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| 1 | Waist Circumference Reference Values for Screening Cardiovascular Risk Factors in Chinese Children and Adolescents显示文摘Objectives To explore the optimal threshold values of waist circumference(WC)for detecting cardiovascular(CV)risk factors among Chinese children and adolescents.Methods Association of WC with CV risk factors was studied among 65 898 children aged 7-18 years whose data were pooled from nine previous studies in China.CV risk factors in this study included hypertension(blood pressure above 95 percentile levels),dyslipidemia(with one or more of the following three indexes:TG≥1.7 mmol/L,TC≥5.18 mmol/L,and HDL-C≤1.04 mmol/L)and elevated glucose level(fasting plasma glucose ≥5.6 mmol/L).Receive-operating characteristic analysis(ROC)and logistic regression were employed to derive optimal age-and sex-specific waist circumference references for predicting CV risk factors.Results A slight increasing trend of CV risk factors was observed starting from the 75th percentile of waist circumference in the study population,while a remarkable increasing trend occurred from the 90th percentile.The optimal waist circumference thresholds for predicting high blood pressures were at the 75th percentile for both boys and girls,which was at the 90th percentiles for detecting at least two of the above three CV risk factors.In comparison with children with waist circumference below the 75th percentile,the odds ratio of two CV risk factors doubled among children with waist circumference between the 75th and the 90th percentile,and increased by 6 times among children with waist circumference above the 90th percentile.The trend of high blood pressure increasing with waist circumference remained significant after having been stratified by BMI category.Conclusion The 75th and the 90th percentiles of WC are the optimal cut-off points for predicting an increased and a substantially increased risk of CV factors in Chinese children and adolescents,respectively. | GUAN-SHENG MA CHENG-YE JI JUN MA JIE MI R1TA YT SLING FENG XIONG WEI-LI YAN XIAO-QI HU YAN-PING LI SONG-M1NG DU HONG-YUN FANG AND J1NG-XIONG JIANG | 2010 | Biomedical and Environmental Sciences2010，23，1： | 25 |
| 2 | Metastasis-associated protein 1 induces VEGF-C and facilitates lymphangiogenesis in colorectal cancer显示文摘AIM:To study the correlation between high metastasisassociated protein 1(MTA1)expression and lymphangiogenesis in colorectal cancer(CRC)and its role in production of vascular endothelial growth factor-C(VEGF-C). METHODS:Impact of high MTA1 and VEGF-C expression levels on disease progression and lymphovasculardensity(LVD,D2-40-immunolabeled)in 81 cases of human CRC was evaluated by immunohistochemistry. VEGF-C mRNA and protein expressions in human LoVo and HCT116 cell lines were detected by real-time polymerase chain reaction and Western blotting,respectively,with a stable expression vector or siRNA. RESULTS:The elevated MTA1 and VEGF-C expression levels were correlated with lymph node metastasis and Dukes stages(P<0.05).Additionally,high MTA1 expression level was correlated with a large tumor size(P< 0.05).A significant correlation was found between MTA1 and VEGF-C protein expressions in tumor cells(r=0.371, P<0.05).Similar to the VEGF-C expression level,high MTA1 expression level was correlated with high LVD in CRC(P<0.05).Furthermore,over-expression of MTA1 significantly enhanced the VEGF-C mRNA and protein expression levels,whereas siRNAs-knocked down MTA1 decreased the VEGF-C expression level. CONCLUSION:MTA1,as a regulator of tumor-associated lymphangiogenesis,promotes lymphangiogenesis in CRC by mediating the VEGF-C expression. | Bin Du Zhen-Yu Yang Xue-Yun Zhon Mao Fang Yong-Rong Yan Guo-Long Qi Yun-Long Pan Xu-Long Zhou | 2011 | World Journal of Gastroenterology2011，17，9： | 23 |
| 3 | Climate and litter C/N ratio constrain soil organic carbon accumulation显示文摘Soil organic carbon(SOC) plays critical roles in stabilizing atmospheric CO2 concentration, but the mechanistic controls on the amount and distribution of SOC on global scales are not well understood. In turn, this has hampered the ability to model global C budgets and to find measures to mitigate climate change. Here, based on the data from a large field survey campaign with 2600 plots across China’s forest ecosystems and a global collection of published data from forested land, we find that a low litter carbon-to-nitrogen ratio(C/N) and high wetness index(P/PET, precipitation-to-potentialevapotranspiration ratio) are the two factors that promote SOC accumulation, with only minor contributions of litter quantity and soil texture. The field survey data demonstrated that high plant diversity decreased litter C/N and thus indirectly promoted SOC accumulation by increasing the litter quality. We conclude that any changes in plant-community composition, plant-species richness and environmental factors that can reduce the litter C/N ratio, or climatic changes that increase wetness index, may promote SOC accumulation. The study provides a guideline for modeling the carbon cycle of various ecosystem scales and formulates the principle for land-based actions for mitigating the rising atmospheric CO2 concentration. | Guoyi Zhou Shan Xu Philippe Ciais Stefano Manzoni Jingyun Fang Guirui Yu Xuli Tang Ping Zhou Wantong Wang Junhua Yan Gengxu Wang Keping Ma Shenggong Li Sheng Du Shijie Han Youxin Ma Deqiang Zhang Juxiu Liu Shizhong Liu Guowei Chu Qianmei Zhang Yuelin Li Wenjuan Huang Hai Ren Xiankai Lu Xiuzhi Chen | 2019 | National Science Review2019，6，4： | 21 |
| 4 | Sensitive assay for measurement of volatile borneol, isoborneol, and the metabolite camphor in rat pharmacokinetic study of Borneolum (Bingpian) and Borneolum syntheticum (synthetic Bingpian)显示文摘 | Chen CHENG Xin-wei LIU Fei-fei DU Mei-juan LI Fang XU Feng-qing WANG Yang LIU Chuan LI Yan SUN | 2013 | Acta Pharmacologica Sinica2013，34，10： | 15 |
| 5 | Pharmacokinetics and disposition of monoterpene glycosides derived from Paeonia lactiflora roots (Chishao) after intravenous dosing of antiseptic XueBiJing injection in human subjects and rats显示文摘瞄准:从 Paeonia lactiflora 根(Chishao ) 导出的 Monoterpene glycosides 被相信为防腐草药的注射 XueBiJing pharmacologically 重要。这研究被设计描绘 monoterpene glycosides.Methods 的 pharmacokinetics 和布置:到 Chishao monoterpene glycosides 的全身的暴露在收到静脉内的注入和 XueBiJing 注射的多重注入的人的题目被估计,由对主要传播混合物的 pharmacokinetics 的评价列在后面。支持的老鼠研究也被执行。膜渗透和血浆蛋白质绑定在 vitro.Results 被估计:18 monoterpene glycosides 的一个总数在 XueBiJing 注射被检测(内容层次, 0.001-2.47 mmol/L ) ,并且 paeoniflorin 说明了检测的 monoterpene glycosides 的 85.5% 全部的剂量。在人的题目,未改变的 paeoniflorin 与 1.2-1.3 h 的消除一半生活展出了全身的暴露的可观的层次;没有重要代谢物被检测。Oxypaeoniflorin 和 albiflorin 展出了低暴露层次,并且留下的次要的 monoterpene glycosides 可以忽略或未被发现。Glomerular-filtration-based 肾的排泄是 paeoniflorin 的主要消除小径,它血浆蛋白质糟糕一定。在老鼠,当剂量被增加, paeoniflorin 的全身的暴露水平按比例增加了。老鼠肺,心,和 paeoniflorin 的肝暴露层次比血浆水平低,与肾水平的例外,它是比血浆水平大的 4.3 褶层;大脑穿入被差的膜 permeability.Conclusion 限制:由于它的重要全身的暴露和适当 pharmacokinetic 侧面,以及以前报导了防腐性质, paeoniflorin 是治疗学的重要性的有希望的 XueBiJing 成分。 | Chen CHENG Jia-zhen LIN Li LI Jun-ling YANG Wei-wei JIA Yu-hong HUANG Fei-fei DU Feng-qing WANG Mei-juan LI Yan-fen LI Fang XU Na-ting ZHANG Olajide E. OLALEYE Yan SUN Jian LI Chang-hai SUN Gui-ping ZHANG Chuan LI | 2016 | Acta Pharmacologica Sinica2016，37，4： | 15 |
| 6 | Salvianolic acid A attenuates vascular remodeling in a pulmonary arterial hypertension rat model显示文摘瞄准:当前的治疗学的途径在 dysregulated 上有有限效果肺的脉管的改变,它肺的动脉的高血压是特征的(哼) 。在我们检验了 salvianolic 酸 A (SAA ) 是否从繁体中文药提取了的这研究,丹·沈稀释了在一个 PAH 老鼠模型的脉管的改变,并且阐明内在的 mechanisms.Methods:哼被注射 monocrotaline 的单个剂量在老鼠导致(MCT 60 mg/kg, sc ) 。老鼠口头上地与任何一个 SAA 被对待(0.3, 1, 3 mg· kg −1·d−1) 或积极控制 bosentan (30 mg·为 4 个星期的 kg −1·d−1) 。Echocardiography 和血液动力学的大小在 d 上被执行 28。然后,心和肺被收获,机关索引和肺的动脉墙厚度被计算,并且生物化学、组织化学的分析被进行。在肺的 apoptotic 和发信号的蛋白质的层次用 immunoblotting.Results 被测量:有 SAA 或 bosentan 的处理有效地改善了改变的导致 MCT 的肺的动脉,肺的血液动力学的畸形和恰好室的收缩压力(RVSP ) 的随后的增加。而且,处理显著地在肺稀释了心肌层, parenchymal 损害和骨胶原免职的导致 MCT 的 hypertrophic 损坏。而且,处理在肺稀释了导致 MCT 的 apoptosis 和纤维变性。处理部分恢复了骨头的导致 MCT 的减小形态基因的蛋白质类型 II 受体(BMPRII ) 和在 lungs.Conclusion 的 phosphorylated Smad1/5:SAA 改善肺的动脉的改变在导致 MCT 哼经由激活 BMPRII-Smad 小径并且禁止 apoptosis 最可能的老鼠。因此, SAA 可以在高风险为病人有治疗学的潜力哼。 | Yu-cai CHEN Tian-yi YUAN Hui-fang ZHANG Dan-shu WANG Yu YAN Zi-ran NIU Yi-huang LIN Lian-hua FANG Guan-hua DU | 2016 | Acta Pharmacologica Sinica2016，37，6： | 13 |
| 7 | Serum Uric Acid is Associated with the Predicted Risk of Prevalent Cardiovascular Disease in a Community-dwelling Population without Diabetes显示文摘Objective To examine the association between serum uric acid levels and cardiovascular disease risk among individuals without diabetes. Methods We investigated the association between serum uric acid levels and the risk of prevalent cardiometabolic diseases, 10-year Framingham risk for coronary heart disease, and 10-year risk for atherosclerotic cardiovascular diseases(ASCVD) among 8,252 participants aged ≥ 40 years without diabetes from Jiading district, Shanghai, China. Results Body mass index, waist circumference, blood glucose, glycated hemoglobin, blood pressure, and serum lipids increased progressively across the sex-specific quartiles of uric acid(all P trend < 0.05). Compared with individuals in the lowest quartile, those in the higher quartiles had a significantly higher prevalence of obesity, hypertension, and dyslipidemia(all P trend < 0.05). A fully adjusted logistic regression analysis revealed that individuals in the highest quartile had an increased risk of predicted cardiovascular disease compared with those in the lowest quartile of uric acid. The multivariate adjusted odds ratios(ORs) [95% confidence intervals(CIs)] for the highest quartiles for high Framingham risk were 3.00(2.00-4.50) in men and 2.95(1.08-8.43) in women. The multivariate adjusted ORs(95% CIs) for the highest quartile for high ASCVD risk were 1.93(1.17-3.17) in men and 4.53(2.57-7.98) in women. Conclusion Serum uric acid level is associated with an increased risk of prevalent obesity, hypertension, dyslipidemia, 10-year Framingham risk for coronary heart disease, and 10-year risk for ASCVD among Chinese adults without diabetes. | CHENG Di DU Rui WU Xue Yan LIN Lin PENG Kui MA Li Na XU Yu XU Min CHEN Yu Hong BI Yu Fang WANG Wei Qing DAI Meng LU Jie Li | 2018 | Biomedical and Environmental Sciences2018，31，2： | 13 |
| 8 | Salvianolic acid A alleviates renal injury in systemic lupus erythematosus induced by pristane in BALB/c mice显示文摘The purpose of this study was to investigate the effects of salvianolic acid A(SAA) in systemic lupus erythematosus(SLE) induced by pristane in BALB/c mice.Lupus mice were established by confirming elevated levels of autoantibodies and IL-6 after intraperitoneal injection of pristane.Mice were then treated with daily oral doses of SAA for 5 months in parallel with mice treated with prednisone and aspirin as positive controls.The levels of autoantibodies were monitored at monthly intervals and nephritic symptoms observed by hematoxylin and eosin(H&E) and periodic acid-Schiff(PAS) staining.Western blot analysis of renal tissue was also employed.SAA treatment caused a significant reduction in the levels of anti-Sm autoantibodies and reduced renal histopathological changes and pathological effects.SAA treatment also significantly inhibited the phosphorylation of IKK,IκB and NFκB in renal tissues of lupus mice.In conclusion,the results suggest that SAA alleviates renal injury in pristane-induced SLE in BALB/c mice through inhibition of phosphorylation of IKK,IκB and NFκB. | Yihuang Lin Yu Yan Huifang Zhang Yucai Chen Yangyang He Shoubao Wang Lianhua Fang Yang Lv Guanhua Du | 2017 | Acta Pharmaceutica Sinica B2017，7，2： | 8 |
| 9 | V4C3Tx MXene:A promising active substrate for reactive surface modification and the enhanced electrocatalytic oxygen evolution activity显示文摘Presented are the synthesis,characterizations,and reactive surface modification(RSM)of a novel nine atomic layered V4C3Tx MXene.With the advantages of the multilayered V4C3Tx MXene that can simultaneously support the RSM reaction and keep the inner skeleton stable,a series of amorphous Ni/Fe/Vternary oxide hydroxides thin layer can be successfully modified on the surface of the V4C3Tx MXene(denoted as MOOH@V4C3Tx,M=Ni,Fe,and V)without disrupting its original structure.Attributed to the in situ reconstruction of highly active oxide hydroxide layer,the nanohybrids exhibited an enhanced oxygen evolution reaction(OER)activity and excellent long-time stability over 70 hours.In particular,a current density of 10 mA cm−2 can be reached by the nanohybrid with the optimized Ni/Fe ratio at an overpotential(η)as low as 275.2 mV,which is comparable to most of the state-of-the-art OER catalysts and better than other MXene-based derivatives.Demonstrated by the tunable physicochemical properties and excellent structural stability of these nanohybrids,we may envision the promising role of the M4X3-based MXenes as substrates for a wide range of energy conversion and storage materials. | Cheng-Feng Du Xiaoli Sun Hong Yu Wei Fang Yao Jing Yonghui Wang Shuiqing Li Xianhu Liu Qingyu Yan | 2020 | InfoMat2020，2，5： | 8 |
| 10 | Methylation and its role in the disposition of tanshinol, a cardiovascular carboxylic catechol from Salvia miltiorrhiza roots (Danshen)显示文摘 | Dan-dan TIAN Wei-wei JIA Xin-wei LIU Dan-dan WANG Jun-hua LIU Jia-jia DONG Li LI Fei-fei DU Fang XU Feng-qing WANG Yan SUN Yu-xing HUANG Mei-juan LI Li-hong HU Yan ZHU Xiu-mei GAO Chuan LI Jun-ling YANG | 2015 | Acta Pharmacologica Sinica2015，36，5： | 7 |
| 11 | Molecular Characterization and Correlation with β-lactam Resistance of Streptococcus pneumonia Isolates in Hangzhou,China显示文摘Penicillin-binding proteins(PBPs) are the target of β-lactam antibiotics(the major treatment for Streptococcus pneumoniae infections),and mutations in PBPs are considered as a primary mechanism for the development of β-lactam resistance in S.pneumoniae.This study was conducted to investigate the mutations in the PBPs of clinical S.pneumoniae isolates in Hangzhou,China,in correlation with β-lactam resistance.Results showed that 19 F was the predominant serotype(7/27) and 14 of the S.pneumoniae isolates were resistant to both penicillin G and cephalosporin.Genotyping results suggested that β-lactam-resistant isolates primarily exhibited single-site mutations in both the STMK and SRNVP motifs of pbp1 a in combination with double-site mutations in the STMK motif of pbp2 x,which might be the primary mechanisms underlying the β-lactam resistance of the isolates in this study. | chu mei fen liu xiao xiang zhang shao ni huang yan ying du peng wang li fang ji lei yan jie sun ai hua | 2018 | Biomedical and Environmental Sciences2018，31，5： | 7 |
| 12 | Family-level leaf nitrogen and phosphorus stoichiometry of global terrestrial plants显示文摘Leaf nitrogen(N) and phosphorus(P) concentrations are critical for photosynthesis, growth, reproduction and other ecological processes of plants. Previous studies on large-scale biogeographic patterns of leaf N and P stoichiometric relationships were mostly conducted using data pooled across taxa, while family/genus-level analyses are rarely reported. Here, we examined global patterns of family-specific leaf N and P stoichiometry using a global data set of 12,716 paired leaf N and P records which includes 204 families, 1,305 genera, and 3,420 species. After determining the minimum size of samples(i.e., 35 records), we analyzed leaf N and P concentrations, N:P ratios and N^P scaling relationships of plants for 62 families with 11,440 records. The numeric values of leaf N and P stoichiometry varied significantly across families and showed diverse trends along gradients of mean annual temperature(MAT) and mean annual precipitation(MAP). The leaf N and P concentrations and N:P ratios of 62 families ranged from 6.11 to 30.30 mg g–1, 0.27 to 2.17 mg g–1, and 10.20 to 35.40, respectively. Approximately 1/3–1/2 of the families(22–35 of 62) showed a decrease in leaf N and P concentrations and N:P ratios with increasing MAT or MAP, while the remainder either did not show a significant trend or presented the opposite pattern. Family-specific leaf N^P scaling exponents did not converge to a certain empirical value, with a range of 0.307–0.991 for 54 out of 62 families which indicated a significant N^P scaling relationship. Our results for the first time revealed large variation in the family-level leaf N and P stoichiometry of global terrestrial plants and that the stoichiometric relationships for at least one-third of the families were not consistent with the global trends reported previously. The numeric values of the family-specific leaf N and P stoichiometry documented in the current study provide critical synthetic parameters for biogeographic modeling and for further studies on the physiological and ecological mechanisms underlying the nutrient use strategies of plants from different phylogenetic taxa. | Di Tian Zhengbing Yan Suhui Ma Yuehong Ding Yongkai Luo Yahan Chen Enzai Du Wenxuan Han Emoke Dalma Kovacs Haihua Shen Huifeng Hu Jens Kattge Bernhard Schmid Jingyun Fang | 2019 | Science China(Life Sciences)2019，62，8： | 7 |
| 13 | Spatial and Seasonal Variations of Heavy Metals in Wetland Soils of the Tidal Flats in the Yangtze Estuary, China: Environmental Implications显示文摘The environment of estuarine wetlands has been attracting worldwide attention. To study the spatial distribution of pollutants in the tidal flats of the Yangtze Estuary, Southeast China, the Eastern Tidal Flat of Chongming Island (EC) and the Jiuduansha Shoal (JS) of the estuary were selected as the study sites. At each of the two sites, a cross-transect from land to sea was established and topsoil and soil core samples in the cross-transect were collected spatially and seasonally to determine their contents of heavy metals (Cu, Zn, Pb, Cd, Cr, Ni, Mn, and Fe) and grain-size characteristics. The results showed that the heavy metal loads were commonly higher in the soils of nearshore high tidal flats and had a tendency of decreasing from land to sea at both of the study sites. The contents of heavy metals in the soils of the high and medial tidal flats were mostly higher in April and November but lower in July. Corresponding spatial and seasonal variations in grain size of the intertidal soils were also observed at the two study sites. The soils in the nearshore high tidal flats were finer and gradually got coarser seawards; they were relatively finer in April and November but coarser in July. Furthermore, the contents of heavy metals in the intertidal soils of both the sites EC and JS were significantly positively correlated with the clay (<2 μm) and 2-20 μm fractions, but negatively with the sand (>63 μm) and 20-63 μm fractions, which suggested that the heavy metals in the intertidal soils were primarily combined with the fine particulate fraction (<20 μm), especially clay, and hence the spatial and seasonal variations in heavy metals were actually caused by the change of the grain-size characteristics of the intertidal soils due to the different sedimentary environments in the estuary. The results of this study may also contribute to a better understanding of the soil formation and classification in the tidal flats of the Yangtze Estuary. | HU Xue-Feng DU Yan FENG Jian-Wei FANG Sheng-Qiong GAO Xiao-Jiang XU Shi-Yuan | 2013 | Pedosphere2013，23，4： | 6 |
| 14 | Downregulation of CD4+CD25+ regulatory T cells may underlie enhanced Th1 immunity caused by immunization with activated autologous T cells显示文摘规章的 T 房间(Treg ) 在免疫系统动态平衡起重要作用,并且可以被压制涉及反肿瘤免疫的 Th1 免疫反应也涉及肿瘤免疫忍耐。我们以前报导了有稀释激活的自体同源的 T 房间的那免疫导致提高的反肿瘤免疫并且在调整 Th1 回答 invivo 上面。然而,内在的分子的机制很好没被理解。这里,我们证明 Tregfunction 是显著地, down 在老鼠调整了稀释激活的自体同源的 T 房间的那收到的免疫。我们发现那 Foxp3 表情从使免疫的老鼠在 CD4+CD25+ T 房间减少了。而且,从使免疫的老鼠获得的 CD4+CD25+Foxp3+ Treg 从天真的老鼠与那些相比展出了减少的免疫力的抑制能力。进一步的分析证明使免疫的鼠标的浆液包含 anti-CD25 抗体(大约 30 ng/ml, p<0.01 对控制) 的高水平。与在 Treg 的 down 规定的 anti-CD25 反应的一个角色一致,到天真的鼠标的从使免疫的鼠标的浆液的采纳转移在接受者鼠标在 Treg 人口和功能导致了重要减少。在使免疫的老鼠被触发 anti-CD25 反应能被 CD25 在激活的自体同源的 T 房间为免疫使用了的 ConA 被导致到高水平的事实解释。我们的结果第一次证明有稀释激活的自体同源的 T 房间的那免疫唤起 anti-CD25 抗体生产,它导致阻碍的 CD4+CD25+Foxp3+Treg 扩大和功能体内。我们建议那阻抑的 Treg 功能多半在使免疫的老鼠贡献提高的 Th1 反应并且是位于 boostedanti 肿瘤免疫下面的机制的至少部分。 | Qi Cao Li Wang Fang Du Huiming Sheng Yan Zhang Juanjuan Wu Baihua Shen TianweiShen Jingwu Zhang Dangsheng Li Ningli Li | 2007 | Cell Research2007，17，7： | 5 |
| 15 | Immunization with autologous T cells enhances in vivo anti-tumor immune responses accompanied by up-regulation of GADD45β显示文摘Immunization with inactivated autoreactive T cells may induce idiotype anti-idiotypic reactions to deplete autoreac-tire T cells,which are involved in autoimmune diseases.However,it is unknown whether attenuated activated healthyautologous T-cell immunization could increase anti-tumor immune responses.To this end,C57B1/6 mice were immunizedwith attenuated activated autologous T cells.The splenocytes from immunized mice showed a higher proliferative abil-ity than that from naive mice.The special phenotype analysis showed that there were more CDS+T cells and CD62L+T cells in immunized mice after 24 h of culture with 10% fetal calf serum complete medium in vitro(P<0.01).Theseresults demonstrated that this immunization may activate T cells in vivo.Furthermore,the splenocytes from immunizedmice revealed resistance to activation-induced cell death(AICD)in vitro.To further study the relative genes that areresponsible for the higher proliferation and resistance to AICD,the expression of Fas/Fas ligand(FasL)and GADD45βwas measured by real-time PCR.The results indicated that GADD45β transcription was higher in the splenocytes fromimmunized mice than that in the naive mice.In addition,the Fas expression showed a parallel higher,but FasL did notchange obviously.To investigate the biologic functions induced by immunization in vivo,a tumor model was establishedby EL-4 tumor cell inoculation in C57/B1 mice.Mice receiving autologous T-cell immunization had significantly inhibitedtumor growth in vivo(P<0.01).This study implicated that immunization with attenuated activated autologous T cellsenhances anti-tumor immune responses that participate in tumor growth inhibition. | Li Wang~(1,2,*) Fang Du~(1,2,*) Qi Cao~(1,2) Huiming Sheng~(1,2) Baihua Shen~(1,2) Yan Zhang~(1,2) Yingna Diao~(1,2) Jingwu Zhang~(1,2) Ningli Li~(1,2) ~1Shanghai diao Tong UniversiO,School of Medicine,280 Chongqing Road,Shanghai 200025,China ~2Shanghai Institute of Immunology,280 Chongqing Road,Shanghai 200025,China | 2006 | Cell Research2006，16，8： | 5 |
| 16 | Association between Lipoprotein(a) Levels and Metabolic Syndrome in a Middle-aged and Elderly Chinese Cohort显示文摘Objective The association between lipoprotein(a)[Lp(a)] levels and metabolic syndrome(MetS) remains uncertain, especially in the Asian population. The purpose of this study was to demonstrate the association between Lp(a) levels and MetS in a middle-aged and elderly Chinese cohort. Methods A cross-sectional study of 10,336 Chinese adults aged 40 years or older was conducted in Jiading District, Shanghai, China. Logistic regression analysis was used to evaluate the association between serum Lp(a) levels and MetS. Results In the overall population, 37.5% of participants had MetS. Compared with individuals in the lowest quartile of serum Lp(a) levels, those in the highest quartile had a lower prevalence of MetS(30.9% vs. 46.9%, P for trend < 0.0001). Multivariate logistic regression analyses showed that compared with participants in the bottom quartile of serum Lp(a) levels, those in the top quartile had decreased odds ratio(OR) for prevalent MetS [multivariate-adjusted OR 0.45(95% confidence interval 0.39-0.51);P < 0.0001]. Additionally, Lp(a) level was conversely associated with the risk of central obesity, high fasting glucose, high triglycerides, and low HDL cholesterol, but not with hypertension. Stratified analyses suggested that increasing levels of Lp(a) was associated with decreased risk of MetS in all the subgroups. Conclusion Serum Lp(a) level was inversely associated with the risk of prevalent MetS in a middle-aged and elderly Chinese cohort. | WU Xue Yan LIN Lin Qi Hong Yan DU Rui HU Chun Yan MA Li Na PENG Kui LI Mian XU Yu XU Min CHEN Yu Hong LU Jie Li BI Yu Fang WANG Wei Qing NING Guang | 2019 | Biomedical and Environmental Sciences2019，32，7： | 5 |
| 17 | King cobra peptide OH-CATH30 as a potential candidate drug through clinic drug-resistant isolates显示文摘Cationic antimicrobial peptides(AMPs) are considered as important candidate therapeutic agents, which exert potent microbicidal properties against bacteria, fungi and some viruses. Based on our previous findings king cobra cathelicidin(OH-CATH) is a 34-amino acid peptide that exerts strong antibacterial and weak hemolytic activity. The aim of this research is to evaluate the efficacy of both OH-CATH30 and its analog D-OH-CATH30 against clinical isolates comparing with routinely utilized antibiotics in vitro.In this study, 584 clinical isolates were tested(spanning 2013-2016) and the efficacy of the candidate peptides and antibiotics were determined by a broth microdilution method according to the CLSI guidelines. Among the 584 clinical isolates, 85% were susceptible to OH-CATH30 and its analogs. Both L-and D-OH-CATH30 showed higher efficacy against(toward) Gram-positive bacteria and stronger antibacterial activity against nearly all Gram-negative bacteria tested compare with antibiotics. The highest bactericidal activity was detected against Acinetobacter spp., including multi-drug-resistant Acinetobacter baumannii(MRAB)and methicillin-resistant Staphylococcus aureus(MRSA). The overall efficacy of OH-CATH30 and its analogs was higher than that of the 9 routinely used antibiotics. OH-CATH30 is a promising candidate drug for the treatment of a wide variety of bacterial infections which are resistant to many routinely used antimicrobial agents. | Feng Zhao Xin-Qiang Lan Yan Du Pei-Yi Chen Jiao Zhao Fang Zhao Wen-Hui Lee Yun Zhang | 2018 | Zoological Research2018，39，2： | 5 |
| 18 | Influence of Annealing on Properties of ZnO Films Grown via Plasma-enhanced MOCVD显示文摘The structural and the optical properties of ZnO films with high quality grown via plasma-enhanced metal\|organic chemical vapour deposition(MOCVD) on C-plane sapphire substrate were studied. The crystallinity and the optical properties of the films are greatly improved having been annealed in oxygen plasma atmosphere. The structure, the band gap and the binding energy of O 1s electrons, and the molar ratio of O to Zn were determined by X-ray diffraction(XRD), photoluminescence(PL) and X-ray photoelectron scan methods. For both the annealed and the as-grown films, the exciton peak features were observed at room temperature. The band-edge photoluminescence of the annealed film is much stronger than that of the as-grown film, and the exciton peak relating to the deep level at 439 nm disappears. The molar ratio of O to Zn in the annealed film is 0 91, while it is 0 78 for the as-grown film. | ZHAO Bai-jun, DU Guo-tong ** , YANG Hong-jun, WANG Jin-zhong ZHANG Yuan-tao, YANG Xiao-tian, LIU Bo-yang, MA Yan YANG Tian-peng, LIU Da-li, LI Wan-cheng and FANG Xiu-jun College of Electronics and Engineering, Jilin University, Changchun 130023, P. R. China | 2003 | Chemical Research in Chinese Universities2003，19，4： | 4 |
| 19 | Metal 2-Hydroxy-1-Naphthaldehyde Thiosemicarbazone (Me-HNT) Complexes-A New Kind of Biomimic Enzyme Catalyst显示文摘Metal (Me=Fe(III), Mo(VI), Mn(II), Co(II), Ni(II), Zn(II) and Cu(II)) 2-hydroxy-1 naphthaldehyde thiosemicarbazone complexes (MeHNT) were synthesized and used as mimic-enzyme catalysts to mimic the active group of horseradish peroxidase (HRP). The results showed that FeHNT. Mo-HNT are effective catalysts, which have similar catalytic activity as HRP. The sequence of catalytic activities of tested biomimic peroxidas is Mo-HNT> Fe-HNT > Zn-HNT > Ni-HNT > MnHNT. Among them. Fe-HNT is used as a mimic-enzyme catalyst in determination of ascorbic acid and glucose by coupling the catalytic reaction of glucose oxidase. | Ming DU Fang Zhen LIANG Bo TANG Yun Jing LUO Han Xi SHEN Bin TENG Yan LIU | 2000 | Chinese Chemical Letters2000，11，1： | 4 |
| 20 | Effect of berberine on hyperglycaemia and gut microbiota composition in type 2 diabetic Goto-Kakizaki rats显示文摘BACKGROUND A recent investigation showed that the prevalence of type 2 diabetes mellitus(T2DM)is 12.8%among individuals of Han ethnicity.Gut microbiota has been reported to play a central role in T2DM.Goto-Kakizaki(GK)rats show differences in gut microbiota compared to non-diabetic rats.Previous studies have indicated that berberine could be successfully used to manage T2DM.We sought to understand its hypoglycaemic effect and role in the regulation of the gut microbiota.AIM To determine whether berberine can regulate glucose metabolism in GK rats via the gut microbiota.METHODS GK rats were acclimatized for 1 wk.The GK rats were randomly divided into three groups and administered saline(Mo),metformin(Me),or berberine(Be).The observation time was 8 wk,and weight,fasting blood glucose(FBG),insulin,and glucagon-like peptide-1(GLP-1)were measured.Pancreatic tissue was observed for pathological changes.Additionally,we sequenced the 16S rRNA V3-V4 region of the gut microbiota and analysed the structure.RESULTS Compared with the Mo group,the Me and Be groups displayed significant differences in FBG(P<0.01)and GLP-1(P<0.05).A significant decrease in weight and homeostatic model assessment-insulin resistance was noted in the Be group compared with those in the Me group(P<0.01).The pancreatic islets of the Me-and Be-treated rats showed improvement in number,shape,and necrosis compared with those of Mo-treated rats.A total of 580 operational taxonomic units were obtained in the three groups.Compared to the Mo group,the Me and Be groups showed a shift in the structure of the gut microbiota.Correlation analysis indicated that FBG was strongly positively correlated with Clostridia_UCG-014(P<0.01)and negatively correlated with Allobaculum(P<0.01).Body weight showed a positive correlation with Desulfovibrionaceae(P<0.01)and a negative correlation with Akkermansia(P<0.01).Importantly,our results demonstrated that Me and Be could significantly decrease Bacteroidetes(P<0.01)and the Bacteroidetes/Firmicutes ratio(P<0.01).Furthermore,Muribaculaceae(P<0.01;P<0.05)was significantly decreased in the Me and Be groups,and Allobaculum(P<0.01)was significantly increased.CONCLUSION Berberine has a substantial effect in improving metabolic parameters and modulating the gut microbiota composition in T2DM rats. | Jin-Dong Zhao Yan Li Min Sun Chan-Juan Yu Jia-Yun Li Si-Hai Wang Di Yang Cheng-Lin Guo Xue Du Wen-Jin Zhang Ruo-Dong Cheng Xiao-Chuan Diao Zhao-Hui Fang | 2021 | World Journal of Gastroenterology2021，27，8： | 2 |
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