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| 1 | 婴幼儿卒中的处理:来自美国心脏协会卒中委员会和青少年心血管病委员会专门写作组的科学声明显示文摘目的:本声明旨在回顾有关儿童卒中的文献,为最佳的诊断和治疗提供推荐意见,供负责诊断和治疗婴儿、儿童和青少年脑血管病的医生使用。方法:写作组成员由美国心脏协会卒中委员会科学声明监督委员会任命,由多个不同领域的专家组成。应用美国心脏协会卒中委员会的证据分级标准对每条推荐意见进行分级。在经过小组成员审查后,草稿由4位同行评议专家和卒中委员会指导委员会成员审阅,并由美国心脏协会科学咨询和协调委员会批准。我们预计该声明需在4年内进行更新。结果:为镰状细胞病、烟雾病、颈一脑动脉夹层分离和心源性栓塞引起的缺血性卒中的预防提供循证推荐,同时为出血性卒中的评价和处理提供推荐意见。提出儿童使用肝素和华法林的剂量方案。另外,还为围产期卒中和儿童脑静脉窦血栓形成的评价和处理提供推荐。 | E.Steve Roach(著) Meredith R. Golomb(著) Robert Adams(著) Jose Biller(著) Stephen Daniels(著) Gabrielle deVeber(著) Donna Ferriero(著) Blaise V. Jones(著) Fenella J. Kirkham(著) R. Michael Scott(著) Edward R. Smith(著) 刘丽芳(译) 王胜男(译) 王伟(译) 林镇洲(译) 朱佳佳(译) 潘速跃(译) | 2008 | 国际脑血管病杂志2008，16，11： | 60 |
| 2 | Randomized controlled trials - mechanistic studies of testosterone and the cardiovascular system显示文摘睾丸激素缺乏是普通的在里面有心血管的疾病( CVD )的人,和使随机化的控制安慰剂的试用( RCT )在长期的稳定的咽峡炎在导致锻练的心脏的局部缺血上报导了睾丸激素治疗的有益的效果,功能的锻练能力,最大的氧消费在锻练期间(在长期的心失败( CHF )的 VO 2max)和肌肉力量,一些心血管的风险因素的 Q-T 间隔,和改进弄短。睾丸激素缺乏与不利 CV 风险侧面和死亡被联系。临床、科学的研究提供了机械学的证据支持并且解释 RCT 的调查结果。睾丸激素包括肺的 vasculature 是在冠的发行量和另外的脉管的床以内的快速发作的动脉的血管扩张药并且能减少全面外部全身的脉管的抵抗。证据证明了那睾丸激素调停通过钙隧道封锁(L 钙隧道) 的脉管的反应上的这效果并且刺激钾隧道由直接 nongenomic 机制开。睾丸激素也由刺激超速的钾刺激心脏的 myocytes 的极化操作隧道的电流。睾丸激素改进心脏的输出,功能的锻练能力, VO 2max 和 vagally 调停的动脉的 baroreceptor 在 CHF 的心脏的反射敏感,和另外的机制。独立于心脏的功能上的睾丸激素的利益,睾丸激素替换可以也增加骨胳的肌肉葡萄糖新陈代谢并且提高肌肉发达的力量,能在能力可以包括的功能的锻练贡献改进的两个因素改进了葡萄糖新陈代谢和肌肉力量。睾丸激素由在关键新陈代谢的小径的规章的酶上由 genomic 的联合和葡萄糖举起和胰岛素受体,葡萄糖 transporters,和表示的利用表示的 nongenomic 行动改进葡萄糖利用和类脂化合物新陈代谢包括身体作文,胰岛素电阻,和血胆脂醇过多改进新陈代谢的 CV 风险因素。高密度的脂蛋白胆固醇(高级数据链路控制) 上的效果在研究之间不同因为掉落,升起,或没有在层次的变化被发现了。睾丸激素代替能压制传播支持 inflammatory cytokines 的层次并且刺激有的 interleukin-10 (IL-10 ) 的生产反煽动性并且在有 CVD 的人的 anti-atherogenic 行动。C 反应的蛋白质上的效果都没被检测。clotting 因素上的不利效果都没被检测。RCT 清楚地没表明那睾丸激素在颈动脉 intima 厚度或冠的钙免职改进或不利地影响象减小那样的动脉粥样硬化的代理人标记的任何重要证据。动脉粥样硬化的预防或改善上的睾丸激素的任何效果是可能的在在在睾丸激素 RCT 使用了的 statin 治疗审判和并非月出现的年发生。从长期的流行病学的研究的证据的重量支持在与睾丸激素缺乏对待人的研究在主要不利 CV 事件(权标) 和死亡由减小证实了的保护的效果。睾丸激素被代替了到正常健康范围的 RCT 都没报导向上的一个重要好处或不利效果也没有任何最近的元分析。 | T Hugh Jones Daniel M Kelly | 2018 | Asian Journal of Andrology2018，20，2： | 6 |
| 3 | Adjuvant therapy in pancreatic cancer显示文摘Pancreatic cancer remains one of the leading causesof cancer related death worldwide with an overall fiveyear survival of less than 5%.Potentially curative surgery,which alone can improve 5-year survival to 10%,is an option for only 10%-20%of patients at presentation owing to local invasion of the tumour or metastaticdisease.Adjuvant chemotherapy has been shown toimprove 5-year survival to 20%-25%but conflicting evidence remains with regards to chemoradiation.In thisarticle we review the current evidence available frompublished randomised trials and discuss ongoing phaseⅢtrials in relation to adjuvant therapy in pancreaticcancer. | Owain Peris Jones James Daniel Melling Paula Ghaneh | 2014 | World Journal of Gastroenterology2014，20，40： | 5 |
| 4 | AHA/ACC Guidelines for Secondary Prevention for Patients With Coronary and Other Atherosclerotic Vascular Disease: 2006 Update: Endorsed by the National Heart, Lung, and Blood Institute显示文摘 | Sidney C. Smith Jerilyn Allen Steven N. Blair Robert O. Bonow Lawrence M. Brass Gregg C. Fonarow Scott M. Grundy Loren Hiratzka Daniel Jones Harlan M. Krumholz Lori Mosca Richard C. Pasternak Thomas Pearson Marc A. Pfeffer Kathryn A. Taubert | 2006 | Circulation2006，，19： | 4 |
| 5 | Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure显示文摘 | Aram V. Chobanian George L. Bakris Henry R. Black William C. Cushman Lee A. Green Joseph L. Izzo Daniel W. Jones Barry J. Materson Suzanne Oparil Jackson T. Wright Edward J. Roccella | 2003 | Hypertension: Journal of The American Heart Association2003，，6： | 4 |
| 6 | RANKL/RANK control Brca1 mutation-driven mammary tumors显示文摘 | Verena Sig Kwadwo Owusu-Boaitey Puma A Joshi Anoop Kavirayani Gerald Wimsberger Maria Novatchkova Ivona Kozieradzki Daniel Schramek Nnamdi Edokobi Jerome Hersl Aishia Sampson Ashley Odai-Afotey Conxi Lazaro Eva Gonzalez-Suarez Miguel A Pujaaa for CIMBA Holger Heyn Enrique Vidal Jennifer Cru. ickshank Hal Berman Renu Sarao Melita Tieevic Iris Uribesalgo Luigi Tortola Shuan Rao Yen Tan Georg Pfeiler Eva YHP Lee Zsuzsanna Bago-Horvath Lukas Kenner Helmuth Popper Christian Singer Rama Khokha LaundeRe P Jones Josef M Penninger | 2016 | Cell Research2016，26，7： | 3 |
| 7 | Transcriptomic and metabolomic analyses of cucumber fruit peels reveal a developmental increase in terpenoid glycosides associated with age-related resistance to Phytophthora capsici显示文摘The oomycete,Phytophthora capsici,infects cucumber(Cucumis sativus L.)fruit.An age-related resistance(ARR)to this pathogen was previously observed in fruit of cultivar‘Vlaspik’and shown to be associated with the peel.Young fruits are highly susceptible,but develop resistance at~10–12 days post pollination(dpp).Peels from resistant(16 dpp)versus susceptible(8 dpp)age fruit are enriched with genes associated with defense,and methanolic extracts from resistant age peels inhibit pathogen growth.Here we compared developing fruits from‘Vlaspik’with those of‘Gy14’,a line that does not exhibit ARR.Transcriptomic analysis of peels of the two lines at 8 and 16 dpp identified 80 genes that were developmentally upregulated in resistant‘Vlaspik’16 dpp versus 8 dpp,but not in susceptible‘Gy14’at 16 dpp.A large number of these genes are annotated to be associated with defense and/or specialized metabolism,including four putative resistance(R)genes,and numerous genes involved in flavonoid and terpenoid synthesis and decoration.Untargeted metabolomic analysis was performed on extracts from 8 and 16 dpp‘Vlaspik’and‘Gy14’fruit peels using Ultra-Performance Liquid Chromatography and Quadrupole Time-of-Flight Mass Spectrometry.Multivariate analysis of the metabolomes identified 113 ions uniquely abundant in resistant‘Vlaspik’16 dpp peel extracts.The most abundant compounds in this group had relative mass defects consistent with terpenoid glycosides.Two of the three most abundant ions were annotated as glycosylated nor-terpenoid esters.Together,these analyses reveal potential mechanisms by which ARR to P.capsici may be conferred. | Ben N Mansfeld Marivi Colle Yunyan Kang A Daniel Jones Rebecca Grumet | 2017 | Horticulture Research2017，4，1： | 3 |
| 8 | A New Era in Esophageal Diagnostics: The Image-Based Paradigm of High-Resolution Manometry显示文摘 | Renato Salvador Attila Dubecz Marek Polomsky Oliver Gellerson Carolyn E. Jones Daniel P. Raymond Thomas J. Watson Jeffrey H. Peters | 2009 | Journal of the American College of Surgeons2009，，6： | 2 |
| 9 | Impact of postoperative intravenous fluid administration on complications following elective hepato-pancreato-biliary surgery显示文摘Background: The impact of perioperative intravenous fluid administration on surgical outcomes has been documented in literature, but not specifically studied in the context of hepato-pancreato-biliary(HPB) surgery. This study aimed to investigate the impact of postoperative intravenous fluid administration on intensive care unit(ICU), in this subgroup of patients. Methods: A single-center retrospective cohort of 241 HPB patients was assessed, focusing on intravenous fluid administration in ICU, during the first 24 h. Intravenous fluid variables were compared to hospital stay and postoperative complications. Data were assessed using Spearman's correlation test for bivariate correlations and logistic regression for multivariate analysis. Results: The median volume of intravenous fluid administered in the first 24 h postoperatively was 4380 mL, of which 2200 mL was crystalloid, 1500 mL colloid and 680 mL 'other' fluid. Patients with one or more complications had a higher median total intravenous fluid input(4790 vs. 4300 mL), higher colloid volume(20 0 0 vs. 150 0 mL), lower urine output(1595 vs. 1900 mL) and greater overall fluid balance( + 3040 vs. + 2553 mL) than those without complications. There were correlations between total intravenous fluid volume administered( r = 0.278, P < 0.001), intravenous colloid input( r = 0.278, P < 0.001), urine output( r =-0.295, P < 0.001), positive fluid balance( r = 0.344, P < 0.001) and length of hospital stay. Logistic regression model was constructed to predict the occurrence of one or more complications; total intravenous fluid volume and overall fluid balance were both independent significant predictors(OR = 2.463, P = 0.007; OR = 1.001, P = 0.011; respectively). Conclusions: Administration of high volumes of intravenous fluids in the first 24 hours post-HPB surgery, along with higher positive fluid balance is associated with a higher rate of complications and longer hospital stay. Moreover, lower urine output is associated with longer hospital stay. Whether these are the cause of complications or the result of them remains unclear. | Daniel Martin Panagis M.Lykoudis Gabriel Jones David Highton Alan Shaw Sarah James Qiang Wei Giuseppe Fusai | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，5： | 2 |
| 10 | A functional type I interferon pathway drives resistance to cornea herpes simplex virus type 1 infection by recruitment of leukocytes显示文摘Type I interferons are critical antiviral cytokines produced following herpes simplex virus type-1 (HSV-1) infection that act to inhibit viral spread.In the present study,we identify HSV-infected and adjacent uninfected corneal epithelial cells as the source of interferon-α.We also report mice deficient in the A1 chain of the type I IFN receptor (CD118-/) are extremely sensitive to ocular infection with low doses (100 PFU) of HSV-1 as seen by significantly elevated viral titers in the cornea compared to wild type (WT) controls.The enhanced susceptibility correlated with a loss of CD4 + and CD8 + T cell recruitment and aberrant chemokine production in the cornea despite mounting an adaptive immune response in the draining mandibular lymph node of CD118-/mice.Taken together,these results highlight the importance of IFN production in both the innate immune response as well as eliciting chemokine production required to facilitate adaptive immune cell trafficking. | Christopher D. Conrady Heather Jones Min Zheng Daniel J.J. Carr | 2011 | The Journal of Biomedical Research2011，25，2： | 2 |
| 11 | Financial liberalization and banking crises in emerging economies显示文摘 | Betty C. Daniel John Bailey Jones | 2006 | Journal of International Economics2006，，1： | 2 |
| 12 | Seize the state, seize the day: state capture and influence in transition economies显示文摘 | Joel S Hellman Geraint Jones Daniel Kaufmann | 2003 | Journal of Comparative Economics2003，，4： | 2 |
| 13 | Role of dissolved organic nitrogen (DON) in soil N cycling in grassland soils显示文摘 | David L. Jones David Shannon Daniel V. Murphy John Farrar | 2004 | Soil Biology and Biochemistry2004，，5： | 2 |
| 14 | Lean logistics显示文摘 | Daniel T Jones | 1997 | International Journal of Physical Distribution & Logistics Management1997，27，34： | 1 |
| 15 | Resistant Hypertension: Diagnosis, Evaluation, and Treatment: A Scientific Statement From the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research显示文摘 | David A. Calhoun Daniel Jones Stephen Textor David C. Goff Timothy P. Murphy Robert D. Toto Anthony White William C. Cushman William White Domenic Sica Keith Ferdinand Thomas D. Giles Bonita Falkner Robert M. Carey | 2008 | Hypertension2008，，6： | 1 |
| 16 | Resistant Hypertension: Diagnosis, Evaluation, and Treatment: A Scientific Statement From the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research显示文摘 | David A. Calhoun Daniel Jones Stephen Textor David C. Goff Timothy P. Murphy Robert D. Toto Anthony White William C. Cushman William White Domenic Sica Keith Ferdinand Thomas D. Giles Bonita Falkner Robert M. Carey | 2008 | Hypertension2008，，6： | 1 |
| 17 | The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin显示文摘 | Gorski JC Jones DR Haehner Daniels BD | 1998 | Clin Pharmacol Ther1998，64，： | 1 |
| 18 | Evolving morphotropic phase boundary in lead-free ( Bil/2 Nal/2 )TiO3 - BaTiO3 pi- ezoceramics 显示文摘 | JO W DANIELS J E JONES J L | 2011 | Journal of Applied Physics2011，109，01： | 1 |
| 19 | Hydrodechlorination of triehloroethylene to hydrocarbons using bimetallic nickel- iron nanoparticles显示文摘 | Schrick Bettina Blough Jennifer L Jones A Daniel | 2002 | Chemistry of Materials2002，14，12： | 1 |
| 20 | The influence of polymer type, print donor and age on the quality of fingerprints developed on plastic substrates using vacuum metal deposition显示文摘 | Naomi Jones Danielle Mansour Milutin Stoilovic Chris Lennard Claude Roux | 2001 | Forensic Science International2001，，2： | 1 |
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