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| 1 | 北京市城区老年人膝关节骨关节炎流行病学调查——与美国白种人膝关节骨关节炎的临床和X线比较分析显示文摘目的 旨在了解北京市城区老年人膝关节骨关节炎 (OA)的患病率 ,并比较北京市城区老年人膝关节炎的患病率同美国白人患病率的差异。方法 从北京市 3个城区 6 0岁以上的北京男女居民随机抽取样本 ,其中男 730例 ,女 1 0 5 1例。所采用研究方案与美国Framingham骨关节研究方案一致。受检者分别完成入户调查及其问卷 ,然后受检者到医院进行双膝关节持重正位X线检查。采用年龄标化患病率比表达该研究和美国Framingham研究中膝关节OA患病率的差异。结果膝关节X线OA患病率女性为 4 2 8%,男性为 2 1 5 %;临床OA患病率女性为 1 5 0 %,男性为 5 6 %。同美国Framingham研究的白人OA患病率比较 ,女性膝关节X线和临床OA患病率均高于美国同龄白种人 ;男性膝关节X线和临床OA患病率与美国同龄白种人相似。结论 北京市城区老年女性膝关节炎患病率较高 ,且高于美国同龄妇女的OA患病率 ,应引起重视。 | 余卫 徐苓 秦明伟 Yu-qing Zhang Michael C.Nevitt Piran Aliabadi Li-Yung Lui David T.Felson | 2005 | 中华放射学杂志2005，39，1： | 94 |
| 2 | Double-stranded DNA in exosomes: a novel biomarker in cancer detection显示文摘 | Basant Kumar Thakur Haiying Zhang Annette Becker Irina Matei Yujie Huang Bruno Costa-Silva Yan Zheng Ayuko Hoshino Helene Brazier Jenny Xiang Caitlin Williams Ruth Rodriguez-Barrueco Jose M Silva Weijia Zhang Stephen Hearn Olivier Elemento Navid Paknejad Katia Manova-Todorova Karl Welte Jacqueline Bromberg Hector Peinado David Lyden | 2014 | Cell Research2014，24，6： | 98 |
| 3 | 不同时间尺度下的湖泊沉积物环境记录——以沉积物粒度为例显示文摘在湖泊沉积记录与古气候研究中,沉积物粒度的环境意义常常解释为:粗粒沉积物指示低水位时期的干旱气候,细粒沉积物指示高水位时期的湿润气候。本文通过对云南洱海和程海现代沉积物粒度的研究,揭示了沉积物粒度在不同时间尺度、不同时间分辨率的研究中具有不同的环境指示意义。在长时间尺度、低分辨率(百年、千年)研究中,粗粒沉积物指示湖泊收缩、湖水较浅的干旱气候期;细粒沉积物指示湖泊扩张、湖水较深的湿润气候期。在短时间尺度、高分辨率(年际、10a)研究中,粗粒沉积物指示降雨量较大的湿润年份;细粒沉积物指示降雨量相对较小的干旱年份。由于不同时间尺度研究中沉积分辨率、采样分辨率和定年精度的不同,湖泊沉积物记录所反映的环境信息在不同尺度下因此可能存在差异。在由以往的长时间尺度、低分辨率研究转向短时间尺度、高分辨率研究的过程中,不能简单套用各种指标在长尺度研究中的环境指示意义,必须结合研究的时间尺度和分辨率,综合分析各种因素对环境记录的影响方式和程度,才能得出可靠结论。 | 陈敬安 万国江 张峰 David Dian Zhang 黄荣贵 | 2003 | 中国科学(D辑)2003，33，6： | 206 |
| 4 | 北京城区老年人膝、髋和手骨关节炎的患病率及其与美国白人患病率的比较研究显示文摘目的 采用与国际上一致的研究设计和诊断标准 ,调查北京老年人膝、髋和手骨关节炎(OA)患病率并与美国的白人资料进行比较。方法 对北京市城区人群进行抽样调查 ,对象为 6 0岁以上的北京老年男女居民 ,知情同意后均进行入户调查及关节放射学检查。入户调查内容包括病史、职业史、关节病史、关节症状史、骨折史、药物史、体力劳动情况、手指动作、生活质量、生活方式、女性生育史及一般人口学资料。关节放射学检查包括双膝关节X线骨盆片及双手平片。研究方法及OA诊断标准均与美国Franmingham骨关节研究一致。结果 共有 10 12名男性和 15 0 7名女性接受了检查。北京老年妇女膝关节放射学OA的患病率高达 4 6 6 % ,临床OA的患病率为 15 .4 % ,高于同年龄的美国妇女。北京男性老人膝关节放射学OA和临床OA的患病率分别为 2 7.6 %和 7.1% ,与美国男性近似。北京男女老人髋关节放射学OA的患病率仅为 0 .4 %~ 0 .8% ,明显低于美国人。北京老年男女手关节放射学OA的患病率分别为 4 4 .5 %和 4 7.0 %。和美国资料比较 ,北京老人手关节OA的患病率较低。结论 与美国人比较 ,北京老年人手和髋关节OA患病率相对较低 ,但膝关节OA患病率极高 ,影响着千百万老人的健康和生活质量。 | 徐苓 Michael C Nevitt Yuqing Zhang 余卫 Piran Alibadi David T Felson | 2003 | 中华医学杂志2003，83，14： | 62 |
| 5 | aunalysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza显示文摘 | Haibin Xu Jingyuan Song Hongmei Luo Yujun Zhang Qiushi Li Yingjie Zhu Jiang Xu Ying Li Chi Song Bo Wang Wei Sun Guoan Shen Xin Zhang Jun Qian Aijia Ji Zhichao Xu Xiang Luo Liu He Chuyuan Li Chao Sun Haixia Yah Guanghong Cui Xiwen Li Xian 'en Li Jianhe Wei Juyan Liu Yitao Wang Alice Hayward David Nelson Zemin Ning Reuben J. Peters Xiaoquan Qi Shilin Chen | 2016 | Molecular Plant2016，9，6： | 70 |
| 6 | A community-derived classification for extant lycophytes and ferns显示文摘发展史长通知了蕨类植物分类。当我们推断进化的树的能力改善了,针对认出生来的组的分类变得逐渐地预兆、稳定。这里,我们为 lycophytes 和蕨纲植物提供一个现代、全面分类,在下面,利用一条基于社区的途径类水平。我们 monophyly 用作主要标准让 taxa,而且目的识别保存两个广泛地被接受的存在 taxa 和界限并且与我们蕨类植物发展史的理解一致。总共,这个分类对待一在 337 个类, 51 个家庭, 14 目,和二个班估计了 11 916 种类。这个分类没在 lycophyte 和蕨纲植物上作为最后的词被打算分类,而是当前的假设的概括陈述,源于最好的可得到的数据并且在问题由熟悉植物的那些大多数塑造了。我们希望它将在蕨类植物上为最近的文学的那些想要的参考用作一个资源发展史和分类,为指导未来调查的一个框架,和推进讲话的刺激。 | Eric Schuettpelz Harald Schneider Alan R. Smith Peter Hovenkamp Jefferson Prado Germinal Rouhan Alexandre Salino Michael Sundue Thafs Elias Almeida Barbara Parris Emily B. Sessa Ashley R. Field Andre Luis de Gasper Carl J. Rothfels Michael D. Windham Marcus Lehnert Benjamin Dauphin Atsushi Ebihara Samuli Lehtonen Pedro Bond Schwartsburd Jordan Metzgar Li-Bing Zhang Li-Yaung Kuo Patrick J. Brownsey Masahiro Kato Marcelo Daniel Arana Francine C. Assis Michael S. Barker David S. Barrington Ho-Ming Chang Yi-Han Chang Yi-Shan Chao Cheng-Wei Chen De-Kui Chen Wen-Liang Chiou Vinicius Antonio de Oliveira Dittrich Yi-Fan Duan Jean-Yves Dubuisson Donald R. Farrar Susan Fawcett Jose Maria Gabriel y Galan Luiz Armando de Araujo Goes-Neto Jason R. Grant Amanda L. Grusz Christopher Haufler Warren Hauk Hai He Sabine Hennequin Regina Yoshie Hirai Layne Huiet Michael Kessler Petra Korall Paulo H. Labiak Anders Larsson Blanca Leen Chun-Xiang Li Fay-Wei Li Melanie Link-Perez Hong-Mei Liu Ngan Thi Lu Esteban I. Meza-Torres Xin-Yuan Miao Robbin Moran Claudine Massi Mynssens Nathalie Nagalingum Benjamin Ollgaard Alison M. Paul Jovani B. de S. Pereira Leon R. Perrie Monica Ponce Tom A. Ranker Christian Schulz Wataru Shinohara Alexander Shmakov Erin M. Sigel Filipe Soares de Souza Lana da Silva Sylvestre Weston Testo Luz Amparo Triana-Moreno Chie Tsutsumi Hanna Tuomisto IvAn A. Valdespino Alejandra Vasco Raquel Stauffer Viveros Alan Weakley Ran Wei Stina Weststrand Paul G. Wolf George Yatskievych Xiao-Gang Xu Yue-Hong Yan Liang Zhang Xian-Chun Zhang Xin-Mao Zhou | 2016 | Journal of Systematics and Evolution2016，54，6： | 44 |
| 7 | Analyses on the climate change responses over China under SRES B2 scenario using PRECIS显示文摘The PRECIS,a regional climate model system developed at the UK Met Office Hadley Cen- tre for Climate Prediction and Research,which is nested in one-way mode within the HadAM3P,a higher-resolution version of the atmospheric com- ponent of the Hadley Centre climate model HadCM3,is employed to simulate the baseline (1961—1990) climate for evaluation of model’s capacity of simu- lating present climate and analyze the future climate change responses in the time-slice of 2071—2100 (2080s) under SRES B2 scenario over China relative to baseline average. It is indicated from the com- parison of the simulated baseline climate with in situ observation that PRECIS can simulate the local dis- tribution characteristics of surface air temperature over China quite well; generally speaking,the simu- lation for precipitation in the north of China and in winter is better than in the south of China and in summer,respectively; the simulation of precipitation in summer is sensitive to topography,and the simu- lated precipitation values are lower than observations over southeast coastal areas. It is shown from the analyses on the simulated climate change responses in 2080s under SRES B2 scenario relative to base- line that there would be an obvious surface air tem- perature increase in the north of China relative to that in the south of China,and especially in Northwest China and Northeast China,the amplitude ofsummer mean surface air temperature increments could reach 5℃; there would be an overall increase of the simulated precipitation in 2080s under SRES B2 scenario over most areas of China,while there would be significant precipitation decreases in South China in winter; there would be obvious precipitation decreases in Northeast China and North China in summer with high surface air temperature increase. However,it presents an obvious precipitation in- crease over the middle and lower reaches of the Yangtze River in summer. | XU Yinlong ZHANG Yong LIN Erda LIN Wantao DONG Wenjie Richard Jones David Hassell Simon Wilson | 2006 | Chinese Science Bulletin2006，51，18： | 39 |
| 8 | Crop Phenomics and High-Throughput Phenotyping:Past Decades,Current Challenges,and Future Perspectives显示文摘Since whole-genome sequencing of many crops has been achieved,crop functional genomics studies have stepped into the big-data and high-throughput era.However,acquisition of large-scale phenotypic data has become one of the major bottlenecks hindering crop breeding and functional genomics studies.Nevertheless,recent technological advances provide us potential solutions to relieve this bottleneck and to explore advanced methods for large-scale phenotyping data acquisition and processing in the coming years.In this article,we review the major progress on high-throughput phenotyping in controlled environments and field conditions as well as its use for post-harvest yield and quality assessment in the past decades.We then discuss the latest multi-omics research combining high-throughput phenotyping with genetic studies.Finally,we propose some conceptual challenges and provide our perspectives on how to bridge the phenotype-genotype gap.It is no doubt that accurate high-throughput phenotyping will accelerate plant genetic improvements and promote the next green revolution in crop breeding. | Wanneng Yang Hui Feng Xuehai Zhang Jian Zhang John H.Doonan William David Batchelor Lizhong Xiong Jianbing Yan | 2020 | Molecular Plant2020，13，2： | 38 |
| 9 | Chinese Stroke Center Alliance:a national effort to improve healthcare quality for acute stroke and transient ischaemic attack:rationale,design and preliminary findings显示文摘Background In June 2015,the Chinese Stroke Association(CSA)initiated the Chinese Stroke Center Alliance(CSCA)to establish the national hospital-based stroke care quality assessment and improvement platform.This article outlines its objectives,operational structure,patient population,quality improvement(QI)intervention tools,data elements,data collection methodology and current patient and hospital data.Methods The CSCA is a national,hospital-based,multicentre,voluntary,multifaceted intervention and continuous QI initiative.This multifaceted intervention includes stroke centre development,written care protocols,workshops and a monitoring/feedback system of evidencebased performance measures.The data coordinating centre of the CSCA resides at the China National Clinical Research Center for Neurological Diseases,Beijing Tiantan Hospital.results As of July 2017,1576 hospitals in China have contributed detailed clinical information to serve as a benchmark for the stroke care quality of 433264 patients with acute stroke/transient ischaemic attacks(TIA),including 352572(81.38%)acute ischaemic stroke,30362(7.01%)TIA,42080(9.71%)spontaneous intracranial haemorrhage,5505(1.27%)subarachnoid haemorrhage and 2745(0.63%)not specified stroke.Conclusion The CSCA programme is designed to establish a continuous national stroke registry and help healthcare providers develop stroke centres and treat patients in a consistent manner in accordance with accepted national guidelines and,ultimately,improve patient outcomes.It supports the CSA mission to reduce stroke burden in China. | Yongjun Wang Zixiao Li Yilong Wang Xingquan Zhao Liping Liu Xin Yang Caiyun Wang Hongqiu Gu Fuying Zhang Chunjuan Wang Ying Xian David Z Wang Qiang Dong Anding Xu Jizong Zhao Chinese Stroke Center Alliance investigators | 2018 | Stroke & Vascular Neurology2018，3，4： | 38 |
| 10 | Geochronology and significance of volcanic rocks in the Ning-Wu Basin of China显示文摘The Ning-Wu(Nanjing-Wuhu) Basin is one of the most important volcanic basins in the Middle-Lower Yangtze River Valley,eastern China.It consists of four volcanic units,i.e.,the Longwangshan,Dawangshan,Gushan,and Niangniangshan Formations.Their LA-ICP MS U-Pb zircon ages are 134.8±1.8,132.2±1.6,129.5±0.8,and 126.8±0.6 Ma,respectively.Results of this study indicate that all volcanic rocks in the Ning-Wu Basin were formed in the Early Cretaceous from 135 to 127 Ma,lasting 8-10 m.y.No Jurassic volcanic activities occurred in any of the volcanic basins of the Middle-Lower Yangtze River Valley,including the Ning-Wu Basin.These new chronological results provide significant evidence for further study of this region to improve our understanding of Mesozoic tectonic,magmatic,and metallogenic processes of eastern China. | ZHOU TaoFa FAN Yu YUAN Feng ZHANG LeJun QIAN Bin MA Liang YANG XiFei David R COOKE | 2011 | Science China Earth Sciences2011，54，2： | 33 |
| 11 | 萨拉乌苏河流域150 ka BP以来的粒度旋回显示文摘萨拉乌苏河流域米浪沟湾地层剖面 1 50 ka BP以来古流动砂丘砂与河湖相和古土壤在粒度上具有多次显著的粗细韵律交替变化 ,粒度参数 - Mz、σ、Sk、Kg和 SC/D亦随之响应为多波动峰谷交替的态势。同时 ,粒度特征值 - Φ5、Φ1 6、Φ2 5、Φ50、Φ75、Φ84、Φ95相应地表现为非常有节奏地跳动。据此 ,将米浪沟湾剖面划分为 2 7个粒度粗细沉积旋回 ,并认为其是 1 50ka BP以来在东亚冬夏古代季风交替影响下沙漠演变的一个颇为完整的气候 | 张宇红 李保生 靳鹤龄 David Dian ZHANG 阎满存 祝一志 李后信 姚春霞 罗开利 | 2001 | 地理学报2001，56，3： | 29 |
| 12 | Environmental records of lacustrine sediments in different time scales:Sediment grain size as an example显示文摘Sediment grain size is a conventional proxy of climatic changes. Larger sediment grain size is often interpreted to indicate dry climate during lower lake level while smaller sedi- ment grain size implies wet climate during higher lake level. Through detailed study on sediment grain sizes in Lake Erhai and Lake Chenghai, this paper reveals the different indication signifi- cances of sediment grain sizes in different time scales, different resolution investigations. For long time-scale and low resolution (102a or 103a) studies, larger sediment grain size indicates lower lake level, smaller lake area and drier climate while smaller sediment grain size indicates higher lake level, larger lake area and wetter climate. For short time-scale and high resolution (a or 10a) studies, larger sediment grain size reflects more rainfall and wetter climate while smaller sediment grain size reflects less rainfall and drier climate. Environmental information revealed by lacustrine sediment records is often different in different time scales because of the variance of sedimentation resolution, sampling resolution and dating precision. Therefore, paleoclimate im- plications of environmental proxies in long time-scale and low resolution investigations could not be mechanically applied to short time-scale and high resolution studies. Only after synthetically analyzing the influence manner and extent of all factors on the sediment records in different time scales, can credible conclusions be obtained. | CHEN Jing’an1, WAN Guojiang1, David Dian Zhang2, ZHANG Feng1 & HUANG Ronggui1 1. State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China 2. Department of Geography and Geology, University of Hong Kong, Pokfulam Road, Hong Kong, China | 2004 | Science China Earth Sciences2004，47，10： | 27 |
| 13 | Origins and evolution of plant diversity in the Hengduan Mountains, China显示文摘1.Introduction The Hengduan Mountains region(HDM)in southwest China,one of the earth's 34 biodiversity hotspots,is characterized by its unique geology,dramatic topography,a climate where snow and below freezing temperatures can occur on any day of the year,by its location at elevations averaging between(1400e)2000 and4500(e5300)meters above sea level(m a.s.l.),and by one of | Hang Sun Jianwen Zhang Tao Deng David E. Boufford | 2017 | Plant Diversity2017，39，4： | 28 |
| 14 | 中国季风沙区晚更新世以来环境及其变化显示文摘本文以对毛乌素沙漠萨拉乌苏河流域米浪沟湾地层剖面晚更新世—全新世砂丘与河湖相、古土壤互为叠覆的高分辨率的气候地层记录的认识出发,同时基于对中国北方现代冬春季节风沙、尘霾活动发生的区域性气候—地质过程的理解,将今释古,反演了该时期中国季风区沙漠沙地曾经历的27个沙漠扩缩的周期性变化,并认为该剖面风砂沉积是过去地质时代季风沙区乃至整个中国沙区类似由现代这种冬春季西伯利亚—蒙古反气旋风系即冬季风向南伸展导致的若干风沙风尘动态过程的结果,而河湖相和古土壤的发育则主要与季风沙区受惠于东亚夏季风的影响有关。 | 李保生 吴正 David Dian ZHANG 范安康 阎满存 孙武 靳鹤龄 董光荣 祝一志 高全洲 张甲申 | 2001 | 地质学报2001，75，1： | 26 |
| 15 | 萨拉乌苏河流域末次间冰期全球变化区域响应的主元素记录显示文摘萨拉乌苏河流域米浪沟湾剖面末次间冰期层系记录了8 5个风成的古砂丘砂与河湖相或/和古土壤构成的沉积旋回。通过对该层系主元素含量分布规律的分析,认为所述沉积旋回主要是由干湿寒暖气候旋回波动所致。研究亦表明,末次间冰期层系60LS—82S可进一步划分为5个层段,它们在时间和气候的主要阶段上与氧同位素5阶段中之5a、5b、5c、5d、5e诸亚段相近。不仅如此,若干反映冷干气候的风成砂丘砂堆积层位与末次间冰期GRIP冰芯δ18O及西太平洋暖池planktonicδ18O记录的冷凉事件,特别是与黄土高原记录的9次粉尘事件在时间上具有很好的对应关系。 | 吕玉晓 李保生 靳鹤龄 David Dian ZHANG 余雪飞 | 2004 | 中国沙漠2004，24，2： | 25 |
| 16 | On the tuning of electrical and thermal transport in thermoelectrics: an integrated theory–experiment perspective显示文摘During the last two decades,we have witnessed great progress in research on thermoelectrics.There are two primary focuses.One is the fundamental understanding of electrical and thermal transport,enabled by the interplay of theory and experiment;the other is the substantial enhancement of the performance of various thermoelectric materials,through synergistic optimisation of those intercorrelated transport parameters.Here we review some of the successful strategies for tuning electrical and thermal transport.For electrical transport,we start from the classical but still very active strategy of tuning band degeneracy(or band convergence),then discuss the engineering of carrier scattering,and finally address the concept of conduction channels and conductive networks that emerge in complex thermoelectric materials.For thermal transport,we summarise the approaches for studying thermal transport based on phonon–phonon interactions valid for conventional solids,as well as some quantitative efforts for nanostructures.We also discuss the thermal transport in complex materials with chemical-bond hierarchy,in which a portion of the atoms(or subunits)are weakly bonded to the rest of the structure,leading to an intrinsic manifestation of part-crystalline part-liquid state at elevated temperatures.In this review,we provide a summary of achievements made in recent studies of thermoelectric transport properties,and demonstrate how they have led to improvements in thermoelectric performance by the integration of modern theory and experiment,and point out some challenges and possible directions. | Jiong Yang Lili Xi Wujie Qiu Lihua Wu Xun Shi Lidong Chen Jihui Yang Wenqing Zhang Ctirad Uher David J Singh | 2016 | npj Computational Materials2016，，1： | 24 |
| 17 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 18 | Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases显示文摘Matrix metalloproteinases(MMPs) are members of the neutral proteinase family. They were previously thought to be anti-fibrotic because of their ability to degrade and remodel of extracellular matrix. However, recent studies have shown that MMPs are implicated in initiation and progression of kidney fibrosis through tubular cell epithelial–mesenchymal transition(EMT) as well as activation of resident fibroblasts, endothelial-mesenchymal transition(Endo MT) and pericyte-myofibroblast transdifferentiation. Interstitial macrophage infiltration has also been shown to correlate with the severity of kidney fibrosis in various chronic kidney diseases. MMPs secreted by macrophages, especially MMP-9, hasbeen shown by us to be profibrotic by induction of tubular cells EMT. EMT is mainly induced by transforming growth factor-β(TGF-β). However, MMP-9 was found by us and others to be up-regulated by TGF-β1 in kidney tubular epithelial cells and secreted by activated macrophages, resulting in EMT and ultimately kidney fibrosis. Therefore, MMP-9 may serve as a potential therapeutic target to prevent kidney fibrosis in chronic kidney disease. This review, by a particular focus on EMT, seeks to provide a comprehensive understanding of MMPs, especially MMP-9, in kidney fibrosis. | Hong Zhao Yanting Dong Xinrui Tian Thian Kui Tan Zhuola Liu Ye Zhao Yun Zhang David CH Harris Guoping Zheng | 2013 | World Journal of Nephrology2013，2，3： | 21 |
| 19 | Structural geometry of orogenic gold deposits: Implications for exploration of world-class and giant deposits显示文摘With very few exceptions, orogenic gold deposits formed in subduction-related tectonic settings in accretionary to collisional orogenic belts from Archean to Tertiary times. Their genesis, including metal and fluid source, fluid pathways, depositional mechanisms, and timing relative to regional structural and metamorphic events, continues to be controversial. However, there is now general agreement that these deposits formed from metamorphic fluids, either from metamorphism of intra-basinal rock sequences or de-volatilization of a subducted sediment wedge, during a change from a compressional to transpressional, less commonly transtensional, stress regime, prior to orogenic collapse. In the case of Archean and Paleoproterozoic deposits, the formation of orogenic gold deposits was one of the last events prior to cratonization. The late timing of orogenic gold deposits within the structural evolution of the host orogen implies that any earlier structures may be mineralized and that the current structural geometry of the gold deposits is equivalent to that at the time of their formation provided that there has been no significant post-gold orogenic overprint. Within the host volcano-sedimentary sequences at the province scale, world-class orogenic gold deposits are most commonly located in second-order structures adjacent to crustal scale faults and shear zones, representing the first-order ore-forming fluid pathways, and whose deep lithospheric connection is marked by lamprophyre intrusions which, however, have no direct genetic association with gold deposition. More specifically, the gold deposits are located adjacent to ~10°-25° district-scale jogs in these crustal-scale faults. These jogs are commonly the site of arrays of ~70° cross faults that accommodate the bending of the more rigid components, for example volcanic rocks and intrusive sills, of the host belts. Rotation of blocks between these accommodation faults causes failure of more competent units and/or reactivation and dilation of pre-existing structures, leading to deposit-scale focussing of ore-fluid and gold deposition.Anticlinal or antiformal fold hinges, particularly those of 'locked-up' folds with ~30° apical angles and overturned back limbs, represent sites of brittle-ductile rock failure and provide one of the more robust parameters for location of orogenic gold deposits.In orogenic belts with abundant pre-gold granitic intrusions, particularly Precambrian granitegreenstone terranes, the boundaries between the rigid granitic bodies and more ductile greenstone sequences are commonly sites of heterogeneous stress and inhomogeneous strain. Thus, contacts between granitic intrusions and volcano-sedimentary sequences are common sites of ore-fluid infiltration and gold deposition. For orogenic gold deposits at deeper crustal levels, ore-forming fluids are commonly focused along strain gradients between more compressional zones where volcano-sedimentary sequences are thinned and relatively more extensional zones where they are thickened. World-class orogenic gold deposits are commonly located in the deformed volcano-sedimentary sequences in such strain gradients adjacent to triple-point junctions defined by the granitic intrusions, or along the zones of assembly of micro-blocks on a regional scale. These repetitive province to district-scale geometrical patterns of structures within the orogenic belts are clearly critical parameters in geology-based exploration targeting for orogenic gold deposits. | David I.Groves M.Santosh Richard J.Goldfarb Liang Zhang | 2018 | Geoscience Frontiers2018，9，4： | 20 |
| 20 | 岭南粤东北地区晚第四纪红土与棕黄色沉积物的古气候转变记录显示文摘通过对南岭以南的粤东北地区河流沿岸晚第四纪地质调查,并主要以对临江地层剖面为代表的红土与棕黄色粉砂的时代、主氧化物——SiO2,Al2O3,TOFE(Fe2O3+FeO)和CIA值反映的古环境的研究结果认为,该地主要分布于一级阶地的红土属末次间冰期(距今132~73ka)湿热的类似于现代热带北缘季风气候环境背景下形成的网纹红土;上覆棕黄色粉砂层主要是末次冰期(距今73~11ka)暖温带季风气候环境的堆积,其中的风成砂——LJ3层位代表了其时气候恶化的极端时期.这一看法与前人对岭南及其以东的大量的古生物指示的古生态的研究结果颇为吻合.由此表明,粤东北甚至整个岭南地区从末次间冰期到末次冰期、从红土为嗣后的棕黄色粉砂沉积替代(甚至从大熊猫-剑齿象动物群演替为澎湖动物群),生物气候带确实经历了一场大规模的急剧的古地理环境变迁,这一研究可为全球变化影响下的中国低纬区域万年尺度的环境响应提供一个重要的地质学实证。 | 李保生 温小浩 David Dian Zhang 邱世藩 董玉祥 李志文 杜恕环 欧先交 李后信 牛东风 杨艺 | 2008 | 科学通报2008，53，22： | 18 |
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