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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | From Rumors to Facts, and Facts to Rumors: The Role of Certainty Decay in Consumer Communications 显示文摘 | Dubois D Derek D R Zakary L T | 2011 | Journal of Marketing Research2011，48，6： | 1 |
| 3 | Incorporating the patient's perspective into drug development and communi- cation:an ad hoc task force report of the patient-reported outcomes (PRO)harmonization group meeting at the food and drug administration, February 16, 2001 显示文摘 | Acquadro C Berzon R Dubois D | 2003 | Value Health2003，6，5： | 1 |
| 4 | Incorporating the patient's perspective into drug development and communication: An ad hoc task force report of the patient reported outcomes (PRO) harmonization group meeting at the food and drug administration显示文摘 | Acquardo C Berzon R Dubois D | 2001 | Value in Health2001，6，5： | 1 |
| 5 | Armored RNA technology for production ofribonuclease-resistant viral RNA controls andstandards显示文摘 | Pasloske B L Walkerpeach C R Obermoeller R D Winkler M DuBois D B | 1998 | J Clin Microbiol1998，36，12： | 1 |
| 6 | Antiviral susceptibility of avian and swine influenza virus of the N1 neuraminidase subtype显示文摘 | Stoner T D Krauss S Dubois R M et ai | 2010 | J Virol2010，84，19： | 1 |
| 7 | Ribonuclease-resistant RNA controls(Armored RNA)for reverse transcription-PCR,branched DNA,and genotyping assays for hepatitis C virus显示文摘 | WalkerPeach C R Winkler M DuBois D B Pasloske B L | 1999 | Clin Chem1999，45，12： | 1 |
| 8 | TG1050,an immunotherapeutic to treat chronic hepatitis B,induces robust T cells and exerts an antiviral effect in HBVpersistent mice显示文摘 | Martin P Dubois C Jacquier E Dion S ManciniBourgine M Godon O Kratzer R Lelu-Santolaria K Evlachev A Meritet J F Schlesinger Y Villeval D Strub J M Van Dorsselaer A Marchand J B Geist M Brandely R Findeli A Boukhebza H Menguy T Silvestre N Michel M L InchauspéG | 2015 | Gut2015，64，12： | 1 |
| 9 | Novel macromolecular architectures based on aliphatic polyesters:relevance of the 'coordination-insertion' ring-opening polymerization显示文摘 | Mecerreyes D Jerome R Dubois P | | 0，，： | 1 |
| 10 | Validation of the PAC-SYM questionnaire for opioid-induced constipation in patients with chronic low back pain显示文摘 | Slappendel R Simpson K Dubois D | 2006 | Eur J Pain2006，10，： | 1 |
| 11 | The role of COX-2 in intestinal inflammation and colorectal cancer显示文摘 | WANG D DUBOIS R N | 2010 | Oncogene2010，29，6： | 1 |
| 12 | Frontiers,opportunities,and challenges in biochemical and chemical catalysis of CO2fixation显示文摘 | Appel A M Bercaw J E Bocarsly A B Dobbek H DuBois D L Dupuis M Ferry J G Fujita E Hille R Kenis P J A Kerfeld C A Morris R H Peden C H F Portis A R Ragsdale S W Rauchfuss T B Reek J N H Seefeldt L C Thauer R K Waldrop G L | 2013 | Chemical Reviews2013，113，8： | 1 |
| 13 | Associations between obesity and cancer:the role of fatty acid synthase显示文摘 | Wang D Dubois R N | 2012 | Journal of National Cancer Institute2012，104，5： | 1 |
| 14 | Determination of the full dose-response relation of intrathecal bupivacaine, levobupivacaine, and ropivacaine, combined with sufentanil, for labor analgesia 显示文摘 | VAN D E VELDE M DREELINCK R DUBOIS J | 2007 | Anesthesiology2007，106，1： | 1 |
| 15 | Conversion of methanol to olefins over cobalt-, manganese- and nickel-incorporated SAPO-34 molecular sieves 显示文摘 | DUBOIS D R OBRZUT D L LIU J | 2003 | Fuel Process Technology2003，83，： | 1 |
| 16 | Cyclooxygenase 2-derived pros- taglandin E2 regulates the angiogenic switch 显示文摘 | Wang D DuBois R N | 2004 | Proc Natl Acad Sci U S A2004，101，2： | 1 |
| 17 | Incorporating the patient's perspective into drug development and communication: An Ad Hoc Task Force Report of the Patient-Reported Outcomes (PRO) Harmonization Group Meeting at the Food and Drug Administration, February 16, 2001显示文摘 | Acquadro C Berzon R Dubois D | 2003 | Value Health2003，6，5： | 1 |
| 18 | Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway显示文摘 | Meraz M A White J M Sheehan K C Bach E A Rodig S J Dighe A S Kaplan D H Riley J K Greenlund A C Campbell D Carver-Moore K DuBois R N Clark R Aguet M Schreiber R D | | 0，，3： | 1 |
| 19 | The role of COX-2 in intestinal inflammation and colorectal cancer显示文摘 | Wang D Dubois R N | 2010 | Oncogene2010，29，6： | 1 |
| 20 | Incorporating the patient Sperspective into drug development and commu- nication:an Ad Hoc Task Force report on the patient- reported outcomes (PRO)harmonization group meeting at the Food and Drug Administration 显示文摘 | Aequadro C Bemon R Dubois D | 2003 | Value Health2003，6，5： | 1 |
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