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| 1 | Tumor cyclooxygenase-2 levels correlate with tumor invasiveness in human hepatocellular carcinoma显示文摘AIM: Recent studies suggested that cyclooxygenase-2(COX-2) enhances tumor angiogenesis via upregulationof vascular endothelial growth factor (VEGF). AlthoughCOX-2 expression has been demonstrated in hepatocellularcarcinoma (HCC), the significance of COX-2 in progressionof HCC remains unclear. This study evaluated the clinico-pathological correlation of COX-2 level and its relationshipwith VEGF level in HCC.METHODS: Fresh tumor tissues were obtained from 100patients who underwent resection of HCC. COX-2 proteinexpression was examined by immunohistochemistry, andquantitatively by an enzyme immunometric assay (EIA)of tumor cytosolic COX-2 levels. Tumor cytosolic VEGFlevels were measured by an ELISA.RESULTS: Immunostaining showed expression of COX-2in tumor cells. Tumor cytosolic COX-2 levels correlatedwith VEGF levels (r = 0.469, P<0.001). Correlation withclinicopathological features showed significantly highertumor cytosolic COX-2 levels in the presence of multipletumors (P = 0.027), venous invasion (P = 0.030),microsatellite lesions (P = 0.037) and advanced tumorstage (P = 0.008). Higher tumor cytosolic COX-2 levelswere associated with worse patient survival.CONCLUSION: This study shows that elevated tumorCOX-2 levels correlate with elevated VEGF levels andinvasiveness in HCC, suggesting that COX-2 plays a significantrole in the progression of HCC. | TerenceC.Tang RonnieT.Poon CeciliaP.Lau Danxie SheungTatFan | 2005 | World Journal of Gastroenterology2005，11，13： | 37 |
| 2 | Oncogenic role of clusterin overexpression in multistage colorectal tumorigenesis and progression显示文摘AIM: To investigate the expression pattern of clusterin in colorectal adenoma-carcinoma-metastasis series, and to explore the potential role of dusterin in multistage colorectal tumorigenesis and progression.METHOD:S: A colorectal carcinoma (CRC)-tissue microarray (TMA), which contained 85 advanced CRCs including 43 cases of Dukes B, 21 of Dukes C and 21 of Dukes D tumors, were used for assessing the expression of clusterin (clone 41D) and tumor cell apoptotic index (AI) by immunohistochemistry and TUNEL assay, respectively. Moreover the potential correlation of dusterin expression with the patient'sclinical-pathological features were also examined. RESULTS: The positive staining of clusterin in different colorectal tissues was primarily a cytoplasmic pattern. Cytoplasmic overexpression of clusterin was detected in none of the normal coloredal mucosa, 17% of the adenomas, 46% of the primary CRCs, and 57% of the CRC metastatic lesions. In addition, a significant positive correlation between overexpression of clusterin and advanced clinical (Dukes) stage was observed (P<0.01). Overexpression of cytoplasmic clusterin in CRCs was inversely correlated with tumor apoptotic index (P<0.01), indicating the anti apoptotic function of cytoplasmic clusterin in CRCs.CONCLUSION: These data suggests that overexpression of cytoplasmic dustin might be involved in the tumorigenesis and/or progression of CRCs. The anti-apoptotic function of cytoplasmic dusterin may be responsible, at least in part, for the development and biologically aggressive behavior of CRC. | DanXie JonathanS.T.Sham Wei-FenZeng Li-HongChe MengZhang Hui-XiWu Han-LiangLin Jian-MingWen SzeHangLau LiangHu Xin-YuanGuan | 2005 | World Journal of Gastroenterology2005，11，21： | 4 |
| 3 | Textural characteristics of coconut shell-based activated carbons with steam activation 显示文摘 | Wang Xinyang Li Danxi Yang Baomin | 2012 | Advance Materials Research2012，，12： | 1 |
| 4 | Preparation of inulin and phenols-rich dietary fibre powder from burdock root 显示文摘 | Zaixiang Lou Hongxin Wang Danxi Wang | 2009 | Carbohydrate Polymers2009，78，： | 1 |
| 5 | Prepa- ration of PVDF membranes via the low-temperature TIPS method with diluent mixtures:The role of coagu- lation conditions and cooling rate显示文摘 | Wang Lei Huang Danxi Wang Xudong | 2015 | Desalination2015，361，21： | 1 |
| 6 | Identifying polyvinylidene fluoride ultrafiltration membrane fouling behavior of different effluent organic matter fractions using colloidal probes显示文摘 | Rui Miao Lei Wang Yongtao Lv Xudong Wang Ling Feng Ziwen Liu Danxi Huang Yongzhe Yang | 2014 | Water Research2014，，： | 1 |
| 7 | Effect of protein on PVDF ultrafiltration membrane fouling behavior under different pH conditions: interface adhesion force and XDLVO theory analysis显示文摘 | Xudong WANG Miao ZHOU Xiaorong MENG Lei WANG Danxi HUANG | 2016 | Frontiers of Environmental Science & Engineering2016，10，4： | 1 |
| 8 | Preparation of inulin and phenols-rich dietary fibre powderfrom burdock root显示文摘 | LOU ZAIXIANG WANG HONGXIN WANG DANXI | 2009 | Carbohydrate Polymers2009，，78： | 1 |
| 9 | Preparation of PVDF membranes via the low-temperature TIPS method with diluent mixtures: The role of coagulation conditions and cooling rate显示文摘 | Lei Wang Danxi Huang Xudong Wang | 2015 | Desalination2015，361，： | 1 |
| 10 | Hsa‐let‐7g inhibits proliferation of hepatocellular carcinoma cells by downregulation of c‐Myc and upregulation of p16<sup>INK4A</sup>显示文摘 | Fei‐FeiLan HuaWang Yang‐ChaoChen Chu‐YanChan Samuel S.Ng KuiLi DanXie Ming‐LiangHe Marie C.Lin Hsiang‐FuKung | 2010 | Int J Cancer2010，，2： | 1 |
| 11 | Preparation of inulin and phenols-rich dietary fibre powder from burdock root显示文摘 | Zaixiang Lou Hongxin Wang Danxi Wang | 2009 | Carbohydrate Polymers2009，78，： | 1 |
| 12 | Overexpression of EIF‐5A2 predicts tumor recurrence and progression in pTa/pT1 urothelial carcinoma of the bladder显示文摘 | Jun‐HangLuo Wen‐FengHua Hui‐LanRao Yi‐JiLiao Hsiang‐FuKung Yi‐XinZeng Xin‐YuanGuan WeiChen DanXie | 2009 | Cancer Science2009，，5： | 1 |
| 13 | Overexpression of EIF‐5A2 predicts tumor recurrence and progression in pTa/pT1 urothelial carcinoma of the bladder显示文摘 | Jun‐HangLuo Wen‐FengHua Hui‐LanRao Yi‐JiLiao Hsiang‐FuKung Yi‐XinZeng Xin‐YuanGuan WeiChen DanXie | 2009 | Cancer Science2009，，5： | 1 |
| 14 | Effect of electrokinetic property membrane on bovine serum of charged polyether sulfone albumin fouling behavior显示文摘 | Xiaorong Meng Shanshan Huo Lei Wang Xudong Wang Yongtao Lv Weiting Tang Rui Miao Danxi Huang | 2017 | Frontiers of Environmental Science & Engineering2017，11，2： | 0 |
| 15 | α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure显示文摘The sarcomeric interaction ofα-myosin heavy chain(α-MHC)with Titin is vital for cardiac structure and contraction.However,the mechanism regulating this interaction in normal and failing hearts remains unknown.Lactate is a crucial energy substrate of the heart.Here,we identify thatα-MHC undergoes lactylation on lysine 1897 to regulate the interaction ofα-MHC with Titin.We observed a reduction ofα-MHC K1897 lactylation in mice and patients with heart failure.Loss of K1897 lactylation inα-MHC K1897R knock-in mice reducesα-MHC–Titin interaction and leads to impaired cardiac structure and function.Furthermore,we identified that p300 and Sirtuin 1 act as the acyltransferase and delactylase ofα-MHC,respectively.Decreasing lactate production by chemical or genetic manipulation reducesα-MHC lactylation,impairsα-MHC–Titin interaction and worsens heart failure.By contrast,upregulation of the lactate concentration by administering sodium lactate or inhibiting the pivotal lactate transporter in cardiomyocytes can promoteα-MHC K1897 lactylation andα-MHC–Titin interaction,thereby alleviating heart failure.In conclusion,α-MHC lactylation is dynamically regulated and an important determinant of overall cardiac structure and function.Excessive lactate efflux and consumption by cardiomyocytes may decrease the intracellular lactate level,which is the main cause of reducedα-MHC K1897 lactylation during myocardial injury.Our study reveals that cardiac metabolism directly modulates the sarcomeric structure and function through lactate-dependent modification ofα-MHC. | Naijin Zhang Ying Zhang Jiaqi Xu Pengbo Wang Boquan Wu Saien Lu Xinxin Lu Shilong You Xinyue Huang Mohan Li Yuanming Zou Mengke Liu Yuanhui Zhao Guozhe Sun Wenbin Wang Danxi Geng Jingwei Liu Liu Cao Yingxian Sun | 2023 | Cell Research2023，33，9： | 0 |
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