006 | J Gastrointest Surg2006，10，4： | 1 |
| 10 | Survival and self-renewing capacity of breast cancer initiating cells during fractionated radiation treatment显示文摘 | Lagadec C Vlashi E Della Donna L | 2010 | Breast Cancer Res2010，12，1： | 1 |
| 11 | Characterization of Cryptosporidium meleagridis of human origin passaged through different host species显示文摘 | DONNA E AKIYOSHI D | 2003 | Infection and Immunity2003，71，： | 1 |
| 12 | Radiation-induced re- programming of breast cancer cells 显示文摘 | Lagadec C Vlashi E Della Donna L | 2012 | Stem Ceils2012，30，5： | 1 |
| 13 | Radiation-in-duced reprogramming of breast cancer cells显示文摘 | Lagadec C Vlashi E Della Donna L | | 0，，05： | 1 |
| 14 | Airway remodeling in asthma:new insight 显示文摘 | Donna E Davies PHD James W | 2003 | J Allergy Clin Immunol2003，111，： | 1 |
| 15 | Obliteration of femoral arterypseu- doaneurysm by thrombininjection 显示文摘 | James E David M Donna N | 2002 | The Annals of Thoracic Surgery2002，74，4： | 1 |
| 16 | How to not-for-profit SMEs attempt to develop a strong brand in an increasingly saturated market显示文摘 | Hina K and Donna E | 2009 | Journal of small business and Enterprise Development2009，16，2： | 1 |
| 17 | How do not for-profit SMEs attempt to develop a strong brand in an increasingly saturated market? 显示文摘 | Hina K and Donna E | 2009 | Journal of Small Business and Enterprise Development2009，16，2： | 1 |
| 18 | Ganglioneuroma of the adrenal gland 显示文摘 | Daniela S A Donna E H | 2009 | J Urology2009，，182： | 1 |
| 19 | Characterization of Cryptosporidiurn meleagridis of human origin passaged through different host species显示文摘 | Donna E Akiyoshi J uliaDilo | 2003 | Infect Immunity2003，71，4： | 1 |
| 20 | Isolation and in vitro differentiation of conditionally immortalized murine olfactory receptor neurons显示文摘 | Robert D Barber Donna E | 2000 | J Neurosci2000，20，10： | 1 |
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