|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | On-treatment monitoring of liver fibrosis with serum hepatitis B core-related antigen in chronic hepatitis B显示文摘BACKGROUND Non-invasive evaluation for liver fibrosis is clinically important,especially in patients with undetectable hepatitis B virus(HBV)DNA treated with nucleoside analogs.AIM To clarify the monitoring power of hepatitis B core-related antigen(HBcrAg)for hepatic histologic changes in patients with chronic hepatitis B(CHB)treated with entecavir.METHODS This prospective multicenter study used multiple ordinal and multivariate logistics regression analysis to assess variables associated with Ishak fibrosis score and regression for fibrosis regression,respectively,in 403 CHB patients,including 374 with entecavir for 72 weeks(291 underwent paired liver biopsy)and 29 as controls.RESULTS Level of HBcrAg correlated negatively with liver fibrosis staging(γ=-0.357,P<0.001)in hepatitis B e antigen(HBeAg)-positive patients,and positively with liver fibrosis staging in HBeAg-negative patients.Higher HBcrAg concentration was associated with younger age,HBeAg positive status,high HBV DNA loads,high level of hepatitis B surface antigen(HBsAg)and higher necroinflammation,but not with HBV genotype.Serum concentration of HBcrAg,basal core promoter/precore(BCP/PC)mutant,quantitation of HBsAg(qHBsAg)and platelet counts were independently associated with Ishak fibrosis score on multiple ordinal regression.HBV DNA was undetectable in 88.37%of patients treated with entecavir at week 72,while their level of HBcrAg was still detectable.A greater reduction in post-treatment HBcrAg concentration was associated with the regression of hepatic fibrosis and histological improvement.HBcrAg concentration>6.33 log IU/mL at baseline and logarithmic reduction>1.03 log IU/mL at week 72 were associated with a higher chance of regression of liver fibrosis and histological improvement,respectively.CONCLUSION HBcrAg level is associated with liver fibrosis progression.HBcrAg is an excellent monitor of hepatic histological changes,especially in CHB patients treated with nucleoside analogs. | Xiu-Juan Chang Chao Sun Yan Chen Xiao-Dong Li Zu-Jiang Yu Zheng Dong Wen-Lin Bai Xiao-Dong Wang Zhi-Qin Li Da Chen Wen-Juan Du Hao Liao Qi-Yu Jiang Li-Jun Sun Yin-Yin Li Cui-Hong Zhang Dong-Ping Xu Yong-Ping Chen Qin Li Yong-Ping Yang | 2019 | World Journal of Gastroenterology2019，25，32： | 12 |
| 2 | Germplasm resources and genetic breeding of Paeonia:a systematic review显示文摘Members of the genus Paeonia,which consists of globally renowned ornamentals and traditional medicinal plants with a rich history spanning over 1500 years,are widely distributed throughout the Northern Hemisphere.Since 1900,over 2200 new horticultural Paeonia cultivars have been created by the discovery and breeding of wild species.However,information pertaining to Paeonia breeding is considerably fragmented,with fundamental gaps in knowledge,creating a bottleneck in effective breeding strategies.This review systematically introduces Paeonia germplasm resources,including wild species and cultivars,summarizes the breeding strategy and results of each Paeonia cultivar group,and focuses on recent progress in the isolation and functional characterization of structural and regulatory genes related to important horticultural traits.Perspectives pertaining to the resource protection and utilization,breeding and industrialization of Paeonia in the future are also briefly discussed. | Yong Yang Miao Sun Shanshan Li Qihang Chen Jaime A.Teixeira da Silva Ajing Wang Xiaonan Yu Liangsheng Wang | 2020 | Horticulture Research2020，7，1： | 8 |
| 3 | A prospective study of vertical transmission of hepatitis C virus显示文摘AprospectivestudyofverticaltransmissionofhepatitisCvirusSUNDeGui1,LIUCaiYun1,MENGZongDa2,SUNYongDe2,WANGShuCong1,YANGYu... | SUN De Gui 1, LIU Cai Yun 1, MENG Zong Da 2, SUN Yong De 2, WANG Shu Cong 1, YANG Yu Qi 1, LIANG Zheng Lun 3 and ZHUANG Hui 3 | 1997 | World Journal of Gastroenterology1997，3，2： | 8 |
| 4 | An Audio Zero-Watermark Scheme Based on Energy Comparing显示文摘Zero-watermark technique,embedding watermark without modifying carriers,has been broadly applied for copyright protection of images.However,there is little research on audio zerowatermark.This paper proposes an audio zero-watermark scheme based on energy relationship between adjacent audio sections.Taking use of discrete wavelet transformation(DWT),it gets power approximations,or energies,of audio segments.Then,it extracts the audio profile,i.e.the zero-watermark,according to the relative size of energies of consecutive fragments.The experimental results demonstrate that the proposed scheme is robust against general malicious attacks including noise addition,resampling,low-pass filtering,etc.,and this approach effectively solves the contradiction between inaudibility and robustness. | YANG Yu LEI Min CHENG Mingzhi LIU Bohuai LIN Guoyuan XIAO Da | 2014 | China Communications2014，11，7： | 7 |
| 5 | Room temperature ferromagnetism in ultra-thin van der Waals crystals of 1T-CrTe2显示文摘Although many emerging new phenomena have been unraveled in two dimensional(2D)materials with long-range spin orderings,the usually low critical temperature in van der Waals(vdW)magnetic material has thus far hindered the related practical applications.Here,we show that ferromagnetism can hold above 300 K in a metallic phase of 1T-CrTe2 down to the ultra-thin limit.It thus makes CrTe2 so far the only known exfoliated ultra-thin vdW magnets with intrinsic long-range magnetic ordering above room temperature.An in-plane room-temperature negative anisotropic magnetoresistance(AMR)was obtained in ultra-thin CrTe2 devices,with a sign change in the AMR at lower temperature,with−0.6%and+5%at 300 and 10 K,respectively.Our findings provide insights into magnetism in ultra-thin CrTe2,expanding the vdW crystals toolbox for future room-temperature spintronic applications. | Xingdan Sun Wanying Li Xiao Wang Qi Sui Tongyao Zhang Zhi Wang Long Liu Da Li Shun Feng Siyu Zhong Hanwen Wang Vincent Bouchiat Manuel Nunez Regueiro Nicolas Rougemaille Johann Coraux Anike Purbawati Abdellali Hadj-Azzem Zhenhua Wang Baojuan Dong Xing Wu Teng Yang Guoqiang Yu Bingwu Wang Zheng Han Xiufeng Han Zhidong Zhang | 2020 | Nano Research2020，13，12： | 6 |
| 6 | Accommodation of curtailed wind power by electric water heaters based on a new hybrid prediction approach显示文摘Wind power curtailment is of great importance with the increase of large-scale wind power connected to the grid. A new concept of redundant wind power accommodated by dispatching electric water heaters(EWHs) is developed in the paper. Precise predictions of wind power and EWHs load power are the basis for this work. A hybrid multi-kernel prediction approach integrating an adaptive fruit fly optimization algorithm(AFOA)and multi-kernel relevance vector machine(MKRVM) is proposed to deal with the sample distribution of multisource heterogeneous features uncovered by an energy entropy method, where AFOA is used to determine the kernel parameters in MKRVM adaptively and avoid the arbitrariness. For the large computation of the prediction approach, parallel computation based on the Hadoop cluster is used to accelerate the calculation. Then, an economic dispatching model for accommodating wind power is built taking into account the penalty of curtailed wind power and the operation cost of EWHs. The proposedscheme is implemented in an intelligent residential district.The results show that the optimization performance of the hybrid prediction approach is superior to those of four usual optimization algorithms in this case. Regular or orderly scheduling of EWHs enables accommodation of superfluous wind power and reduces dispatch cost. | Yang YU Zengqiang MI Xiaoming ZHENG Da CHANG | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，3： | 6 |
| 7 | Association between ApoE Polymorphism and Type 2 Diabetes: A Meta-Analysis of 59 Studies显示文摘Objective To identify the important risk factors for type 2 Diabetes Mellitus(T2 DM) and develop effective strategies to address the problem of T2 DM. Our study aimed to evaluate the association between apolipoprotein E(Apo E) genetic polymorphism and type 2 diabetes, and to provide clues for the etiology of T2 DM.Methods Based on the criteria of inclusion and exclusion, we extracted, pooled, analyzed and assessed the case-control studies of Apo E polymorphism and T2 DM published in Pub Med, Web of Science,Medline, Wan Fang, VIP, and CNKI databases by R soft-ware(version 3.4.3). We used Random-effect models when heterogeneity was present in between-study, and fixed-effect models otherwise.Results We had 59 studies covering 6,872 cases with T2 DM and 8,250 controls, and compared the alleles and genotypes of Apo E between cases and controls. When we conducted a comparison between Apo E ε4 and ε3 alleles, we produced a pooled OR of 1.18(95% CI: 1.09-1.28;P < 0.001). Apo E ε2/ε2 genotype displayed a possible association with T2 DM(OR = 1.46;95% CI: 1.11-1.93;P = 0.007), ε3/ε4 genotype showed a 1.11-fold risk(OR = 1.11;95% CI: 1.01-1.22;P = 0.039) and ε4/ε4 genotype had a1.71-fold risk of developing T2 DM(OR = 1.71;95% CI: 1.33-2.19;P < 0.001) when they were compared with ε3/ε3 genotype.Conclusions There is an association between Apo E polymorphism and T2 DM: allele ε4 and genotypes(ε2/ε2, ε3/ε4, and ε4/ε4) are associated with the increased risk for the development of T2 DM, and they may be risk factors for T2 DM. | CHEN Da Wei SHI Ji Kang LI Yun YANG Yu REN Shu Ping | 2019 | Biomedical and Environmental Sciences2019，32，11： | 4 |
| 8 | GeoPyTool:A cross-platform software solution for common geological calculations and plots显示文摘GeoPyTool is an open source application developed for geological calculations and plots,such as geochemical classification,parameter calculation,basic statistical analysis and diagrams for structural geology.More than acting as a link from raw data stored in Microsoft Excel■(MS Excel)files to vector graphic files,GeoPyTool includes recently developed routines that have not been included in previous software,such as the calculation of the Ce(Ⅳ)/Ce(Ⅲ)ratio for zircons as a method to examine the temporal evolution of oxygen fugacity in the magmatic source for igneous rocks,and the temperature calculator with titanium in zircon and zirconium in rutile.Besides these routines,GeoPyTool also allows users to load any figure from articles or books as a base map.As a Python-based crossplatform program,GeoPyTool works on Windows?,MacOS X?and GNU/Linux.GeoPyTool can do the whole process from data to results without the dependence of Microsoft Excel?,CorelDraw?and other similar software.It takes Excel?XLSX and CSV(Comma Separated Value)as the formats of both the input data source files and the output calculation results files.The figures generated by GeoPyTool can be saved as portable network graphics(PNG),scalable vector graphics(SVG)or portable document format(PDF).Another highlight of GeoPyTool is the multilingual support,the official versio n of GeoPyTool supports both Chinese and English,and additional languages can be loaded through interface files.GeoPyTool is still in the development stage and will be expanded with further geochemical and structural geology routines.As an open source project,all source code of GeoPyTool are accessible on Github(http://gffzz188fe103f8f1460asuoqpf5wnwxux6wxf.ffgz.tsg.suse.edu.cn/GeoPyTool/GeoPyTool).Users with Python experience can join in the development team and build more complex functions expanding the capabilities of GeoPyTool. | Qiu-Ye Yu Leon Bagas Ping-Hua Yang Da Zhang | 2019 | Geoscience Frontiers2019，10，4： | 3 |
| 9 | Analysis for remedial alternatives of unregulated municipal solid waste landfills leachate-contaminated groundwater显示文摘地下水流动和溶质运输模型为预报沾染物运输并且基于 unregulated 垃圾堆的案例研究估计补救选择的效果用视觉 Modflow 被开发在东方中国的污染 leachate 的地下水。结果证明那根砷羽毛是到达在八年,和砷羽毛的最长侧面、纵的距离以后在下游的农田抽很好是分别地到达 200 m 和 260 m。但是砷羽毛的区域是不显然从八年增加到十年和羽毛的高集中的区域是在 20 年以后传播到下游的河和农田区域;当垃圾堆磨擦了时被变硬,羽毛是不在八年以后到达下游的农田区域;当抽的井下游地在羽毛被安装,分泌物率是 200m ^ 时,啜 3 ^/d,羽毛将有效地被制止;为防漏的障碍,它可能有效地在一个程度时间范围以内保护敏感目标的地下水。要不是连续的点来源,羽毛仍然是防漏的障碍到圆;当排水阴沟的分泌物率是 170.26 m ^ 时,啜 3 ^/d,羽毛有效地被控制;有排水阴沟的联合地面变硬能在控制沾染物散开给最好的效果的全面方法,和分泌物率将被归结为 111.43 m ^ 啜 3 ^/d。因此,当 leachate 漏发生在 unregulated 垃圾堆时,有排水阴沟的全面补救其他的联合地面变硬将为阻止地下水污染被推荐[出版摘要] | Da AN Yonghai JIANG Beidou XI Zhifei MA Yu YANG Queping YANG Mingxiao LI Jinbao ZHANG Shunguo BAI Lei JIANG | 2013 | Frontiers of Earth Science2013，7，3： | 3 |
| 10 | A Risk Prediction Model for Ischemic Stroke in Southern Chinese Population:Impact of Multiple Genetic Variants and Clinical/Lifestyle Factors显示文摘With a global prevalence of 7.7 million,ischemic stroke(IS)is one of the leading causes of death and disability worldwide.In China,IS alone contributed to 69.6%of stroke events and accounted for 37.1%of the mortality/disability rate[1].IS is a complex disease that is known to be associated with various genetic variants and clinical and lifestyle risk factors[2].Genome-wide association studies(GWAS)provided evidence for the occurrence of more than 160 IS-associated single nucleotide polymorphisms(SNPs).In terms of clinical risk factors,patients with a history of chronic diseases like hypertension,dyslipidemia,and diabetes mellitus,display a higher risk of developing IS.Among the various lifestyle components,leading a sedentary lifestyle,smoking,and having an unhealthy diet are known to be associated with the risk of IS.Thus,integration of various genetic,clinical,and lifestyle variables might prove to be highly beneficial in the prediction and prevention of IS at the individual level[3]. | YE Cheng Yin LI Jin Mei WU Jing Hua LI Zheng XIAO Juan YIN Xiao Yu WANG Da Hui XU Guo Zhang YANG Lei | 2021 | Biomedical and Environmental Sciences2021，34，8： | 2 |
| 11 | Preparation of horizontally aligned single-walled carbon nanotubes with floating catalyst显示文摘A strategy to prepare horizontally aligned single-walled carbon nanotubes(SWNTs) at moderate temperatures(≤600 ℃) were developed.Using ferocene as the catalyst precursor,Fe nanoparticles are formed in the gaseous phase and catalyze the nucleation and growth of SWNTs in situ.Then the resultant SWNTs are deposited onto the substrates downstream and aligned by the surface lattice of the ST-cut single crystal quartz.The preparation of SWNT arrays at moderate temperatures is important for combining the tube growth with device fabrication. | Rongli Cui Xiulan Zhao Ruoming Li Yu Liu Da Luo Feng Yang Yan Li | 2017 | Science China Chemistry2017，60，4： | 2 |
| 12 | An Off-Diagonal Marcinkiewicz Interpolation Theorem on Lorentz Spaces显示文摘让(X,慥? 鏦鲽釥 ? 鮼 ? 牡楣歮敩楷穣銏胥骮郧 ? 鮼 ? 牯湥穴? 韩 ? 鮼駩?? ? 黥 ?????? 耀吗?? | Yi Yu LIANG Li Guang LIU Da Chun YANG | 2011 | Acta Mathematica Sinica,English Series2011，27，8： | 2 |
| 13 | Two new nonacosanetriols from the pollen of Typha angustifolia显示文摘Chemical investigation of the pollen of Typha angustifolia Linn.has led to the isolation of two new nonacosanetriols,7,8,10- nonacosanetriol(1) and 7,9,10-nonacosanetriol(2).Their structures were elucidated by chemical reaction and spectral analysis. Compounds 1 and 2 exhibited weak activity of antiplatelet aggregation in vitro. | Tao, Wei Wei Yang, Nian Yun Duan, Jin Ao Wu, De Kang Shang, Er Xin Qian, Da Wei Tang, Yu Ping | 2010 | Chinese Chemical Letters2010，21，2： | 2 |
| 14 | Urinary concentrations of phenols, oxidative stress biomarkers and thyroid cancer: Exploring associations and mediation effects显示文摘Phenols have been shown to influence the cellular proliferation and function of thyroid in experimental models. However, few human studies have investigated the association between phenol exposure and thyroid cancer, and the underlying mechanisms are also poorly understood. We conducted a case-control study by age- and sex-matching 143 thyroid cancer and 224 controls to investigate the associations between phenol exposures and the risk of thyroid cancer, and further to explore the mediating role of oxidative stress. We found that elevated urinary triclosan (TCS), bisphenol A (BPA) and bisphenol S (BPS) levels were associated with increased risk of thyroid cancer (all P for trends < 0.05), and the adjusted odds ratios (ORs) comparing the extreme exposure groups were 3.52 (95% confidence interval (CI):2.08, 5.95), 2.06 (95% CI: 1.06, 3.97) and 7.15 (95% CI: 3.12, 16.40), respectively. Positive associations were also observed between urinary TCS, BPA and BPS and three oxidative stress biomarkers measured by 8-hydroxy-2 -deoxyguanosine (8-OHdG), 8-iso-prostaglandin F(8-iso PGF) and 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA), as well as between urinary 8-iso PGFand HNE-MA and the risk of thyroid cancer. Mediation analysis showed that urinary 8-iso PGFmediated 28.95%, 47.06% and 31.08% of the associations between TCS, BPA and BPS exposures and the risk of thyroid cancer, respectively (all P < 0.05). Our results suggest that exposure to TCS, BPA and BPS may be associated with increased risk of thyroid cancer and lipid peroxidation may be an intermediate mechanism. Further studies are warranted to confirm the findings. | Pan-Pan Chen Pan Yang Chong Liu Yan-Ling Deng Qiong Luo Yu Miao Min Zhang Fei-Peng Cui Jia-Yue Zeng Tian Shi Ting-Ting Lu Da Chen Long-Qiang Wang Chun-Ping Liu Ming Jiang Qiang Zeng | 2022 | Journal of Environmental Sciences2022，34，10： | 1 |
| 15 | Apoptosis of non-tumor cells contributes to increased serum cytochrome c level in a neuroblastoma xenograft model显示文摘背景 Neuroblastoma ( NB )是 childhood.It 的最普通的恶意的稳固的肿瘤之一仍然不是清楚的肿瘤房间或非肿瘤房间的 apoptosis 是否在这研究的癌症 patients.The 目的浆液贡献细胞色素 c ( Cyt c )的集中的增加,到过当肿瘤由人的 NB 房间的下的接种长大进我们皮下地接种的裸体 mice.Methods 时,在浆液识别 Cyt c 的来源人的 NB 房间( KP-N-NS )进 | Zhang Da Yu Jie-kai Yang Fu-quan Wang Lei Zhang Guo-feng Meng Qing-lei Mu Xin Ma Wei Jia Zhan-kui Wang Jia-xiang | 2012 | Chinese Medical Journal2012，，2： | 1 |
| 16 | Surface modification of poly(L-lactic acid) membrane via layerby-layer assembly of silver nanoparticle-embedded polyelectrolyte multilayer 显示文摘 | Da Guang Yu Wen Ching Lin Ming Chien Yang | 2007 | Bioconjugate Chem2007，18，： | 1 |
| 17 | Elemental and spectroscopic methods with chemometric analysis for characterizing composition and transformation of dissolved organic matter during chicken manure composting显示文摘 | Xiao-Song He Bei-Dou Xi Yong-Hai Jiang Ming-Xiao Li Hui-Bin Yu Da An Yu Yang Hong-Liang Liu | 2012 | Environmental Technology2012，，17： | 1 |
| 18 | Ambroxol inter- feres with pseudomonas aeruginosa quorum sensing 显示文摘 | Da Q Yu J Yang X | 2010 | Int J Antimicrob Agents2010，36，3： | 1 |
| 19 | Influence of activation temperature on the properties of polyacrylonitrile-based activated carbon hollow fiber 显示文摘 | Ming Chien Yang Da Guang Yu | 1998 | Journal of Applied Polymer Science1998，68，8： | 1 |
| 20 | Influence of Activated Temperature on the Properties of Polyacrylonitrile-Based Activated Carbon Hollow Fibers 显示文摘 | Chen Yang Ming Guang Yu Da | 1998 | J Appl Polym Sci1998，68，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员