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| 1 | Consensus on the application of negative pressure wound therapy of diabetic foot wounds显示文摘Because China is becoming an aging society,the incidence of diabetes and diabetic foot have been increasing.Diabetic foot has become one of the main health-related killers due to its high disability and mortality rates.Negative pressure wound therapy(NPWT)is one of the most effective techniques for the treatment of diabetic foot wounds and great progress,both in terms of research and its clinical application,has been made in the last 20 years of its development.However,due to the complex pathogenesis and management of diabetic foot,irregular application of NPWT often leads to complications,such as infection,bleeding and necrosis,that seriously affect its treatment outcomes.In 2020,under the leadership of Burns,Trauma and Tissue Repair Committee of the Cross-Straits Medicine Exchange Association,the writing group for‘Consensus on the application of negative pressure wound therapy of diabetic foot wounds’was established with the participation of scholars from the specialized areas of burns,endocrinology,vascular surgery,orthopedics and wound repair.Drawing on evidence-based practice suggested by the latest clinical research,this consensus proposes the best clinical practice guidelines for the application and prognostic evaluation of NPWT for diabetic foot.The consensus aims to support the formation of standardized treatment schemes that clinicians can refer to when treating cases of diabetic foot. | Shizhao Ji Xiaobin Liu Jie Huang Junmin Bao Zhaohong Chen Chunmao Han Daifeng Hao Jingsong Hong Dahai Hu Yufeng Jiang Shang Ju Hongye Li Zongyu Li Guangping Liang Yan Liu Gaoxing Luo Guozhong Lv Xingwu Ran Zhongmin Shi Juyu Tang Aiping Wang Guangyi Wang Jiangning Wang Xin Wang Bing Wen Jun Wu Hailin Xu Maojin Xu Xiaofei Ye Liangxi Yuan Yi Zhang Shichu Xiao Zhaofan Xia | 2021 | Burns & Trauma2021，9，1： | 17 |
| 2 | Enhanced orange emission by doping CeB_6 in CaAlSiN_3:Ce^(3+) phosphor for application in white LEDs显示文摘A series of CeB6-doped and CeO_2-doped Ca_(1-x)SiAlN_3:xCe3+(denoted as CASN:Ce3+@CeB6 and CASN:Ce3+@CeO_2, respectively) were synthesized by alloy-nitridation method under high-purity nitrogen atmosphere. The morphologies, crystal phases, and luminescence properties were investigated in detail.With an increase in the concentration of CeB_6, the unit cell volume of CASN:Ce3+@CeB_6 slightly increases due to the substitution between ions, which leads to a change of micro structure around Ce3+. CASN:Ce3+@CeB6 efficiently emits yellow-orange light with a maximum emission intensity at around 550 nm for the content x of 0.01(being in comparable situation, CASN:Ce3+@CeO_2 is x = 0.04) when excited at460 nm. Compared with CASN:Ce3+@CeO_2, the red emission component of Ce3+ in CASN:Ce3+@CeB6 is much stronger. This is ascribed to energy transfer of intra-Ce3+(within one Ce3+ ion) and inter-Ce3+(between Ce3+ and Ce3+ ions). In addition, the replacements of N3-(0.132 nm for CN = 4) and O^(2-)(0.124 nm for CN = 4) by B^(2-)(0.140 nm for CN = 4), which can lead to a marked expansion of the host lattice and a decrease of the oxidation of samples, are also responsible for the increase of red emission component. Furthermore, CASN:Ce3+@CeB_6 phosphor has an excellent thermal stability because of the partial substitution of Ce-O(Ce-N) bonds by more covalent Ce-B. As a result, the outstanding luminescent properties of CASN:Ce3+@CeB6 phosphor make it practical to use in the single phosphor-coated high-color-rendering power white LED. | Wenjie Wu Kefu Chao Wenquan Liu Lesi Wei Dahai Hu Taiyang Wang O. Tegus | 2018 | Journal of Rare Earths2018，36，12： | 6 |
| 3 | miR-378 attenuates muscle regeneration by delaying satellite cell activation and differentiation in mice显示文摘骨胳的肌肉质量和动态平衡大部分在出生后的肌肉开发和新生期间取决于成年肌肉干细胞(卫星房间) 。我们最近证明 miR-378 的全球 overexpression 显著地在老鼠减少了骨胳的肌肉质量。在当前的学习,我们使用了 miR-378 转基因(Tg ) 估计的老鼠在里面 vivo 骨胳的肌肉生长和新生上的 miR-378 的功能的效果。骨胳的肌肉纸巾的代表性的分析证明 myofibers 的数字和尺寸比在野类型的老鼠在 miR-378 Tg 老鼠是显著地更低的。在 miR-378 Tg 老鼠的稀释导致 cardiotoxin 的肌肉新生被发现与推迟的卫星房间激活和区别被联系。机械学地, miR-378 被发现直接在 vitro 并且在 vivo 在肌肉房间指向 Igf1r。这些 miR-378 Tg 老鼠可以为在人在联系肌肉的疾病调查骨胳的肌肉的生理、病理学的角色提供一个模型,特别地在 sarcopenia。 | Ping Zeng Wanhong Han Changyin Li Hu Li Dahai Zhu Yong Zhang Xiaohong Liu | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 4 |
| 4 | Overexpression of miR-101 suppresses collagen synthesis by targeting EZH2 in hypertrophic scar fibroblasts显示文摘Background:MicroRNA-101(miR-101)is a tumor suppressor microRNA(miRNA)and its loss is associated with the occurrence and progression of various diseases.However,the biological function and target of miR-101 in the pathogenesis of hypertrophic scars(HS)remains unknown.Methods:We harvested HS and paired normal skin(NS)tissue samples from patients and cultured their fibroblasts(HSF and NSF,respectively).We used quantitative reverse transcriptase polymerase chain reaction(qRT-PCR),fluorescence in situ hybridization(FISH),enzyme-linked immunosorbent assays(ELISA)and Western blot analyses to measure mRNA levels and protein expression of miR-101,enhancer of zeste homolog 2(EZH2),collagen 1 and 3(Col1 and Col3)andα-smooth muscle actin(α-SMA)in different in vitro conditions.We also used RNA sequencing to evaluate the relevant signaling pathways and bioinformatics analysis and dual-luciferase reporter assays to predict miR-101 targets.We utilized a bleomycin-induced fibrosis mouse model in which we injected miR-101 mimics to evaluate collagen deposition in vivo.Results:We found low expression of miR-101 in HS and HSF compared to NS and NSF.Overexpressing miR-101 decreased Col1,Col3 andα-SMA expression in HSF.We detected high expression of EZH2 in HS and HSF.Knockdown of EZH2 decreased Col1,Col3 andα-SMA in HSF.Mechanistically,miR-101 targeted the 3-untranslated region(3UTR)of EZH2,as indicated by the decreased expression of EZH2.Overexpressing EZH2 rescued miR-101-induced collagen repression.MiR-101 mimics effectively suppressed collagen deposition in the bleomycin-induced fibrosis mouse model.Conclusions:Our data reveal that miR-101 targets EZH2 in HS collagen production,providing new insight into the pathological mechanisms underlying HS formation. | Jie Li Yan Li Yunchuan Wang Xiang He Jing Wang Weixia Cai Yanhui Jia Dan Xiao Jian Zhang Ming Zhao Kuo Shen Zichao Li Wenbin Jia Kejia Wang Yue Zhang Linlin Su Huayu Zhu Dahai Hu | 2021 | Burns & Trauma2021，9，1： | 3 |
| 5 | Threonine 32 (Thr32) of FoxO3 is critical for TGF-β-induced apoptosis via Bim in hepatocarcinoma cells显示文摘转变生长因素 --(TGF-) 在恶意的细胞的各种各样的类型上施加 apoptotic 效果,包括肝癌症细胞。然而, TGF- 由导致 apoptosis 的精确机制仍然保持糟糕已知。在现在的学习,我们显示出那 threonine 32 (Thr32 ) FoxO3 的残余是批评的让 TGF- 在 hepatocarcinoma Hep3B 房间经由 Bim 导致 apoptosis。我们的数据证明 TGF- 在 Thr32 通过特定的 de-phosphorylation 导致了 FoxO3 激活。TGF -- 激活的 FoxO3 与 Smad2/3 合作了调停 Bim 起来规定和 apoptosis。在 Thr32 的 FoxO3 (de ) phosphorylation 被酷蛋白 kinase 调整我 --(CKI-) 。由小分子 D4476 的 CKI 抑制能废除 TGF -- 导致的 FoxO/Smad 激活,反向的 Bim 起来规定,和块顺序的 apoptosis。更重要地, CKI- 和 p32FoxO3 的 deregulated 层次在人的恶意的肝纸巾被发现。一起拿,我们的调查结果建议可能有 FoxO3 的 Thr32 为 TGF 是枢轴的一台 CKI-FoxO/Smad-Bim 在引擎 -- 导致的 apoptosis,为肝癌症治疗使它成为一个潜在的治疗学的目标。 | Xiangxuan Zhao Yong Liu Lei Du Leya He Biyun Ni Junbo Hu Dahai Zhu Quan Chen | 2015 | Protein & Cell2015，6，2： | 3 |
| 6 | Polarization-sensitive and wide-spectrum photovoltaic detector based on quasi-1D ZrGeTe_(4)nanoribbon显示文摘Low-dimensional semiconductors with in-plane anisotropy and narrow bandgap have been extensively applied to polarized detection in the near-infrared(NIR)region.However,the narrow bandgap can cause noise owing to the high dark current in photodetectors.This article reports quasi-1D ZrGeTe_(4)nanoribbonbased photodetectors with low dark current and broadband polarization detection.The photodetector was fabricated by evaporating 50-nm-thick Au electrodes on a ZrGeTe_(4)nanoribbon.Benefiting from the photovoltaic characteristics in the ZrGeTe_(4)nanoribbon and Au electrodes,these photodetectors can operate without bias voltage,with decreased dark current,and improved device performance.Furthermore,the quasi-1D ZrGeTe_(4)nanoribbon-based photodetectors demonstrate a polarization sensitivity in a broadband from visible(VIS)to the NIR region,such as a high photoresponsivity of 625.65 mA W1,large external quantum efficiency of 145.9%at 532 nm,and photocurrent anisotropy ratio of 2.04 at 1064 nm.They exhibit a novel perpendicular optical reversal of 90in polarization-sensitive photodetection,angle-resolved absorption spectra,and azimuth-dependent reflectance difference microscopy(ADRDM)from VIS to the NIR region,as opposed to other nanoribbon-based polarization-sensitive photodetectors.This work paves the way for utilizing photovoltaic photodetectors based on low-dimensional materials for broad-spectrum polarized photodetection. | Ruixue Bai Tao Xiong Jinshu Zhou Yue-Yang Liu Wanfu Shen Chunguang Hu Faguang Yan Kaiyou Wang Dahai Wei Jingbo Li Juehan Yang Zhongming Wei | 2022 | InfoMat2022，4，3： | 2 |
| 7 | The Notch pathway attenuates burn-induced acute lung injury in rats by repressing reactive oxygen species显示文摘Background:Acute lung injury(ALI)is a common complication following severe burns.The underlying mechanisms of ALI are incompletely understood;thus,available treatments are not sufficient to repair the lung tissue after ALI.Methods:To investigate the relationship between the Notch pathway and burn-induced lung injury,we established a rat burn injury model by scalding and verified lung injury via lung injury evaluations,including hematoxylin and eosin(H&E)staining,lung injury scoring,bronchoalveolar lavage fluid and wet/dry ratio analyses,myeloperoxidase immunohistochemical staining and reac-tive oxygen species(ROS)accumulation analysis.To explore whether burn injury affects Notch1 expression,we detected the expression of Notch1 and Hes1 after burn injury.Then,we extracted pulmonary microvascular endothelial cells(PMVECs)and conducted Notch pathway inhibition and activation experiments,via aγ-secretase inhibitor(GSI)and OP9-DLL1 coculture,respectively,to verify the regulatory effect of the Notch pathway on ROS accumulation and apoptosis in burn-serum-stimulated PMVECs.To investigate the regulatory effect of the Notch pathway on ROS accumulation,we detected the expression of oxidative-stress-related molecules such as superoxide dismutase,nicotinamide adenine dinucleotide phosphate(NADPH)oxidase(NOX)2,NOX4 and cleaved caspase-3.NOX4-specific small interfering RNA(siRNA)and the inhibitor GKT137831 were used to verify the regulatory effect of the Notch pathway on ROS via NOX4.Results:We successfully established a burn model and revealed that lung injury,excessive ROS accumulation and an inflammatory response occurred.Notch1 detection showed that the expression of Notch1 was significantly increased after burn injury.In PMVECs challenged with burn serum,ROS and cell death were elevated.Moreover,when the Notch pathway was suppressed by GSI,ROS and cell apoptosis levels were significantly increased.Conversely,these parameters were reduced when the Notch pathway was activated by OP9-DLL1.Mechanistically,the inhibition of NOX4 by siRNA and GKT137831 showed that the Notch pathway reduced ROS production and cell apoptosis by downregulating the expression of NOX4 in PMVECs.Conclusions:The Notch pathway reduced ROS production and apoptosis by downregulating the expression of NOX4 in burn-stimulated PMVECs.The Notch-NOX4 pathway may be a novel therapeutic target to treat burn-induced ALI. | Weixia Cai Kuo Shen Peng Ji Yanhui Jia Shichao Han Wanfu Zhang Xiaolong Hu Xuekang Yang Juntao Han Dahai Hu | 2022 | Burns & Trauma2022，10，1： | 2 |
| 8 | Reducing Subspace of Analytic Toeplitz Operators on the Bergman Space显示文摘 | Junyun Hu Shunhua Sun Xianmin Xu Dahai Yu | 2004 | Integral Equations and Operator Theory2004，，3： | 1 |
| 9 | miR-378-mediated glycolytic metabolism enriches the Pax7^(Hi) subpopulation of satellite cells显示文摘Adult skeletal muscle stem cells,also known satellite cells(SCs),are a highly heterogeneous population and reside between the basal lamina and the muscle fiber sarcolemma.Myofibers function as an immediate niche to support SC self-renewal and activation during muscle growth and regeneration.Herein,we demonstrate that microRNA 378(miR-378)regulates glycolytic metabolism in skeletal muscle fibers,as evidenced by analysis of myofiber-specific miR-378 transgenic mice(TG).Subsequently,we evaluate SC function and muscle regeneration using miR-378 TG mice.We demonstrate that miR-378 TG mice significantly attenuate muscle regeneration because of the delayed activation and differentiation of SCs.Furthermore,we show that the miR-378-mediated metabolic switch enriches Pax7^(Hi) SCs,accounting for impaired muscle regeneration in miR-378 TG mice.Mechanistically,our data suggest that miR-378 targets the Akt1/FoxO1 pathway,which contributes the enrichment of Pax7^(Hi) SCs in miR-378 TG mice.Together,our findings indicate that miR-378 is a target that links fiber metabolism to muscle stem cell heterogeneity and provide a genetic model to approve the metabolic niche role of myofibers in regulating muscle stem cell behavior and function. | Hu Li Lin Kang Rimao Wu Changyin Li Qianying Zhang Ran Zhong Lijing Jia Dahai Zhu Yong Zhang | 2022 | Cell Regeneration2022，11，1： | 1 |
| 10 | Epi demiology of chronic cutaneous wounds in China显示文摘 | Jiang Yufeng Huang Sha Fu Xiaobing Liu Hongwei Ran Xingwu Lu Shuliang Hu Dahai Li Qiang Zhang Hongwei Li Ying Wang Runxiu Xie Ting Cheng Biao Wang Ling {eng Liu Yi Ye Xiangbai Han Chunmao Chen Huade | 2011 | Wound Rep Reg2011，，19： | 1 |
| 11 | Lycium barbarum polysaccharides reduce intestinal ischemia/reperfusion injuries in rats显示文摘 | Xuekang Yang Hua Bai Weixia Cai Jun Li Qin Zhou Yunchuan Wang Juntao Han Xiongxiang Zhu Maolong Dong Dahai Hu | 2013 | Chemico-Biological Interactions2013，，3： | 1 |
| 12 | Bone Marrow Transplantation Combined with Mesenchymal Stem Cells Induces Immune Tolerance without Cytotoxic Conditioning显示文摘 | Yunchuan Wang Jiaqi Liu Chengfeng Xu Wanfu Zhang Li Bai Na Li Yang Liu Yaojun Wang Yingjun Su Dahai Hu | 2011 | Journal of Surgical Research2011，，1： | 1 |
| 13 | Reducing subspace of analytic Toeplitz operators on the Bergman space显示文摘 | Hu Junyun Sun Shunhua Xu Xianmin Yu Dahai | 2004 | Inter Equ Oper Theory2004，49，： | 1 |
| 14 | Is an appropriate cutoff of hypertriglyceridemic waist designated for type 2 diabetes among Chinese adults?显示文摘 | Dahai Yu Jianfeng Huang Dongsheng Hu Jichun Chen Jie Cao Jianxin Li | 2009 | Clinical Nutrition2009，，2： | 1 |
| 15 | Linc-RAM is a metabolic regulator maintaining whole-body energy homeostasis in mice显示文摘Long noncoding RNAs(lncRNAs)are known to have profound functions in regulating cell fate specification,cell differentiation,organogenesis,and disease,but their physiological roles in controlling cellular metabolism and whole-body metabolic homeostasis are less well understood.We previously identified a skeletal muscle-specific long intergenic noncoding RNA(linc-RNA)activator of myogenesis,Linc-RAM,which enhances muscle cell differentiation during development and regeneration.Here,we report that Linc-RAM exerts a physiological function in regulating skeletal muscle metabolism and the basal metabolic rate to maintain whole-body metabolic homeostasis.We first demonstrate that Linc-RAM is preferentially expressed in type-II enriched glycolytic myofibers,in which its level is more than 60-fold higher compared to that in differentiated myotubes.Consistently,genetic deletion of the Linc-RAM gene in mice increases the expression levels of genes encoding oxidative fiber versions of myosin heavy chains and decreases those of genes encoding rate-limiting enzymes for glycolytic metabolism.Physiologically,Linc-RAM-knockout mice exhibit a higher basal metabolic rate,elevated insulin sensitivity and reduced fat deposition compared to their wild-type littermates.Together,our findings indicate that Linc-RAM is a metabolic regulator of skeletal muscle metabolism and may represent a potential pharmaceutical target for preventing and/or treating metabolic diseases,including obesity. | Qianying Zhang Lili Zhai Qian Chen Yixia Zhao Ruiting Wang Hu Li Tian Gao Meihong Chen Dahai Zhu Yong Zhang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，11： | 0 |
| 16 | Spatial Heterogeneity of Marine Environment Changes:A Case Study in Laizhou Bay and Its Adjacent Waters,China显示文摘Temporal and spatial heterogeneity identifications of marine environment and its changes have great significances in marine spatial planning and offshore pollution control.In this study,considering the integration of marine ecological environment and sea-land interaction,we built a spatialized evaluation model named Marine Environment Change Spatial Assessment(MECSA)to quantify the marine environment status and changes.In MECSA,we applied the geospatial model and the pressure-state-response(PSR)model for processing and integrating evaluation indicators.A case study in the Laizhou Bay showed that the marine environment quality was generally in a declining state from 2009 to 2015.In 2015,the Marine Environment Index(MEI)had decreased by 0.1 compared with 2009,although the two years all reached a‘Good'level.The spatial MEI layers of the two years showed a same distribution:the southwestern part was in poorer status,with a fan ring shape gradually getting better to the northeast.The Marine Organisms Response Index(MORI)contributed the most to the MEI.Therefore,future marine environmental assessment and spatial planning should focus on the identification the marine environment with its changes from the perspective of spatial heterogeneity and systemicity.Based on single indicators and comprehensive evaluation results,we can propose spatially targeted policies and recommendations scientifically. | WANG Youxiao YU Ge HU Guobin LIU Dahai | 2021 | Journal of Ocean University of China2021，20，1： | 0 |
| 17 | Linc-RAM promotes muscle cell differentiation via regulating glycogen phosphorylase activity显示文摘Long non-coding RNAs(lncRNAs)are important regulators of diverse biological processes,especially skeletal muscle cell differentiation.Most of the lncRNAs identified to date are localized in the nucleus and play regulatory roles in gene expression.The cytoplasmic lncRNAs are less well understood.We previously identified a long intergenic non-coding RNA(linc-RNA)activator of myogenesis(Linc-RAM)that directly binds MyoD in the nucleus to enhance muscle cell differentiation.Here,we report that a substantial fraction of Linc-RAM is localized in the cytoplasm of muscle cells.To explore the molecular functions of cytoplasmic Linc-RAM,we sought to identify Linc-RAM-binding proteins.We report here that Linc-RAM physically interacts with glycogen phosphorylase(PYGM)in the cytoplasm.Knockdown of PYGM significantly attenuates the function of Linc-RAM in promoting muscle cell differentiation.Loss-of-function and gain-of function assays demonstrated that PYGM enhances muscle cell differentiation in an enzymatic activity-dependent manner.Finally,we show that the interaction between Linc-RAM and PYGM positively regulates the enzymatic activity of PYGM in muscle cells.Collectively,our findings unveil a molecular mechanism through which cytoplasmic Linc-RAM contributes to muscle cell differentiation by regulating PYGM activity.Our findings establish that there is crosstalk between lncRNAs and cellular metabolism during myogenic cell differentiation. | Lili Zhai Xin Wan Rimao Wu Xiaohua Yu Hu Li Ran Zhong Dahai Zhu Yong Zhang | 2022 | Cell Regeneration2022，11，1： | 0 |
| 18 | Correction to: miR-378-mediated glycolytic metabolism enriches the Pax7Hi subpopulation of satellite cells显示文摘Following publication of the original article(Li et al.,2022),due to a typesetting error,the sentence below was missing in the article.Hu Li and Lin Kang contributed equally to this work.The correct information has been provided in this Correction and the original article(Li et al.,2022)has been updated. | Hu Li Lin Kang Rimao Wu Changyin Li Qianying Zhang Ran Zhong Lijing Jia Dahai Zhu Yong Zhang | 2022 | Cell Regeneration2022，11，1： | 0 |
| 19 | Assessment of popular techniques for co-processing municipal solid waste in Chinese cement kilns显示文摘Cement kiln co-processing techniques have been developed in the past 20 years in China,and more than 60 factories now use fermentation,screening,and gasification pre-treatment techniques to coprocess municipal solid waste(MSW).There three complete MSW pre-treatment techniques,coprocessing procedures,and environmental risk assessments have been described in few publications.In this study,we assessed the effectiveness of each technique.The results suggested that the pollutant content released by each pre-treatment technology was lower than the emission standard.To reveal the mechanisms of pollutant migration and enrichment,the substances in the kiln and kiln products are investigated.The input of co-processing materials(Co-M)produced by fermentation caused formation of polychlorinated dibenzo-p-dioxins and dibenzoftiran(PCDD/Fs)in the bypass flue gas(By-gas)in excess of the regulatory standard.The Co-M input produced by the screening and gasifier technologies caused the total organic carbon(TOC)concentration to exceed the standard.In addition,the NOx,TOC,and PCDD/Fs in the By-gas exceeded the regulatory standard.Raw meal was the primary chlorine and heavy metals input stream,and clinker(CK)and cement kiln dust(CKD)accounted for>90%of the total chlorine output stream.Flue gas and CKD were the primary volatile heavy metal(Hg)output streams.Greater than 70%of the semi-volatile heavy metals(Cd,Pb,T1 and Se)distributed in hot raw meal and bypass cement kiln dust.The low-volatility heavy metals were concentrated in the CK.These results indicated that co-processing techniques used in China still require improvement. | Hua Long Yang Liao Changhao Cui Meijia Liu Zeiwei Liu Li Li Wenzheng Hu Dahai Yan | 2022 | Frontiers of Environmental Science & Engineering2022，16，4： | 0 |
| 20 | miR-378 and its host gene Ppargc1β exhibit independent expression in mouse skeletal muscle显示文摘MicroRNAs (miRNAs) are implicated in multiple biological processes in physiological and pathological settings. Nearly half of the known miRNAs are classified as ‘intronic’ miRNAs because they are embedded within the introns of protein-coding or noncoding genes. Such miRNAs were thought to be processed from primary host gene transcripts and share the promoter of their host. Recent analyses predicted that some intronic miRNAs might be transcribed and regulated as independent units, but there is little direct evidence for this in a specific biological context. Here, we focused on miR-378, which is located within the first intron of the peroxisome proliferator-activated receptor γ coactivator 1-beta (Ppargc1β) gene and critically regulates skeletal muscle cell differentiation and muscle regeneration. We demonstrate that miR-378 and Ppargc1β exhibit distinct expression patterns during skeletal muscle cell differentiation. In terminally differentiated adult skeletal muscle tissues of mice, miR-378 is predominantly expressed in glycolytic muscle, whereas Ppargc1β is mainly expressed in oxidative soleus muscle. Mechanistically, miR-378, but not Ppargc1β, is regulated by the transcription factor, MyoD, in muscle cells. Our findings identify a regulatory model of miR-378 expression, thereby helping us to understand its physiological function in skeletal muscle. | Lin Kang Chunmiao Han Guangyan Yang Hu Li Tingting Li Shu Yang Na Liang Ran Zhong Lijing Jia Dahai Zhu Yong Zhang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，8： | 0 |
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