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| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | The association of layperson characteristics with the quality of simulated cardiopulmonary resuscitation performance显示文摘BACKGROUND: Few studies have examined the association of layperson characteristics with cardiopulmonary resuscitation(CPR) provision. Previous studies suggested provider characteristics, including age and gender, were associated with CPR quality, particularly chest compression(CC) depth. We sought to determine the association of subject characteristics, including age and gender with layperson CPR quality during an unannounced simulated CPR event. We hypothesized shallower CC depth in females, and older-aged subjects.METHODS: As part of a larger multicenter randomized controlled trial of CPR training for cardiac patients' caregivers, CPR skills were assessed 6 months after training. We analyzed associations between subject characteristics and CC rate, CC depth and no-? ow time. Each variable was analyzed independently; signi? cant predictors determined via univariate analysis were assessed in a multivariate regression model.RESULTS: A total of 521 laypersons completed a 6-month CPR skills assessment and were included in the analysis. Mean age was 51.8±13.7 years, 75% were female, 57% were Caucasian. Overall, mean CC rate was 88.5±25.0 per minute, CC depth was 50.9±2.0 mm, and mean no-flow time was 15.9±2.7 sec/min. CC depth decreased signi? cantly in subjects >62 years(P<0.001). Male subjects performed deeper CCs than female subjects(47.5±1.7 vs. 41.9±0.6, P<0.001).CONCLUSION: We found that layperson age >62 years and female gender are associated with shallower CC depth. | Marion Leary David G.BucMer Daniel J.Ikeda Daiane A.Saraiva Robert A.Berg Vinay M.Nadkarni Audrey L.Blewer Benjamin S.Abella | 2017 | World Journal of Emergency Medicine2017，8，1： | 5 |
| 3 | lnsulin-Like Growth Factor-I Enhances Transforming Growth Factor-b-Induced Extracellular Matrix Protein Production Through the P38/Activating Transcription Factor-2 Signaling Pathway in Keloid Fibroblasts 显示文摘 | Daian T Ohtsuru A Rogounovitch T | 2003 | J Invest Dermatol2003，12，6： | 1 |
| 4 | The role of a typical organisms in asthma显示文摘 | Daian CM Wolf AH Bielory L et a l | 2002 | Allergy Asthma Proe2002，21，2： | 1 |
| 5 | 3D reconstitution of porous media from image processing data using a mulfiscale percolation system 显示文摘 | DAIAN J F FERNANDES C P PHILIPPI P C BELLINI DA CUNHA NETO J A | 2004 | Journal of Petroleum Science and Engineering2004，42，1： | 1 |
| 6 | Insulin-like growth fac-tor-Ⅰenhances transforming growth factor-beta induced extracel-lular matrix protein production through the P38/activating tran-scription factor-2 signaling pathway in keloid fibroblasts显示文摘 | Daian T Ohtsuru A Rogounovitch T | 2003 | J In-vest Dermatol2003，120，6： | 1 |
| 7 | The role of a typical organi-smsin asthma显示文摘 | Daian CM Wolff AH Bielory L et a1 | 2000 | Allergy Asthma Proc2000，21，2： | 1 |
| 8 | The role of atypical organisms in asthma显示文摘 | Daian CM Wolf AH Bielory L | 2000 | Allergy Asthma Proe2000，21，2： | 1 |
| 9 | Rapid assessment of metal contamination in commercial fruit juices by inductively coupled mass spectrometry after a simple dilution显示文摘 | Luciano Tormen Daiane Placido Torres Ingrid Maria Dittert Rennan G.O. Araújo Vera L.A. Frescura Adilson José Curtius | 2010 | Journal of Food Composition and Analysis2010，，1： | 1 |
| 10 | The role of a typical ganisms in asthma显示文摘 | Daian CM Wolff AH Bielory L | 2000 | Allergy Asthma Proc2000，21，2： | 1 |
| 11 | l The role of a typical organismsin asthma显示文摘 | Daian CM WolffAH Bielory L et a | 2000 | AllergyAsthma Proe2000，21，2： | 1 |
| 12 | The role of a typical organisms in asthma 显示文摘 | Daian CM Wolff AH Bielory L | 2000 | Allergy Asthma Proc2000，21，2： | 1 |
| 13 | The role of atypical organisms in asthma 显示文摘 | Daian CM Wolff AH BieIory L | 2000 | Allergy Asthma Proc2000，21，2： | 1 |
| 14 | The role of a typical organisms in asthma显示文摘 | Daian CM Wolff AH Bielory L | 2000 | Allergy Asthma Proc2000，21，2： | 1 |
| 15 | Multiscale Structures to Describe Porous Media Part I: Theoretical Background and Invasion by Fluids显示文摘 | Ke Xu Jean-fran?ois Daian Daniel Quenard | 1997 | Transport in Porous Media1997，，1： | 1 |
| 16 | The role of atypical organisms in asthma显示文摘 | Daian CM Wolff AH Bielory L | 2002 | Allergy Asthma Proc2002，21，2： | 1 |
| 17 | The role of atypical organisms in asthma显示文摘 | Daian CM Wolff AH Bielory L | 2000 | Allergy Asthma Proc2000，21，2： | 1 |
| 18 | Insulin-like growth factor-1 enhances transforming growth factor-beta-induced extracellular matrix protein production through the p38/activating transcription factor-2 signaling pathway in keloid fibroblasts显示文摘 | Daian T Ohtsuru A Rogounovitch T | | 0，，： | 1 |
| 19 | The role of atypical organisms in asthma显示文摘 | Daian CM Wolff AH Bielory L | 2000 | Allergy Asthma Proc2000，21，2： | 1 |
| 20 | Genetic and phenotypic diversity of plant-growth-promoting bacilli isolated from wheat fields in southern Brazil显示文摘 | Anelise Beneduzi Daiane Peres Pedro Beschoren da Costa Maria Helena Bodanese Zanettini Luciane Maria Pereira Passaglia | 2008 | Research in Microbiology2008，，4： | 1 |
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