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| 1 | Express,on of the novel adipokine ClqTNF-related protein 4 (CTRP4) suppresses colitis and colitis- associated colorectal cancer in mice显示文摘 | Yang Luo Xiaotong Wu Zhuang Ma Weifeng Tan Lanlan Wang Daxiang Na Guoying Zhang Ang Yin He Huang Dan Xia Yingmei Zhang Xueying Shi Lu Wang | 2016 | Cellular & Molecular Immunology2016，13，5： | 6 |
| 2 | Oligomeric proanthocyanidin protects retinal ganglion cells against oxidative stress-induced apoptosis显示文摘The death of retinal ganglion cells is a hallmark of many optic neurodegenerative diseases such as glaucoma and retinopathy.Oxidative stress is one of the major reasons to cause the cell death Oligomeric proanthocyanidin has many health beneficial effects including antioxidative and neuroprotective actions.Here we tested whether oligomeric proanthocyanidin may protect retina ganglion cells against oxidative stress induced-apoptosis in vitro.Retinal ganglion cells were treated with hydrogen peroxide with or without oligomeric proanthocyanidin3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay showed that treating retinal ganglion cell line RGC-5 cells with 20μmol/L oligomeric proanthocyanidin significantly decreased the hydrogen peroxide(H2O2)induced death.Results of flow cytometry and Hoechst staining demonstrated that the death of RGC-5 cells was mainly caused by cell apoptosis.We further found that expression of pro-apoptotic Bax and caspase-3 were significantly decreased while anti-apoptotic Bcl-2 was greatly increased in H2O2damaged RGC-5 cells with oligomeric proanthocyanidin by western blot assay.Furthermore,in retinal explant culture,the number of surviving retinal ganglion cells in H2O2-damaged retinal ganglion cells with oligomeric proanthocyanidin was significantly increased.Our studies thus demonstrate that oligomeric proanthocyanidin can protect oxidative stress-injured retinal ganglion cells by inhibiting apoptotic process. | Hui Wang Chanjuan Zhang Dan Lu Xiaoming Shu Lihong Zhu Renbing Qi Kwok-Fai So Daxiang Lu Ying Xu | 2013 | Neural Regeneration Research2013，8，25： | 5 |
| 3 | Functional characterization of the NF-kB binding site in the human NOD2 promoter显示文摘Nucleotide-binding and oligomerization domain 2(NOD2),a member of the NOD protein family,plays an important role in innate immunity.In response to pathogen attack,NOD2 stimulates cytokine and defensin production by activating nuclear factor(NF)-kB,a key transcription factor responsible for mediating downstream reactions.However,the mechanism linking NOD2 regulation and NF-kB activation is poorly understood.Using bioinformatics,we found a completely preserved canonical NF-kB binding site in the NOD2 core promoter(216 to 225 bp)in both humans and chimpanzees.The functional role of this NF-kB binding site was investigated using the enhanced green fluorescent protein(EGFP)reporter system,site-directed mutagenesis,the NF-kB activation inhibitor(JSH-23)and the chromatin immunoprecipitation(ChIP)assay.The results show that the NF-kB binding site is critical for regulation of the NOD2 gene.Either deletion of the NF-kB binding elements within the NOD2 promoter or treatment with an NF-kB activation inhibitor could lead to a significant loss of NOD2 promoter activity as detected by reporter gene assay.The canonical NF-kB binding site was bound by NF-kB as determined by the ChIP method.Based on these results,we suggest a positive feedback regulation between NF-kB and NOD2,which may represent an efficient mechanism in response to pathogen invasion. | Chaofeng Hu Liping Sun Yiling Hu Daxiang Lu Huadong Wang Suisheng Tang | 2010 | Cellular & Molecular Immunology2010，7，4： | 3 |
| 4 | R11 peptides can promote the molecular imaging of spherical nucleic acids for bladder cancer margin identification显示文摘One of the critical problems in bladder cancer(BC)management is the local recurrence of disease.However,achieving the accurate delineation of tumor margins intraoperatively remains extremely difficult due to the lack of effective tumor margin recognition technology.Herein,survivin molecular beacon(MB)and R11 peptide-linked spherical nucleic acids(SNAs)were synthesized as nanoprobes(AuNP-MB@R11)for sensitive detection of BC margins.Physicochemical properties proved that R11 peptides and survivin MB were successfully loaded onto the surface of SNAs.AuNP-MB@R11 had good stability against nuclease activity and high sensitivity and specificity to detect survivin single strand DNA(ssDNA)in vitro.According to cytology,R11 peptides could increase the BC targeting ability and membrane penetrability of SNAs.Notably,R11 peptides significantly promoted the disintegration of lysosomes and the release of SNAs to enhance fluorescence imaging quality.Further RNA sequencing proved that some genes and pathways related to endocytosis and lysosomes were significantly regulated,such as AGPAT5,GPD1L,and GRB2.In orthotopic BC models and a clinical sample from a patient with BC,AuNP-MB@R11 showed a more legible cancerous fluorescence margin and offered remarkably improved detection compared to those achieved by SNAs.R11 peptide-linked SNAs present promising potential to identify BC margin,which may help to improve the R0 resection rate in surgery and improve patients’quality of life. | Minghai Ma Pu Zhang Xiao Liang Daxiang Cui Qiuya Shao Haibao Zhang Mengzhao Zhang Tao Yang Lu Wang Nan Zhang Minxuan Jing Lu Zhang Weichao Dan Rundong Song Xi Liu Jiatao Hao Yuhang Chen Lijiang Gu Lei Wang Jinhai Fan | 2022 | Nano Research2022，15，3： | 1 |
| 5 | Rhynchophylline prevents cardiac dysfunction and improves survival in lipopolysaccharide-challenged mice via suppressing macrophage I-κBα phosphorylation显示文摘 | Wenjuan Cao Yuan Wang Xiuxiu Lv Xiaohui Yu Xiaojian Li Hongmei Li Yanping Wang Daxiang Lu Renbin Qi Huadong Wang | 2012 | International Immunopharmacology2012，，3： | 1 |
| 6 | Experimental investigation on capillary force of composite wick structure by IR thermal imaging camera显示文摘 | Tang Yong Deng Daxiang Lu Longsheng | 2010 | Experimental Thermal and Fluid Science2010，34，2： | 1 |
| 7 | Paeoniflorin improves survival in LPS-challenged mice through the suppression of TNF-α and IL-1β release and augmentation of IL-10 production显示文摘 | Wenjuan Cao Wei Zhang Jingjing Liu Yuan Wang Xuemei Peng Daxiang Lu Renbin Qi Yanping Wang Huadong Wang | 2010 | International Immunopharmacology2010，，2： | 1 |
| 8 | Curcumin improves spatial memory impairment induced by human immunodeficiency virus type 1 glycoprotein 120 V3 loop peptide in rats显示文摘 | TANG HONGMEI LU DAXIANG PAN RUI | 2009 | Life Sci2009，85，12： | 1 |
| 9 | Luteolin protects PC12 cells from rotenone-induced apoptosis显示文摘The 4-hydroxy-flavonoid compound luteolin is a phytoestrogen with antioxidant,anti-inflammatory,and anti-tumor properties.The present study analyzed the protective effects of luteolin against rotenone-induced PC12 cell apoptosis in a model of Parkinson's disease(PD). Rotenone(1.6 μmol/L) was utilized to establish the in vitro PD model,resulting in low cell viability and an apoptotic rate of 36.1%. Luteolin(100 μmol/L) pretreatment significantly ameliorated rotenone-induced damage,improved cell morphology and viability,decreased comet tail length,reduced the rate of apoptosis(11.8%),and down-regulated cleaved caspase-3 expression. Results demonstrate that luteolin protects PC12 cells against rotenone-induced apoptosis by decreasing cleaved caspase-3 expression. | Lihong Zhu Renbin Qi Huadong Wang Wei Bi Zhigang Wang Qi Zeng Yanru Zhao Daxiang Lu | 2010 | Neural Regeneration Research2010，5，24： | 0 |
| 10 | Assembly of Nanowires into Macroscopic One‑Dimensional Fibers in Liquid State显示文摘Natural structural materials,such as spider silk,wood,and bone,are universally acknowledged as the gold standard for the ideal combinations of strength and toughness.The exceptional integrated performance of these biological materials can be ascribed to their multiscale hierarchical architectures and components.Mimicking the hierarchical assembly feature of natural materials,artificial fibers,which are generated through the one-dimensional(1D)assembly of nanowires,have been widely reported with remarkable flexibility and functionality.Furthermore,the distinguishing feature of nanowires’1D assembly can bridge the unique properties of nanowires with their potential functional applications.This tutorial review summarizes the recent developments in the assembly of nanowires into macroscopic 1D fibers in the liquid state.We begin by introducing the general strategies and mechanisms for assembling nanowires in one direction and then,illustrate their potential applications in energy storage,sensors,biomedical engineering,etc.Finally,a brief summary and some personal perspectives on the future research directions of nanowires’1D assembly are also proposed. | Wentao Cao Xinyu Zhao Bingqiang Lu Daxiang Cui Feng Chen | 2023 | Advanced Fiber Materials2023，5，3： | 0 |
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