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| 1 | Enhancing both selectivity and coking-resistance of a single-atom Pd1/C3N4 catalyst for acetylene hydrogenation显示文摘选择加氢是在化学升级的一个重要工业催化过程,在因为他们的高加氢活动,基于 Pd 的催化剂广泛地被使用的地方。然而,因为重焦炭形成,差的选择和短催化剂一生是主要担心。在这个工作,原子地驱散 Pd 原子成功地在 graphitic 碳氮化物上被综合(g-C 3 用原子层免职的 N 4) 。没有 Pd nanoparticle (NP ) ,改正错误的高角度的环形的黑暗地的扫描传播电子显微镜学(HAADF 茎) 证实了孤立的 Pd 原子的主导的存在形成。在在过量乙烯的乙炔的选择加氢期间, g-C 3 N 4-supported Pd NP 催化剂比常规 Pd/Al 2 O 3 和 Pd/SiO 2 催化剂。在原处, X 光检查光致核裂变光谱学表明可观的费用从 Pd NP 转到 g-C 3 N 4 多半在催化表演改进起一个重要作用。更给人深刻印象地,单个原子的 Pd 1/C3 N 4 催化剂展出了两种更高的乙烯选择和更高的 coking 抵抗。我们的工作证明单个原子的 Pd 催化剂是在加氢反应改进选择和焦炭抵抗的一个有希望的候选人。 | Xiaohui Huang Yujia Xia Yuanjie Cao Xusheng Zheng Haibin Pan Junfa Zhu Chao Ma Hengwei Wang Junjie Li Rui You Shiqiang Wei Weixin Huang Junling Lu | 2017 | Nano Research2017，10，4： | 16 |
| 2 | Research on failure scenarios of domes based on form vulnerability显示文摘In this paper, form vulnerability theory was applied to the analysis of the failure mechanisms of single-layer latticed spherical shells subjected to seismic excitations. Three 1/10 scale testing models were designed with characteristics as follows: Model 1 possesses overall uniform stiffness and is expected to collapse in the strength failure mode as some members become plastic; Model 2 possesses six man-made weak parts located on six radial main rib zones and is expected to collapse in the dynamic instability mode with all members still in the elastic stage; Model 3 strengthens the six weak zones of Model 2, and therefore, its stiffness is uniform. Model 3 is proposed to collapse in the strength failure mode when the members are still in the elastic stage. By increasing the peak ground accelerations of seismic waves gradually, the shaking table tests were carried out until all three models collapsed (or locally collapsed). On the basis of form vulnerability theory, topological hierarchy models of the test models were established through a clustering process, and various failure scenarios, including overall collapse scenarios and partial collapse scenarios, were identified by unzipping corresponding hierarchical models. By comparison of the failure scenarios based on theoretical analysis and experiments, it was found that vulnerability theory could effectively reflect the weakness zones in topological relations of the structures from the perspective of internal causes. The internal mechanisms of the distinct failure characteristics of reticulated shells subjected to seismic excitations were also revealed in this process. The well-formedness of structural clusters, Q, is closely related to the collapse modes, i.e., uniform changes of Q indicate a uniform distribution of overall structural stiffness, which indicates that strength failure is likely to happen; conversely, non-uniform changes of Q indicate that weak zones exist in the structure, and dynamic instability is likely to occur. | YE JiHong LIU WenZheng PAN Rui | 2011 | Science China(Technological Sciences)2011，54，11： | 15 |
| 3 | Oroxindin inhibits macrophage NLRP3 inflammasome activation in DSS-induced ulcerative colitis in mice via suppressing TXNIP-dependent NF-κB pathway显示文摘Oroxindin is a flavonoid isolated from the traditional Chinese medicine Huang-Qin,which has shown various pharmacological activities including anti-inflammatory,antitumor,antioxidant,etc.Thus far,the effect of oroxindin on colonic inflammation and the underlying mechanism remain unknown.In this study,we investigated the tissue distribution of oroxindin and its therapeutic effects on ulcerative colitis(UC)as well as the underlying mechanisms.UC model was established in mice by administrating dextran sulfate sodium(DSS)in drinking water for 7 d.We first showed that oroxindin was largely absorbed by the colon as an active ingredient after normal mice received Huang-Qin-Tang,a traditional Chinese medicine decoction.UC mice were then treated with oroxindin(12.5,25,50 mg-kg^-1·d^-1,i.g.)for 10 d.We found that oroxindin treatment greatly suppressed massive macrophages infiltration and attenuated pathological changes in colonic tissue.Furthermore,oroxindin treatment significantly inhibited the generation of IL-13 and IL-18 in the colon via inhibiting the nucleotide-binding oligomerization domain-like receptor 3(NLRP3)inflammasome formation and activation.In cultured macrophages,LPS induced NLRp3 inflammasome formation and caspase-1 activation,which were suppressed by oroxindin(12.5-50μM).In LPS-treated macrophages,oroxindin dose-dependently restored the expression of TXNIP protein,leading to suppressing TXNIP-dependent NF-κB activation.In conclusion,these results demonstrate that oroxindin could be absorbed by the colon and attenuate inflammatory responses via inhibiting NLRP3 inflammasome formation and activation,which is related to the inhibitory effect on TXNIP-dependent NF-κB-signaling pathway.Hence,oroxindin has the potential of becoming an effective drug for treating UC. | Qi Liu Rui Zuo Kai Wang Fei-fei Nong Ya-jun Fu Shao-wei Huang Zeng-feng Pan Yi Zhang Xia Luo Xiang-liang Deng Xiao-xue Zhang Lian Zhou Yang Chen | 2020 | Acta Pharmacologica Sinica2020，41，6： | 15 |
| 4 | Curcumin improves learning and memory ability and its neuroprotective mechanism in mice显示文摘背景增加证据建议许多神经原可以在 Alzheimer 的疾病(广告) 通过 apoptosis 死 .Mitochondrial 机能障碍在 neuronal 房间死亡的这个过程被含有。为阻止广告的一条有希望的途径在 anti-apoptosis 之上被基于到神经细胞的减少死亡。在这研究,我们观察了在老鼠改进 curcumin 的性质的记忆并且 intraperitoneally 在 vitro 并且在老鼠口头上地被给 AlCl3 的 vivo.Methods 和 D 半乳糖的注射调查了 curcumin 的 neuroprotective 效果 90 天建立 AD 动物模型。从白天 45, curcumin 组与 curcumin 被对待 45 天。随后,走彻底地测试,在马头鱼尾的怪兽的 neuropathological 变化和 Bax 和 Bcl-2 的表达式被执行在 AD 模型鼠标上评估 curcumin 的效果。在有教养的 PC12 房间, AlCl3 暴露导致了 apoptosis。MTT 试金被用来测量房间生存能力;流动 cytometric 分析将调查房间 apoptosis 的率;观察原子核的DNA有约束力的 fluorochrome Hoechst 33258 在 apoptotic 房间和 Bax 的西方的污点分析变化,调查 curcumin 显著地由保护房间免受 toxicity.Results Curcumin 的伤害的机制的 Bcl-2 在走彻底地测试改进了广告老鼠的记忆能力,是由走彻底地错误的减少的数字显示了( P < 0.05 )并且延长走彻底地潜伏( P < 0.05 )。Curcumin 也稀释了在马头鱼尾的怪兽和禁止的 apoptosis 的变化由 Bcl-2 水平的增加伴随了的 neuropathological (P < 0.05 ) ,但是 Bax 的活动没变化(P > 0.05 ) 。AlCl3 显著地减少了 PC12 房间的生存能力(P < 0.01 ) 。Curcumin 面对 AlCl3 增加了房间生存能力(P < 0.01 ) 。apoptosis 的率在 curcumin 组显著地减少了(P < 0.05 ) 当由流动 cytometric 分析测量了时。Curcumin 由增加 Bcl-2 水平保护了房间(P < 0.05 ) ,但是 Bax 的水平没变化(P > 0.05 ) 这研究表明的 .Conclusions curcumin 改进广告鼠标的存储器能力并且在有教养的 PC12 房间禁止 apoptosis,这由 AlCl3 导致了。它的机制可以涉及提高 Bcl-2 的水平。 | PAN Rui QIU Sheng LU Da-xiang DONG Jun | 2008 | Chinese Medical Journal2008，，9： | 14 |
| 5 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 6 | Improving grain yield, nitrogen use efficiency and radiation use efficiency by dense planting, with delayed and reduced nitrogen application, in double cropping rice in South China显示文摘Improving both grain yield and resource use efficiencies simultaneously is a major challenge in rice production.However,few studies have focused on integrating dense planting with delayed and reduced nitrogen application to enhance grain yield,nitrogen use efficiency (NUE) and radiation use efficiency (RUE) in rice (Oryza sativa L.) in the double rice cropping system in South China.A high-yielding indica hybrid rice cultivar (Yliangyou 143) was grown in field experiments in Guangxi,South China,with three cultivation managements:farmers’practice (FP),dense planting with equal N input and delayed N application (DPEN) and dense planting with reduced N input and delayed N application (DPRN).The grain yields of DPRN reached 10.6 and 9.78 t ha^(–1) in the early and late cropping seasons,respectively,which were significantly higher than the corresponding yields of FP by 23.9–29.9%.The grain yields in DPEN and DPRN were comparable.NUE in DPRN reached 65.2–72.9 kg kg^(–1),which was 61.2–74.1% higher than that in FP and 24.6–30.2% higher than that in DPEN.RUE in DPRN achieved 1.60–1.80 g MJ^(–1),which was 28.6–37.9% higher than that in FP.The productive tiller percentage in DPRN was 7.9–36.2% higher than that in DPEN.Increases in crop growth rate,leaf area duration,N uptake from panicle initiation to heading and enhancement of the apparent transformation ratio of dry weight from stems and leaf sheaths to panicles all contributed to higher grain yield and higher resource use efficiencies in DPRN.Correlation analysis revealed that the agronomic and physiological traits mentioned above were significantly and positively correlated with grain yield.Comparison trials carried out in Guangdong in 2018 and 2019 also showed that DPRN performed better than DPEN.We conclude that DPRN is a feasible approach for simultaneously increasing grain yield,NUE and RUE in the double rice cropping system in South China. | FU You-qiang ZHONG Xu-hua ZENG Jia-huan LIANG Kai-ming PAN Jun-feng XIN Ying-feng LIU Yan-zhuo HU Xiang-yu PENG Bi-lin CHEN Rong-bing HU Rui HUANG Nong-rong | 2021 | Journal of Integrative Agriculture2021，20，2： | 12 |
| 7 | Benzene alkylation with methanol over phosphate modified hierarchical porous ZSM-5 with tailored acidity显示文摘The acidity and acid distribution of hierarchical porous ZSM-5 were tailored via phosphate modification. The catalytic results showed that both benzene conversion and selectivity of toluene and xylene increased with the presence of appropriate amount of phosphorus. Meanwhile, side reactions such as methanol to olefins related with the formation of by-product ethylbenzene formation and isomerization of xylene to meta-xylene were suppressed efficiently. The acid strength and sites amount of Br?nsted acid of the catalyst were crucial for improving benzene conversion and yield of xylene, whereas passivation of external surface acid sites played an important role in breaking thermodynamic equilibrium distribution of xylene isomers. | Jinghui Lyu Hualei Hu Carolyn Tait Jiayao Rui Caiyi Lou Qingtao Wang Wenwen Han Qunfeng Zhang Zhiyan Pan Xiaonian Li | 2017 | Chinese Journal of Chemical Engineering2017，25，9： | 11 |
| 8 | Commissioning progress of the FAST显示文摘The Five-hundred-meter Aperture Spherical radio Telescope(FAST) was completed with its main structure installed on September 25, 2016, after which it entered the commissioning phase. This paper aims to introduce the commissioning progress of the FAST over the past two years. To improve its operational reliability and ensure effective observation time, FAST has been equipped with a real-time information system for the active reflector system and hierarchical commissioning scheme for the feed support system, which ultimately achieves safe operation of the two systems. For meeting the high-performance indices, a highprecision measurement system was set up based on the effective control methods that were implemented for the active reflector system and feed support system. Since the commissioning of the FAST, a low-frequency ultra-wideband receiver and 19-beam1.05-1.45 GHz receiver have been mainly used. Telescope efficiency, pointing accuracy, and system noise temperature were completely tested and ultimately achieved the acceptance indices of the telescope. The FAST has been in the process of national acceptance preparations and has begun to search for pulsars. In the future, it will still strive to improve its capabilities and expand its application prospects. | Peng Jiang YouLing Yue HengQian Gan Rui Yao Hui Li GaoFeng Pan JingHai Sun DongJun Yu HongFei Liu NingYu Tang Lei Qian JiGuang Lu Jun Yan Bo Peng ShuXin Zhang QiMing Wang Qi Li Di Li | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，5： | 11 |
| 9 | Associations between individual and environmental factors and habitual physical activity among older Chinese adults:A social–ecological perspective显示文摘Purpose: To examine, within a social–ecological framework, associations between multifaceted individual and environmental factors and habitual physical activity(HPA) among older Chinese adults.Methods: Through a mix of qualitative and quantitative methods, a survey instrument assessing various factors underlying 3 social–ecological dimensions of intrapersonal, interpersonal, and community and environmental resources was developed. Using a cross-sectional design, older adults(n = 1580, aged 67 ± 7 years) recruited from 10 communities in Shandong province completed the social–ecological survey of HPA. Data were analyzed using Partial Least Squares Path Modeling.Results: Factors related to intrapersonal(medical knowledge, motivation, physical function, sport skills, socioeconomic status, and education),interpersonal(social support, social activity, and social norms), and community and physical environmental resources(safety, capacity, availability of and access to physical activity facilities) were found to be significantly associated with older adults' participation in HPA.Conclusion: The findings provide an initial validation of a social–ecological approach to the study of HPA in China, suggesting that strategies aimed at promoting physical activity in older adults should address multiple levels of factors that may contribute to the likelihood of older Chinese adults being physically active. | Xiangren Yi Zachary Pope Zan Gao Shumei Wang Fang Pan Jingpeng Yan Meng Liu Peipei Wu Jingjing Xu Rui Wang | 2016 | Journal of Sport and Health Science2016，5，3： | 11 |
| 10 | Percent free prostate-specific antigen is effective to predict prostate biopsy outcome in Chinese men with prostate-specific antigen between 10.1 and 20.0 ng ml^-1显示文摘 | Rui Chen Li-Qun Zhou Xiao-Bing Cai Li-Ping Xie Yi-Ran Huang Da-Lin He Xu Gao Chuan-Liang Xu Qiang Ding Qiang wei Chang-Jun Yin Shan-Cheng Ren Fu-Bo Wang Ye Tian Zhong-Quan Sun Qiang Fu Lu-Lin Ma Jun-Hua Zheng Zhang-Qun Ye Ding-Wei Ye Dan-Feng Xu Jian-Quan Hou Ke-Xin Xu Jian-Lin Yuan Xin Gao Chun-Xiao Liu Tie-Jun Pan Ying-Hao Sun | 2015 | Asian Journal of Andrology2015，17，6： | 10 |
| 11 | Effects of estrogen receptor GPR30 agonist G1 on neuronal apoptosis and microglia polarization in traumatic brain injury rats显示文摘 | Meng-Xian Pan Jun-Chun Tang Rui Liu Yu-Gong Feng Qi Wan | 2018 | Chinese Journal of Traumatology2018，21，4： | 10 |
| 12 | Mangiferin inhibited neuroinflammation through regulating microglial polarization and suppressing NF-κB,NLRP3 pathway显示文摘Inflammation plays important roles in the progress of neurodegenerative diseases,such as Parkinson’s disease and Alzheimer’s disease.Microglia is responsible for the homeostasis of the central nervous system(CNS),and involved in the neuroinflammation.Therefore,it could be potential in treatment of neurodegenerative diseases to suppress the microglia-mediated neuroinflammation.Mangiferin,a major glucoside of xanthone in Anemarrhena Rhizome,has anti-inflammatory,anti-diabetes,and anti-oxidative properties.However,the effect of mangiferin on the inflammatary responses of microglia cells are still poorly understand.In this study,we investigated the mechanism by which mangiferin inhibited inflammation in LPS-induced BV2 microglia cells.BV2 cells were pretreatment with mangiferin followed by LPS stimulation.In vitro assays,NO and cytokines production were quantified.Western blot and immunocytochemistry were used to examine the effect of mangiferin on the polarization of BV2 cells and signaling pathway.The results showed that mangiferin treatment significantly reduced NO,IL-1β,IL-6 and TNF-αproduction,also reduced the mRNA and protein of iNOS and COX-2,promoted the polarization of inflammatory toward anti-inflammatory,and inhibited activation of NF-κB and NLRP3 inflammasome.These data suggest that mangiferin has an anti-neuroinflammatory property via regulating microglia macrophage polarization and suppressing NF-κB and NLRP3 signaling pathway,and may act as a potential natural therapeutic candidate for neuroinflammatory diseases. | LEI Li-Yan WANG Rui-Cheng PAN Ya-Lei YUE Zheng-Gang ZHOU Rui XIE Pei TANG Zhi-Shu | 2021 | Chinese Journal of Natural Medicines2021，19，2： | 10 |
| 13 | Sediment texture and grain-size implications: the Changjiang subaqueous delta显示文摘Sediment cores were collected from the subaqueous delta of the Changjiang Estuary. Sediment grain-size profiles and their fractal dimensions were analyzed, to elucidate responses to long-term sedimentary processes. In addition, the environmental sensitive populations of grain size have been extracted. The sediment cores can be divided into two parts, according to the sedimentary structures present. The upper part (0-12 cm) is interpreted as being the active layer, which is influenced frequently by changes in the short-term hydrodynamic environment. The lower part extends from a depth of 12 cm, to the bottom of the core. The pattern of fluctuation is linked to sediment grain size. Moreover, two grain-size sensitive populations can be identified. The fine sensitive population is 6.0-7.2 μm, which is a similar grain size to the suspended sediment from up-river. The coarse sensitive population varies from 40.7 to 57.5 μm, revealing complex changes. Thus, the riverine inputs from the Changjiang River may be an important source, which contributes to seasonal fluctuations of grain-size distribution, over the area. The sediments, with grain-sizes ranging from 0.9 to 20.3 μm, are characterised by self-similar in the fractal non-scale region. The fractal dimension is consistant with the grain-size parameter varatioins, which could be used as a replacement index to reveal and reconstruct the sedimentary environmental evolution. | ZHANG Rui WANG Yaping GAO Jianhua PAN Shaoming | 2009 | Acta Oceanologica Sinica2009，28，4： | 7 |
| 14 | Distribution of organic carbon in sediments and its influences on adjacent sea area in the turbidity maximum of Changjiang Estuary in China显示文摘Distributions and sources of total organic carbon(TOC)in seabed sediments and their implications for hydrodynamics are analyzed,in the turbidity maximum of the Changjiang Estuary.Ecology ecoenvironmental effects of estuary water on the continuously increasing terrigenous organic carbon from the Changjiang River are also explored through variations of organic carbon content and water quality indicators.Results show that,hydrodynamics exert important influences on distributions of organic carbon in the turbidity maximum of Changjiang Estuary.For their redistribution effect of terrigenous organic carbon within the moving layer in the whole region,variations from land to sea are not indicated by surficial and vertical average values of TOC and total nitrogen(TN)contents in core sediment,as well as organic stable carbon isotopes in surface sediments.However,on the long-time scale,the trend of terrigenous organic carbon decreasing from land to sea is still displayed by variations of stable carbon isotopic average values becoming heavier from land to sea.Previous studies have shown that high content of Chl a cannot appear in the Changjiang Estuary in despite of adequate nourishment supply,because photosynthesis of phytoplankton is constrained by high suspended sediment concentration(SSC).However,an area with a high content of Chl a occurs,which may be caused by resuspended benthic algae with bottom fine grain-size sediments.Tremendous pressures are imposed on the environment of Changjiang Estuary,because of ultrophication trends and special hydrodynamics.Phytoplankton bloom area tends to extend from the outer sea to the mouth of Changjiang River. | GAO Jianhua WANG Yaping PAN Shaoming ZHANG Rui LI Jun BAI Fenglong | 2008 | Acta Oceanologica Sinica2008，27，4： | 7 |
| 15 | Morphologies of Al_4Sr Intermetallic Phase and Its Modification Property upon A356 Alloys显示文摘In general,the modification performance of Al-Sr master alloys is primarily dependent upon the morphologies and sizes of the Al_4Sr intermetallic phase.In this paper,the crystal structure,morphologies,sizes,hardness and elastic modulus of Al_4Sr in Al-Sr master alloys prepared from variant processes were studied by means of optical metallurgical microscope,X-ray diffraction(XRD),scanning electron microscopy(SEM),and nanoindentation system.The results revealed that the microstructures and modification performance of the Al_4Sr phase were related to the preparation processes.That is to say,when a 'direct reaction-hot extrusion' process was used,the Al_4Sr phase exhibited a homogeneous distribution in the Al matrix with small size and roundish shapes,which ensured the Al-Sr master alloy wire advantages involving high recovery,good reproducibility,no delitescence of modification,no corrosion on equipments,and good workability.However,in the case of the traditional 'direct reaction' process,the Al4Sr phase was in large size with shapes of rectangular stripe and plates,which limited the Sr content increasing due to the brittleness of the Al-Sr alloy.It was also found that the morphology and size of the Al_4Sr phases changed during heat treatment at high temperature up to 600 ℃. | Chengwei Liao Jianchun Chun Yang Li Rui Tu Chunxu Pan | 2012 | Journal of Materials Science & Technology2012，28，6： | 7 |
| 16 | Spatial distributions of organic carbon and nitrogen and their isotopic compositions in sediments of the Changjiang Estuary and its adjacent sea area显示文摘全部的器官的碳和全部的氮的空间分发模式与华东海架的水流显示出重要关联。相应于这些水流的分布。 | GAO Jianhua WANG Yaping PAN Shaoming ZHANG Rui LI Jun BAI Fenglong | 2008 | Journal of Geographical Sciences2008，18，1： | 7 |
| 17 | FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation显示文摘F 盒子和 WD 重复包含域 7 (FBW7 ) , E3 ubiquitin ligase SCF FBW7 (SKP1, cullin-1 和 FBW7 的建筑群) ,在各种各样的生理、病理学的过程起重要作用。尽管 FBW7 为脉管的开发被要求,它在内皮细胞层的函数尚待被调查。在这研究,我们证明 FBW7 是 endothelial 功能的一个重要管理者,包括 angiogenesis,白血球粘附和 endothelial 障碍正直。用 RNA 干扰,我们发现 FBW7 的弄空显著地在 vitro 并且在 vivo 损害 angiogenesis。我们识别了锌手指抄写因素 Krü象 ppel 一样因素 2 (KLF2 ) 作为在 endothelial 房间的 FBW7 的一个生理的目标。FBW7 击倒表示在 endothelial 房间导致了内长的 KLF2 蛋白质的累积。调停 FBW7 的 KLF2 破坏被显示在二保存 phosphodegrons 经由肝糖 synthase kinase-3 (GSK3 ) 取决于 KLF2 的 phosphorylation。变异这些 phosphodegron 主题废除了 KLF2 的调停 FBW7 的降级和 ubiquitination。调停 siRNA 显示出的 FBW7 击倒 KLF2 是在 endothelial 的规定的 FBW7 的一个必要目标,这工作。而且,调停 FBW7 的 KLF2 降级被显示为在 teratomas 并且在 zebrafish 开发的 angiogenesis 批评。一起拿,我们的学习在 endothelial 房间移植, angiogenesis,发炎和障碍完整的进程为 FBW7 建议一个角色,并且在 vivo 提供新奇卓见进 KLF2 稳定性的规定。 | Rui Wang Yah Wang Ning Liu Chunguang Ren Cong Jiang Kai Zhang Su Yu Yunfei Chen Hui Tang Qi Deng Cong Fu Yingcong Wang Rong Li Mingyao Liu Weijun Pan Ping Wang | 2013 | Cell Research2013，23，6： | 7 |
| 18 | Sarsasapogenin-AA13 inhibits LPS-induced inflammatory responses in macrophage cells in vitro and relieves dimethylbenzene-induced ear edema in mice显示文摘Sarsasapogenin-AA13 (AA13 ) 是从中国植物根茎 Anemarrhenae 提取的 sarsasapogenin 的新奇合成衍生物。在我们调查了的这研究, lipopolysaccharide (LPS ) 上的 AA13 的效果在导致 dimethylbenzene 的耳朵浮肿的一个煽动性的模型在巨噬细胞房间和 AA13 的反煽动性的活动导致了煽动性的因素的生产。巨噬细胞房间(RAW264.7 房间和老鼠腹巨噬细胞) 暴露于 LPS (1 g/mL ) ;有 AA13 (5-20 mol/L ) 的预告的处理 dose-dependently 禁止了导致 LPS 的生产没有, TNF- 和 PGE 2, 和 COX-2 和 iNOS 的刺激 LPS 的表示层次。而且,有 AA13 的预告的处理 dose-dependently 压制了 p38 和 JNK 的刺激 LPS 的 phosphorylation,但是没在 RAW264.7 房间在英皇家空军之阶级最低之兵上有效果。而且,有 AA13 的预告的处理禁止了原子因素(NF ) 的导致 LPS 的激活在 RAW264.7 房间的 -B。在里面 vivo AA13 的反煽动性的活动在一只老鼠被表明煽动性的模型:有任何一个 AA13 的预告的处理(20 mg 戠潬正牥 ? 均 ? 财?? | Dong DONG Nan-nan ZHOU Rui-xuan LIU Jia-wei XIONG Hui PAN Si-qi SUN Lei MA Rui WANG | 2017 | Acta Pharmacologica Sinica2017，38，5： | 7 |
| 19 | Nitridation:A simple way to improve the catalytic performance of hierarchical porous ZSM-5 in benzene alkylation with methanol显示文摘Nitrided hierarchical porous ZSM-5 was synthesized by nitridation of hierarchical porous ZSM-5 with flowing ammonia at elevated temperature.The samples were characterized by XRD,SEM,Nitrogen sorption isotherms,NH3-TPD and Py-IR,and evaluated in alkylation of benzene and methanol.The result indicated that the high specific surface area of parent ZSM-5 was maintained,while the Bronsted acidity was effectively adjusted by nitridation.Moreover,the high suppression of ethylbenzene was observed on nitrided catalyst and this could be attributed to the decrease of Bronsted acidity which suppressed the methanol to olefins reactions. | Jing-Hui Lyu Hua-Lei Hu Jia-Yao Rui Qun-Feng Zhang Jie Cen Wen-Wen Han Qing-Tao Wang Xiao-Kun Chen Zhi-Yan Pan Xiao-Nian Li | 2017 | Chinese Chemical Letters2017，28，2： | 6 |
| 20 | Famitinib in combination with concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 1, open-label, dose-escalation Study显示文摘Background:Famitinib is a tyrosine kinase inhibitor against multiple targets,including vascular endothelial growth factor receptor 2/3,platelet-derived growth factor receptor,and stem cell factor receptor(c-kit).Previous studies have demonstrated anti-tumour activities of famitinib against a wide variety of advanced-stage solid cancers.We aimed to determine the safety and efficacy of famitinib with concurrent chemoradiotherapy(CCRT)in patients with locoregionally advanced nasopharyngeal carcinoma(NPC).We also evaluated the feasibility of contrast-enhanced ultrasound(D-CEUS)as a predictor of early tumour response to famitinib and to correlate functional parameters with clinical efficacy.Methods:The trial was conducted in subjects with stage III or IVa-b NPC using a 3+3 design of escalating fami-tinib doses.Briefly,subjects received 2 weeks of famitinib monotherapy followed by 7 weeks of famitinib plus CCRT.D-CEUS of the neck lymph nodes was performed at day 0,8 and 15 after famitinib was administered before starting concurrent chemoradiotherapy.End points included safety,tolerability and anti-tumour activity.Results:Twenty patients were enrolled(six each for 12.5,16.5 and 20 mg and two for 25 mg).Two patients in the 25 mg cohort developed dose-limiting toxicities,including grade 4 thrombocytopenia and grade 3 hypertension.The most common grade 3/4 adverse events were leukopenia,neutropenia and radiation mucositis.D-CEUS tests showed that more than 60%of patients achieved a perfusion parameter response after 2 weeks taking famitinib alone,and the parameter response was associated with disease improvement.In the famitinib monotherapy stage,three patients(15%)showed partial responses.The complete response rate was 65%at the completion of treatment and 95%3 months after the treatment ended.After a median follow-up of 44 months,the 3-year progression-free survival(PFS)and distant metastasis-free survival were 70%and 75%,respectively.Subjects with a decrease of perfusion parameter response,such as peak intensity decreased at least 30%after 1 week of famitinib treatment,had higher 3-year PFS(90.9%vs.44.4%,95%CI 73.7%-100%vs.11.9%-76.9%,P<0.001)than those with an increase or a reduction of less than 30%.Conclusions:The recommended famitinib dose for phase II trial is 20 mg with CCRT for patients with local advanced NPC.D-CEUS is a reliable and early measure of efficacy for famitinib therapies.Further investigation is required to confirm the effects of famitinib plus chemoradiotherapy. | Qiuyan Chen Linquan Tang Na Liu Feng Han Ling Guo Shanshan Guo Jianwei Wang Huai Liu Yanfang Ye Lu Zhang Liting Liu Pan Wang Yingqin Li Qingmei He Xiaoqun Yang Qingnan Tang Yang Li YuJing Liang XueSong Sun Chuanmiao Xie Yunxian Mo Ying Guo Rui Sun Haoyuan Mo Kajia Cao Xiang Guo Musheng Zeng Haiqiang Mai Jun Ma | 2018 | Cancer Communications2018，38，1： | 6 |
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