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| 1 | Biological identity of nanomaterials:Opportunities and challenges显示文摘The emergence of nanoparticles(NPs)has attracted tremendous interest of the scientific community for decades due to their unique properties and potential applications in diverse areas,including drug delivery and therapy.Many novel NPs have been synthesized and used to reduce drug toxicity,improve bio-availability,prolong circulation time,control drug release,and actively target to desired cells or tissues.However,clinical translation of NPs with the goal of treating particularly challenging diseases,such as cancer,will require a thorough understanding of how the NP properties influence their fate in biological systems,especially in vivo.Many efforts have been paid to studying the interactions and mechanisms of NPs and cells.Unless deliberately designed,the NPs in contact with biological fluids are rapidly covered by a selected group of biomolecules especially proteins to form a corona that interacts with biological systems.In this view,the recent development of NPs in drug delivery and the interactions of NPs with cells and proteins are summarized.By understanding the protein-NP interactions,some guidelines for safety design of NPs,challenges and future perspectives are discussed. | DENG Jun YU DaHai GAO ChangYou | 2013 | Science China Chemistry2013，56，11： | 3 |
| 2 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 3 | Preparation and cellular uptake of PLGA particles loaded with lamivudine显示文摘Poly (D, L-lactide-co-glycolide )(PLGA ) nanoparticles 与 lamivudine 装载了并且与牛的浆液白朊(BSA ) 涂经由一个双乳剂方法被准备。象内部水的阶段,器官的阶段的集中和粒子尺寸和药陷阱效率上的 ultrasonication 时间的体积那样的实验参数的影响被调查,获得有 260 nm 的一条直径和 35% 的药陷阱效率的 PLGA 粒子。粒子被扫描电子显微镜学和发射度电子显微镜学观察,显示出核心壳结构。发现那 58 mg BSA 的 BCA 试金在 1 个 g LPB 粒子上 / 在是在场的。装载 lamivudine 在开始显示出一个爆炸版本并且处于生理的条件支撑了版本直到 24 h。低 pH 能从 PLGA 粒子加速 lamivudine 的版本,使 PLGA 粒子成为潜在的聪明的细胞内部的药搬运人。PLGA 粒子乐意地在一短时间以内被使内在化进人的肝房间并且不管装载 lamivudine 与孵化时间的延伸逐渐地增加了。粒子任何一个在 lysosomes 以内住了或转了到细胞质,但是不能进入房间原子核。房间生存能力显著地没不管 lamivudine 封装面对粒子被影响,建议这种粒子可以是细胞内部的反肝炎 B 药交货的一个好候选人。 | WANG Bing CHEN GuanQun MAO ZhengWei ZHANG YuYing YU DaHai GAO ChangYou | 2012 | Chinese Science Bulletin2012，57，31： | 1 |
| 4 | Determination of corrosion types from electrochemical noise by phase space reconstruction theory显示文摘 | Dahai Xia Shizhe Song Jihui Wang Jiangbo Shi Huichao Bi Zhiming Gao | 2011 | Electrochemistry Communications2011，，1： | 1 |
| 5 | Linc-RAM is a metabolic regulator maintaining whole-body energy homeostasis in mice显示文摘Long noncoding RNAs(lncRNAs)are known to have profound functions in regulating cell fate specification,cell differentiation,organogenesis,and disease,but their physiological roles in controlling cellular metabolism and whole-body metabolic homeostasis are less well understood.We previously identified a skeletal muscle-specific long intergenic noncoding RNA(linc-RNA)activator of myogenesis,Linc-RAM,which enhances muscle cell differentiation during development and regeneration.Here,we report that Linc-RAM exerts a physiological function in regulating skeletal muscle metabolism and the basal metabolic rate to maintain whole-body metabolic homeostasis.We first demonstrate that Linc-RAM is preferentially expressed in type-II enriched glycolytic myofibers,in which its level is more than 60-fold higher compared to that in differentiated myotubes.Consistently,genetic deletion of the Linc-RAM gene in mice increases the expression levels of genes encoding oxidative fiber versions of myosin heavy chains and decreases those of genes encoding rate-limiting enzymes for glycolytic metabolism.Physiologically,Linc-RAM-knockout mice exhibit a higher basal metabolic rate,elevated insulin sensitivity and reduced fat deposition compared to their wild-type littermates.Together,our findings indicate that Linc-RAM is a metabolic regulator of skeletal muscle metabolism and may represent a potential pharmaceutical target for preventing and/or treating metabolic diseases,including obesity. | Qianying Zhang Lili Zhai Qian Chen Yixia Zhao Ruiting Wang Hu Li Tian Gao Meihong Chen Dahai Zhu Yong Zhang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，11： | 0 |
| 6 | Comparative transcriptome analysis between abundant and deficient spore strains provides novel insight into gene regulatory networks and mechanisms of monospore production in bladed Bangiales显示文摘As an important seedling source,monospores closely associate with yields in nori farming.However,the molecular mechanism underlying differences in monospore production for different strains remains unknown.Comparative transcriptome analysis was performed to examine gene expression differences between the spore abundant wild-type strain(WT)and spore deficient mutant(Y1)of Pyropia chauhanii.The WT strain that produces monospores in abundance exhibited more differentially expressed genes(DEGs)in both number and higher fold-changes than the Y1 strain incapable of producing monospores,indicating that the specific regulation of genes is involved in monospore production.Three lists of DEGs were obtained between the two strains using intersection and displayed in Venn diagram:one expressed only in WT strain,another expressed only in Y1 strain,and the third shared in both strains.DEGs annotated as homologous genes of Arabidopsis thaliana in these 3 lists were curated for online functional enrichment analysis on Metascape website.Gene regulatory networks of WT were functionally enriched in the processing,proteolysis,and transport of proteins,especially within the small GTPase protein family,which might be account for the monospore production ability,whereas Y1 were functionally enriched in the metabolism of essential substance and utilization of indispensable energy,which might be account for the rapid growth of blades.We found the differentially enriched gene regulatory networks between strains might be the intrinsic mechanisms of the different monospore production traits.These findings provide novel insights into the genes and regulatory networks associated with monospore production abilities,which are essential for developing accurate breeding technologies for optimal release of monospores and increase of total nori production. | Qingjie Zhang Shanshan Song Dahai Gao Xinghong Yan | 2023 | Aquaculture and Fisheries2023，8，2： | 0 |
| 7 | Erratum to:Development of chloroplast marker for identification of Ulva species显示文摘Erratum to:http://gffzzd3cc09b8251d45dfsb0vu0bx5fwwn65wn.ffgz.tsg.suse.edu.cn/10.1007/s00343-022-2154-6 The financial supporting information of this article contains a mistake.The correct one is given below. | Dahai GAO Qingchun ZHANG Zhongmin SUN | 2023 | Journal of Oceanology and Limnology2023，41，1： | 0 |
| 8 | Sources and Transport of Terrigenous Organic Matters Along the East China Sea Inner Shelf: Insights from Lignin and Alkane Biomarkers显示文摘The area of East China Sea(ECS)inner shelf is an important sink of suspended particulates from Yangtze River(YR)and materials originated from YR basin.In this study,the parameters of lignin and alkane biomarkers in surface sediment samples from ECS inner shelf were determined to distinguish the sources and to trace the transport of terrigenous organic matters in the region.Our dataset showed that total alkanes with carbon numbers from 10 to 38(T-alkanes)were significantly correlated to both TAR(terrigenous/aquatic ratio)and HMW/LMW(the ratio of high molecular weight to low molecular weight alkanes)(r=0.88,P<0.05 for both),indicating that the majority of T-alkanes was predominantly originated from terrestrial sources,and T-alkanes are important constituents of terrestrial organic matters in the study area.The area was probably affected by petroleum pollution to a certain degree,as indicated by the values of carbon preference index(CPI),odd-over-even carbon number predominance(OEP)and the ratio of pristane to phytane(Pr/Ph).The values of Pr/n-C_(17) and Ph/n-C_(18) suggested a strong reductive sedimentary condition in the region with no obvious biodegradation.The content of eight lignin phenols(Σ8)decreased from the coast to the open sea,indicative of riverine input and hydrodynamic transport of terrigenous organic matters.Lignin degradation parameters presented an increasing trend from the coastline toward the open sea.The lignin vegetation parameters and alkane index(AI)suggested the predominance of non-woody angiosperms in the YR basin.The obvious correlation betweenΛ8(Σ8 normalized to 100 mg organic carbon),TAR and HMW/LMW reveals the significantly concurrent input of lignin and alkanes from terrestrial sources. | LIU Xiaojie HAO Ting FENG Lijuan JI Yinli WANG Qianqian ZHANG Dahai PAN Gang GAO Xianchi MENG Chunxia LI Xianguo | 2021 | Journal of Ocean University of China2021，20，4： | 0 |
| 9 | Development of chloroplast marker for identification of Ulva species显示文摘Large-scale Ulva-caused green tides has posed various environmental and ecological problems as well as economic consequences.It is important to identify them accurately and quickly.The current universal markers based on ITS,rbc L,and 5S spacer sequences were defective to distinct closely related species in the genus of Ulva.In this study,by investigating the intergenic regions of chloroplast(cp)genome,a novel marker of c15(based on ycf 3-rps 7)were reliable for discrimination of Ulva species.Notably,the resolution of c15 was suitable for resolve the closely related species of U.linza and U.prolifera,which may provide tools for deciphering the blooming mechanisms of green tides. | Dahai GAO Qingchun ZHANG Zhongmin SUN | 2022 | Journal of Oceanology and Limnology2022，40，6： | 0 |
| 10 | Exosome/metformin-loaded self-healing conductive hydrogel rescues microvascular dysfunction and promotes chronic diabetic wound healing by inhibiting mitochondrial fission显示文摘Chronic diabetic wounds remain a globally recognized clinical challenge.They occur due to high concentrations of reactive oxygen species and vascular function disorders.A promising strategy for diabetic wound healing is the delivery of exosomes,comprising bioactive dressings.Metformin activates the vascular endothelial growth factor pathway,thereby improving angiogenesis in hyperglycemic states.However,multifunctional hydrogels loaded with drugs and bioactive substances synergistically promote wound repair has been rarely reported,and the mechanism of their combinatorial effect of exosome and metformin in wound healing remains unclear.Here,we engineered dual-loaded hydrogels possessing tissue adhesive,antioxidant,self-healing and electrical conductivity properties,wherein 4-armed SH-PEG cross-links with Ag^(+),which minimizes damage to the loaded goods and investigated their mechanism of promotion effect for wound repair.Multiwalled carbon nanotubes exhibiting good conductivity were also incorporated into the hydrogels to generate hydrogen bonds with the thiol group,creating a stable three-dimensional structure for exosome and metformin loading.The diabetic wound model of the present study suggests that the PEG/Ag/CNT-M+E hydrogel promotes wound healing by triggering cell proliferation and angiogenesis and relieving peritraumatic inflammation and vascular injury.The mechanism of the dual-loaded hydrogel involves reducing the level of reactive oxygen species by interfering with mitochondrial fission,thereby protecting F-actin homeostasis and alleviating microvascular dysfunction.Hence,we propose a drug-bioactive substance combination therapy and provide a potential mechanism for developing vascular function-associated strategies for treating chronic diabetic wounds. | Yue Zhang Meng Li Yunchuan Wang Fei Han Kuo Shen Liang Luo Yan Li Yanhui Jia Jian Zhang Weixia Cai Kejia Wang Ming Zhao Jing Wang Xiaowen Gao Chenyang Tian Baolin Guo Dahai Hu | 2023 | Bioactive Materials2023，，8： | 0 |
| 11 | Selenium enhances photodynamic therapy of C-phycocyanin against lung cancer via dual regulation of cytotoxicity and antioxidant activity显示文摘As a natural photosensitizer,phycocyanin(PC)has high efficiency and uses low-intensity irradiation.To enhance the photodynamic therapy(PDT)of PC,we extract selenium-enriched phycocyanin(Se-PC)from Se-enriched Spirulina platensis and examine the synergistic effect of PC combined with selenium against lung tumors.In vitro experiments reveal that Se-PC PDT more efficiently reduce the survival rate of mouse lung cancer cells(LLC cell line)than PC PDT treatment by increasing the level of ROS and decreasing the level of GPx4,which is confirmed by the Chou-Talalay assay.In vivo imaging system analysis reveal that tumor volume is more markedly decreased in both the Se-PC PDT and PC PDT plus Na2SeO3 groups than in the PC PDT group,with inhibition rates reaching 90.4%,68.3%and 53.1%,respectively,after irradiation with 100 J/cm^(2) laser light at 630 nm.In normal tissues,Se-PC promotes the synthesis of antioxidant enzymes and the immune response by the IL-6/TNF-αpathway against tumor proliferation and metastasis.Using Se-PC as a photosensitizer in tumors,apoptosis and pyroptosis are the primary types of cell death switched by Caspases-1/3/9,which is confirmed by TEM.Based on the transcriptome analysis,Se-PC PDT treatment inhibits angiogenesis,regulates inflammation by the HIF-1,NF-κB and TGF-βsignaling pathways and dilutes tumor metabolism by reducing the synthesis of glucose transporters and transferrin.Compared to PC PDT,Se-PC increases the expression levels of some chemokines in the tumor niche,which recruits inflammatory cells to enhance the immune response.Our study may provide evidence for Se-PC as an effective photosensitizer to treat lung cancer. | Jie Shen Haidong Xia Xiaojing Zhou Lei Zhang Qian Gao Kan He Dahai Liu Bei Huang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，12： | 0 |
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