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1Combined glucocorticoid and antiviral therapy of hepatitis B virus-related liver failure显示文摘Acute hepatic failure due to hepatitis B virus(HBV)can occur both during primary infection as well as after reactivation of chronic infection.Guidelines recommend considering antiviral therapy in both situations,although evidence supporting this recommendation is weak.Since HBV is not directly cytopathic,the mechanism leading to fulminant hepatitis B is thought to be primarily immunemediated.Therefore,immunosuppression combined with antiviral therapy might be a preferred therapeutic intervention in acute liver failure in hepatitis B.Here wereport our favourable experience in three hepatitis B patients with fulminant hepatic failure who were treated by combining high-dose steroid therapy with standard antiviral treatment,which resulted in a rapid improvement of clinical and liver parameters.Jan-Hendrik Bockmann Maura Dandri Stefan Lüth Nadine Pannicke Ansgar W Lohse 2015World Journal of Gastroenterology2015,21,7:13
2Control of cccDNA function in hepatitis B virus infection显示文摘Massimo Levrero Teresa Pollicino Jorg Petersen Laura Belloni Giovanni Raimondo Maura Dandri 2009Journal of Hepatology2009,,3:8
3Mobilization of hematopoietic progenitor cells in patients with liver cirrhosis显示文摘AIM:To test the hypothesis that liver cirrhosis is associated with mobilization of hematopoietic progenitor cells. METHODS:Peripheral blood samples from 72 patients with liver cirrhosis of varying etiology were analyzed by flow cytometry.Identified progenitor cell subsets were immunoselected and used for functional assays in vitro. Plasma levels of stromal cell-derived factor-1(SDF-1) were measured using an enzyme linked immunosorbent assay.RESULTS:Progenitor cells with a CD133 + /CD45 + CD14 + phenotype were observed in 61%of th patients.Between 1%and 26%of the peripheral bloo mononuclear cells(MNCs)displayed this phenotype Furthermore,a distinct population of c-kit + progenito cells(between 1%and 38%of the MNCs)could b detected in 91%of the patients.Additionally,18% of the patients showed a population of progenito cells(between 1%and 68%of the MNCs)that wa characterized by expression of breast cancer resistanc protein-1.Further phenotypic analysis disclosed tha the circulating precursors expressed CXC chemokin receptor 4,the receptor for SDF-1.In line with thi finding,elevated plasma levels of SDF-1 were presen in all patients and were found to correlate with th number of mobilized CD133 + progenitor cells.Ursula M Gehling Marc Willems Kathleen Schlagner Ralf A Benndorf Maura Dandri Jrg Petersen Martina Sterneck Joerg-Matthias Pollok Dieter K Hossfeld Xavier Rogiers 2010World Journal of Gastroenterology2010,16,2:4
4IFN-[alpha] inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome显示文摘Belloni Laura Allweiss Lena Guerrieri Francesca Pediconi Natalia Volz Tassilo Pollicino Teresa Petersen Joerg Raimondo Giovanni Dandri Maura Levrero Massimo 2012EN2012,,2:2
5Hepatitis B Virus Limits Response of Human Hepatocytes to Interferon-α in Chimeric Mice显示文摘Marc Lütgehetmann Till Bornscheuer Tassilo Volz Lena Allweiss Jan–Hendrick Bockmann Joerg M. Pollok Ansgar W. Lohse Joerg Petersen Maura Dandri 2011Gastroenterology2011,,7:2
6Increased hepatocyte turnover and inhibition of woodchuck hepatitis B virus replication by adefovir in vitro do not lead to reduction of the closed circular DNA显示文摘Dandri M Burda MR Will H 2000Hepatology2000,32,1:1
7Control of cccDNA function in hepatitis B virus infection显示文摘Levrero M Pollicino T Petersen J Belloni L Raimondo G Dandri M Journal of Hepatology0,,:1
8Increase in de novo HBV DNA integrations in response to oxidative DNA damage or inhibition of poly (ADP-ribosyl)ation显示文摘Dandri M Burda MR Bürkle A 2002Hepatology2002,35,1:1
9Peginterferon alpha-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B显示文摘Wursthorn K Lutgehetmann M Dandri M 0,,03:1
10Animal models for the study of HBV replication and its variant显示文摘Dandri M Volz TK Lutegehetmann M 2005Clin Virol2005,,:1
11Chronic infection with hepatitis B viruses and antiviral drug evaluation in uPA mice after liver repopulation with tupaia hepatoeytes显示文摘Dandri M Burdal MR Zuekerman DM 2005Journal of Hepatology2005,42,1:1
12New insight in the pathobiology of hepatitis B vires infection显示文摘Dandri M Loearnini S 2012Gut2012,61,:1
13Repopulation of mouse liverwith human hepatocytes and in vivo infection with hepatitis B virus显示文摘Dandri M Burda MR Torok E 2001Hepatology2001,33,4:1
14Animal models for the study of HBV replication and its variants 显示文摘Dandri M Volz TK LUtgehetmann M 2005J Clin Virol2005,341,:1
15Woodchuck hepatocytes remain permissive for hepadnavirus infection and mouse liver repopulation after cryopreservation显示文摘Dandri M Burda MR Gocht A 2001Hepatology2001,,:1
16Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus显示文摘Dandri M Burda M R Torok E 2001Hepatology2001,33,:1
17Repopulation of mouse liver with human hepatoeytes and In vivo infection with hepatitis B virus显示文摘Dandri M Burda MR Torok E 2001Hepatology2001,33,:1
18Peginterferonα-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B显示文摘Wursthorn K Lutgehetmann M Dandri M Volz T Buggisch P Zollner B Hepatology0,,:1
19Peginterferon alpha - 2b plus adefovir induce strong cccDNA decline and HB- sAg reduction in patients with chronic hepatitis B显示文摘Wursthorn K Lutgehetmann M Dandri M 2006Hepatolo- gy2006,44,3:1
20Increase in de novo HBV DNA integrations in response to oxidative DNA damage or inhibition of poly( ADP-ribosy1) ation 显示文摘DANDRI M BURDA M R BURKLE A 2002Hepatology2002,35,1:1
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