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| 1 | Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial显示文摘 | Kris V Kowdley Eric Lawitz Israel Crespo Tarek Hassanein Mitchell N Davis Michael DeMicco David E Bernstein Nezam Afdhal John M Vierling Stuart C Gordon Jane K Anderson Robert H Hyland Hadas Dvory-Sobol Di An Robert G Hindes Efsevia Albanis William T Symo | 2013 | The Lancet2013，，9883： | 3 |
| 2 | CD133 expression is not restricted to stem cells, and both CD133^sup +^ and CD133^sup -^ metastatic colon cancer cells initiate tumors显示文摘 | Shmelkov Sergey V Butler Jason M Hooper Andrea T Hormigo Adilia Kushner Jared Milde Till Clair Ryan St Baljevic Muhamed White Ian Jin David K Chadburn Amy Murphy Andrew J Valenzuela David M Gale Nicholas W Thurston Gavin Yancopoulos George | 2008 | Journal of Clinical Investigation2008，，： | 2 |
| 3 | Lymphoepithelial cysts and cystic lymphangiomas: Underrecognized benign cystic lesions of the pancreas显示文摘AIM: To identify their diagnostic and prognostic clinical characteristics in a large series.METHODS: Retrospective review of clinicopathologic and imaging characteristics of patients diagnosed with lymphoepithelial cysts and cystic lymphangiomas of the pancreas at Massachusetts General Hospital.RESULTS: Twelve patients were identified between 1/1/1997 and 8/1/2007. Their median age was 55.5 years(range 19-78 years), and 6 were females. The le-sion was incidentally discovered in half of the patients.Contrast enhanced computed tomography demonstrat-ed that the cysts had thin walls, without calcifications, pancreatic duct dilation or pancreatic parenchyma inva-sion. Endoscopic ultrasound with fine needle aspiration(EUS/FNA) confirmed the diagnosis of a lymphoepithe-lial cyst in 3 patients, one of whom was spared an op-eration and continues to do well after 6 years. Eleven patients had a resection: 3 pancreaticoduodenecto-mies, 7 distal pancreatectomies, and 1 enucleation. The median size of the cysts was 3 cm(range 2-20 cm). At a median follow-up of 57 mo no recurrences or other pancreas-related conditions occurred.CONCLUSION: Lymphoepithelial cysts and cystic lymphangiomas of the pancreas can be diagnosed with a combination of contrast-enhanced computed tomog-raphy scans and EUS/FNA. If the lesion is asymptom-atic, an operation might be avoided. | Ioannis T Konstantinidis Avinash Kambadakone Onofrio A Catalano Dushyant V Sahani Vikram Deshpe David G Forcione Jennifer A Wargo Carlos Fernandez-del Castillo Keith D Lillemoe Andrew L Warshaw Cristina R Ferrone | 2014 | World Journal of Gastrointestinal Surgery2014，6，7： | 2 |
| 4 | Personalising pancreas cancer treatment:When tissue is the issue显示文摘The treatment of advanced pancreatic cancer has not moved much beyond single agent gemcitabine until recently when protocols such as FOLFIRINOX(fluorouracil,leucovorin,irinotecan and oxaliplatin)and nab-paclitaxelgemcitabine have demonstrated some improved outcomes.Advances in technology especially in massively parallel genome sequencing has progressed our understanding of the biology of pancreatic cancer especially the candidate signalling pathways that are involved in tumourogenesis and disease course.This has allowed identification of potentially actionable mutations that may be targeted by new biological agents.The heterogeneity of pancreatic cancer makes tumour tissue collection important with the aim of being able to personalise therapies for the individual as opposed to a one size fits all approach to treatment of the condition.This paper reviews the developments in this area of translational research and the ongoing clinical studies that will attempt to move this into the everyday oncology practice. | Katrin M Sjoquist Venessa T Chin Lorraine A Chantrill Chelsie O'Connor Chris Hemmings David K Chang Angela Chou Marina Pajic Amber L Johns Adnan M Nagrial Andrew V Biankin Desmond Yip | 2014 | World Journal of Gastroenterology2014，20，24： | 2 |
| 5 | Late Glacial temperature and precipitation changes in tile lowland Neotropics by tandem measurement of lSO in biogenic carbonate and gypsum hydration water显示文摘 | DAVID A H ALEXANDRA V T CAMILLA J W | 2012 | Geochimica et Cosmochimica Acta2012，77，： | 1 |
| 6 | Phosphorus Trans- port Pathways to Streams in Tile-Drained Agricultural Watersheds 显示文摘 | GENTRY L E DAVID M B ROYER T V | 2007 | Journal of Environmental Quality2007，36，2： | 1 |
| 7 | Structural insights into the mechanical regulation of molecular in Biotechnology显示文摘 | WENDY E T Trends DAVID W C | 2001 | recognition sites2001，19，10： | 1 |
| 8 | Effect of different sanitizers on microbial and sensory quality of fresh-cut potato strips Stored under modified atmosphere or vacuum packaglng显示文摘 | David B Marla V S Juan A T | | Postharvest Biology and Technology0，200，1： | 1 |
| 9 | The NIH human microbiome project显示文摘 | NIH HMP Working Group Peterson J Garges S Giovanni M McInnes P Wang L Schloss JA Bonazzi V McEwen JE Wetterstrand KA Deal C Baker CC Di Francesco V Howcroft TK Karp RW Lunsford RD Wellington CR Belachew T Wright M Giblin C David H Mills M Salomon R Mullins C Akolkar B Begg L Davis C Grandison L Humble M Khalsa J Little AR Peavy H Pontzer C Portnoy M Sayre MH Starke-Reed P Zakhari S Read J Watson B Guyer M | 2009 | Genome Res2009，19，12： | 1 |
| 10 | Estimation of incidence and reflection angles from passive polarimetric imagery: extension to out-of-plane scattering显示文摘 | Anand P Vimal T David G V | 2007 | Proc of SHE2007，6682，66820： | 1 |
| 11 | Complete Quantum Tele- portation with a Kerr nonlinearity 显示文摘 | David V Mauro F Paolo T | 2000 | Physical Review Letters2000，85，： | 1 |
| 12 | Estimating the complex index of refraction and view angle of an object using multiple polarization measurements显示文摘 | Vimal T Charles D C David G V | 2007 | Applied Optics2007，46，30： | 1 |
| 13 | Export of dissolved organic carbon from agricultural stream in Illiois,USA显示文摘 | Royer T V David M B | 2005 | Aquatic Science2005，67，4： | 1 |
| 14 | An extensive cochlodinium bloom along the Western coast of Palawan, Philippines显示文摘 | AZANZA R V DAVID L T BORJA R T BAUIA I U FUKUYO Y | 2008 | Harmful Algae2008，7，： | 1 |
| 15 | The antecedent factors on trust and commitment in supply chain relationships显示文摘 | JENGCHUNG V C DAVID C Y RAJKUMAR T M | 2011 | Computer Standards & In- terfaces2011，33，3： | 1 |
| 16 | A population-based study of the drug interaction between proton pump inhibitors and clopidogrel显示文摘 | Juurlink David N Gomes Tara Ko Dennis T Szmitko Paul E Austin Peter C Tu Jack V Henry David A Kopp Alex Mamdani Muhammad M | 2009 | Canadian Medical Association. Journal2009，，7： | 1 |
| 17 | Polarization-based index of refraction and reflection angle estimation for remote sensing applications 显示文摘 | Vimal T David G V Charles D C | 2007 | Applied Optics2007，46，30： | 1 |
| 18 | Restructuring hospital industry to control public health care expenditure:the role of input substitutability显示文摘 | Massimiliano P Gilberto T Davide V | 2010 | Economic Modelling2010，27，4： | 1 |
| 19 | Purification and characterization of an enterotoxin from Bacteroides fragilis 显示文摘 | ROGER L V T DAVID M TRACY D W | 1992 | Infect Immun1992，60，4： | 1 |
| 20 | Antiglycative and neuroprotective activity of colon-derived polyphenol catabolites 显示文摘 | Elena V Claudia P Davide T | 2011 | Mol Nutr Food Res2011，55，： | 1 |
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