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| 1 | Mobilization of hematopoietic progenitor cells in patients with liver cirrhosis显示文摘AIM:To test the hypothesis that liver cirrhosis is associated with mobilization of hematopoietic progenitor cells. METHODS:Peripheral blood samples from 72 patients with liver cirrhosis of varying etiology were analyzed by flow cytometry.Identified progenitor cell subsets were immunoselected and used for functional assays in vitro. Plasma levels of stromal cell-derived factor-1(SDF-1) were measured using an enzyme linked immunosorbent assay.RESULTS:Progenitor cells with a CD133 + /CD45 + CD14 + phenotype were observed in 61%of th patients.Between 1%and 26%of the peripheral bloo mononuclear cells(MNCs)displayed this phenotype Furthermore,a distinct population of c-kit + progenito cells(between 1%and 38%of the MNCs)could b detected in 91%of the patients.Additionally,18% of the patients showed a population of progenito cells(between 1%and 68%of the MNCs)that wa characterized by expression of breast cancer resistanc protein-1.Further phenotypic analysis disclosed tha the circulating precursors expressed CXC chemokin receptor 4,the receptor for SDF-1.In line with thi finding,elevated plasma levels of SDF-1 were presen in all patients and were found to correlate with th number of mobilized CD133 + progenitor cells. | Ursula M Gehling Marc Willems Kathleen Schlagner Ralf A Benndorf Maura Dandri Jrg Petersen Martina Sterneck Joerg-Matthias Pollok Dieter K Hossfeld Xavier Rogiers | 2010 | World Journal of Gastroenterology2010，16，2： | 4 |
| 2 | 早期将抗生素由静脉转为口服治疗严重社区获得性肺炎:多中心随机试验显示文摘目的比较早期由静脉转换成口服抗生素与常规静脉使用7天抗生素治疗严重社区获得性肺炎(CAP)的疗效。设计多中心随机对照试验。地点荷兰5家教学医院和2所大学的医学中心。参加者非 ICU 住院的严重 CAP 患者302例,其中265例满足研究要求。干预静脉抗生素治疗3天,病情稳定后换成口服抗生素,或静脉使用抗生素治疗7天。主要评价结果临床治愈和住院天数。结果 302例患者被随机分组(平均年龄69.5岁,标准差14.0),肺炎严重度评分平均112.7(26.0)。37例患者因为提前3天退出而未纳入分析,对其余265例患者进行分析研究。第28天的死亡率在干预组是4%,对照组是6%(平均差2%,95%可信区间-3%~8%)。临床治愈率在干预组是83%,对照组是85%(2%;-7%~10%)。与对照组相比,干预组患者静脉治疗时间为3.4天[3.6(1.5)比7.0(2.0)天;2.8~3.9],患者住院天数减少1.9天[9.6(5.0)比11.5(4.9)天;0.6~3.2]。结论早期将抗生素由静脉应用转换成口服治疗严重 CAP 是安全的,并且可以减少住院时间2天。试验注册号临床试验 NCT00273676。 | Jan Jelrik Oosterheert Marc J M Bonten Margriet M E Schneider Erik Buskens Jan-Willem J Lammers Willem M N Hustinx Mark H H Kramer Jan M Prins Peter H Th J Slee Karin Kaasjager Andy I M Hoepelman 王伟巍(译) 童朝辉(校) | 2007 | 英国医学杂志中文版2007，10，2： | 1 |
| 3 | Intestinal Barrier Dysfunction in a Randomized Trial of a Specific Probiotic Composition in Acute Pancreatitis显示文摘 | Marc G. Besselink Hjalmar C. van Santvoort Willem Renooij Martin B. de Smet Marja A. Boermeester Kathelijn Fischer Harro M. Timmerman Usama Ahmed Ali Geert A. Cirkel Thomas L. Bollen Bert van Ramshorst Alexander F. Schaapherder Ben J. Witteman Rutger J. P | 2009 | Annals of Surgery2009，，5： | 1 |
| 4 | Knowledge Sharing in Public Sector Organizations : The Effect of Organizational Characteristics on Interdepartmental Knowledge Sharing 显示文摘 | Annick Willem Marc Buelens | 2007 | Journal of Public Administration Research and Theory2007，17，4： | 1 |
| 5 | 31 P-NMR spectroscopy and the metabolic properties of different muscle fibers显示文摘 | ACHTEN E MARC VAN CAUTEREN RUDOLPH WILLEM | 1990 | Am Physiol Soc1990，68，2： | 1 |
| 6 | Identification of high-risk enterococcal clonal complexes: global dispersion and antibiotic resistance显示文摘 | Helen L Leavis Marc JM Bonten Rob JL Willems | 2006 | Current Opinion in Microbiology2006，，5： | 1 |
| 7 | Sterocoplex formation in ABA triblock copolymers of poly(lactide)(A) and poly(ethylene glycol)(B)显示文摘 | Willem M S Marc J K Ankone | 1995 | Macromol Chem Phys1995，196，： | 1 |
| 8 | Outcomes of extended versus limited indications for patients undergoing a liver resection for colorectal cancer liver metastases显示文摘 | Ronald M. Dam Toine M. Lodewick Maartje A.J. Broek Mechteld C. Jong Jan Willem Greve Rob L.H. Jansen Marc H.A. Bemelmans Ulf P. Neumann Steven W.M. Olde Damink Cornelis H.C. Dejong | 2014 | HPB2014，，6： | 1 |
| 9 | A food quality management research methodology integrating technological and managerial theories显示文摘 | Pieternel A Luning Willem J Marcelis | 2009 | Trends in Food Science & Technology2009，20，15： | 1 |
| 10 | Intestinal Barrier Dysfunction in a Randomized Trial of a Specific Probiotic Composition in Acute Pancreatitis显示文摘 | Marc G. Besselink Hjalmar C. van Santvoort Willem Renooij Martin B. de Smet Marja A. Boermeester Kathelijn Fischer Harro M. Timmerman Usama Ahmed Ali Geert A. Cirkel Thomas L. Bollen Bert van Ramshorst Alexander F. Schaapherder Ben J. Witteman Rutger J. P | 2009 | Annals of Surgery2009，，5： | 1 |
| 11 | Knowledge Sharing in Inter-unit Cooperative Episodes: The Impact of Organizational Structure Dimensions显示文摘 | Annick Willem Marc Buelens | 2009 | International Journal of Information Management2009，，2： | 1 |
| 12 | Neuroendocrine-immune interactions in fish:a role for interleukin-1显示文摘 | Marc Y Engelsma M O Willem B | 2002 | Veterinary Immunology and Immunopathology2002，87，： | 1 |
| 13 | Knowledge Sharing in Inter-unit Cooperative Episodes:The Impact of Organizational Structure Dimensions显示文摘 | Annick Willem& Marc Buelens | 2009 | International Journal of Information Management2009，，29： | 1 |
| 14 | Knowledge Sharing in Pub- lic Sector Organizations:The Effect of Organizational Char- acteristics on Interdepartmental Knowledge Sharing显示文摘 | Annick Willem Marc Buelens | | 0，，17： | 1 |
| 15 | Inhibition of VCAM-1 expression in endothelial cells by CORM-3: The role of the ubiquitin–proteasome system, p38, and mitochondrial respiration显示文摘 | Claudia Bergstraesser Simone Hoeger Hui Song Linda Ermantraut Maxi Hottenrot Tobias Czymai Marc Schmidt Matthias Goebeler Norbert Ponelies Carsten Stich Ralf Loesel Grietje Molema Marc Seelen Willem van Son Benito A. Yard Neysan Rafat | 2011 | Free Radical Biology and Medicine2011，，4： | 1 |
| 16 | Shared reservoir of ccrB gene sequences between coagulase-negative staphylococci and methicillin-resistant Staphylococcus aureus显示文摘 | Ad C. Fluit Neeltje Carpaij Eline A. M. Majoor Marc J. M. Bonten Rob J. L. Willems | 2013 | Journal of Antimicrobial Chemotherapy2013，，8： | 1 |
| 17 | MBL2 and fever during neutropenia in children with acute lymphoblastic leukaemia显示文摘 | Esther M.te Poele MateuszSiedlinski P. J.Anne de Pagter Marc B.Bierings Frank J. G.Scherpen Tiny G. J.Meeuwsen‐de Boer Gerard H.Koppelman Dirkje S.Postma Willem A.Kamps H. M.Boezen Eveline S. J. M.de Bont | 2012 | British Journal of Haematology2012，，1： | 1 |
| 18 | Contribution of the enterococcal surface protein Esp to pathogenesis of Enterococcus faecium endocarditis显示文摘 | Esther Heikens Kavindra V. Singh Karen D. Jacques-Palaz Miranda van Luit-Asbroek Evelien A.N. Oostdijk Marc J.M. Bonten Barbara E. Murray Rob J.L. Willems | 2011 | Microbes and Infection2011，，14： | 1 |
| 19 | Neuroendocrine-immune interactions in fish: a role for interleukin-1显示文摘 | Marc Y Engelsma M O Willem B | 2002 | Veterinary Immunology and Immunopathology2002，87，： | 1 |
| 20 | Activation of the Ergoreceptors in Cardiac Patients With and Without Heart Failure显示文摘 | Sofie Pardaens Marc Vanderheyden Patrick Calders Anne-Marie Willems Jozef Bartunek Johan de Sutter | 2014 | Journal of Cardiac Failure2014，，： | 1 |
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