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| 1 | Classic axon guidance molecules control correct nerve bridge tissue formation and precise axon regeneration显示文摘The peripheral nervous system has an astonishing ability to regenerate following a compression or crush injury;however,the potential for full repair following a transection injury is much less.Currently,the major clinical challenge for peripheral nerve repair come from long gaps between the proximal and distal nerve stumps,which prevent regenerating axons reaching the distal nerve.Precise axon targeting during nervous system development is controlled by families of axon guidance molecules including Netrins,Slits,Ephrins and Semaphorins.Several recent studies have indicated key roles of Netrin1,Slit3 and EphrinB2 signalling in controlling the formation of new nerve bridge tissue and precise axon regeneration after peripheral nerve transection injury.Inside the nerve bridge,nerve fibroblasts express EphrinB2 while migrating Schwann cells express the receptor EphB2.EphrinB2/EphB2 signalling between nerve fibroblasts and migrating Schwann cells is required for Sox2 upregulation in Schwann cells and the formation of Schwann cell cords within the nerve bridge to allow directional axon growth to the distal nerve stump.Macrophages in the outermost layer of the nerve bridge express Slit3 while migrating Schwann cells and regenerating axons express the receptor Robo1;within Schwann cells,Robo1 expression is also Sox2-dependent.Slit3/Robo1 signalling is required to keep migrating Schwann cells and regenerating axons inside the nerve bridge.In addition to the Slit3/Robo1 signalling system,migrating Schwann cells also express Netrin1 and regenerating axons express the DCC receptor.It appears that migrating Schwann cells could also use Netrin1 as a guidance cue to direct regenerating axons across the peripheral nerve gap.Engineered neural tissues have been suggested as promising alternatives for the repair of large peripheral nerve gaps.Therefore,understanding the function of classic axon guidance molecules in nerve bridge formation and their roles in axon regeneration could be highly beneficial in developing engineered neural tissue for more effective peripheral nerve repair. | Xin-Peng Dun David BParkinson | 2020 | Neural Regeneration Research2020，15，1： | 13 |
| 2 | 迁移的雪旺细胞指导周围神经桥内的轴突再生显示文摘周围神经系统内的雪旺细胞具有强大的再生潜力。目前的研究表明,周围神经相关的雪旺细胞具有促进多种组织修复的能力,包括周围神经间隙桥接、皮肤伤口愈合、指尖修复以及牙齿再生。专门修复的雪旺细胞的关键特征之一是它们变得高度能动。它们不仅迁移到受损组织区域,成为组织再生的关键组成部分,还分泌信号分子来吸引巨噬细胞,支持神经元存活,促进轴突再生,激活局部间充质干细胞,并与其他细胞类型相互作用。目前,迁移性雪旺细胞在组织再生中的重要性在周围神经横断损伤的情况证据最为充分。神经横断后,来自近端和远端神经残端的雪旺氏细胞均迁移到神经桥中并形成雪旺细胞索以引导轴突再生。神经桥中雪旺细胞索的形成是横断损伤后周围神经成功修复的关键。本篇综述首先探讨了神经桥的形成以及神经桥中雪旺细胞迁移的行为,然后讨论迁移的雪旺细胞如何将再生轴突引导到远端神经中。我们还回顾了目前对可激活雪旺细胞迁移的信号以及雪旺细胞用于指导轴突再生的信号的理解。了解雪旺细胞迁移的分子机制可能为周围神经修复提供新的治疗策略。 | Qing Min David B Parkinson Xin-Peng Dun 杜一星(编译) | 2021 | 神经损伤与功能重建2021，16，9： | 5 |
| 3 | Tailoring spin mixtures by ion-enhanced Maxwell magnetic coupling in colortunable organic electroluminescent devices显示文摘In this work,we show that the spin dynamics of excitons can be dramatically altered by Maxwell magnetic field coupling,together with an ion-enhanced,low-internal-splitting-energy organic semiconducting emitter.By employing a unique,alternating current(AC)-driven organic electroluminescent(OEL)device architecture that optimizes this magnetic field coupling,almost complete control over the singlet-to-triplet ratio(from fluorescent to phosphorescent emission in a single device)is realized.We attribute this spin population control to magnetically sensitive polaron–spin pair intersystem crossings(ISCs)that can be directly manipulated through external driving conditions.As an illustration of the utility of this approach to spin-tailoring,we demonstrate a simple hybrid(double-layer)fluorescence–phosphorescence(F–P)device using a polyfluorene-based emitter with a strong external Zeeman effect and ion-induced long carrier diffusion.Remarkable control over de-excitation pathways is achieved by controlling the device-driving frequency,resulting in complete emission blue–red color tunability.Picosecond photoluminescence(PL)spectroscopy directly confirms that this color control derives from the magnetic manipulation of the singlet-totriplet ratios.These results may pave the way to far more exotic organic devices with magnetic-field-coupled organic systems that are poised to usher in an era of dynamic spintronics at room temperature. | Junwei Xu Yue Cui Gregory M.Smith Peiyun Li Chaochao Dun Linqi Shao Yang Guo Hongzhi Wang Yonghua Chen David L.Carroll | 2018 | Light(Science & Applications)2018，7，1： | 2 |
| 4 | Diagnosis of Ischemia-Causing Coronary Stenoses by Noninvasive Fractional Flow Reserve Computed From Coronary Computed Tomographic Angiograms显示文摘 | Bon-Kwon Koo Andrejs Erglis Joon-Hyung Doh David V. Daniels Sanda Jegere Hyo-Soo Kim Allison Dunning Tony DeFrance Alexandra Lansky Jonathan Leipsic James K. Min | 2011 | Journal of the American College of Cardiology2011，，19： | 1 |
| 5 | Unskilled and unaware of it:How difficulties in recognizing one's own incompetence lead to inflated self-assessments 显示文摘 | Kruger Justin Dunning David | 1999 | Journal of Personality and Social Psychology1999，77，6： | 1 |
| 6 | Turning up the con- trast:Self-enhancement motives prompt egocentric contrast effects in social judgments显示文摘 | Beauregard S Keith Dunning David | 1998 | Journal of Personality and So- cial Psychology1998，74，3： | 1 |
| 7 | Construal processes and trait ambiguity: Implications for self-peer agreement in personality judgment 显示文摘 | Hayes F Andrew Dunning David | 1997 | Journal of Personality and Social Psychology1997，72，3： | 1 |
| 8 | Criteria for developing castable,creep-resistant aluminum-based alloys显示文摘 | Keith E Knipling David C Dun Seidman N | 2006 | Z Metallkd2006，97，3： | 1 |
| 9 | Guideline for the surgical treatment of atrial fibrillation显示文摘 | Joel Dunning Myura Nagendran Ottavio R. Alfieri Stefano Elia A. Pieter Kappetein Ulf Lockowandt George E. Sarris Phillippe H. Kolh Maruthappu Mahiben Sunderland Nicholas Camm Christian Xiu Phillip Gray Robert Chen Yang MacDonald David Basu Sumoyee | 2013 | European Journal of Cardio-Thoracic Surgery2013，，： | 1 |
| 10 | A Large Study of Androgen Receptor Germline Variants and Their Relation to Sex Hormone Levels and Prostate Cancer Risk. Results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium显示文摘 | Sara Lindstr?m Jing Ma David Altshuler Edward Giovannucci Elio Riboli Demetrius Albanes Naomi E. Allen Sonja I. Berndt Heiner Boeing H. Bas Bueno-de-Mesquita Stephen J. Chanock Alison M. Dunning Heather Spencer Feigelson J. Michael Gaziano Christopher A. | 2010 | The Journal of Clinical Endocrinology & Metabolism2010，，9： | 1 |
| 11 | Finite element modeling mesh quality, energy balance and validation methods: A review with recommendations associated with the modeling of bone tissue显示文摘 | Timothy A. Burkhart David M. Andrews Cynthia E. Dunning | 2013 | Journal of Biomechanics2013，，9： | 1 |
| 12 | How chronic self-views influence(and potentially mislead)estimates of performance显示文摘 | Joyce Ehrlinger David Dunning | 2003 | Journal of Personality and Social Psychology2003，84，1： | 1 |
| 13 | Do people trust too much or too little?显示文摘 | Detlef Fetchenhauer David Dunning | 2008 | Journal of Economic Psychology2008，，3： | 1 |
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