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| 1 | Microcalorimetric investigation of the effect of berberine alkaloids from Coptis chinensis Franch on Staphylococcus aureus growth显示文摘The inhibitory effects of three berberine alkaloids (BAs) from rhizome of Coptis chinensis Franch, a traditional Chinese medicinal (TCM) herb, on Staphylococcus aureus growth were investigated by mi- crocalorimetry. The power–time curves of S. aureus with and without BAs were acquired; meanwhile the extent and duration of inhibitory effects on the metabolism were evaluated by studying the growth rate constant (k), half inhibitory ratio (IC50), maximum heat-output power (Pmax), peak time of maximum heat-output power (tp) and total heat production (Qt). The value of k of S. aureus in the presence of the three BAs decreased with the increasing concentrations of BAs. Moreover, Pmax was reduced and the value of tp increased with increasing concentrations of the three drugs. The inhibitory activity varied with different drugs. The values of IC50 of the three BAs are respectively, 101.4 μg/mL for berberine, 241.0 μg/mL for palmatine and 792.3 μg/mL for jateorrhizine. The sequence of antimicrobial activity of the three BAs is: berberine > palmatine > jateorrhizine. It is suggested that the functional group me- thylenedioxy or methoxyl at C2 on the phenyl ring could possibly improve antimicrobial activity more strongly than hydroxyl at C2 on the phenyl ring. | YAN Dan XIAO XiaoHe JIN Cheng DONG XiaoPing | 2008 | Science China Chemistry2008，51，7： | 27 |
| 2 | Endoscopic papillary large balloon dilation vs endoscopic sphincterotomy for retrieval of common bile duct stones:A meta-analysis显示文摘AIM:To compare the efficacy and safety of endoscopic papillary large balloon dilation(EPLBD)with endoscopic sphincterotomy(EST)in retrieval of common bile duct stones(≥10 mm).METHODS:PubMed,Web of Knowledge,EBSCO,the Cochrane Library,and EMBASE were searched for eligible studies.Randomized controlled trials(RCTs)that compared EPLBD with EST were identified.Data extraction and quality assessment were performed by two independent reviewers using the same criteria.Any disagreement was discussed with a third reviewer until a final consensus was reached.Pooled outcomes of complete bile duct stone clearance,stone clearance in one session,requirement for mechanical lithotripsy,and overall complication rate were determined using relative risk and 95%CI.The separate post-endoscopic retrograde cholangiopancreatography complications were pooled and determined with the Peto odds ratio and95%CI because of the small number of events.Heterogeneity was evaluated with the chi-squared test with P≤0.1 and I2 with a cutoff of≥50%.A fixed effects model was used primarily.A random effects model was applied when significant heterogeneity was detected.Sensitivity analysis was applied to explore the potential bias.RESULTS:Five randomized controlled trials with 621participants were included.EPLBD compared with EST had similar outcomes with regard to complete stone removal rate(93.7%vs 92.5%,P=0.54)and complete duct clearance in one session(82.2%vs 77.7%,P=0.17).Mechanical lithotripsy was performed less in EPLBD in the retrieval of whole stones(15.5%vs25.2%,P=0.003),as well as in the stratified subgroup of stones larger than 15 mm(24.2%vs 40%,P=0.001).There was no statistically significant difference in the incidence of overall adverse events(7.9%vs 10.7%,P=0.25),post-ERCP pancreatitis(4.0%vs 5.0%,P=0.54),hemorrhage(1.7%vs 2.8%,P=0.32),perforation(0.3%vs 0.9%,P=0.35)or acute cholangitis(1.3%vs 1.3%,P=0.92).CONCLUSION:EPLBD could be advocated as an alternative to EST in the retrieval of large common bile duct stones. | Piao-Piao Jin Jian-Feng Cheng Dan Liu Mei Mei Zhao-Qi Xu Lei-Min Sun | 2014 | World Journal of Gastroenterology2014，20，18： | 25 |
| 3 | Growth-inhibiting effects of taxol on human liver cancer in vitro and in nude mice显示文摘AIM To investigate the effects of taxol onSMMC-7721 human hepatoma and itsmechanisms.METHODS In vitro cell growth was assessedby trypan blue exclusion method.Experimentalhepatoma model was established by seedingSMMC-7721 cells subcutaneously into Balb/c(nu/nu)nude mice.In vivo tumor growth wasdetermined by measurement of tumor diameterwith Vernier calipers.The syntheses of DNA,RNA and protein were analyzed by incorporationof ~3H-thymidine,~3H-uridine and ~3H-leucinerespectively.Using light and electronmicroscopes to observe the morphologicalchanges of cells including mitosis andapoptosis.RESULTS Taxol was effective against SMMC-7721 human hepatoma cell growth in the rangesof 2.5 nmol/L-10 nmol/L with mitotic arrestand apoptosis in vitro.DNA,RNA and proteinsyntheses in cells were also obviouslysuppressed by in vitro treatment of taxol for72 h.Taxol at 2.5 nmol/L reduced ~3H-thymidineuptake to about 34% of the control value(P<0.05).Increasing the dose of taxol to20 nmol/L resulted in a greater decrease in ~3H-thymidine incorporation to 60% of the controlvalue(P<0.01).At a concentration of 20 nmol/L,the ~3H-uridine and ~3H-leucine uptakeswere reduced to 52%(P<0.05)and 63%(P<0.01),respectively.In vivo,taxolsignificantly inhibited SMMC-7721 tumor growthat 10 mg/kg,i.p.,once daily for 10 d.A morethan 90% decrease in tumor volume wasobserved by day 11(P<0.01)similarly withmitotic arrest and cell apoptosis.CONCLUSION Taxol has a marked anticanceractivity in SMMC-7721 human hepatoma both invitro and in nude mice.Its mechanisms might beassociated with mitotic arrest,subsequently,apoptosis of the hepatoma cells.No obvioustoxicity was observed with in vivoadministration of taxoi. | Jin Hui Yuan Ru Ping Zhang Ru Gang Zhang Li Xia Guo Xing Wang Wang Dan Luo Yong Xie Hong Xie | 2000 | World Journal of Gastroenterology2000，6，2： | 18 |
| 4 | Soil Bacterial Communities Under Different Long-Term Fertilization Regimes in Three Locations Across the Black Soil Region of Northeast China显示文摘Although soil bacteria play critical roles in agro-ecosystems, the knowledge of their response to long-term fertilization across the black soil region of Northeast China is limited. In this study, we sequenced 16 S rRNA genes to assess the effects of four long-term fertilization regimes—non-fertilization(NoF), chemical fertilizer(CF), manure(M), and chemical fertilizer plus manure(CFM)—on soil properties and bacterial communities in three locations, the northern, middle, and southern parts, across the black soil region. Results showed that the influence of fertilization regimes on soil properties varied significantly among the three locations. Manure fertilization significantly increased microbial biomass carbon and relative abundance of copiotrophic bacteria. Principal component analysis(PCA)showed that the total bacterial communities were separated into three groups according to the sampling location despite long-term fertilization, and that soil pH was the most important factor in shifting bacterial communities. In addition, similar fertilization regimes resulted in different influences on bacterial community composition, and the most influential soil properties varied among the three locations. Our results highlighted that geographical separation was a more dominant factor affecting bacterial communities than fertilization, and that long-term similar fertilization regimes did not induce consistent changes in bacterial community composition in the black soil region. | HU Xiaojing LIU Junjie WEI Dan ZHU Ping CUI Xi'an ZHOU Baoku CHEN Xueli JIN Jian LIU Xiaobing WANG Guanghua | 2018 | Pedosphere2018，28，5： | 17 |
| 5 | Tissue-specific alterations in expression and function of P-glycoprotein in streptozotocin-induced diabetic rats显示文摘瞄准: 在导致 streptozocin 的糖尿病的老鼠的服的外皮,马头鱼尾的怪兽,肝,肠的 mucosa 和肾调查表达式的变化和 P-glycoprotein (P-GP ) 的功能。 | Lu-lu ZHANG Liang LU Shi JIN Xin-yue JING Dan YAO Nan HU Li LIU Ru DUAN Xiao-dong LIU Guang-ji WANG Lin XIE | 2011 | Acta Pharmacologica Sinica2011，32，7： | 15 |
| 6 | The Chromosome-Based Rubber Tree Genome Provides New Insights into Spurge Genome Evolution and Rubber Biosynthesis显示文摘The rubber tree,Hevea brasiliensis,produces natural rubber that serves as an essential industrial raw material.Here,we present a high-quality reference genome for a rubber tree cultivar GT1 using single-molecule real-time sequencing(SMRT)and Hi-C technologies to anchor the~1.47-Gb genome assembly into 18 pseudochromosomes.The chromosome-based genome analysis enabled us to establish a model of spurge chromosome evolution,since the common paleopolyploid event occurred before the split of Hevea and Manihot.We show recent and rapid bursts of the three Hevea-specific LTR-retrotransposon families during the last 10 million years,leading to the massive expansion by~65.88%(~970 Mbp)of the whole rubber tree genome since the divergence from Manihot.We identify large-scale expansion of genes associated with whole rubber biosynthesis processes,such as basal metabolic processes,ethylene biosynthesis,and the activation of polysaccharide and glycoprotein lectin,which are important properties for latex production.A map of genomic variation between the cultivated and wild rubber trees was obtained,which contains~15.7 million high-quality single-nucleotide polymorphisms.We identified hundreds of candidate domestication genes with drastically lowered genomic diversity in the cultivated but not wild rubber trees despite a relatively short domestication history of rubber tree,some of which are involved in rubber biosynthesis.This genome assembly represents key resources for future rubber tree research and breeding,providing novel targets for improving plant biotic and abiotic tolerance and rubber production. | Jin Liu Cong Shi Cheng-Cheng Shi Wei Li Qun-Jie Zhang Yun Zhang Kui Li Hui-Fang Lu Chao Shi Si-Tao Zhu Zai-Yun Xiao Hong Nan Yao Yue Xun-Ge Zhu Yu Wu Xiao-Ning Hong Guang-Yi Fan Yan Tong Dan Zhang Chang-Li Mao Yun-Long Liu Shi-Jie Hao Wei-Qing Liu Mei-Qi Lv Hai-Bin Zhang Yuan Liu Ge-Ran Hu-tang Jin-Peng Wang Jia-Hao Wang Ying-Huai Sun Shu-Bang Ni Wen-Bin Chen Xing-Cai Zhang Yuan-Nian Jiao Evan E.Eichler Guo-Hua Li Xin Liu Li-Zhi Gao | 2020 | Molecular Plant2020，13，2： | 15 |
| 7 | A new bone repair scaffold combined with chitosan/ hydroxyapatite and sustained releasing icariin显示文摘Icariin, a plant-derived flavonol glycoside, has been proved as an osteoinductive agent for bone tissue engineering. A new bone repair scaffold was generated by thorough mixing of icariin and chitosan/ hydroxyapatite (icariin-CS/HA) using freeze-drying technigue. Characteristics of morphology, mechanical properties, biocompatibility, drug release behavior and bone repair abilities in vivo were evaluated. The results show that drug loading process of icariin did not affect physical structure of CS/HA composite significantly but decreased mechanical properies of CS/HA composite, which happened with a high dosage; icariin-CS/HA had favorable cell compatibility and promoted osteogenic differentiation of hBMSCs; the controlled release of icariin was satisfactory and the release retained after 90 d in vitro. In addition, icariin-CS/HA scaffolds had favorable osteoconduction and osteoinduction in vivo, and could fill bone defect sites and stimulate newborn bone tissues formation at early stage. On the basis of these data, icariin-CS/HA is believed to be an optical bone repair scaffold for tissue engineering. | WU Tao NAN KaiHui CHEN JingDi JIN Dan JIANG Shan ZHAO PeiRan XU JunChang DU Hao ZHANG XiaoQiang LI JianWei PEI GuoXian | 2009 | Chinese Science Bulletin2009，54，17： | 14 |
| 8 | p53-dependent Fas expression is critical for Ginsenoside Rh2 triggered caspase-8 activation in HeLa cells显示文摘我们最近报导了人参皂甙 Rh2 (G-Rh2 ) 在人的癌症房间导致二开始者 caspases, caspase-8 和 caspase-9 的激活。然而,它的导致死亡的功能的分子的机制仍然保持不清楚。这里,我们证明 G-Rh2 在 HeLa 房间同时刺激了 caspase-8 和 caspase-9 的激活。在 G-Rh2 治疗下面,膜死亡受体船边交货和 TNFR1 是显著地 upregulated。然而,船边交货然而并非 TNFR1 的导致的表示被贡献 apoptosis 过程。而且,船边交货表示的重要增加和 caspase-8 活动时间地在 G-Rh2 治疗之上随 p53-non-mutated HeLa 和 SK-HEP-1 房间的 p53 表示的增加与一致。相反,船边交货表示和 caspase-8 活动在变异 p53 的 SW480 和 PC-3 房间与 G-Rh2 治疗仍然保持不变。另外,调停 siRNA p53 击倒减少的 G-Rh2-induced 船边交货表示和 caspase-8 激活。这些结果显示 G-Rh2-triggered 外来的 apoptosis 依靠调停 p53 的船边交货在表示上。在内在的 apoptotic 小径, G-Rh2 在 HeLa 并且在 SW480 房间导致了 cytosolic BAK 和 BAX 的强壮、立即的 translocation 到线粒体, mitochondrial 细胞色素 c 版本,和随后的 caspase-9 激活。象 p53 独立的 caspase-9 激活一样的调停 p53 的船边交货表示和随后的下游的 caspase-8 激活都贡献下游的受动器 caspase-3/-7 的激活,导致肿瘤房间死亡。一起拿,我们建议 G-Rh2 以一种多路径方式导致癌症房间 apoptosis 并且因此是反肿瘤药开发的一个有希望的候选人。 | Xiao-Xi Guo Yang Li Chao Sun Dan Jiang Ying-Jia Lin Feng-Xie Jin Seung-Ki Lee Ying-Hua Jin | 2014 | Protein & Cell2014，5，3： | 14 |
| 9 | Efficacy and Safety of Tripterygium wilfordii Hook F Versus Acitretin in Moderate to Severe Psoriasis Vulgaris:A Randomized Clinical Trial显示文摘 | Chao Wu Hong-Zhong Jin Dan Shu Feng Li Chun-Xia He Ju Qiao Xiao-Ling Yu | 2015 | Chinese Medical Journal2015，，4： | 14 |
| 10 | Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC-China,July-August,2021显示文摘Starting from December 2019,Wuhan,China,encountered the first outbreak of coronavirus disease 2019(COVID-19)(1-2).The epidemic was successfully suppressed by strict containment so that the number of infected people was reduced to 0 on April 8,2020(3–4).After that,China experienced roughly 3 dozen outbreaks with local transmission caused by imported severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). | Lei Zhou Kai Nie Hongting Zhao Xiang Zhao Bixiong Ye Ji Wang Cao Chen Hong Wang Jiangli Di Jinsong Li Chao Li Zhixiao Chen Ruiqi Ren Peihua Niu Hui Chen Tao Chen Yali Wang Lili Li Bingxue Han Ruhan A Si Chen Dan Li Dan Li Chunxia Jin Xin Zhang Jiangmei Liu Chunyu Xu Yecheng Yao Yenan Feng Zhili Li Bike Zhang Yang Song Peter Hao Yanping Zhang Hao Li Qun Li George F.Gao Guoqing Shi Wenbo Xu | 2021 | China CDC weekly2021，3，41： | 13 |
| 11 | In vitro chondrogenesis of the goat bone marrow mesenchymal stem cells directed by chondrocytes in monolayer and 3-dimetional indirect co-culture system显示文摘背景软骨损害为内在的新生有一个很差的能力。为使用的软骨修理的基于房间的治疗策略区分了骨头髓间充质的干细胞(BMSC ) 然而,是软骨的修理的一条有希望的途径。这研究被瞄准在 Transwell 合作文化系统和 poly-laetide-co-glycolide (PLGA ) scaffolds.Methods 探索山羊 BMSC 的 chondrogenic 潜力 BMSC 从山羊被孤立肠骨的冠当 chondrocytes 从山羊的家被获得时上次肋骨的软骨。在 Transwell 合作文化系统,与 chondrocytes co 有教养的 BMSC 作为组 A 被设计,而山羊与 chondrogenic 媒介导致的 BMSC 是组 B。组 A 和 B 是试验性的组,当仅仅包含了 BMSC 的组 C 是控制组时。在 PLGA 脚手架合作文化系统, BMSC 被播种进 PLGA 脚手架,它在 24 井板中被推迟,并且控制组被 chondrocytes 的存在或缺席在 24 井板的底部建立。染色的 Toluidine 蓝色,染色的 Alcian 蓝色,骨胶原 immunofluoresence ,骨胶原免疫化学的染色,骨胶原,骨胶原, COL2a Q-PCR 和 osteopontin Q-PCR 被用来检验 chondrogenic 条件以及 chondrogenic 和从山羊骨头髓的aspirates 孤立的 osteogenic genes.Results 房间的表情很快增殖了并且在经过 4 获得了干细胞的特征。然而, chondrocytes 的区别不在经过 3 是明显的。从染色的 Toluidine 蓝色的结果,骨胶原 immunofluoresence 和 PCR 在 Transwell 合作文化系统和 PLGA 脚手架显示出 BMSC 的转变到 chondrocytes。尽管软骨基因表达式在 chondrogenesis 组和合作文化系统被升级, osteopontin 基因表达式,代表 osteogenic 水平,也是 Transwell 合作文化系统和 PLGA 脚手架合作文化系统能支持的 up-regulated.Conclusions 山羊的 BMSC 的 chondrogenic 区别,当在 Transwell 合作文化系统的起来调整的 osteopontin 基因表示暗示 BMSC 的 osteogenic 潜力时。 | LI Jian-wei GUO Xiao-lei HE Chun-la TUO Yong-hua WANG Zhao WEN Jun JIN Dan | 2011 | Chinese Medical Journal2011，，19： | 13 |
| 12 | Comparisons in finite element analysis of minimally invasive, locking,and non-locking plates systems used in treating calcaneal fractures of Sanders type Ⅱ and type Ⅲ显示文摘 | He Kai Fu Su Liu Song Wang Zhifa Jin Dan | 2014 | Chinese Medical Journal2014，，22： | 13 |
| 13 | Irregular surface of carotid atherosclerotic plaque is associated with ischemic stroke: a magnetic resonance imaging study显示文摘Objective To determine the association between the irregularity of carotid plaque surface using multidimensional magnetic resonance imaging(MRI) of ipsilateral acute cerebral infarction(ACI) cases. Methods Patients with recent cerebrovascular symptoms(stroke or transient ischemic attack < 2 weeks) and atherosclerotic plaque in at least one carotid artery were diagnosed by B-mode ultrasound imaging(intima-media thickness ≥ 1.5 mm) and recruited for the present study. Irregular surface was defined when plaque surface was uneven with high and low fluctuation or plaque with surface ulceration. The irregularity of carotid plaque surface was determined on axial or oblique images alone(single-dimension) and on both axial images and oblique images(multidimensions), separately. Univariate and multivariate logistic regression analyses were performed to calculate the odds ratio(OR) and the corresponding 95% CI of the irregular plaque surface in discriminating the presence of ipsilateral ACI. Results A total of 217 included subjects(mean age: 60.7 ± 10.2 years, 149 men) were recruited and 89(41.0%), 88(40.6%) and 118(54.4%) of them exhibited irregular plaque surface on axial, oblique and multidimensional MR images, respectively. The OR of irregularity of the plaque surface was determined by multidimensional MRI to be 5.88(95% CI: 3.16–10.96, P < 0.001) in discriminating the presence of ipsilateral ACI. Following adjustment for clinical confounding factors, this association remained statistically significant(OR = 5.65, 95% CI: 2.53–12.60, P < 0.001). The analysis included further adjustment for the presence of lipid-rich necrotic core, intraplaque hemorrhage and stenosis and the results included that this association also remained statistically significant(OR = 6.08, 95% CI: 2.52–14.68, P < 0.001). Conclusions The irregular plaque surface was determined by multidimensional MRI as an independent indicator for ipsilateral acute cerebral infarction. | Dan ZHOU Jin LI Dong LIU Li-Ya JI Na-Qin WANG Jie DENG Ji-Chen WANG Min YE Xi-Hai ZHAO | 2019 | Journal of Geriatric Cardiology2019，16，12： | 13 |
| 14 | Mechanical properties, biodegradability and cytocompatibility of biodegradable Mg-Zn-Zr-Nd/Y alloys显示文摘Biodegradable magnesium alloys have been turned out to be a promising candidate for orthopedic applications.In this study,the mechanical properties,degradation behaviorand cytocompatibility of MgZn-Zr-Nd and Mg-Zn-Zr-Y alloys were studied in comparison with pure Mg.Mechanical tests showed that the strength and ductility of Mg-Zn-Zr-Nd and Mg-Zn-Zr-Y alloys were excellent.The corrosion resistance analyzed by electrochemical test and immersion test in alpha modified eagle(α-MEM) medium with 10% fetal bovine serum(FBS) revealed the degradation of Mg-Zn-Zr-Nd and Mg-Zn-Zr-Y alloys were faster than pure Mg at an early stage but slowed down after long time immersion.The metal ion concentrations were consistent with the corrosion rate.Mg-Zn-Zr-Nd alloy shows better mechanical properties than pure Mg and better corrosion resistance than Mg-Zn-Zr-Y alloy.The direct and indirect in vitro tests with MC3 T3-E1 cells demonstrate that Mg-Zn-Zr-Nd shows the best cytocompatibility and osteogenesis.The results suggest that Mg-Zn-Zr-Nd alloy shows an ideal combination of mechanical,corrosive and biological properties.In summary,these results implying the Mg-Zn-Zr-Nd alloy has great potential to benefit the future development of orthopedic applications. | Shi Jin Dan Zhang Xiaopeng Lu Yang Zhang Lili Tan Ying Liu Qiang Wang | 2020 | Journal of Materials Science & Technology2020，47，12： | 12 |
| 15 | Chemoresistance of CD133+ cancer stem cells in laryngeal carcinoma显示文摘背景增长证据建议肿瘤是组织学地异构的并且被肿瘤房间的一张小人口维持称为的癌症干细胞。CD133 在喉的癌作为癌症干细胞的一个候选人标记被识别了。这研究试图分析 CD133+ 癌症茎 cells.Methods 的 chemoresistance 到不同化学疗法的代理人的 Hep-2 细胞的反应被调查, CD133 的表示被学习。激活荧光的房间排序分析在殖民地形成试金被用来识别 CD133 ,并且房间的CD133+子集被分开并且分析,房间侵略试金,化疗抵抗研究,并且关于 Hep-2 房间的1%-2%为药抵抗基因 ABCG2.Results 的表示分析了是CD133+房间,并且CD133+比例被chemotherapy.CD133+癌症干细胞充实为 clonogenicity 和侵略展出了更高的潜力,并且对化疗更抵抗。这个电阻与这研究建议了的 ABCG2.Conclusions 的更高的表示被相关 CD133+ 癌症干细胞对化疗更抵抗。ABCG2 的表示能为这部分负责。指向 CD133+ 癌症干细胞的这张小人口能是策略为喉的癌开发更有效的治疗。 | YANG Jing-pu LIU Yan ZHONG Wei YU Dan WEN Lian-ji JIN Chun-shun | 2011 | Chinese Medical Journal2011，，7： | 12 |
| 16 | Serum IgA,IgM,and IgG responses in COVID-19显示文摘Currently,detecting SARS-CoV-2 RNAs is a standard approach for COVID-19 diagnosis.However,there is an urgent need for reliable and rapid serological diagnostic methods to screen SARS-CoV-2-infected people including those who do not have overt symptoms.Most emerging studies described serological tests based on detection of SARS-CoV-2-specific IgM and IgG.1–4 Although detection of SARS-CoV-2-specific IgA in serum has been reported in few papers,5,6 analyses of IgA levels in a larger number of COVID-19 patients are still lacking. | Huan Ma Weihong Zeng Hongliang He Dan Zhao Dehua Jiang Peigen Zhou Linzhao Cheng Yajuan Li Xiaoling Ma Tengchuan Jin | 2020 | Cellular & Molecular Immunology2020，17，7： | 12 |
| 17 | Interface engineering gifts CsPbI2.25Br0.75 solar cells high performance显示文摘Organic-inorganic halide perovskite (ABX3) solar cells (PSCs)have made great progress in recent years [1]. The power conversion efficiency (PCE) has increased up to 25.2%(NREL Best Research-Cell Efficiency Chart, http://gffzz8798726073dc471cs060xq5ncc9b96qoo.ffgz.tsg.suse.edu.cn/pv/cell-efficiency.html, Accessed August 2019). However, they suffer from poor thermal stability due to the volatile A-site organic cations. | Zhimin Fang Xianyi Meng Chuantian Zuo Dan Li Zuo Xiao Chenyi Yi Mingkui Wang Zhiwen Jin Shangfeng Yang Liming Ding | 2019 | Science Bulletin2019，64，23： | 11 |
| 18 | Advances and disputes of posterior malleolus fracture显示文摘 | Fu Su Zou Zhen-yu Mei Gang Jin Dan | 2013 | Chinese Medical Journal2013，，20： | 11 |
| 19 | Lead Induced Changes in the Growth and Antioxidant Metabolism of the Lead Accumulating and Non-accumulating Ecotypes of Sedum alfredii显示文摘The phytotoxicity and antioxidative adaptations of lead (Pb) accumulating ecotype (AE) and non-accumulating ecotype (NAE) of Sedum alfredii Hance were investigated under different Pb treatments involving 0,0.02 mmol/L Pb,0.1 mmol/L Pb and 0.1 mmol/L Pb/0.1 mmol/L ethylenediaminetetraacetic acid (EDTA) for 6 days. With the increasing Pb level,the Pb concentration in the shoots of AE plants enhanced accordingly, and EDTA supply helped 51% of Pb translocation to shoots of AE compared with those treated with 0.1 mmol/L Pb alone. Moreover, the presence of EDTA alleviated Pb phytotoxicity through changes in plant biomass, root morphology and chlorophyll contents. Lead toxicity induced hydrogen peroxide (H2O2) accumulation and lipid peroxidation in both ecotypes of S. alfredii. The activities of superoxide dismutase (SOD), guaiacol peroxidase (G-POD), ascorbate peroxidase, and dehydroascorbate reductase elevated in both leaves and roots of AE as well as in leaves of NAE with the increasing Pb levels, but SOD and G-POD declined in roots of NAE. Enhancement in glutathione reductase activity was only detected in roots of NAE while a depression in catalase activity was recorded in the leaves of NAE. A significant enhancement in glutathione and ascorbic acid (AsA) levels occurred in both ecotypes exposed to Pb and Pb/EDTA treatment compared with the control, however, the differences between these two treatments were insignificant. The dehydroascorbate (DHA) contents in roots of both ecotypes were 1.41 to 11.22-fold higher than those in leaves, whereas the ratios of AsA to DHA (1.38 to 6.84) in leaves altering more to the reduced AsA form were much higher than those in roots. These results suggested that antioxidative enzymes and antioxidants play an important role in counteracting Pb stress in S. alfredii. | Dan Liu Ting-Qiang Li Xiao-Fen Jin Xiao-E Yang Ejazul Islam Qaisar Mahmood | 2008 | Journal of Integrative Plant Biology2008，50，2： | 10 |
| 20 | Characteristics of interior noise of a Chinese high-speed train under a variety of conditions显示文摘目的:研究高速列车在不同速度(260~385 km/h)、无砟和有砟轨道以及明线和隧道运行时的车内噪声特性,为高速列车车内减振降噪和车体低噪声设计提供科学依据。创新点:系统分析高速列车在不同运行条件下的车内噪声总值变化、空间分布、频谱特性和声源贡献,掌握车内噪声随列车运行速度的变化规律、轨道型式和隧道混响对车内噪声的影响,研究轮轨噪声、气动噪声和弓网噪声对车内噪声的作用。方法:1.根据不同的列车运行速度,分析车内噪声的变化规律;通过进一步对比头尾车运行时,不同测点位置的噪声总值、显著频率和声源贡献,研究气动作用对车内噪声的影响。2.针对不同轨道型式,分析车内噪声的差异特性;通过进一步对比不同速度下的前、后转向架上方车内噪声测点(其中一个还位于受电弓下方)的噪声总值、显著频率和声源贡献,研究有砟和无砟轨道、弓网噪声对车内噪声的影响以及速度因素的作用。3.对于隧道运行,分析不同速度下在明线和隧道运行时的车内噪声总值和显著频率,研究隧道混响对车内噪声的影响以及速度因素的作用。结论:1.TC01车无论作为头车或尾车运行,车内观光区的噪声均主要受气动作用影响。2.随着列车运行速度的提高,轨道型式的不同对车内噪声的影响有所降低。3.隧道混响对中间车的影响要高于头车。 | Jie ZHANG Xin-biao XIAO Xiao-zhen SHENG Rong FU Dan YAO Xue-song JIN | 2017 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2017，18，8： | 10 |
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