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| 1 | Validation of Zebrafish (Danio rerio) Reference Genes for Quantitative Real-time RT-PCR Normalization显示文摘The normalization of quantitative real time RT-PCR (qRT-PCR) is important to obtain accurate gene expression data. The most common method for qRT-PCR normalization is to use reference, or house- keeping genes. However, there is emerging evidence that even reference genes can be regulated under different conditions, qRT-PCR has only recently been used in terms of zebrafish gene expression studies and there is no validated set of reference genes. This study characterizes the expression of nine possible reference genes during zebrafish embryonic development and in a zebrafish tissue panel. All nine reference genes exhibited variable expression. The β-actin, EF1α and Rp113α genes comprise a validated reference gene panel for zebrafish developmental time course studies, and the EF1α, Rp113α and 18S rRNA genes are more suitable as a reference gene panel for zebrafish tissue analysis. Importantly, the zebrafish GAPDH gene appears unsuitable as reference gene for both types of studies. | Rongying TANG Andrew DODD Daniel LAI Warren C. MCNABB Donald R. LOVE | 2007 | Acta Biochimica et Biophysica Sinica2007，39，5： | 31 |
| 2 | Psychometrics of the chronic liver disease questionnaire for Southern Chinese patients with chronic hepatitis B virus infection显示文摘AIM:To test the psychometric properties of a Chinese [(Hong Kong) HK] translation of the chronic liver disease questionnaire (CLDQ).METHODS:A Chinese (HK) translation of the CLDQ was developed by iterative translation and cognitive debriefing.It was then administered to 72 uncomplicated and 78 complicated chronic hepatitis B (CHB) patients in Hong Kong together with a structured questionnaire on service utilization,and the Chinese (HK) SF-36 Health Survey Version 2 (SF-36v2).RESULTS:Scaling success was ≥ 80% for all but three items.A new factor assessing sleep was found and items of two (Fatigue and Systemic Symptoms) subscales tended to load on the same factor.Internal consistency and test-retest reliabilities ranged from 0.58-0.90 for different subscales.Construct validity was confirmed by the expected correlations between the SF-36v2 Health Survey and CLDQ scores.Mean scores of CLDQ were significantly lower in complicated compared with uncomplicated CHB,supporting sensitivity in detecting differences between groups.CONCLUSION:The Chinese (HK) CLDQ is valid,reliable and sensitive for patients with CHB.Some modif ications to the scaling structure might further improve its psychometric properties. | Elegance Ting Pui Lam Cindy Lo Kuen Lam Ching Lung Lai Man Fung Yuen Daniel Yee Tak Fong | 2009 | World Journal of Gastroenterology2009，15，26： | 16 |
| 3 | Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B显示文摘 | Man-Fung Yuen Yasuhito Tanaka Daniel Yee-Tak Fong James Fung Danny Ka-Ho Wong John Chi-Hang Yuen David Yiu-Kuen But Annie On-On Chan Benjamin Chun-Yu Wong Masashi Mizokami Ching-Lung Lai | 2008 | Journal of Hepatology2008，，1： | 5 |
| 4 | Improved clearing of lipid droplet-rich tissues for three-dimensional structural elucidation显示文摘 | Mengjie Lai Xiaowei Li Jun Li Yan Hu Daniel M. Czajkowsky Zhifeng Shao | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 2 |
| 5 | Drug-induced autoimmune hepatitis:A minireview显示文摘Drug-induced autoimmune hepatitis(DIAIH)is a specific phenotype of druginduced liver injury that may lead to the devastating outcome of acute liver failure requiring liver transplantation.Drugs implicated in DIAIH include antimicrobials such as nitrofurantoin and minocycline,non-steroidal anti-inflammatory drugs,statins as well as anti-tumor necrosis agents.The clinical features of druginduced liver injury are indistinguishable from idiopathic autoimmune hepatitis(AIH)as both may have positive AIH-related autoantibodies,elevated immunoglobulin G,as well as similar histopathological findings.In patients who show no clinical improvement,or there is progressive liver injury despite cessation of the suspected drug,a liver biopsy should be considered,whereby the presence of advance fibrosis on histology favors the diagnosis of idiopathic AIH.Empirical treatment with corticosteroids may be required in patients with non-resolving liver injury.A typical clinical scenario supportive of DIAIH includes a history of drug exposure with spontaneous resolution of liver injury after drug withdrawal and the absence of relapse after rapid steroid taper.In this article we report two cases of DIAIH secondary to Sorafenib and Atorvastatin along with a review of currently available literature.Early identification and treatment often lead to a favorable outcome in DIAIH. | Chin Kimg Tan Danielle Ho Lai Mun Wang Rahul Kumar | 2022 | World Journal of Gastroenterology2022，28，24： | 2 |
| 6 | Long‐term outcomes of short dental implants supporting single crowns in posterior region: a clinical retrospective study of 5–10 years显示文摘 | Hong‐Chang Lai Mi‐Si Si Long‐Fei Zhuang Hui Shen Yue‐lian Liu Daniel Wismeijer | 2012 | Clin. Oral Impl. Res2012，，2： | 1 |
| 7 | Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B显示文摘 | Man-Fung Yuen Yasuhito Tanaka Daniel Yee-Tak Fong James Fung Danny Ka-Ho Wong John Chi-Hang Yuen David Yiu-Kuen But Annie On-On Chan Benjamin Chun-Yu Wong Masashi Mizokami Ching-Lung Lai | 2008 | Journal of Hepatology2008，，1： | 1 |
| 8 | Entecavir versus Lamivudine for Patients with HBeAg-Negative Chronic Hepatitis B显示文摘 | Ching-Lung Lai Daniel Shouval Anna S Lok | 2006 | The New England journal of medicine2006，354，： | 1 |
| 9 | Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B显示文摘 | Man-Fung Yuen Yasuhito Tanaka Daniel Yee-Tak Fong James Fung Danny Ka-Ho Wong John Chi-Hang Yuen David Yiu-Kuen But Annie On-On Chan Benjamin Chun-Yu Wong Masashi Mizokami Ching-Lung Lai | 2008 | Journal of Hepatology2008，，1： | 1 |
| 10 | Effects of Static Compression With Different Loading Magnitudes and Durations on the Intervertebral Disc: An In Vivo Rat-Tail Study显示文摘 | Alon Lai Daniel H. K. Chow Sammy W. Siu S S. Leung Emily F. L. Lau F H. Tang Malcolm H. Pope | 2008 | Spine2008，，25： | 1 |
| 11 | Polyphenolic compounds as functional ingredients in cheese显示文摘 | JAEJOON HAN MICHEL BRITTEN DANIEL ST-GE- LAIS | 2011 | Food Chemistry2011，，124： | 1 |
| 12 | An examination of the nature of trust in logis-tics outsourcing relationship显示文摘 | TianY Lai F Daniel F | 2008 | Industrial Management and Data Sys-tems2008，108，3： | 1 |
| 13 | A pseudoknot ribozyme structure is active in vivo and required for hepatitis delta virus RNA replication显示文摘 | Jeng K S Daniel A Lai M M | 1996 | J Virol1996，70，： | 1 |
| 14 | Relative Contribution of Genetic and Nongenetic Modifiers to Intestinal Obstruction in Cystic Fibrosis显示文摘 | Scott M. Blackman Rebecca Deering–Brose Rita McWilliams Kathleen Naughton Barbara Coleman Teresa Lai Marilyn Algire Suzanne Beck Julie Hoover-Fong Ada Hamosh M. Daniele Fallin Kristen West Dan E. Arking Aravinda Chakravarti David J. Cutler Garry R. Cuttin | 2006 | Gastroenterology2006，，4： | 1 |
| 15 | An examination of the nature of trust in logistics outsourcing relationship显示文摘 | Tian Y Lai F Daniel F | 2008 | Industrial Management and Data Systems2008，108，34： | 1 |
| 16 | Early is superior to deferred preemptive lamivudine therapy for hepatitis B patients undergoing chemotherapy显示文摘 | George K.K Lau Harry H.Y Yiu Daniel Y.T Fong Hoi-Ching Cheng Wing-Yan Au Lydia S.F Lai Micheal Cheung Hai-Ying Zhang Albert Lie Roger Ngan Raymond Liang | 2003 | Gastroenterology2003，，6： | 1 |
| 17 | Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism显示文摘 | Gan Zhenji Rumsey John Hazen Bethany C Lai Ling Leone Teresa C Vega Rick B Xie Hui Conley Kevin E Auwerx Johan Smith Steven R Olson Eric N Kralli Anastasia Kelly Daniel P | 2013 | Journal of Clinical Investigation2013，，6： | 1 |
| 18 | Angiotensinogen Gene Haplotype and Hypertension: Interaction With ACE Gene I Allele显示文摘 | Chia-Ti Tsai Daniele Fallin Fu-Tien Chiang Juey-Jen Hwang Ling-Ping Lai Kuan-Lih Hsu Chuen-Den Tseng Chiau-Suong Liau Yung-Zu Tseng | 2003 | Hypertension: Journal of the American Heart Association2003，，1： | 1 |
| 19 | Sick building syndrome and perceived indoor environmental quality: A survey of apartment buildings in Hong Kong 显示文摘 | Siu-Kei Wong Lawrence Wai-Chung Lai Daniel Chi-Wing Ho | 2009 | Habitat International2009，33，4： | 1 |
| 20 | Enteeavir versus Lamivu- dine for Patients with HBeAg - Negative Chronic Hepatitis B显示文摘 | Ching- lung Lai Daniel S Anna SL | 2006 | N En- gl J Med2006，354，10： | 1 |
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