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| 1 | ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer显示文摘 | Shunrong Ji Yi Qin Si Shi Xiangyuan Liu Hongli HU Hu Zhou Jing Gao Bo Zhang Wenyan Xu Jiang Liu Dingkong Liang Liang Liu Chen Liu Jiang Long Haijun Zhou Paul J Chiao Jin Xu Quanxing Ni Daming Gao Xianjun Yu | 2015 | Cell Research2015，25，5： | 19 |
| 2 | Quantification of microcystin-producing and non-microcystin producing Microcystis populations during the 2009 and 2010 blooms in Lake Taihu using quantitative real-time PCR显示文摘Lake Taihu,a large,shallow hypertrophic freshwater lake in eastern China,has experienced lake-wide toxic cyanobacterial blooms annually during summer season in the past decades.Spatial changes in the abundance of hepatotoxin microcystin-producing and nonmicrocystin producing Microcystis populations were investigated in the lake in August of 2009 and 2010.To monitor the densities of the total Microcystis population and the potential microcystin-producing subpopulation,we used a quantitative real-time PCR assay targeting the phycocyanin intergenic spacer(PC-IGS) and the microcystin synthetase gene(mcyD),respectively.On the basis of quantification by real-time PCR analysis,the abundance of potential toxic Microcystis genotypes and the ratio of the mcyD subpopulation to the total Microcystis varied significantly,from 4.08×104 to 5.22×107 copies/mL,from 5.7% to 65.8%,respectively.Correlation analysis showed a strong positive relationship between chlorophyll-a,toxic Microcystis and total Microcystis;the abundance of toxic Microcystis correlated positively with total phosphorus and ortho-phosphate concentrations,but negatively with TN:TP ratio and nitrate concentrations.Meanwhile the proportion of potential toxic genotypes within Microcystis population showed positive correlation with total phosphorus and ortho-phosphate concentrations.Our data suggest that increased phosphorus loading may be a significant factor promoting the occurrence of toxic Microcystis bloom in Lake Taihu. | Daming Li Fanxiang Kong Xiaoli Shi Linlin Ye Yang Yu Zhen Yang | 2012 | Journal of Environmental Sciences2012，24，2： | 5 |
| 3 | IL1RN promotes osteoblastic differentiation via interacting with ITGB3 in osteoporosis显示文摘The occurrence and progress of osteoporosis(OP)are partially caused by impaired osteoblast differentiation.Interleukin-I receptor antagonist(IL1RN)is an immune modulatory molecule that commonly functions by means of competing the binding site of IL-1R with IL-1.Although it was recently reported that IL1RN is involved in osteoblast differentiation,the role of IL1RN in osteogenesis remains unclear.In this work,we first investigated the expression pattern of IL1RN in ovariectomy mice and in vitro osteogenic induction of MC3T3-E1 and C3H10T1/2 cells.To verify the exact role of IL1RN in osteoblast differentiation,we established IL1RN-downregulated/upregulated cell lines.The results indicated that IL1RN was constantly expressed in MC3T3-E1 and C3H10T1/2 cells.Interestingly,an increase of IL1RN expression in osteoblasts occurred when osteoblasts were cultured in osteogenic medium(OM).As expected,silencing of IL1RN attenuated the osteogenic effect of OM,while IL1RN overexpression increased the osteogenic staining and promoted the expression of osteogenic markers,including alkaline phosphatase,osterix,and osteocalcin.In addition to evaluating the function of IL1RN in osteoblasts,we also investigated the molecular mechanism of the role of IL1RN in osteoblasts.We found that IL1RN interacts with integrinβ3 to activateβ-catenin signaling,which finally regulates osteoblast differentiation.Taken together,this study provides the framework that IL1RN,as a novel regulator of osteogenesis,may be a potential therapeutic target for the treatment of OP. | Zehua Zou Ruixuan Liu Yiwen Wang Yufei Xing Zuowei Shi Kaifu Wang Daming Dong | 2021 | Acta Biochimica et Biophysica Sinica2021，53，3： | 3 |
| 4 | Key issues on watershed ecological security assessment显示文摘有关分水岭基于关键问题的分析包括评价的题目,内容,和方法论的生态的安全评价,这篇论文指出那生态的安全应该在不同层次动态地被估计(例如分水岭和生态系统层次) 与是的人一起主要评价题目。功能的安全和结构的安全必须在分水岭被认为生态的安全评价。以便反映分水岭的全面、及时的安全地位, PSR (pressure-state-response ) 方法应该被采用。纵的范围峡区域(LRGR ) 作为一个例子被研究。分水岭的一个索引系统生态的安全评价被建议了,它包括结构的索引,功能的索引,压力和反应索引,并且生态的安全的状态在云南为 LRGR 被分析省。 | GAO JiXI ZHANG XiangHui JIANG Yun OU XiaoKun HE DaMing SHI JianBin | 2007 | Chinese Science Bulletin2007，52，A02： | 3 |
| 5 | Robust facial landmark detection and tracking across poses and expressions for in-the-wild monocular video显示文摘We present a novel approach for automatically detecting and tracking facial landmarks acrossposesandexpressionsfromin-the-wild monocular video data,e.g.,You Tube videos and smartphone recordings.Our method does not require any calibration or manual adjustment for new individual input videos or actors.Firstly,we propose a method of robust 2D facial landmark detection across poses,by combining shape-face canonical-correlation analysis with a global supervised descent method.Since 2D regression-based methods are sensitive to unstable initialization,and the temporal and spatial coherence of videos is ignored,we utilize a coarse-todense 3D facial expression reconstruction method to refine the 2D landmarks.On one side,we employ an in-the-wild method to extract the coarse reconstruction result and its corresponding texture using the detected sparse facial landmarks,followed by robust pose,expression,and identity estimation.On the other side,to obtain dense reconstruction results,we give a face tracking flow method that corrects coarse reconstruction results and tracks weakly textured areas;this is used to iteratively update the coarse face model.Finally,a dense reconstruction result is estimated after it converges.Extensive experiments on a variety of video sequences recorded by ourselves or downloaded from You Tube show the results of facial landmark detection and tracking under various lighting conditions,for various head poses and facial expressions.The overall performance and a comparison with state-of-art methods demonstrate the robustness and effectiveness of our method. | Shuang Liu Yongqiang Zhang Xiaosong Yang Daming Shi Jian J.Zhang | 2017 | Computational Visual Media2017，3，1： | 2 |
| 6 | An Extension Matrix Approach to Chinese Character Recognition显示文摘 | Shu Wenhao Shi Daming Qian Guolian | 2006 | Proceedings of the IEEE2006，，8： | 1 |
| 7 | Effect of All-Trans Retinoic Acid on the Differentiation of U87 Glioma Stem/Progenitor Cells显示文摘 | Zhe Shi Meiqing Lou Yaodong Zhao Quanbin Zhang Daming Cui Ke Wang | 2013 | Cellular and Molecular Neurobiology2013，，7： | 1 |
| 8 | Identification of weathered troughs in granites for tunneling at Daya Bay reactor-neutrino experiment site显示文摘Weathered troughs are frequently encountered in granites.They can cause problems to tunneling in the rocks and have to be properly addressed.The structures or spatial shapes of weathered troughs were seldom clarified in the past.In this paper,four weathered troughs are identified by means of geophysical exploration,core drilling,logging,and in-situ stress measurement at Daya Bay reactor-neutrino experiment site in Shenzhen,China.The weathered troughs are exposed on the ground or partially covered by grass and soils,which will threaten the safety of horizontal tunneling at a shallow depth.High electrical resistivity(HER) method is adopted for its feasibility and practicality,in combination with field geological observation,ultrasonic televiewer in boreholes and in-situ stress measurement.By comparing the HER values of completely decomposed to fresh rocks,it is indicated that the HER values of weathered troughs in natural state are 0.4-100 ·m,and the in-situ stress is abnormally lower than those at upper and lower layers.Field investigations show that the depths of the four weathered troughs are 30-182 m,with bottom elevation over 10 m.The volume of each weathered trough is mostly over 1×10 6 m 3 in inverted conic form.The weathered troughs often occur in various kinds of landforms,such as ridges,gullies or gently dipping dish-like depression areas.Faults and boundaries of different granitic plutons as well as joints govern the formation,locations and strikes of these troughs under development. | Yanjun Shang Yongyue Shi Weijun Jin Daming Lin Fengbo Wu Wei Zhang | 2012 | Journal of Rock Mechanics and Geotechnical Engineering2012，4，2： | 1 |
| 9 | Dynamics of dissolved organic carbon after a cyanobacterial bloom in hypereutrophic Lake Taihu (China)显示文摘 | Linlin Ye Xiao Shi Xiaodong Wu Min Zhang Yang Yu Daming Li Fanxiang Kong | 2011 | Limnologica2011，，4： | 1 |
| 10 | Advanced hough transform using a multilayer fractional fourier method显示文摘 | SHI Daming ZHEN Liying LIU Jigang | 2010 | IEEE Signal Processing Society2010，19，6： | 1 |
| 11 | Science with the 2.5-meter Wide Field Survey Telescope(WFST)显示文摘The Wide Field Survey Telescope(WFST) is a dedicated photometric surveying facility being built jointly by University of Science and Technology of China(USTC) and the Purple Mountain Observatory(PMO). It is equipped with a 2.5-meter diameter primary mirror, an active optics system, and a mosaic CCD camera with 0.73 gigapixels on the primary focal plane for highquality image capture over a 6.5-square-degree field of view. The installation of WFST near the summit of Saishiteng mountain in the Lenghu region is scheduled in summer of 2023, and the operation is planned to start three months later. WFST will scan the northern sky in four optical bands(u, g, r and i) at cadences from hourly/daily in the deep high-cadence survey(DHS) program, to semi-weekly in the wide field survey(WFS) program. During a photometric night, a nominal 30 s exposure in the WFS program will reach a depth of 22.27, 23.32, 22.84, and 22.31(AB magnitudes) in these four bands, respectively, allowing for the detection of a tremendous amount of transients in the low-z universe and a systematic investigation of the variability of Galactic and extragalactic objects. In the DHS program, intranight 90 s exposures as deep as 23(u) and 24 mag(g), in combination with target of opportunity follow-ups, will provide a unique opportunity to explore energetic transients in demand for high sensitivities, including the electromagnetic counterparts of gravitational wave events, supernovae within a few hours of their explosions,tidal disruption events and fast, luminous optical transients even beyond redshift of unity. In addition, the final 6-year co-added images, anticipated to reach g■25.8 mag in WFS or 1.5 mags deeper in DHS, will be of fundamental importance to general Galactic and extragalactic science. The highly uniform legacy surveys of WFST will serve as an indispensable complement to those of the Vera C. Rubin Observatory's Legacy Survey of Space and Time(LSST) that monitors the southern sky. | Tinggui Wang Guilin Liu Zhenyi Cai Jinjun Geng Min Fang Haoning He Ji-an Jiang Ning Jiang Xu Kong Bin Li Ye Li Wentao Luo Zhizheng Pan Xuefeng Wu Ji Yang Jiming Yu Xianzhong Zheng Qingfeng Zhu Yi-Fu Cai Yuanyuan Chen Zhiwei Chen Zigao Dai Lulu Fan Yizhong Fan Wenjuan Fang Zhicheng He Lei Hu Maokai Hu Zhiping Jin Zhibo Jiang Guoliang Li Fan Li Xuzhi Li Runduo Liang Zheyu Lin Qingzhong Liu Wenhao Liu Zhengyan Liu Wei Liu Yao Liu Zheng Lou Han Qu Zhenfeng Sheng Jianchun Shi Yiping Shu Zhenbo Su Tianrui Sun Hongchi Wang Huiyuan Wang Jian Wang Junxian Wang Daming Wei Junjie Wei Yongquan Xue Jingzhi Yan Chao Yang Ye Yuan Yefei Yuan Hongxin Zhang Miaomiao Zhang Haibin Zhao Wen Zhao | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，10： | 1 |
| 12 | Entropy Learning and Relevance Criteria for Neural Network Pruning显示文摘 | GEOK SEE NG ABDULWAHAB DAMING SHI | 2003 | International Journal of Neural Systems2003，13，05： | 1 |
| 13 | CRISPR Immunity Relies on the Consecutive Binding and Degradation of Negatively Supercoiled Invader DNA by Cascade and Cas3显示文摘 | Edze R. Westra Paul B.G. van Erp Tim Künne Shi Pey Wong Raymond H.J. Staals Christel L.C. Seegers Sander Bollen Matthijs M. Jore Ekaterina Semenova Konstantin Severinov Willem M. de Vos Remus T. Dame Renko de Vries Stan J.J. Brouns John van der Oost | 2012 | Molecular Cell2012，，5： | 1 |
| 14 | Significant VectorLearning to Construct Sparse Kernel Regression Models显示文摘 | Gao Junbin Shi Daming Liu Xiaomao | 2007 | NeuralNetworks2007，20，7： | 1 |
| 15 | Handwritten Chinese character recognition using kernel active handwriting model显示文摘 | Daming Shi Yew Soon Ong Eng Chong Tan | 2003 | Systems Man and Cybernetics2003，1，： | 1 |
| 16 | Fish Assemblage Responses to a Low-head Dam Removal in the Lancang River显示文摘Dam removal is becoming an effective approach for aquatic biodiversity restoration in damming river in order to balance the aquatic ecosystem conservation with large-scale cascade damming. However, the effects of dam removal on fish communities in Asian mountainous rivers, which are dominated by Cypriniformes fishes, are still not well known. To determine whether dam removal on a mountainous river benefit restoration of fish diversity, we investigated the response of fish assemblage to dam removal using a before-after-control-impact design in two tributaries of the Lancang River(dam removal river: the Jidu River, and control river: the Fengdian River). Fish surveys were conducted one year prior to dam removal(2012) and three years(2013–2015) following dam removal. We observed rapidly and notably spatio-temporal changes in fish biodiversity metrics and assemblage structure, occurring in the Jidu River within the first year after dam removal. Overall, fish species richness, density and Shannon-Wiener diversity all increased immediately in above-and below-dam sites, and maintained a stable level in subsequent years, compared to unchanged situation in the control river. All sites in the Jidu River experienced shifts in fish composition after dam removal, with the greatest temporal changes occurred in sites below-and above-the former dam, resulting in a temporal homogenization tendency in the dam removed river. These findings suggest that dam removal can benefit the recovery of habitat conditions and fish community in Asian mountainous rivers, but the results should be further evaluated when apply to other dammed rivers since the dam age, fluvial geomorphology and situation of source populations could all affect the responses of fish assemblages. | DING Chengzhi JIANG Xiaoming WANG Lieen FAN Hui CHEN Liqiang HU Jinming WANG Hailong CHEN Yifeng SHI Xiaotao CHEN Hao PAN Bohui DING Liuyong ZHANG Chao HE Daming | 2019 | Chinese Geographical Science2019，29，1： | 1 |
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