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| 1 | Synthesis of MoX2 (X =Se or S) monolayers with high-concentration 1T'phase on 4H/fcc-Au nanorods for hydrogen evolution显示文摘Controlled synthesis of transition metal dichalcogenide (TMD) monolayers with unusual crystal phases has attracted increasing attention due to their promising applications in electrocatalysis.However,the facile and large-scale preparation of TMD monolayers with high-concentration unusual crystal phase still remains a challenge.Herein,we report the synthesis of MoX2 (X =Se or S) monolayers with high-concentration semimetallic 1T'phase by using the 4H/face-centered cubic (fcc)-Au nanorod as template to form the 4H/fcc-Au@MoX2 nanocomposite.The concentrations of 1T'phase in the prepared MoSe2 and MoS2 monolayers are up to 86% and 81%,respectively.As a proof-of-concept application,the obtained Au@MoS2 nanocomposite is used for the electrocatalytic hydrogen evolution reaction (HER) in acid medium,exhibiting excellent performance with a low overpotential of 178 mV at the current density of 10 mNcm^2,a small Tafel slope of 43.3 mV/dec,and excellent HER stability.This work paves a way for direct synthesis of TMD monolayers with high-concentration of unusual crystal phase for the electrocatalytic application. | Zhengqing Liu Xiao Zhang Yue Gong Qipeng Lu Zhicheng Zhang Hongfei Cheng Qinglang Ma Junze Chen Meiting Zhao Bo Chen Ye Chen Xue-Jun Wu Pengfei Yin Lin Gu Yaping Du Hua Zhang | 2019 | Nano Research2019，12，6： | 3 |
| 2 | All in one theranostic nanoplatform enables efficient anti-tumor peptide I delivery for triple-modal imaging guided cancer therapy显示文摘Developing a reliable system to efficiently and safely deliver peptide drugs into tumor tissues still remains a great challenge since the instability of peptide drugs and low ability to traverse the cell membrane. Herein, we constructed a multifunctional nanoplatform based on porous europium/gadolinium (Eu/Gd)-doped NaLa(MoO4)2 nanoparticles (NLM NPs) to deliver antitumor peptide of B-cell lymphoma/leukemia-2-like protein 11 (BIM) for cancer therapy. The porous NLM NPs exhibited inherent photoluminescent, magnetic and X-ray absorbable properties, which enable them for triple-modal bioimaging, including fluorescence, magnetic resonance imaging (MRI) and computed tomography (CT). This triple-modal bioimaging can contribute to monitoring NLM NPs biodistribution and guiding therapy in vitro and in vivo. Furthermore, the NLM NPs showed negligible cytotoxicity in vitro and tissue toxicity in vivo. Importantly, NLM NPs could load the antitumor peptide of BIM and efficiently improve the resistance of peptide drugs to proteolysis. The BIM peptide was efficiently delivered into the tumor cells by NLM NPs, which can inhibit the growth and promote the apoptosis of cancer cells in vitro, significantly inhibit the tumor growth in vivo. Notably, NLM-BIM theranostic nanoplatform exhibits low systemic toxicity and fewer side effects in vivo. The NLM NPs can serve as a promising multifunctional peptide delivery nanoplatform for multi-modal bioimaging and cancer therapy. | Xiaoyan Qu Zhengqing Liu Bohan Ma Na Li Hongyang Zhao Tian Yang Yumeng Xue Xiaozhi Zhang Yongping Shao Ying Chang Jun Xu Bo Lei Yaping Du | 2019 | Nano Research2019，12，3： | 2 |
| 3 | Sulfur dioxide derivativesmodulation of high-threshold calcium currents in rat dorsal rootganglion neurons显示文摘 | DU Zhengqing MENG Ziqiang | 2006 | Neuroscience Letters2006，405，： | 1 |
| 4 | Visualization of the electrocatalytic activity of three- dimensional MoSe2@reduced graphene oxide hybrid nanostructures for oxygen reduction reaction显示文摘nanostructured 转变金属 dichalcogenides (TMD ) 的开发材料作为氧的新奇 electrocatalyst 候选人,减小反应(ORR ) 是新策略支持非宝贵的金属 ORR 催化剂的开发。在这个工作,一三维(3D ) 像玫瑰花蕾的 MoSe 2 nanostructures 的混血儿在减少的 graphene 上支持了氧化物(rGO ) nanosheets 成功地通过灵巧的热水的策略被综合。混合 nanostructure 显示出的准备 MoSe 2@rGO 与纯 MoSe 2, rGO ,和他们的简单物理混合的相比在碱的媒介为 ORR 提高了 electrocatalytic 活动,它能得益于 ultrathin MoSe 2层的富有地暴露的活跃的边地点的优秀的氧吸附能力,传导性和 rGO 站台的限制聚集的效果,以及唯一的 3D 混合材料的像玫瑰花蕾的建筑学。向 ORR 的 MoSe 2@rGO 混血儿的 electrocatalytic 活动比得上商业 Pt/C 催化剂的。并且支持的反应被揭示包含一将近,由获得的 Koutecky-Levich 的分析的 four-electron-dominated ORR 过程阴谋。扫描电气化学的显微镜学( SECM )技术与在一个单个实验与高空间的分辨率和不同催化剂的同时评估的活动样品的本地催化活动调查的优点,进一步被使用调查 MoSe 2@rGO 的本地 ORR electrocatalytic 活动并且通过使用不同样品潜力另外的催化剂样品把它与那些作比较。优秀稳定性和对甲醇的 3D nanostructured MoSe 2@rGO 混血儿的甲醇忍耐进一步在燃料房间和金属空气电池在潜在的应用程序的碱的答案作为有希望的 ORR electrocatalyst 证明 3D nanostructured MoSe 2@rGO 混合。 | Shuli Xin Zhengqing Liu Li Ma Yao Sun Chunhui Xiao Fei Li Yaping Du | 2016 | Nano Research2016，9，12： | 1 |
| 5 | Effects of SO_(2)derivatives on sodium currents in acutely isolated rat hippocampal lead-exposed neurons显示文摘In this study, the effects of acute SO_2 derivatives and chronic lead exposure together on sodium cur-rents (INa) were investigated in acutely isolated rat hippocampal neurons by using the whole-cell patch clamp techniques. We found that chronic lead exposure hardly reduced the amplitudes of INa. In the normal condition, sodium current started to appear at around ?70 mV, and reached the peak current at around ?40 mV. After chronic lead exposure, the data changed to ?70 and ?30 mV. After adding SO2 derivatives, the data changed to ?80 and ?40 mV, respectively. SO_2 derivatives caused a significant in-crease of INa in hippocampal chronic-lead exposed neurons. Chronic lead exposure induced a right shift of the activation curve and a left shift of the inactivation curve of sodium channels. SO_2 derivatives caused negative shifts of the activation and inactivation curves of INa in hippocampal chronic-lead ex-posed neurons. Lead exposure put off the time reaching the peak of INa activation. SO_2 derivatives in-creased the time constants of inactivation after lead exposure. The interaction of lead and SO_2 deriva-tives with voltage-dependent sodium channels may lead to changes in electrical activity and contribute to worsening the neurotoxicological damage. | DU ZhengQing Lü GuoPing | 2008 | Science China(Life Sciences)2008，51，9： | 1 |
| 6 | The effects of rises in external K^+ on the hyperpolarization-activated cation current I_h in rat dorsal root ganglion neurons显示文摘The effects of rises in external K+(Kext) were examined on the hyperpolarization-activated cation current(Ih) in rat dorsal root ganglion neurons using the whole-cell patch clamp technique.The results showed that Kext increased Ih in a certain concentration and voltage-dependent manner.At the basal Kext level(4 mmol/L),Ih had a maximal amplitude of 1085 ± 340 pA which was enhanced by ~45% and ~92% at 8 and 16 mmol/L Kext,respectively.The midpoint activation voltage was significantly shifted from -98 mV in the hyperpolarizing direction by 8 and 12 mV at 8 and 16 mmol/L Kext,respectively with alteration of the activation course of Ih.The short time constants of activation became longer with the increasing amplitude of the command potential upon rises in Kext.The long time constants became shorter.The reversal potentials were shifted in the positive direction without significant alterations upon rises in Kext.According to the functional role of Ih,Kext increased Ih,resulting in an enhanced neuronal excitability,which might produce activation potential abnormality and perhaps neuropathic pain involved. | DU ZhengQing WU WenJie ZHOU YuFen | 2009 | Science China Chemistry2009，52，8： | 0 |
| 7 | Microscopic defects formation and dynamic mechanical response analysis of Q345 steel plate subjected to explosive load显示文摘As the basic protective element, steel plate had attracted world-wide attention because of frequent threats of explosive loads. This paper reports the relationships between microscopic defects of Q345 steel plate under the explosive load and its macroscopic dynamics simulation. Firstly, the defect characteristics of the steel plate were investigated by stereoscopic microscope(SM) and scanning electron microscope(SEM). At the macroscopic level, the defect was the formation of cave which was concentrated in the range of 0-3.0 cm from the explosion center, while at the microscopic level, the cavity and void formation were the typical damage characteristics. It also explains that the difference in defect morphology at different positions was the combining results of high temperature and high pressure. Secondly, the variation rules of mechanical properties of steel plate under explosive load were studied. The Arbitrary Lagrange-Euler(ALE) algorithm and multi-material fluid-structure coupling method were used to simulate the explosion process of steel plate. The accuracy of the method was verified by comparing the deformation of the simulation results with the experimental results, the pressure and stress at different positions on the surface of the steel plate were obtained. The simulation results indicated that the critical pressure causing the plate defects may be approximately 2.01 GPa. On this basis, it was found that the variation rules of surface pressure and microscopic defect area of the Q345 steel plate were strikingly similar, and the corresponding mathematical relationship between them was established. Compared with Monomolecular growth fitting models(MGFM) and Logistic fitting models(LFM), the relationship can be better expressed by cubic polynomial fitting model(CPFM). This paper illustrated that the explosive defect characteristics of metal plate at the microscopic level can be explored by analyzing its macroscopic dynamic mechanical response. | Zhengqing Zhou Zechen Du Yulong Zhang Guili Yang Ruixiang Wang Yuzhe Liu Peize Zhang Yaxin Zhang Xiao Wang | 2024 | Defence Technology(防务技术)2024，32，2： | 0 |
| 8 | Effect of ytterbium on sodium current and its kinetics in rat hippocampal neurons显示文摘This study addressed the effects of Yb3+ on voltage-gated sodium currents in rat hippocampal neurons using the whole-cell patch-clamp technique. Voltage-clamp recordings in single neurons were filtered and stored in a computer. Yb3+ increased the amplitude of sodium currents in a concentration-dependent and voltage-dependent manner. The 50 % enhancement concentration of Yb3+ on sodium currents was about 8.97 lmol/L, which was different from the inhibitory effects of Yb3+ on potassium current. The analysis on the activation and inactivation kinetics of Na+ current showed that 100 lmol/L Yb3+ did not change the process of activation and inactivation. In addition, the times reaching the peak of current(t) and inactivated time constant(s) were voltage dependent. 100 lmol/L Yb3+ significantly prolonged the time to peak at-70 and-80 mV. The effect disappeared at the positive direction of-70 mV. Furthermore, Yb3+ decreased s values to more positive values than-80 mV. In total, Yb3+ did not change the process of activation, but impelled inactivated process. Yb3+ mainly increased the Na+ current through changing its conductance. It might be one of the mechanisms that Yb3+ affected the hippocampal neurons. | Zhengqing Du Kun Tian | 2014 | Chinese Science Bulletin2014，59，7： | 0 |
| 9 | Crystalline/Amorphous Heterophase with Self-Assembled Hollow Structure for Highly Efficient Electrochemical Hydrogen Production显示文摘Heterophase nanomaterials composed of multiple phases have attracted increasing attention due to their enhanced performance in electrocatalytic field.Nevertheless,constructing two-dimensional(2D)crystalline/amorphous heterophase nanostructures with the samechemical composition remains a great challenge.Herein,we report the preparation of a 2D crystalline/amorphous heterophase of MoS2 nanosheets with the same elemental components via a facile solvothermal method. | Zhengqing Liu Kunkun Nie Yanling Yuan Binjie Li Pei Liu Shaokun Chong Yaping Du Wei Huang | 2022 | CCS Chemistry2022，4，10： | 0 |
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