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| 1 | Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity显示文摘AIM: To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds. METHODS: Because NDRG1 is a downstream target of p53 and hypoxia inducible factor-1α (HIF-1α),we examined NDRG1 expression together with p53 and HIF-1α by immunohistochemistry. A total of 157 colorectal cancer specimens including 80 from Japanese patients and 77 from US patients were examined. The correlation between protein expression with clinicopathological features and survival after surgery was analyzed.in colorectal tumor compared with normal epithelium in both Japanese and US patient groups. Expression of NDRG1 protein was significantly correlated with lymphatic invasion,venous invasion,depth of invasion,histopathological type,and Dukes' stage in Japanese colorectal cancer patients. NDRG1 expression was correlated to histopathological type,Dukes' stage and HIF-1α expression in US-Caucasian patients but not in US-African American patients. Interestingly,Kaplan-Meier survival analysis demonstrated that NDRG1 expression correlated significantly with poorer survival in US-African American patients but not in other patient groups. However,in p53-positive US cases,NDRG1 positivity correlated significantly with better survival. In addition,NDRG1 expression also correlated significantly with improved survival in US patients with stages Ⅲ and Ⅳ tumors without chemotherapy. In Japanese patients with stages Ⅱ and Ⅲ tumors,strong NDRG1 staining in p53-positive tumors correlated significantly with improved survival but negatively in patients without chemotherapy. CONCLUSION: NDRG1 expression was correlated with various clinicopathological features and clinical outcomes in colorectal cancer depending on the race/ethnicity of the patients. NDRG1 may serve as a biological basis for the disparity of clinical outcomes of colorectal cancer patients with different ethnic backgrounds. | Minori Koshiji Kensuke Kumamoto Keiichirou Morimura Yasufumi Utsumi Michiko Aizawa Masami Hoshino Shinji Ohki Seiichi Takenoshita Max Costa Thérèse Commes David Piquemal Curtis C Harris Kam-Meng Tchou-Wong | 2007 | World Journal of Gastroenterology2007，13，20： | 25 |
| 2 | Global Wheat Head Detection(GWHD)Dataset:A Large and Diverse Dataset of High-Resolution RGB-Labelled Images to Develop and Benchmark Wheat Head Detection Methods显示文摘The detection of wheat heads in plant images is an important task for estimating pertinent wheat traits including head population density and head characteristics such as health,size,maturity stage,and the presence of awns.Several studies have developed methods for wheat head detection from high-resolution RGB imagery based on machine learning algorithms.However,these methods have generally been calibrated and validated on limited datasets.High variability in observational conditions,genotypic differences,development stages,and head orientation makes wheat head detection a challenge for computer vision.Further,possible blurring due to motion or wind and overlap between heads for dense populations make this task even more complex.Through a joint international collaborative effort,we have built a large,diverse,and well-labelled dataset of wheat images,called the Global Wheat Head Detection(GWHD)dataset.It contains 4700 high-resolution RGB images and 190000 labelled wheat heads collected from several countries around the world at different growth stages with a wide range of genotypes.Guidelines for image acquisition,associating minimum metadata to respect FAIR principles,and consistent head labelling methods are proposed when developing new head detection datasets.The GWHD dataset is publicly available at http://gffzzef49fa24bca249bbhq0pvfpkffp0w6bpx.ffgz.tsg.suse.edu.cn/and aimed at developing and benchmarking methods for wheat head detection. | Etienne David Simon Madec Pouria Sadeghi-Tehran Helge Aasen Bangyou Zheng Shouyang Liu Norbert Kirchgessner Goro Ishikawa Koichi Nagasawa Minhajul A.Badhon Curtis Pozniak Benoit de Solan Andreas Hund Scott C.Chapman Frédéric Baret Ian Stavness Wei Guo | 2020 | Plant Phenomics2020，2，1： | 13 |
| 3 | Regulation of drug metabolism and toxicity by multiple factors of genetics,epigenetics,lncRNAs,gut microbiota,and diseases:a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations(MDO)显示文摘Variations in drug metabolism may alter drug efficacy and cause toxicity;better understanding of the mechanisms and risks shall help to practice precision medicine.At the 21 st International Symposium on Microsomes and Drug Oxidations held in Davis,California,USA,in October 2-6,2016,a number of speakers reported some new findings and ongoing studies on the regulation mechanisms behind variable drug metabolism and toxicity,and discussed potential implications to personalized medications.A considerably insightful overview was provided on genetic and epigenetic regulation of gene expression involved in drug absorption,distribution,metabolism,and excretion(ADME) and drug response.Altered drug metabolism and disposition as well as molecular mechanisms among diseased and special populations were presented.In addition,the roles of gut microbiota in drug metabolism and toxicology as well as long non-coding RNAs in liver functions and diseases were discussed.These findings may offer new insights into improved understanding of ADME regulatory mechanisms and advance drug metabolism research. | Ai-Ming Yu Magnus Ingelman-Sundberg Nathan J.Cherrington Lauren M.Aleksunes Ulrich M.Zanger Wen Xie Hyunyoung Jeong Edward M.Morgan Peter J.Turnbaugh Curtis D.Klaassen Aadra P.Bhatt Matthew R.Redinbo Pengying Hao David J.Waxman Li Wang Xiao-bo Zhong | 2017 | Acta Pharmaceutica Sinica B2017，7，2： | 3 |
| 4 | Global Wheat Head Detection 2021:An Improved Dataset for Benchmarking Wheat Head Detection Methods显示文摘The Global Wheat Head Detection(GWHD)dataset was created in 2020 and has assembled 193,634 labelled wheat heads from 4700 RGB images acquired from various acquisition platforms and 7 countries/institutions.With an associated competition hosted in Kaggle,GWHD_2020 has successfully attracted attention from both the computer vision and agricultural science communities.From this first experience,a few avenues for improvements have been identified regarding data size,head diversity,and label reliability.To address these issues,the 2020 dataset has been reexamined,relabeled,and complemented by adding 1722 images from 5 additional countries,allowing for 81,553 additional wheat heads.We now release in 2021 a new version of the Global Wheat Head Detection dataset,which is bigger,more diverse,and less noisy than the GWHD_2020 version. | Etienne David Mario Serouart Daniel Smith Simon Madec Kaaviya Velumani Shouyang Liu Xu Wang Francisco Pinto Shahameh Shafiee Izzat SATahir Hisashi Tsujimoto Shuhei Nasuda Bangyou Zheng Norbert Kirchgessner Helge Aasen Andreas Hund Pouria Sadhegi-Tehran Koichi Nagasawa Goro Ishikawa Sébastien Dandrifosse Alexis Carlier Benjamin Dumont Benoit Mercatoris Byron Evers Ken Kuroki Haozhou Wang Masanori Ishii Minhajul ABadhon Curtis Pozniak David Shaner LeBauer Morten Lillemo Jesse Poland Scott Chapman Benoit de Solan Frédéric Baret Ian Stavness Wei Guo | 2021 | Plant Phenomics2021，3，1： | 2 |
| 5 | 共形阵列天线技术显示文摘现代天线技术最重要的创新之一是将共形天线设计引入许多应用领域,包括雷达、数据链、移动蜂窝基站和通信终端等。 | David Curtis | 2007 | 电子工程信息2007，，5： | 2 |
| 6 | The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years显示文摘 | Mark R Nelson Christine Katlama Julio S Montaner David A Cooper Brian Gazzard Bonaventura Clotet Adriano Lazzarin Knud Schewe Joep Lange Christina Wyatt Sue Curtis Shan-Shan Chen Stephen Smith Norbert Bischofberger James F Rooney | 2007 | AIDS2007，，10： | 2 |
| 7 | SPINK1 Is a Susceptibility Gene for Fibrocalculous Pancreatic Diabetes in Subjects from the Indian Subcontinent显示文摘 | Zahid Hassan Viswananthan Mohan Liaquat Ali Rebecca Allotey Khalid Barakat M. Omar Faruque Raj Deepa Michael F. McDermott Alan E. Jackson Paul Cassell David Curtis Susan V. Gelding Shanti Vijayaravaghan Niklaus Gyr David C. Whitcomb A.K. Azad Khan Graham | 2002 | The American Journal of Human Genetics2002，，4： | 1 |
| 8 | Solar Forcing of Drought Frequency in the Maya Lowlands 显示文摘 | David A Hodell Mark Brenner Jason H Curtis | 2001 | SCIENCE2001，292，18： | 1 |
| 9 | Finite element analysis of an embankment on a soft estuarine deposit using an elastic-viscoplastic soil model显示文摘 | CURTIS K JITENDRA S DAVID H | 2009 | Canadian Geotechnical Journal2009，46，3： | 1 |
| 10 | Reporting Standards for Endovascular Treatment of Lower Extremity Deep Vein Thrombosis显示文摘 | Suresh Vedantham Clement J. Grassi Hector Ferral Nilesh H. Patel Patricia E. Thorpe Vittorio P. Antonacci Bertrand M. Janne d’Othée Lawrence V. Hofmann John F. Cardella Sanjoy Kundu Curtis A. Lewis Marc S. Schwartzberg Robert J. Min David Sacks | 2009 | Journal of Vascular and Interventional Radiology2009，，7： | 1 |
| 11 | Defective Interplay of Activators and Repressors with TFIIH in Xeroderma Pigmentosum显示文摘 | Juhong Liu Sasha Akoulitchev Achim Weber Hui Ge Sergei Chuikov Daniel Libutti Xin W Wang Joan Weliky Conaway Curtis C Harris Ronald C Conaway Danny Reinberg David Levens | 2001 | Cell2001，，3： | 1 |
| 12 | ACC/AHA 2005 Practice Guidelines for the Management of Patients With Peripheral Arterial Disease (Lower Extremity, Renal, Mesenteric, and Abdominal Aortic): A Collaborative Report from the American Association for Vascular Surgery/Society for Vascular Sur显示文摘 | Alan T. Hirsch Ziv J. Haskal Norman R. Hertzer Curtis W. Bakal Mark A. Creager Jonathan L. Halperin Loren F. Hiratzka William R.C. Murphy Jeffrey W. Olin Jules B. Puschett Kenneth A. Rosenfield David Sacks James C. Stanley Lloyd M. Taylor Christopher J. W | 2006 | Circulation2006，，11： | 1 |
| 13 | Differences in End-of-Life Care in the ICU Across Patients Cared for by Medicine, Surgery, Neurology, and Neurosurgery Physicians显示文摘 | Erin K. Kross Ruth A. Engelberg Lois Downey Joseph Cuschieri Matthew R. Hallman W.T. Longstreth David L. Tirschwell J. Randall Curtis | 2014 | Chest2014，，2： | 1 |
| 14 | HYPERLIPIDEMIA AFTER LIVER TRANSPLANTATION: Natural History and Treatment with the Hydroxy-Methylglutaryl-Coenzyme A Reductase Inhibitor Pravastatin1显示文摘 | David K. Imagawa Sherfield Dawson Curtis D. Holt Pamela S. Kirk Fady M. Kaldas Christopher R. Shackleton Philip Seu Steve M. Rudich Milan M. Kinkhabwala Paul Martin Leonard I. Goldstein Natalie G.B. Murray Paul I. Terasaki Ronald W. Busuttil | 1996 | Transplantation1996，，7： | 1 |
| 15 | Supporting knowledge work with physical design显示文摘 | | 2002 | Knowledge Management Review2002，5，5： | 1 |
| 16 | Position state- ment on the use of the ankle brachial index in the evaluation of patients with peripheral vascular disease 显示文摘 | DAVID S CURTIS WB PETER TB | 2002 | J Vasc lnterv Ra- diol2002，13，4： | 1 |
| 17 | The Relationship between Prostate Inflammation and Lower Urinary Tract Symptoms: Examination of Baseline Data from the REDUCE Trial <ce:link locator='eulogo1'/>显示文摘 | J. Curtis Nickel Claus G. Roehrborn Michael P. O’Leary David G. Bostwick Matthew C. Somerville Roger S. Rittmaster | 2007 | European Urology2007，，6： | 1 |
| 18 | Update on K awasaki disease: Epidemiology, aetiology and pathogenesis显示文摘 | Deane Yim Nigel Curtis Michael Cheung David Burgner | 2013 | J Paediatr Child Health2013，，9： | 1 |
| 19 | Dynamic holographic optical tweezers显示文摘 | Jennifer E. Curtis Brian A. Koss David G. Grier | 2002 | Optics Communications2002，，1： | 1 |
| 20 | Hospital Improvement in Time to Reperfusion in Patients With Acute Myocardial Infarction, 1999 to 2002显示文摘 | Robert L. McNamara Jeph Herrin Elizabeth H. Bradley Edward L. Portnay Jeptha P. Curtis Yongfei Wang David J. Magid Martha Blaney Harlan M. Krumholz | 2006 | Journal of the American College of Cardiology2006，，1： | 1 |
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