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| 1 | Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients显示文摘Background:A patient’s infectivity is determined by the presence of the virus in different body fluids,secretions,and excreta.The persistence and clearance of viral RNA from different specimens of patients with 2019 novel coronavirus disease(COVID-19)remain unclear.This study analyzed the clearance time and factors influencing 2019 novel coronavirus(2019-nCoV)RNA in different samples from patients with COVID-19,providing further evidence to improve the management of patients during convalescence.Methods:The clinical data and laboratory test results of convalescent patients with COVID-19 who were admitted to from January 20,2020 to February 10,2020 were collected retrospectively.The reverse transcription polymerase chain reaction(RT-PCR)results for patients’oropharyngeal swab,stool,urine,and serum samples were collected and analyzed.Convalescent patients refer to recovered non-febrile patients without respiratory symptoms who had two successive(minimum 24 h sampling interval)negative RT-PCR results for viral RNA from oropharyngeal swabs.The effects of cluster of differentiation 4(CD4)+T lymphocytes,inflammatory indicators,and glucocorticoid treatment on viral nucleic acid clearance were analyzed.Results:In the 292 confirmed cases,66 patients recovered after treatment and were included in our study.In total,28(42.4%)women and 38 men(57.6%)with a median age of 44.0(34.0-62.0)years were analyzed.After in-hospital treatment,patients’inflammatory indicators decreased with improved clinical condition.The median time from the onset of symptoms to first negative RT-PCR results for oropharyngeal swabs in convalescent patients was 9.5(6.0-11.0)days.By February 10,2020,11 convalescent patients(16.7%)still tested positive for viral RNA from stool specimens and the other 55 patients’stool specimens were negative for 2019-nCoV following a median duration of 11.0(9.0-16.0)days after symptom onset.Among these 55 patients,43 had a longer duration until stool specimens were negative for viral RNA than for throat swabs,with a median delay of 2.0(1.0-4.0)days.Results for only four(6.9%)urine samples were positive for viral nucleic acid out of 58 cases;viral RNA was still present in three patients’urine specimens after throat swabs were negative.Using a multiple linear regression model(F=2.669,P=0.044,and adjusted R2=0.122),the analysis showed that the CD4+T lymphocyte count may help predict the duration of viral RNA detection in patients’stools(t=-2.699,P=0.010).The duration of viral RNA detection from oropharyngeal swabs and fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group(15 days vs.8.0 days,respectively;t=2.550,P=0.013)and the duration of viral RNA detection in fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group(20 days vs.11 days,respectively;t=4.631,P<0.001).There was no statistically significant difference in inflammatory indicators between patients with positive fecal viral RNA test results and those with negative results(P>0.05).Conclusions:In brief,as the clearance of viral RNA in patients’stools was delayed compared to that in oropharyngeal swabs,it is important to identify viral RNA in feces during convalescence.Because of the delayed clearance of viral RNA in the glucocorticoid treatment group,glucocorticoids are not recommended in the treatment of COVID-19,especially for mild disease.The duration of RNA detection may relate to host cell immunity. | Yun Ling Shui-Bao Xu Yi-Xiao Lin Di Tian Zhao-Qin Zhu Fa-Hui Dai Fan Wu Zhi-Gang Song Wei Huang Jun Chen Bi-Jie Hu Sheng Wang En-Qiang Mao Lei Zhu Wen-Hong Zhang Hong-Zhou Lu | 2020 | Chinese Medical Journal2020，，9： | 58 |
| 2 | Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 expression in Asherman's syndrome显示文摘Asherman's syndrome(AS) is a common disease that presents endometrial regeneration disorder. However, little is known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning endometrium for the patients with AS. Here, we report that ΔNp63 is significantly upregulated in residual epithelial cells of the impaired endometrium in AS; the upregulated-ΔNp63 induces endometrial quiescence and alteration of stemness. Importantly, we demonstrate that engrafting high density of autologous bone marrow mononuclear cells(BMNCs) loaded in collagen scaffold onto the uterine lining of patients with AS downregulates ΔNp63 expression, reverses ΔNp63-induced pathological changes, normalizes the stemness alterations and restores endometrial regeneration. Finally, five patients achieved successful pregnancies and live births. Therefore, we conclude that ΔNp63 is a crucial therapeutic target for AS. This novel treatment significantly improves the outcome for the patients with severe AS. | Guangfeng Zhao Yun Cao Xianghong Zhu Xiaoqiu Tang Lijun Ding Haixiang Sun Juan Li Xinan Li Chenyan Dai Tong Ru Hui Zhu Jingjie Lu Caimei Lin Jingmei Wang Guijun Yan Huiyan Wang Lei Wang Yimin Dai Bin Wang Ruotian Li Jianwu Dai Yan Zhou Yali Hu | 2017 | Science China(Life Sciences)2017，60，4： | 39 |
| 3 | The Chromosome-Level Reference Genome of Tea Tree Unveils Recent Bursts of Nonautonomous LTR Retrotransposons in Driving Genome Size Evolution显示文摘Dear Editor,The tea tree Camellia sinensis,a member of the genus Camellia in the Theaceae family,includes two major cultivated varieties,C.sinensis var.assamica(CSA\Assam type)and C.sinensis var.sinensis(CSS;Chinese type)(Ming and Bartholomew,2007).Due to the high economic importance of the tea tree,considerable efforts have been made to explore genetic basis of the biosynthesis of natural metabolites that determine health benefits and diverse tea flavors(Shi et al.,2011;Li et al.,2011;Li et al.,2015;Xia et aL,2017;Liu et al.,2019). | Qun-Jie Zhang Wei L i Kui Li Hong Nan Cong Shi Yun Zhang Zhang-Yan Dai Yang-Lei Lin Xiao-Lan Yang Yan Tong Dan Zhang Cui Lu Li-Ying Feng Chen-Feng Wang Xiao-Xin Liu Jian-An Huang Wen-Kai Jiang Xing-Hua Wang Xing-Cai Zhang Evan E.Eichler Zhong-Hua Liu and Li-Zhi Gao | 2020 | Molecular Plant2020，13，7： | 27 |
| 4 | Species clarification of the prize medicinal Ganoderma mushroom“Lingzhi”显示文摘“Lingzhi”is a mushroom that has been renowned in China for more than 2,000 years because of its claimed medicinal properties plus its symbolic fortune.“Lingzhi”has high economic value mostly as a dietary supplement in the modern market especially in East Asia,and its medicinal functions have become a hot study topic.For over a century,the highly prized medicinal fungus,known as“Lingzhi”in East Asia,has been assigned to Ganoderma lucidum,a species originally described from Europe.Molecular studies in recent years have revealed that the commercially cultivated‘G.lucidum’(“Lingzhi”)in East Asia is a different species from the true G.lucidum.The present study aims to clarify the species identity of“Lingzhi”based on morphological studies and analysis of rDNA nuc-ITS sequences,and additional gene fragments of mt-SSU,RPB1,RPB2,and TEF1-αof“Lingzhi”were provided.All Ganoderma species that mostly resemble“Lingzhi”in phylogeny and/or morphology were included for analysis.We propose a new species G.lingzhi for“Lingzhi”,which has an East Asia distribution.The most striking characteristics which differentiate G.lingzhi from G.lucidum are the presence of melanoid bands in the context,a yellow pore surface and thick dissepiments(80–120μm)at maturity.G.curtisii is most closely related to G.lingzhi in phylogeny and is from North America.Ganoderma flexipes,G.multipileum,G.sichuanense,G.tropicum and‘G.tsugae’,are also closely related with G.lingzhi and are reported from China.These species are compared and discussed.‘Ganoderma tsuage’reported from China is determined as conspecific with G.lucidum,hence the distribution of G.lucidum extends from Europe to northeastern China. | Yun Cao Sheng-Hua Wu Yu-Cheng Dai | 2012 | Fungal Diversity2012，，5： | 25 |
| 5 | Antisense telomerase RNA induced human gastric cancer cell apoptosis显示文摘INTRODUCTION Human tissue homeostasis is precisely regulated bycellular division,differentiation and death.Normalhuman somatic cells progressively lose telomererestriction fragment(TRF)length with eachsuccessive cell division,eventually leading tocellular quiescence,chromosomal end-degradationand apoptosis.On the contrary,stabilization oftelomere lengths by expressing telomerase,an RNA-dependent DNA polymerase,may be involved incellular immortality and carcinogenesis. | Fang Xin Zhang Xue Yong Zhang Dai Ming Fan Zi Yun Deng Yan Yan Han Ping Wu Jun Jie Fan | 2000 | World Journal of Gastroenterology2000，6，3： | 24 |
| 6 | Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats显示文摘在糖尿病的可勃起的机能障碍(编辑) 的高发生为有效处理策略加亮需要。Resveratrol,沉默信息管理者 2-related 酶的使活跃之物 1 (sirtuin1, SIRT1 ) ,在癌症, neurodegenerative 疾病,长寿和心血管的疾病为它的珍贵效果收到了注意。在导致糖尿病的编辑探索 resveratrol 的效果, resveratrol 与 streptozocin 予老鼠被以(65 mg kg −1)-induced 糖尿病。可勃起的功能,多孔的结构,沉默信息管理者 2-related 酶的织物蛋白质表示 1 (sirtuin1, SIRT1 ) , p53 和 O 3a (FOXO3a )(MDA ) , superoxide dismutase (草皮) 活动和 malondialdehyde 在阴茎海绵体铺平的 forkhead 抄写因素被学习。我们发现 SIRT1 在 cavernosal 组织被表示,并且它是在糖尿病的老鼠的宫体的 downregulated。resveratrol upregulated 的管理 SIRT1 和恢复可勃起的功能的表示。相反, resveratrol downregulated p53 和 FOXO3a 的表示,调整 apoptosis 和氧化应力。而且,对待 resveratrol 的组在光滑的肌肉内容,草皮活动和 MDA 层次看了改进什么时候与糖尿病患者相比组织。因此, resveratrol 的能力改进导致糖尿病的编辑与它 SIRT1 表示的激活有关是可能的,因此向氧化应力引起 apoptosis 和抵抗的抑制。 | Wen Yu Zan Wan Xue-Feng Qiu Yun Chen Yu-Tian Dai | 2013 | Asian Journal of Andrology2013，15，5： | 15 |
| 7 | Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation显示文摘Sirtuin 3(SIRT3)is a potential therapeutic target for cardiovascular,metabolic,and other aging-related diseases.In this study,we investigated the role of SIRT3 in diabetic cardiomyopathy(DCM).Mice were injected with streptozotocin(STZ,60 mg/kg,ip)to induce diabetes mellitus.Our proteomics analysis revealed that SIRT3 expression in the myocardium of diabetic mice was lower than that of control mice,as subsequently confirmed by real-time PCR and Western blotting.To explore the role of SIRT3 in DCM,SIRT3-knockout mice and 129S1/SvImJ wild-type mice were injected with STZ.We found that diabetic mice with SIRT3 deficiency exhibited aggravated cardiac dysfunction,increased lactate dehydrogenase(LDH)level in the serum,decreased adenosine triphosphate(ATP)level in the myocardium,exacerbated myocardial injury,and promoted myocardial reactive oxygen species(ROS)accumulation.Neonatal rat cardiomyocytes were transfected with SIRT3 siRNA,then exposed to high glucose(HG,25.5 mM).We found that downregulation of SIRT3 further increased LDH release,decreased ATP level,suppressed the mitochondrial membrane potential,and elevated oxidative stress in HG-treated cardiomyocytes.SIRT3 deficiency further raised expression of necroptosis-related proteins including receptor-interacting protein kinase 1(RIPK1),RIPK3,and cleaved caspase 3,and upregulated the expression of inflammation-related proteins including NLR family pyrin domain-containing protein 3(NLRP3),caspase 1 p20,and interleukin-1βboth in vitro and in vivo.Collectively,SIRT3 deficiency aggravated hyperglycemia-induced mitochondrial damage,increased ROS accumulation,promoted necroptosis,possibly activated the NLRP3 inflammasome,and ultimately exacerbated DCM in the mice.These results suggest that SIRT3 can be a molecular intervention target for the prevention and treatment of DCM. | Shu Song Yue Ding Guo-liang Dai Yue Zhang Meng-ting Xu Jie-ru Shen Ting-ting Chen Yun Chen Guo-liang Meng | 2021 | Acta Pharmacologica Sinica2021，42，2： | 14 |
| 8 | BRI1-Associated Receptor Kinase 1 Regulates Guard Cell ABA Signaling Mediated by Open Stomata 1 in Arabidopsis显示文摘有气孔的运动在为在植物纸巾和空气之间的光合作用和水平衡调整煤气的交换是批评的。植物荷尔蒙 abscisic 酸(骆驼毛的织物) 戏在在各种各样的不能生活的压力下面调整有气孔的闭合给角色调音。在这研究,我们在警卫房间骆驼毛的织物发信号揭示了 BAK1 的一个新奇角色。我们发现表明变异的 bak1 的 brassinosteroid (BR ) 比野类型的植物失去了更多的水并且在有气孔的闭合显示出骆驼毛的织物 insensitivity。导致骆驼毛的织物的 OST1 表示和生产也是的反应的氧种类(ROS ) 在 bak1 损害了。有 H 2 OST1 的 O 2, overexpression 完全没救 bak1 的 insensitivity 到骆驼毛的织物。我们证明 BAK1 在血浆膜附近与 OST1 形成建筑群并且 BAK1/OST1 建筑群在 planta 响应骆驼毛的织物被增加。Brassinolide,最活跃的 BR,在 BAK1/OST1 建筑群和 OST1 表示的导致骆驼毛的织物的形成上施加了否定效果。而且,我们发现 BAK1 和 ABI1 相对地调整 OST1 phosphorylation invitro,和那 ABI1 与 BAK1 交往并且禁止 BAK1 和 OST1 的相互作用。一起拿,我们的结果建议 BAK1 在警卫房间调整导致骆驼毛的织物的有气孔的闭合。 | Yun Shang Changbo Dai Myeong Min Lee June M. Kwak Kyoung Hee Nam | 2016 | Molecular Plant2016，9，3： | 13 |
| 9 | Esophageal Helicobacter pylori colonization aggravates esophageal injury caused by reflux显示文摘AIM: To investigate esophageal Helicobacter pylori(H. pylori) colonization on esophageal injury caused by reflux and the related mechanisms. METHODS: An esophagitis model, with acid and bile reflux, was surgically produced in male rats. The rats were randomly divided into either:(1) an esophagogastroduodenal anastomosis(EGDA) group;(2) an EGDA with H. pylori infection group;(3) a pseudo-operation with H. pylori infection group; or(4) a pseudooperation group. All rats were kept for 36 wk. Based on the location of H. pylori colonization, the EGDA rats with H. pylori infection were subdivided into those with concomitant esophageal H. pylori colonization or those with only gastric H. pylori colonization. The esophageal injuries were evaluated grossly and microscopically. The expressions of CDX2 and MUC2 were determined by real-time polymerase chain reaction(RT-PCR) and immunohistochemistry. Ki-67 antigen expression was determined by immunohistochemistry. The m RNA levels of cyclin D1, c-Myc, Bax and Bcl-2 were determined by RT-PCR. Cell apoptosis was evaluated using the Td Tmediated d UTP nick-end labeling method.RESULTS: Esophagitis, Barrett's esophagus(BE), and esophageal adenocarcinoma(EAC) developed in rats that underwent EGDA. When comparing rats with EGDA and concomitant esophageal H. pylori colonization to EGDA-only rats, the severity of injury(87.9 ± 5.2 vs 77.2 ± 8.6, macroscopically, 92.5 ± 8.0 vs 83.8 ± 5.5, microscopically, both P < 0.05) and the incidences of BE(80.0% vs 33.3%, P = 0.055) and EAC(60.0% vs 11.1%, P < 0.05) were increased. These increases were associated with upregulation of CDX2 and MUC2 m RNA(10.1 ± 5.4 vs 3.0 ± 2.9, 8.4 ± 4.6 vs 2.0 ± 3.2, respectively, P s < 0.01) and protein(8.1 ± 2.3 vs 3.3 ± 3.1, 7.3 ± 4.0 vs 1.8 ± 2.7, respectively, all P < 0.05). The expression of Ki-67(8.9 ± 0.7 vs 6.0 ± 1.7, P < 0.01) and the presence of apoptotic cells(8.3 ± 1.1 vs 5.3 ± 1.7, P < 0.01) were also increased significantly in rats with EGDA and concomitant esophageal H. pylori colonization compared with rats with EGDA only. The m RNA levels of cyclin D1(5.8 ± 1.9 vs 3.4 ± 1.3, P < 0.01), c-Myc(6.4 ± 1.7 vs 3.7 ± 1.2, P < 0.01), and Bax(8.6 ± 1.6 vs 5.1 ± 1.3, P < 0.01) were significantly increased, whereas the m RNA level of Bcl-2(0.6 ± 0.3 vs 0.8 ± 0.3, P < 0.01) was significantly reduced in rats with EGDA and concomitant esophageal H. pylori colonization compared with rats with EGDA only.CONCLUSION: Esophageal H. pylori colonization increases esophagitis severity, and facilitates the development of BE and EAC with the augmentation of cell proliferation and apoptosis in esophageal mucosa. | Yun-Xiang Chu Wei-Hong Wang Yun Dai Gui-Gen Teng Shu-Jun Wang | 2014 | World Journal of Gastroenterology2014，20，42： | 12 |
| 10 | Superparamagnetic iron oxide nanoparticle targeting of adipose tissue-derived stem cells in diabetes-associated erectile dysfunction显示文摘可勃起的机能障碍(编辑) 是糖尿病的主要复杂并发症,并且有编辑的许多糖尿病的人对普通编辑治疗倔强。脂肪质的导出织物的干细胞(ADSC ) 被显示了在糖尿病的动物模型改进可勃起的功能。然而,到损坏地点的不适当的房间 homing 限制了他们的功效。因此,我们探索了在与一个外部磁场改进导致 streptozotocin 的糖尿病的老鼠的可勃起的功能上用 superparamagnetic 氧化铁 nanoparticles (SPION ) 标记的 ADSC 的效果。我们发现那 SPION 有效地合并了到 ADSC 并且没在干细胞性质上施加任何否定效果。ADSC 的磁性的指向在阴茎海绵体贡献了长期的细胞保留并且独自与 ADSC 注射相比改进了糖尿病的老鼠的可勃起的功能。另外, ADSC 的 paracrine 效果看起来在功能、结构的恢复起主要作用。因此,磁性的指导地的 ADSC 治疗是为联系糖尿病的编辑治疗的一条有效途径。 | Lei-Lei Zhu Zheng Zhang He-Song Jiang Hai Chen Yun Chen Yu-Tian Dai | 2017 | Asian Journal of Andrology2017，19，4： | 11 |
| 11 | Efficacy and safety of the long-acting fusion inhibitor albuvirtide in antiretroviral-experienced adults with human immunodeficiency virus-1:interim analysis of the randomized,controlled,phase 3,non-inferiority TALENT study显示文摘Background:Albuvirtide is a once-weekly injectable human immunodeficiency virus(HIV)-1 fusion inhibitor.We present interim data for a phase 3 trial assessing the safety and efficacy of albuvirtide plus lopinavir-ritonavir in HIV-1-infected adults already treated with antiretroviral drugs.Methods:We carried out a 48-week,randomized,controlled,open-label non-inferiority trial at 12 sites in China.Adults on the World Health Organization(WHO)-recommended first-line treatment for>6 months with a plasma viral load>1000 copies/mL were enrolled and randomly assigned(1:1)to receive albuvirtide(once weekly)plus ritonavir-boosted lopinavir(ABT group)or the WHO-recommended second-line treatment(NRTI group).The primary endpoint was the proportion of patients with a plasma viral load below 50 copies/mL at 48 weeks.Non-inferiority was prespecified with a margin of 12%.Results:At the time of analysis,week 24 data were available for 83 and 92 patients,and week 48 data were available for 46 and 50 patients in the albuvirtide and NRTI groups,respectively.At 48 weeks,80.4%of patients in the ABT group and 66.0%of those in the NRTI group had HIV-1 RNA levels below 50 copies/mL,meeting the criteria for non-inferiority.For the per-protocol population,the superiority of albuvirtide over NRTI was demonstrated.The frequency of grade 3 to 4 adverse events was similar in the two groups;the most common adverse events were diarrhea,upper respiratory tract infections,and grade 3 to 4 increases in triglyceride concentration.Renal function was significantly more impaired at 12 weeks in the patients of the NRTI group who received tenofovir disoproxil fumarate than in those of the ABT group.Conclusions:The TALENT study is the first phase 3 trial of an injectable long-acting HIV drug.This interim analysis indicates that once-weekly albuvirtide in combination with ritonavir-boosted lopinavir is well tolerated and non-inferior to the WHO-recommended second-line regimen in patients with first-line treatment failure.Trial registration:ClinicalTrials.gov Identifier:NCT02369965;http://gffzz90ed6ce9d87f4798s0puuvwvxwu6u6obw.ffgz.tsg.suse.edu.cn Clinical Trial Registry No.ChiCTR-TRC-14004276;http://gffzz62a03ee25e6f4a77h0puuvwvxwu6u6obw.ffgz.tsg.suse.edu.cn/enindex.aspx. | Bin Su Cheng Yao Qing-Xia Zhao Wei-Ping Cai Min Wang Hong-Zhou Lu Yuan-Yuan Chen Li Liu Hui Wang Yun He Yu-Huang Zheng Ling-Hua Li Jin-Feng Chen Jian-Hua Yu Biao Zhu Min Zhao Yong-Tao Sun Wen-Hui Lun Wei Xia Li-Jun Sun Li-Li Dai Tai-Yi Jiang Mei-Xia Wang Qing-Shan Zheng Hai-Yan Peng Yao Wang Rong-Jian Lu Jian-Hua Hu Hui Xing Yi-Ming Shao Dong Xie Tong Zhang Fu-Jie Zhang Hao Wu TALENT Study Team | 2020 | Chinese Medical Journal2020，，24： | 10 |
| 12 | 局部麻醉药物治疗早泄的疗效和安全性:系统性回顾和荟萃分析显示文摘本文的目的是评估局部麻醉药物往治疗早泄方面的疗效及安全性。我们制定了原始文献纳入标准及检索策略,检索了Cochrane图忙馆,PUBMED[1EMBASE数据库,检索并收集相关麻醉药物治疗早泄的随机对照研究,观察指标包括15月道内射精潜伏期(IELT),患者报告结局指标(PRO)和药物不良事件。采用State11.0软件进行荟萃分析。实验结果显示,总共有7篇符合纳入标准的随机对照研究进入荟萃分析,治疗组56660,安慰组388例。荟萃分析结果表明,早泄患者应用局部麻醉药物治疗与安慰剂相比,IELT的标化平均差(SMD)变化为5.02(95%CI:3.03—7.00):与此同时,局部麻醉药物巧不良事件的发生率要比安慰剂高(OR:3.30。95%CI:1.71-36),但值得注意的是,这些不良事件都足局部不良反应;此外,药物治疗组患者的报告结局指标有明显的改善。 | Jia-Dong Xia You-Feng Hart Liu-Hua Zhou Yun Chen Yu-Tian Dai | 2013 | Asian Journal of Andrology2013，15，4： | 10 |
| 13 | Comparison of surgical effect and postoperative patient experience between laparoendoscopic single-site and conventional laparoscopic varicocelectomy, a systematic.review and meta-analysis显示文摘现在的元分析被进行比较临床的效果和 laparoendoscopic 的耐心的经验单个地点的 varicocelectomy (LESSV ) 和常规 laparoscopic varicocelectomy。候选人研究在数据库 Cochrane 图书馆, PubMed, EMBASE,和 MEDLINE 的文学搜索以后被包括。必要数据和结果措施的相关信息被二个独立作者从合格研究提取,并且元分析用 STATA 12.0 软件被进行。亚群分析被学习设计(RCT 和 non-RCT ) 进行。机会比率(或) 或标准化吝啬的差别(SMD ) 和他们的 95% 信心间隔(95% CI ) 被用来估计结果措施。七篇文章在我们的元分析被包括。结果显示经历了 LESSV 的那个病人有更短的持续时间回到工作(外套:SMD =-1.454,95% CI:-2.502--0.405, P = 0.007;non-RCT:SMD =-2.906,95% CI:-3.796--2.017, P = 0.000;并且 RCT:SMD =-0.841,95% CI:-1.393--0.289, P = 0.003 ) 并且在 3 h 或 6 h 的更少的疼痛经验(SMD =-0.447,95% CI:-0.754--0.139, P = 0.004 ) ,白天 1 (SMD =-0.477,95% CI:-0.905--0.05, P = 0.029 ) ,并且白天 2 (SMD =-0.612,95% CI:-1.099--0.125, P = 0.014 ) 手术后地基于 RCT 研究。然而,元分析基于操作时间,临床的效果(精液质量的改进和阴囊的疼痛地势) ,和复杂并发症(阴囊积水和复发) 产出不重要的结果。在结论, LESSV 在常规 laparoscopic varicocelectomy 上有快速的恢复和更少的疼痛经验。然而,以临床的效果和阴囊积水和精索静脉曲张复发的发生二种 varicocelectomy 技术之间没有统计上重要的差别。更高质量的研究为一个全面结论被保证。 | Zheng Zhang Shu-Juan Zheng Wen Yu You-Feng Han Hai Chen Yun Chen Yu-Tian Dai | 2017 | Asian Journal of Andrology2017，19，2： | 10 |
| 14 | Pancreatic kininogenase improves erectile function in streptozotocin-induced type 2 diabetic rats with erectile dysfunction显示文摘 | Guo-Tao Chen Bai-Bing Yang Jian-Huai Chen Zheng Zhang Lei-Lei Zhu He-Song Jiang Wen Yu Yun Chen Yu-Tian Dai | 2018 | Asian Journal of Andrology2018，20，5： | 9 |
| 15 | Non-steroidal anti-inflammatory drugs in prevention of gastric cancer显示文摘包括 cyclooxygenase 的 Non-steroidal 反煽动性的药(NSAID ) 2 (COX-2 ) 选择禁止者,是为胃的癌症的 chemoprevention 的潜在的代理人。尽管许多问题仍然保持未答复例如治疗的最佳的剂量和持续时间,流行病学、试验性的研究证明了 NSAID 使用与胃的癌症的减少的风险被联系。为致癌作用上的 NSAID 的 suppress 或效果的可能的机制是在血管生成的上皮细胞和规定导致 apoptosis 的能力。艇长依赖者和艇长无关的小径在 NSAID 的生物活动有一个角色。NSAID 怎么阻止肿瘤的生长的知识将极大地为胃的癌症帮助更好的 chemopreventive 药和新奇治疗的设计。 | Yun Dai Wei-Hong Wang | 2006 | World Journal of Gastroenterology2006，12，18： | 9 |
| 16 | Novel Ru - K/Carbon Nanotubes Catalyst for Ammonia Synthesis显示文摘A novel ammonia synthesis catalyst, potassium-promoted ruthenium supported on carbon nanotubes, was developed. It was found that the Ru-K/carbon nanotubes catalyst had higher activity for ammonia synthesis (20.85 ml NH3/h/g-cat ) than the Ru-K/fullerenes (13.3 ml NH3/h/g-cat ) at atmospheric pressure and 623 K. The catalyst had activity even at 473 K. and had the highest activity (23.46 ml NH3/h/g-cat ) at 643 K. It was suggested that the multi-walled structure favored the electron transfer the hydrogen-storage and the hydrogen-spill which were favorable to ammonia synthesis. | Yun CAI Jing Dong LIN Hong Bo CHEN Hong Bin ZHANG Guo Dong LIN Dai Wei LIAO (State Key Lab of Physical Chemistry on Solid Surfaces. Department of Chemistry Institute of Physical Chemistry. Xiamen University, Xiamen 361005) | 2000 | Chinese Chemical Letters2000，11，4： | 8 |
| 17 | A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer显示文摘The immune checkpoint blockade therapy has profoundly revolutionized the field of cancer immunotherapy. However, despite great promise for a variety of cancers, the efficacy of immune checkpoint inhibitors is still low in colorectal cancer(CRC). This is mainly due to the immunosuppressive feature of the tumor microenvironment(TME). Emerging evidence reveals that certain chemotherapeutic drugs induce immunogenic cell death(ICD), demonstrating great potential for remodeling the immunosuppressive TME. In this study, the potential of ginsenoside Rg3(Rg3) as an ICD inducer against CRC cells was confirmed using in vitro and in vivo experimental approaches. The ICD efficacy of Rg3 could be significantly enhanced by quercetin(QTN) that elicited reactive oxygen species(ROS). To amelioratein vivo delivery barriers associated with chemotherapeutic drugs, a folate(FA)-targeted polyethylene glycol(PEG)-modified amphiphilic cyclodextrin nanoparticle(NP) was developed for co-encapsulation of Rg3 and QTN. The resultant nanoformulation(CD-PEG-FA.Rg3.QTN) significantly prolonged blood circulation and enhanced tumor targeting in an orthotopic CRC mouse model, resulting in the conversion of immunosuppressive TME. Furthermore, the CD-PEG-FA.Rg3.QTN achieved significantly longer survival of animals in combination with Anti-PD-L1. The study provides a promising strategy for the treatment of CRC. | Dandan Sun Yifang Zou Liu Song Shulan Han Hao Yang Di Chu Yun Dai Jie Ma Caitriona M.O’Driscoll Zhuo Yu Jianfeng Guo | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 8 |
| 18 | Effect of a transverse plasma jet on a shock wave induced by a ramp显示文摘We conducted experiments in a wind tunnel with Mach number 2 to explore the evolution of a transverse plasma jet and its modification effect on a shock wave induced by a ramp with an angle of 24°. The transverse plasma jet was created by arc discharge in a small cylindrical cavity with a 2 mm diameter orifice. Three group tests with different actuator arrangements in the spanwise or streamwise direction upstream from the ramp were respectively studied to compare their disturbances to the shock wave. As shown by a time-resolved schlieren system, an unsteady motion of the shock wave by actuation was found: the shock wave was significantly modified by the plasma jet with an upstream motion and a reduced angle. Compared to spanwise actuation, a more intensive impact was obtained with two or three streamwise actuators working together. From shock wave structures, the control effect of the plasma jet on the shock motion based on a thermal effect, a potential cause of shock modification, was discussed. Furthermore, we performed a numerical simulation by using the Improved Delayed Detached Eddy Simulation(IDDES) method to simulate the evolution of the transverse plasma jet plume produced by two streamwise actuators. The results show that flow structures are similar to those identified in schlieren images. Two streamwise vortices were recognized, which indicates that the higher jet plume is the result of the overlap of two streamwise jets. | Hongyu WANG Jun LI Di JIN Hui DAI Tian GAN Yun WU | 2017 | Chinese Journal of Aeronautics2017，30，6： | 7 |
| 19 | Translational Research in Oncology Research & Development and Its Impact on Early Development in China: report of the 5th Annual Meeting of the US Chinese Anti-Cancer Association (USCACA) at 2013 AACR Annual Meeting显示文摘In April 2013, the US Chinese Anti-Cancer Association (USCACA) held its 5th annual meeting in conjunction with the American Association for Cancer Research (AACR) 2013 Annual Meeting in Washington DC. The USCACA executive committee reported activities and programs and highlighted the partnership and collaboration between USCACA and other major organizations. The key initiatives and programs of USCACA included 1) USCACA-TIGM Esophageal Cancer Program that funds translational research of esophageal cancer prevention and treatment at the Xinxiang Medical University in Henan province, China; 2) the USCACA-NFCR-AFCR Scholarship Program, which has supported 10 young outstanding Chinese cancer researchers and will award 4 fellowships at the Guangzhou International Symposium on Oncology in November this year; 3) USCACA-Hengrui Training Program for Early Phase Clinical Research, which has supported the training of a Chinese scholar at two major cancer centers in the US; and 4) USCACA has continued its partnership with the Chinese Journal of Cancer, which has reached significant international impact. | Lingjie Guan Yun Dai Roger Luo | 2013 | Chinese Journal of Cancer2013，32，7： | 6 |
| 20 | Association between Metabolic Syndrome and Carotid Atherosclerosis: A Cross-sectional Study in Northern China显示文摘Objective Increased carotid artery intima-media thickness(CIMT)and carotid plaque as manifestations of carotid atherosclerosis have been used as markers of cardiovascular disease(CVD).The components of metabolic syndrome(Met S)are linked to CVD,but the association between Met S and CVD is controversial.Methods A total of 8,933 Chinese adults aged 40 years or older from 2010 to 2014 were selected from the Jidong and Kailuan communities.Met S was defined by the International Diabetes Federation criteria.CIMT and carotid plaque were measured using color Doppler ultrasound.Logistic regression models were used to assess the association of Met S with carotid plaque and CIMT.Results Met S was found among 3,461(3,461/8,933)participants.The odds ratio and 95%confidence internal(CI)for carotid plaques in participants with Met S was 1.16(1.03-1.30).The risk of carotid plaques increased with the number of Met S components.The average CIMT was higher in participants with Met S(β=0.020,95%CI,0.014-0.027)and in participants with more Met S components.Conclusion Individuals with Met S are at an increased risk for carotid atherosclerosis compared to those without MetS. | ZHOU Ping An ZHANG Chen Huan CHEN Yan Ru LI Dong SONG Dai Yu LIU Hua Min ZHOU Ming Yue SONG Guo Shun CHEN Sheng Yun | 2019 | Biomedical and Environmental Sciences2019，32，12： | 6 |
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